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  1. Article ; Online: Management of pediatric pemphigus vulgaris with rituximab: A case report and review of the literature.

    Mistry, Bhavik Dipak / Leis, Maria / Lee, David Michael / Levy, Rebecca

    Pediatric dermatology

    2022  Volume 39, Issue 6, Page(s) 960–966

    Abstract: Pemphigus vulgaris (PV), an acquired autoimmune bullous disease, is caused by autoantibodies targeting desmosomal proteins in the skin and mucous membranes. Recent data from the adult PV population supports the use of rituximab, a chimeric anti-CD20 IgG1 ...

    Abstract Pemphigus vulgaris (PV), an acquired autoimmune bullous disease, is caused by autoantibodies targeting desmosomal proteins in the skin and mucous membranes. Recent data from the adult PV population supports the use of rituximab, a chimeric anti-CD20 IgG1 antibody, as a primary treatment strategy, but limited data exist regarding treatment in the pediatric population. We report the case of a 13-year-old male with PV treated successfully with systemic corticosteroids and rituximab, and review the literature supporting the treatment of pediatric PV with rituximab.
    MeSH term(s) Male ; Adult ; Child ; Humans ; Adolescent ; Pemphigus/drug therapy ; Rituximab/therapeutic use ; Autoantibodies ; Skin ; Immunologic Factors/therapeutic use
    Chemical Substances Rituximab (4F4X42SYQ6) ; Autoantibodies ; Immunologic Factors
    Language English
    Publishing date 2022-07-24
    Publishing country United States
    Document type Review ; Case Reports
    ZDB-ID 605539-4
    ISSN 1525-1470 ; 0736-8046
    ISSN (online) 1525-1470
    ISSN 0736-8046
    DOI 10.1111/pde.15095
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1882: Show issues Location:
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  2. Article: Prurigo Nodularis: Review and Emerging Treatments.

    Leis, Maria / Fleming, Patrick / Lynde, Charles W

    Skin therapy letter

    2021  Volume 26, Issue 3, Page(s) 5–8

    Abstract: Prurigo nodularis (PN) is a chronic, recalcitrant inflammatory skin condition characterized by the presence of pruritic nodules. The exact pathogenesis of the disease is unknown, although immune and neural dysregulation are indicated in driving the ... ...

    Abstract Prurigo nodularis (PN) is a chronic, recalcitrant inflammatory skin condition characterized by the presence of pruritic nodules. The exact pathogenesis of the disease is unknown, although immune and neural dysregulation are indicated in driving the itchscratch cycle. Specifically, interleukin-4 and interleukin-31 pathways have been recently implicated in transmission of the pruritic sensation. There are currently no US FDA-approved targeted therapies for the treatment of PN. This article aims to review our present understanding of the disease pathogenesis and treatments, with a focus on emerging therapeutics. Specifically, this article explores the developing use of monoclonal antibodies nemolizumab and dupilumab, opioid receptor modulation and cannabinoids as potential treatments for PN.
    MeSH term(s) Antibodies, Monoclonal/therapeutic use ; Humans ; Neurodermatitis ; Prurigo/drug therapy
    Chemical Substances Antibodies, Monoclonal
    Language English
    Publishing date 2021-07-24
    Publishing country Canada
    Document type Journal Article ; Review
    ZDB-ID 2065394-3
    ISSN 1201-5989
    ISSN 1201-5989
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  3. Article ; Online: Auditing a recently implemented massive hemorrhage protocol: feasibility of assessing pre-specified metrics and compliance.

    Leis, Maria / Clarfield, Lauren / Lin, Yulia / Gupta, Akash / Da Luz, Luis

    CJEM

    2023  Volume 25, Issue 3, Page(s) 255–256

    MeSH term(s) Humans ; Benchmarking ; Feasibility Studies ; Hemorrhage/diagnosis ; Hemorrhage/etiology ; Hemorrhage/therapy ; Guideline Adherence
    Language English
    Publishing date 2023-01-05
    Publishing country England
    Document type Letter
    ISSN 1481-8043
    ISSN (online) 1481-8043
    DOI 10.1007/s43678-023-00449-7
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  4. Article: Emergency departments as under-utilized venues to provide HIV prevention services to female sex workers in Nairobi, Kenya.

    Poxon, Amanda / Leis, Maria / McDermott, Miranda / Kariri, Antony / Kaul, Rupert / Kimani, Joshua

    International journal of emergency medicine

    2023  Volume 16, Issue 1, Page(s) 47

    Abstract: Background: Female sex workers (FSW) in sub-Saharan Africa are disproportionately affected by HIV and remain a key target population for efforts to reduce transmission. While HIV prevention tools such as PEP and PrEP are available through outpatient FSW ...

    Abstract Background: Female sex workers (FSW) in sub-Saharan Africa are disproportionately affected by HIV and remain a key target population for efforts to reduce transmission. While HIV prevention tools such as PEP and PrEP are available through outpatient FSW clinics, these services are underused. Emergency medicine is a rapidly expanding field in Kenya and may provide a novel venue for initiating or optimizing HIV prevention services. This study examined the characteristics of FSW from Nairobi, Kenya, who had utilized an emergency department (ED) during the past year to broaden our understanding of the patient factors related to usage.
    Methods: An anonymous questionnaire was administered to a convenience sample of 220 Nairobi FSW attending dedicated clinics from June to July 2019. The participants were categorized into those who attended an ED over the past year (acute care users) and clinic-only users (control). A modified version of the WHO Violence Against Women Instrument assessed gender-based violence. Multivariable negative binomial logistic regressions evaluated predictors of health care use among these populations.
    Results: Of the total 220 women (median [IQR] age 32 [27-39]), 101 and 116 were acute care and control populations, respectively. Acute care users had 12.7 ± 8.5 healthcare visits over a 12-month period, and the control population had 9.1 ± 7.0 (p < 0.05). ED attendance did not improve the PrEP usage, with 48.5%, and 51% of acute care and clinic users indicated appropriate PrEP use. Patient factors that correlated with health care utilization among acute care users included client sexual violence (OR 2.2 [1.64-2.94], p < 0.01), PrEP use (OR 1.54 (1.25-1.91), < 0.01), and client HIV status (OR 1.35 (1.02-1.69), p < 0.01).
    Conclusions: Many FSW at high risk for HIV were not accessing HIV prevention tools despite attending a dedicated FSW clinic offering such services. FSW who had attended an ED over the past year had a higher prevalence of HIV risk factors, demonstrating that emergency departments may be important acute intervention venues to prevent HIV transmission in this population. These results can guide policy design, health care provider training, and facility preparedness to support strategies aimed at improving HIV prevention strategies for FSW in Kenyan ED's.
    Language English
    Publishing date 2023-08-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 2411462-5
    ISSN 1865-1380 ; 1865-1372
    ISSN (online) 1865-1380
    ISSN 1865-1372
    DOI 10.1186/s12245-023-00516-x
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  5. Article ; Online: Impacts of COVID-19 on Dermatologic Practice, Disease Presentation, and Immunomodulator Prescriptions.

    Leis, Maria / Fleming, Patrick / Lynde, Charles W

    Journal of cutaneous medicine and surgery

    2020  Volume 25, Issue 1, Page(s) 106–108

    MeSH term(s) Ambulatory Care/statistics & numerical data ; COVID-19 ; Dermatologic Agents/therapeutic use ; Dermatologists/statistics & numerical data ; Dermatology/organization & administration ; Dermatology/statistics & numerical data ; Humans ; Immunologic Factors/therapeutic use ; Prescriptions/statistics & numerical data ; SARS-CoV-2 ; Skin Diseases/diagnosis ; Skin Diseases/drug therapy
    Chemical Substances Dermatologic Agents ; Immunologic Factors
    Keywords covid19
    Language English
    Publishing date 2020-09-16
    Publishing country United States
    Document type Letter
    ZDB-ID 1361720-5
    ISSN 1615-7109 ; 1203-4754
    ISSN (online) 1615-7109
    ISSN 1203-4754
    DOI 10.1177/1203475420960437
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    Zs.A 4987: Show issues Location:
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  6. Article: Certolizumab Pegol in Plaque Psoriasis: Considerations for Pregnancy.

    Strain, Jeremy / Leis, Maria / Lee, Kyle O / Fleming, Patrick

    Skin therapy letter

    2021  Volume 26, Issue 2, Page(s) 1–5

    Abstract: Psoriasis is a chronic, immune-mediated skin condition which commonly affects women of childbearing age. Certolizumab pegol (CZP) is an anti-tumor necrosis factor-alpha (anti-TNFα) agent that has demonstrated long-term safety and efficacy in treating ... ...

    Abstract Psoriasis is a chronic, immune-mediated skin condition which commonly affects women of childbearing age. Certolizumab pegol (CZP) is an anti-tumor necrosis factor-alpha (anti-TNFα) agent that has demonstrated long-term safety and efficacy in treating moderate-to-severe plaque psoriasis. Previously, there has been limited safety data surrounding its use in pregnancy. The objective of this article is to review pivotal clinical trial data for CZP and explore safety considerations for this agent in pregnancy. This review demonstrates that CZP offers a safe and effective treatment option for women during childbearing years based on pharmacokinetics and available safety data. The observed occurrence of major congenital malformations and miscarriages appears to be no greater than the background occurrence of those in the general population, and risks to the mother are minimal based on its known safety profile. The use of CZP for treatment of plaque psoriasis should be considered and discussed with patients considering childbearing or whom are currently pregnant or breastfeeding.
    MeSH term(s) Certolizumab Pegol/adverse effects ; Certolizumab Pegol/therapeutic use ; Female ; Humans ; Immunosuppressive Agents/adverse effects ; Immunosuppressive Agents/therapeutic use ; Pregnancy ; Pregnancy Complications/drug therapy ; Prenatal Care ; Psoriasis/drug therapy
    Chemical Substances Immunosuppressive Agents ; Certolizumab Pegol (UMD07X179E)
    Language English
    Publishing date 2021-03-26
    Publishing country Canada
    Document type Journal Article ; Review
    ZDB-ID 2065394-3
    ISSN 1201-5989
    ISSN 1201-5989
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5605: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  7. Article: Risk of Vulvar Squamous Cell Carcinoma in Lichen Sclerosus and Lichen Planus: A Systematic Review.

    Leis, Maria / Singh, Ashmita / Li, Calandra / Ahluwalia, Renita / Fleming, Patrick / Lynde, Charles W

    Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC

    2021  Volume 44, Issue 2, Page(s) 182–192

    Abstract: Objectives: The objectives of this study were to determine: 1) the prevalence of lichen sclerosus (LS) and lichen planus (LP) present in association with vulvar squamous cell carcinoma (VSCC), and 2) the incidence and absolute risk of developing VSCC in ...

    Abstract Objectives: The objectives of this study were to determine: 1) the prevalence of lichen sclerosus (LS) and lichen planus (LP) present in association with vulvar squamous cell carcinoma (VSCC), and 2) the incidence and absolute risk of developing VSCC in LS and LP.
    Methods: A search was performed of MEDLINE, EMBASE and CINAHL databases. Three independent reviewers screened articles published before September 1, 2020, first on title/abstract and then on the full text. Women with a history of VSCC, human papillomavirus, smoking, or autoimmune disease were excluded. Newcastle-Ottawa observational study scales were used to assess the risk of bias and methodological quality of the included studies. Of the 3132 studies assessed, 31 were selected for analysis. Due to study heterogeneity, a qualitative synthesis was conducted.
    Results: The prevalence of LS and LP in association with VSCC ranged from 0% (95% CI 0-5) to 83% (95% CI 36-100) and 1% (95% CI 0-7) to 33% (95% CI 4-78), respectively. The incidence of VSCC ranged from 1.16 (95% CI 0.03-6.44) to 13.67 (95% CI 5.50-28.17) per 1000 person-years for LS. The absolute risk of developing VSCC in patients ranged from 0.0% (95% CI 0.0-5.52) to 21.88% (95% CI 9.28-39.97) with LS and was 1.16% (95% CI 0.1-4.1) with LP. Incidence was not calculable for LP owing to study characteristics.
    Conclusions: This review provides evidence that there is an increased risk of developing VSCC in women with LS, while associations with LP are less clear. Early identification, treatment, and long-term follow-up are essential to prevent potential malignant progression of these vulvar dermatoses.
    MeSH term(s) Carcinoma, Squamous Cell/epidemiology ; Carcinoma, Squamous Cell/pathology ; Female ; Humans ; Lichen Planus/complications ; Lichen Planus/epidemiology ; Lichen Sclerosus et Atrophicus/complications ; Lichen Sclerosus et Atrophicus/epidemiology ; Observational Studies as Topic ; Vulva/pathology ; Vulvar Neoplasms/epidemiology ; Vulvar Neoplasms/pathology
    Language English
    Publishing date 2021-10-19
    Publishing country Netherlands
    Document type Journal Article ; Review ; Systematic Review
    ZDB-ID 2171082-X
    ISSN 1701-2163
    ISSN 1701-2163
    DOI 10.1016/j.jogc.2021.09.023
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    Zs.A 6445: Show issues Location:
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  8. Article ; Online: Recognition of vocal socioemotional expressions at varying levels of emotional intensity.

    Morningstar, Michele / Gilbert, Annie C / Burdo, Jessica / Leis, Maria / Dirks, Melanie A

    Emotion (Washington, D.C.)

    2021  Volume 21, Issue 7, Page(s) 1570–1575

    Abstract: Nonverbal expressions of emotion can vary in intensity, from ambiguous to prototypical exemplars: for instance, facial displays of happiness may range from a faint smile to a full-blown grin. Previous work suggests that the accuracy with which facial ... ...

    Abstract Nonverbal expressions of emotion can vary in intensity, from ambiguous to prototypical exemplars: for instance, facial displays of happiness may range from a faint smile to a full-blown grin. Previous work suggests that the accuracy with which facial expressions are recognized as the intended emotion increases with emotional intensity, although this pattern depends on the displayed emotion. Less is known about the association between emotional intensity and the recognition of vocal emotional expressions (affective prosody), which also convey information about others' socioemotional intent but are perceived and interpreted differently than facial expressions. The current study examined listeners' ability to recognize emotional intent in morphed vocal prosody recordings that varied in emotional intensity from neutral to prototypical exemplars of basic emotions (anger, disgust, fear, happiness, sadness) and social expressions (friendliness, meanness). Results suggest that listeners' accuracy in identifying the intended emotional intent in each recording increased nonlinearly with emotional intensity. This pattern varied by emotion type: for instance, accuracy for anger rose steeply with increasing emotional intensity before plateauing, whereas accuracy for happiness remained unchanged across low-intensity exemplars but increased thereafter. These findings highlight emotion-specific ways in which dynamic changes in emotional intensity inform perceptions of socioemotional intent in emotional prosody. Moreover, these results also point to potential challenges in emotional communication in social interactions that rely primarily on the voice, with many low-intensity expressions having a higher probability of being misinterpreted. (PsycInfo Database Record (c) 2021 APA, all rights reserved).
    MeSH term(s) Emotions ; Facial Expression ; Happiness ; Humans ; Recognition, Psychology ; Voice
    Language English
    Publishing date 2021-09-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2102391-8
    ISSN 1931-1516 ; 1528-3542
    ISSN (online) 1931-1516
    ISSN 1528-3542
    DOI 10.1037/emo0001024
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  10. Article ; Online: Impacts of COVID-19 on Dermatologic Practice, Disease Presentation, and Immunomodulator Prescriptions

    Leis, Maria / Fleming, Patrick / Lynde, Charles W.

    Journal of Cutaneous Medicine and Surgery

    2020  , Page(s) 120347542096043

    Keywords Surgery ; Dermatology ; covid19
    Language English
    Publisher SAGE Publications
    Publishing country us
    Document type Article ; Online
    ZDB-ID 1361720-5
    ISSN 1615-7109 ; 1203-4754
    ISSN (online) 1615-7109
    ISSN 1203-4754
    DOI 10.1177/1203475420960437
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