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  1. Article ; Online: Can SARS-CoV-2 induce hematologic malignancies in predisposed individuals? A case series and review of the literature.

    Costa, Bruno Almeida / da Luz, Kaiza Vilarinho / Campos, Sarah Emanuelle Viana / Lopes, Germison Silva / Leitão, João Paulo de Vasconcelos / Duarte, Fernando Barroso

    Hematology, transfusion and cell therapy

    2022  Volume 44, Issue 1, Page(s) 26–31

    Abstract: Introduction: Coronavirus disease 2019 (COVID-19) may present with extrapulmonary manifestations, including hematologic changes. Previous studies suggest that severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) can interact with the renin- ... ...

    Abstract Introduction: Coronavirus disease 2019 (COVID-19) may present with extrapulmonary manifestations, including hematologic changes. Previous studies suggest that severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) can interact with the renin-angiotensin system, ultimately causing increased production of angiotensin II. By reporting the cases of previously healthy young adults diagnosed with a hematologic malignancy after experiencing COVID-19, we raise the hypothesis that the SARS-Cov-2 infection could act as a trigger for leukemogenesis in predisposed individuals.
    Methods: This was a case series performed through extraction of relevant clinical information from the medical records of three patients admitted to our Hematology unit between August 2020 and September 2020.
    Main results: Considering the relatively rapid development of cytopenias following recovery from COVID-19, it cannot be ruled out that SARS-Cov-2 played a role in leukemogenesis in those patients. Based on previous
    Conclusion: Despite the advances in pathophysiological and clinical characterization of COVID-19, the consequences of the pandemic to the incidence of hematologic diseases are still to be elucidated. In this context, future dissection of the status of the local bone marrow renin-angiotensin system in leukemogenesis is a clinically relevant basic research area.
    Language English
    Publishing date 2022-01-19
    Publishing country Brazil
    Document type Journal Article
    ISSN 2531-1387
    ISSN (online) 2531-1387
    DOI 10.1016/j.htct.2021.11.015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: T-cell/myeloid mixed-phenotype acute leukemia with monocytic differentiation and isolated 17p deletion.

    Lopes, Germison Silva / Leitão, João Paulo de Vasconcelos / Kaufman, Jacques / Duarte, Fernando Barroso / Matos, Daniel Mazza

    Revista brasileira de hematologia e hemoterapia

    2014  Volume 36, Issue 4, Page(s) 293–296

    Abstract: Mixed phenotype acute leukemia is a rare subtype of leukemia that probably arises from a hematopoietic pluripotent stem cell. The co-expression of two of myeloid, B- or T-lymphoid antigens is the hallmark of this disease. Herein, the case of a 28-year- ... ...

    Abstract Mixed phenotype acute leukemia is a rare subtype of leukemia that probably arises from a hematopoietic pluripotent stem cell. The co-expression of two of myeloid, B- or T-lymphoid antigens is the hallmark of this disease. Herein, the case of a 28-year-old female patient is reported who presented with hemoglobin of 5.8g/dL, white blood cell count of 138×10(9)/L and platelet count of 12×10(9)/L. The differential count of peripheral blood revealed 96% of blasts. Moreover, the patient presented with lymphadenopathy, splenomegaly and bone marrow infiltration by monocytoid blasts characterized as 7% positivity by Sudan Black cytochemical staining. Immunophenotyping revealed the involvement of blasts of both T- and monocytic lineages. The cytogenetic analysis showed an isolated 17p deletion. Thus, the diagnosis of T-cell/myeloid mixed phenotype acute leukemia was made with two particular rare features, that is, the monocytic differentiation and the 17p deletion as unique cytogenetic abnormalities. The possibility of concomitant expressions of T-cell and monocytic differentiation antigens in the same blast population is hard to explain using the classical model of hematopoiesis. However, recent studies have suggested that myeloid potential persists even when the lineage branches segregate toward B- and T-cells. The role of an isolated 17p deletion in the pathogenesis of this condition is unclear. At present, the patient is in complete remission after an allogeneic stem cell transplantation procedure.
    Language English
    Publishing date 2014-04-03
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 2105177-X
    ISSN 1806-0870 ; 1516-8484
    ISSN (online) 1806-0870
    ISSN 1516-8484
    DOI 10.1016/j.bjhh.2014.03.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Immunohistochemistry contribution in the diagnosis of splenic marginal zone lymphoma.

    Mesquita, Juliene Lima / Rosales, Yensy Mariana Zelaya / Garcia, Yhasmine Delles Oliveira / Rocha Filho, Francisco Dario / Araujo, Beatriz Stela Gomes de Sousa Pitombeira / Leitão, João Paulo de Vasconcelos / Costa, Jesus Irajacy / Duarte, Beatrice Araújo / Duarte, João Vitor Araújo / Lemes, Romélia Pinheiro Gonçalves / Duarte, Fernando Barroso

    Revista da Associacao Medica Brasileira (1992)

    2020  Volume 66, Issue 5, Page(s) 580–582

    MeSH term(s) Humans ; Immunohistochemistry ; Lymphoma/immunology ; Lymphoma/pathology ; Lymphoma/surgery ; Male ; Middle Aged ; Splenectomy ; Splenic Neoplasms/immunology ; Splenic Neoplasms/pathology ; Splenic Neoplasms/surgery ; Splenomegaly/etiology ; Treatment Outcome
    Language English
    Publishing date 2020-07-03
    Publishing country Brazil
    Document type Case Reports ; Journal Article
    ZDB-ID 731969-1
    ISSN 1806-9282 ; 0104-4230 ; 0004-5241 ; 0102-843X
    ISSN (online) 1806-9282
    ISSN 0104-4230 ; 0004-5241 ; 0102-843X
    DOI 10.1590/1806-9282.66.5.580
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  4. Article ; Online: Wernicke's encephalopathy in a patient with non-Hodgkin's lymphoma post-Autologous HSCT.

    Leitão, João Paulo de Vasconcelos / Lemes, Romélia Pinheiro Gonçalves / Barbosa, Maritza Cavalcante / Araújo, Beatriz Stela Gomes de Souza Pitombeira / Barroso, Karine Sampaio Nunes / Kaufman, Jacques / Santos, Talyta Ellen de Jesus Dos / Moura, Anna Thawanny Gadelha / Barreto, André Rodrigues Façanha / Duarte, Fernando Barroso

    Revista da Associacao Medica Brasileira (1992)

    2018  Volume 64, Issue 10, Page(s) 882–884

    Abstract: Wernick's Encephalopathy (WE) is an acute neuropsychiatric syndrome caused by thiamine deficiency post hematopoietic stem cell transplant (HSCT). WE is associated with high mortality and morbidity rates, but due to its rare occurrence, it is rarely ... ...

    Abstract Wernick's Encephalopathy (WE) is an acute neuropsychiatric syndrome caused by thiamine deficiency post hematopoietic stem cell transplant (HSCT). WE is associated with high mortality and morbidity rates, but due to its rare occurrence, it is rarely considered in patients submitted to this procedure. Considering that, the manuscript reports the clinical characteristics and the possible factors that predisposed the occurrence of WE in a patient with non-Hodgkin's lymphoma post-Autologous HSCT. We conclude that WE should be considered in patients submitted to autologous HSCT associated with prolonged use of TPN and malnutrition.
    MeSH term(s) Adult ; Female ; Hematopoietic Stem Cell Transplantation/adverse effects ; Humans ; Lymphoma, Non-Hodgkin/therapy ; Risk Factors ; Thiamine Deficiency/complications ; Transplantation, Autologous ; Wernicke Encephalopathy/diagnostic imaging ; Wernicke Encephalopathy/etiology
    Language English
    Publishing date 2018-12-03
    Publishing country Brazil
    Document type Case Reports ; Journal Article
    ZDB-ID 2027973-5
    ISSN 1806-9282 ; 0104-4230
    ISSN (online) 1806-9282
    ISSN 0104-4230
    DOI 10.1590/1806-9282.64.10.882
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Aortobronchopulmonary fistula in the postoperative period of aortic coarctation.

    Coelho Júnior, Antônio Fernando / Araújo Filho, Antônio Amorim de / Leitão, João Paulo de Vasconcelos / Cabral Júnior, Francisco

    Arquivos brasileiros de cardiologia

    2009  Volume 92, Issue 4, Page(s) e50–2

    Abstract: Background and objectives: In patients with hemoptysis and a history of aortic surgery, the possibility of aortobronchopulmonary fistula must always be considered. The objective of this study was to report a rare case of hemoptysis due to ... ...

    Abstract Background and objectives: In patients with hemoptysis and a history of aortic surgery, the possibility of aortobronchopulmonary fistula must always be considered. The objective of this study was to report a rare case of hemoptysis due to aortobronchopulmonary fistula in the late postoperative period of aortic surgery.
    Case report: Female patient, 34 years, surgical correction of aortic coarctation, presenting massive hemoptysis. The echocardiogram disclosed a pseudoaneurysm. The surgical correction was performed and a Dacron tube graft was implanted in the affected aortic segment successfully.
    Conclusions: Aortobronchopulmonary fistulas must be considered in patients with previous aortic surgery, due to the elevated morbimortality if they are not promptly diagnosed and treated.
    MeSH term(s) Adult ; Aortic Aneurysm, Thoracic/surgery ; Aortic Coarctation/surgery ; Bronchial Fistula/etiology ; Female ; Hemoptysis/etiology ; Humans ; Postoperative Complications/etiology ; Vascular Fistula/etiology
    Language Spanish
    Publishing date 2009-06-27
    Publishing country Brazil
    Document type Case Reports ; Journal Article
    ZDB-ID 730261-7
    ISSN 1678-4170 ; 0066-782X
    ISSN (online) 1678-4170
    ISSN 0066-782X
    DOI 10.1590/s0066-782x2009000400016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 548: Show issues Location:
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  6. Article ; Online: L-alanyl-glutamine dipeptide pretreatment attenuates ischemia-reperfusion injury in rat testis.

    Leitão, João Paulo de Vasconcelos / Santos, Jefferson Menezes Viana / Vasconcelos, Raquel Cavalcante de / Garcia, José Huygens Parente / Vasconcelos, Paulo Roberto Leitão de / Guimarães, Sergio Botelho

    Acta cirurgica brasileira

    2011  Volume 26 Suppl 1, Page(s) 21–25

    Abstract: Purpose: To investigate the effect of alanyl-glutamine dipeptide (L-Ala-Gln) pre-treatment on ischemia-reperfusion (I/R) injury after unilateral testicular torsion-detorsion in a comparative controlled experiment.: Methods: Forty-eight rats (150-200 ... ...

    Abstract Purpose: To investigate the effect of alanyl-glutamine dipeptide (L-Ala-Gln) pre-treatment on ischemia-reperfusion (I/R) injury after unilateral testicular torsion-detorsion in a comparative controlled experiment.
    Methods: Forty-eight rats (150-200 g) randomly distributed into 4 groups (n=12), and distributed in 2 subgroups (n=6) each, were treated with saline 2.0 ml (G-1, G-3) or L-Ala-Gln 20%, 0.75g/kg dissolved in saline (total volume 2.0 ml) administered in the left saphenous vein 30 minutes before ischemia. Anesthetized rats were subjected to I/R induced by torsion (720°) of the right spermatic cord lasting 1h (G-1, G-2) or 3 hours (G-3, G4). Anesthesia was again applied at the end of ischemia time (T-0) for testis detorsion and 6 hours later (T-6) for orchiectomy. All operations were performed on the right testes through transverse scrotal incisions. Right orchiectomy was carried out at the end of ischemia (T-0), and 6 hours later (T-6) to evaluate the concentrations of malondialdehyde (MDA) and reduced glutathione (GSH) in the testis.
    Results: Pretreatment with L-Ala-Gln reduced MDA contents in rat testis at the end of ischemia lasting 3 hours. There was significant increase of GSH levels in T-6 time-point after 1 hour of ischemia. GSH levels also increased in T-0 and T-6 time-points in rats subjected to ischemia for 3 hours.
    Conclusion: L-Ala-Gln administered before torsion/detorsion of the spermatic cord decreases lipid peroxidation during ischemia and protects the testis from oxidative stress by upregulating GSH levels during reperfusion.
    MeSH term(s) Animals ; Dipeptides/blood ; Dipeptides/pharmacology ; Disease Models, Animal ; Glutathione/blood ; Ischemia/complications ; Ischemic Preconditioning/methods ; Male ; Malondialdehyde/blood ; Oxidative Stress/drug effects ; Random Allocation ; Rats ; Rats, Wistar ; Reperfusion Injury/prevention & control ; Spermatic Cord Torsion/complications ; Testis/blood supply ; Time Factors ; Treatment Outcome
    Chemical Substances Dipeptides ; Malondialdehyde (4Y8F71G49Q) ; Glutathione (GAN16C9B8O) ; alanylglutamine (U5JDO2770Z)
    Language English
    Publishing date 2011-09-04
    Publishing country Brazil
    Document type Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2012156-8
    ISSN 1678-2674 ; 0102-8650
    ISSN (online) 1678-2674
    ISSN 0102-8650
    DOI 10.1590/s0102-86502011000700005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Hodgkin's Lymphoma - evaluation of patients submitted to Autologous transplantation of hematopoietic cells in the Hematology Service of the Hospital Walter Cantídio - Fortaleza, Brazil.

    Duarte, Fernando Barroso / Fernandes, Mabel Gomes de Brito / Kaufmann, Jacques / Barroso, Karine Sampaio Nunes / Leitão, João Paulo de Vasconcelos / Araujo, Beatriz Stela Gomes de Souza Pitombeira / Costa, Clara Maria Bastos Eloy da / Quixadá-Medica, Acy Teles / Holanda, Jacqueline de Souza / Landim, Samuel Vasconcelos / Pitombeira, Maria Helena

    Revista da Associacao Medica Brasileira (1992)

    2016  Volume 62 Suppl 1, Page(s) 34–38

    Abstract: The Autologous HSCT is an important alternative for refractory or recurrent HL patients in terms of survival and improved quality of life. This study analyzes the results of autologous BMT performed in HL patients in the Transplant Unit of the HUWC/ ... ...

    Abstract The Autologous HSCT is an important alternative for refractory or recurrent HL patients in terms of survival and improved quality of life. This study analyzes the results of autologous BMT performed in HL patients in the Transplant Unit of the HUWC/ HEMOCE (Fortaleza - CE, Brazil). Fifty-two transplanted patients were studied from January 2009 to October 2015, among them, 30 men and 22 women, mean age of 28.2 years. All of them received GCS-F during the mobilization, in some cases associated with Vinorelbine or Plerixafor, with CD34 collection averaging 4.8 CD34/kg. The conditioning was performed with BEAC, NEAM or BEAM and the grafting with an average of 10 days. The evaluation on D + 100 showed: CR - 42 (82.7%), PR - 08 (13.5%) and 02 (3.8%) deaths, three and six days after cell infusion. After the D+100, 08 patients in CR showed HL recurrence from 06 to 36 months; 03 died and 05 are being treated with brentuximab; among the 08 patients in PR, 01 died due to HL activity, 04 months after BMT and 07 patients are undergoing treatment. The final evaluation of HL transplant patients showed an OS of 88.5% and a DFS of 61.5% in 6 years, with OS of the chemosensitive patients of 81% and of the chemoresistant ones, of 72.6%. It is possible to conclude that the Autologous HSCT has shown to be an excellent rescue therapy regarding tolerance, as well as the overall survival.
    MeSH term(s) Adolescent ; Adult ; Brazil ; Disease-Free Survival ; Female ; Hematopoietic Stem Cell Transplantation/methods ; Hematopoietic Stem Cell Transplantation/mortality ; Hodgkin Disease/mortality ; Hodgkin Disease/surgery ; Humans ; Male ; Middle Aged ; Time Factors ; Transplantation Conditioning/methods ; Transplantation, Autologous/methods ; Treatment Outcome ; Young Adult
    Language English
    Publishing date 2016-10
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 2027973-5
    ISSN 1806-9282 ; 0104-4230
    ISSN (online) 1806-9282
    ISSN 0104-4230
    DOI 10.1590/1806-9282.62.suppl1.34
    Database MEDical Literature Analysis and Retrieval System OnLINE

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