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  1. Article ; Online: Successful hematopoietic stem cell mobilization with vinorelbine and filgrastim in germ cell tumor.

    Carneiro-Silva, Fabiana Aguiar / Brunetta, Denise Menezes / Kaufman, Jacques / Leitão, João Paulo Vasconcelos / Barroso, Karine Sampaio Nunes / Barbosa, Suzanna Araújo Tavares / Carlos, Luciana Maria de Barros / Barroso-Duarte, Fernando

    Clinical and experimental medicine

    2017  Volume 17, Issue 3, Page(s) 417–418

    Abstract: Germ cell tumor (GCT) is the most frequent cancer in young men and is highly curable. Almost 80 % of patients with the disease in an advanced stage achieve a reliable response to cisplatin combination chemotherapy. For relapsing or refractory disease, ... ...

    Abstract Germ cell tumor (GCT) is the most frequent cancer in young men and is highly curable. Almost 80 % of patients with the disease in an advanced stage achieve a reliable response to cisplatin combination chemotherapy. For relapsing or refractory disease, autologous hematopoietic stem cell transplantation (HSCT) is an effective therapy. The two most used mobilization strategies for HSC collection are filgrastim alone or filgrastim after chemotherapy (chemomobilization). HSC collection with filgrastim mobilization can be difficult, especially in highly treated patients. While the addition of chemotherapy improves mobilization and reduces the number of apheresis sessions, it can increase morbidity rate as well. We describe a case of a 45-year-old male with classical seminoma who was submitted to orchiectomy. Two months after, he presented progression of the tumor. He received four cycles of cisplatin, etoposide and bleomycin, with residual retroperitoneal mass and cervical lymphadenopathy. Further, he was submitted to three more cycles of cisplatin, ifosfamide and paclitaxel. Thereupon, he showed partial response. At that moment, autologous HSC transplantation was considered. In the first mobilization, filgrastim alone was used without success in harvesting. The second mobilization consisted of vinorelbine at day 1 (35 mg/m
    Language English
    Publishing date 2017-08
    Publishing country Italy
    Document type Letter
    ZDB-ID 2053018-3
    ISSN 1591-9528 ; 1591-8890
    ISSN (online) 1591-9528
    ISSN 1591-8890
    DOI 10.1007/s10238-016-0425-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Association of oxidative stress and DNA damage with grafting time in patients with multiple myeloma and lymphoma submitted to autologous hematopoietic stem cell transplantation.

    Santos, Thayna Nogueira Dos / Duarte, Fernando Barroso / Maia Filho, Pedro Aurio / Santos, Talyta Ellen de Jesus Dos / Barbosa, Maritza Cavalcante / Almeida Filho, Tarcísio Paulo de / Cavalcanti, Bruno Coelho / Vasconcelos, Paulo Roberto Leitão de / Dutra, Luana Leticia / Lopes, Germison Silva / Costa, Franciclea Oliveira / Leitão, João Paulo Vasconcelos / KauFman, Jacques / AraúJo, Beatriz Stella Pitombeira / Barroso, Karine Sampaio Nunes / Lemes, Romélia Pinheiro Gonçalves

    Revista da Associacao Medica Brasileira (1992)

    2016  Volume 62 Suppl 1, Page(s) 39–43

    Abstract: The aim of the study was to investigate the association between oxidative stress and DNA damage with grafting time in patients submitted to autologous hematopoietic stem-cell transplantation (HSCT). The study included 37 patients submitted to autologous ... ...

    Abstract The aim of the study was to investigate the association between oxidative stress and DNA damage with grafting time in patients submitted to autologous hematopoietic stem-cell transplantation (HSCT). The study included 37 patients submitted to autologous HSCT diagnosed with Multiple Myeloma (MM) and lymphoma (Hodgkin's and non-Hodgkin's). Biomarkers of oxidative stress and DNA damage index (DI) were performed at baseline (pre-CR) of the disease and during the conditioning regimen (CR), one day after the HSCT, ten days after HSCT and twenty days after HSCT, as well as in the control group consisting of 30 healthy individuals. The outcomes showed that both groups of patients had an hyperoxidative state with high DI when compared to baseline and to the control group and that the CR exacerbated this condition. However, after the follow-up period of the study, this picture was re-established to the baseline levels of each pathology. The study patients with MM showed a mean grafting time of 10.75 days (8 to 13 days), with 10.15 days (8 to 15 days) for the lymphoma patients. In patients with MM, there was a negative correlation between the grafting time and the basal levels of GPx (r = -0.54; p = 0.034), indicating that lower levels of this important enzyme are associated with a longer grafting time. For the DI, the correlation was a positive one (r = 0.529; p = 0.030). In the group with lymphoma, it was observed that the basal levels of NOx were positively correlated with grafting time (r = 0.4664, p = 0.032). The data indicate the potential of these biomarkers as predictors of toxicity and grafting time in patients with MM and Lymphomas submitted to autologous HSCT.
    MeSH term(s) Analysis of Variance ; Biomarkers ; Case-Control Studies ; DNA Damage/physiology ; Female ; Hematopoietic Stem Cell Transplantation/methods ; Humans ; Lymphoma/genetics ; Lymphoma/metabolism ; Lymphoma/surgery ; Male ; Malondialdehyde/analysis ; Multiple Myeloma/genetics ; Multiple Myeloma/metabolism ; Multiple Myeloma/surgery ; Oxidative Stress/physiology ; Reference Values ; Time Factors ; Transplantation, Autologous/methods ; Treatment Outcome
    Chemical Substances Biomarkers ; Malondialdehyde (4Y8F71G49Q)
    Language English
    Publishing date 2016-10
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 2027973-5
    ISSN 1806-9282 ; 0104-4230
    ISSN (online) 1806-9282
    ISSN 0104-4230
    DOI 10.1590/1806-9282.62.suppl1.39
    Database MEDical Literature Analysis and Retrieval System OnLINE

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