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  1. Book ; Online: Rethinking Social Media and Extremism

    Leitch, Shirley / Pickering, Paul

    2022  

    Keywords Internet: general works ; Social networking ; online extremism ; social media ; digital technology ; cybercrime ; electoral fraud ; fake news ; far-right violence ; hate speech
    Language 0|e
    Size 1 electronic resource (194 pages)
    Publisher ANU Press
    Publishing place Canberra
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021613792
    ISBN 9781760465247 ; 1760465240
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article: The Impact of Glutamatergic Synapse Dysfunction in the Corticothalamocortical Network on Absence Seizure Generation.

    Leitch, Beulah

    Frontiers in molecular neuroscience

    2022  Volume 15, Page(s) 836255

    Abstract: Childhood absence epilepsy (CAE) is the most common pediatric epilepsy affecting 10-18% of all children with epilepsy. It is genetic in origin and the result of dysfunction within the corticothalamocortical (CTC) circuitry. Network dysfunction may arise ... ...

    Abstract Childhood absence epilepsy (CAE) is the most common pediatric epilepsy affecting 10-18% of all children with epilepsy. It is genetic in origin and the result of dysfunction within the corticothalamocortical (CTC) circuitry. Network dysfunction may arise from multifactorial mechanisms in patients from different genetic backgrounds and thus account for the variability in patient response to currently available anti-epileptic drugs; 30% of children with absence seizures are pharmaco-resistant. This review considers the impact of deficits in AMPA receptor-mediated excitation of feed-forward inhibition (FFI) in the CTC, on absence seizure generation. AMPA receptors are glutamate activated ion channels and are responsible for most of the fast excitatory synaptic transmission throughout the CNS. In the stargazer mouse model of absence epilepsy, the genetic mutation is in stargazin, a transmembrane AMPA receptor trafficking protein (TARP). This leads to a defect in AMPA receptor insertion into synapses in parvalbumin-containing (PV+) inhibitory interneurons in the somatosensory cortex and thalamus. Mutation in the
    Language English
    Publishing date 2022-02-14
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2452967-9
    ISSN 1662-5099
    ISSN 1662-5099
    DOI 10.3389/fnmol.2022.836255
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Genome evolution: On the nature of trade-offs with polyploidy and endopolyploidy.

    Leitch, Andrew R / Leitch, Ilia J

    Current biology : CB

    2022  Volume 32, Issue 18, Page(s) R952–R954

    Abstract: A new study uncovers a novel trade-off in polyploid plants. While the larger cells of polyploids benefit from increased cell storage and water retention, this comes at the cost of reduced structural stability, potentially impacting survival. ...

    Abstract A new study uncovers a novel trade-off in polyploid plants. While the larger cells of polyploids benefit from increased cell storage and water retention, this comes at the cost of reduced structural stability, potentially impacting survival.
    MeSH term(s) Genome, Plant ; Plants/genetics ; Polyploidy ; Water
    Chemical Substances Water (059QF0KO0R)
    Language English
    Publishing date 2022-07-08
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 1071731-6
    ISSN 1879-0445 ; 0960-9822
    ISSN (online) 1879-0445
    ISSN 0960-9822
    DOI 10.1016/j.cub.2022.08.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3208: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: Recent Observations on the Treatment of Gonorrhea.

    Leitch, Thomas C

    Atlanta journal-record of medicine

    2022  Volume 2, Issue 11, Page(s) 737–742

    Language English
    Publishing date 2022-08-26
    Publishing country United States
    Document type Journal Article
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: "BIFloraExplorer": A Taxonomic, Genetic, and Ecological Data Resource for the Vascular Plants of Britain and Ireland.

    Henniges, Marie C / Leitch, Andrew R / Leitch, Ilia J

    Methods in molecular biology (Clifton, N.J.)

    2023  Volume 2703, Page(s) 83–90

    Abstract: The vascular flora of Britain and Ireland is a historically well-documented and clearly delimited study system that offers itself to large-scale analyses of ecology and species assemblages. However, such analyses require clean, curated, and taxonomically ...

    Abstract The vascular flora of Britain and Ireland is a historically well-documented and clearly delimited study system that offers itself to large-scale analyses of ecology and species assemblages. However, such analyses require clean, curated, and taxonomically resolved data, which are often unavailable. In this chapter, we describe how to access and use a key data resource that combines a taxonomically stable species list with genetic data (genome size, chromosome counts, and DNA barcode information), ecological information (such as life-form, realized niche description, and geographic origin) and distribution records. The data resource enables and encourages the study of natural ecological and evolutionary patterns and processes within the vascular flora of Britain and Ireland.
    MeSH term(s) Ireland ; United Kingdom ; Tracheophyta ; Biological Evolution ; Genome Size
    Language English
    Publishing date 2023-08-18
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-3389-2_7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Book ; Online: Romance Rewritten : The Evolution of Middle English Romance. A Tribute to Helen Cooper

    Archibald, Elizabeth / Leitch, Megan / Saunders, Corinne

    2018  

    Keywords Literature & literary studies ; Literature; European and World Literature: General Interest
    Size 1 electronic resource (297 pages)
    Publisher Boydell and Brewer
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021047472
    ISBN 9781787443341 ; 1787443345
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  7. Article ; Online: Time to Move Forward: Resilience and Trauma-Informed Care.

    Leitch, Laurie / McCaw, Brigid

    The Permanente journal

    2023  Volume 28, Issue 1, Page(s) 188–192

    MeSH term(s) Humans ; Resilience, Psychological
    Language English
    Publishing date 2023-10-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2062823-7
    ISSN 1552-5775 ; 1552-5775
    ISSN (online) 1552-5775
    ISSN 1552-5775
    DOI 10.7812/TPP/23.076
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Thermodynamics of hybrid quantum rotor devices.

    Leitch, Heather / Hammam, Kenza / De Chiara, Gabriele

    Physical review. E

    2024  Volume 109, Issue 2-1, Page(s) 24108

    Abstract: We investigate the thermodynamics of a hybrid quantum device consisting of two qubits collectively interacting with a quantum rotor and coupled dissipatively to two equilibrium reservoirs at different temperatures. By modeling the dynamics and the ... ...

    Abstract We investigate the thermodynamics of a hybrid quantum device consisting of two qubits collectively interacting with a quantum rotor and coupled dissipatively to two equilibrium reservoirs at different temperatures. By modeling the dynamics and the resulting steady state of the system using a collision model, we identify the functioning of the device as a thermal engine, a refrigerator, or an accelerator. In addition, we also look into the device's capacity to operate as a heat rectifier and optimize both the rectification coefficient and the heat flow simultaneously. Drawing an analogy to heat rectification and since we are interested in the conversion of energy into the rotor's kinetic energy, we introduce the concept of angular momentum rectification, which may be employed to control work extraction through an external load.
    Language English
    Publishing date 2024-03-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2844562-4
    ISSN 2470-0053 ; 2470-0045
    ISSN (online) 2470-0053
    ISSN 2470-0045
    DOI 10.1103/PhysRevE.109.024108
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Idiopathic multicentric Castleman disease: bringing order to chaos.

    Leitch, Heather A

    The Lancet. Haematology

    2020  Volume 7, Issue 3, Page(s) e180–e181

    MeSH term(s) Castleman Disease ; Humans
    Language English
    Publishing date 2020-02-03
    Publishing country England
    Document type Journal Article
    ISSN 2352-3026
    ISSN (online) 2352-3026
    DOI 10.1016/S2352-3026(20)30001-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: The Role of Chromatin Modifications in the Evolution of Giant Plant Genomes.

    Leitch, Andrew R / Ma, Lu / Dodsworth, Steven / Fuchs, Jörg / Houben, Andreas / Leitch, Ilia J

    Plants (Basel, Switzerland)

    2023  Volume 12, Issue 11

    Abstract: Angiosperm genome sizes (GS) range ~2400-fold and comprise genes and their regulatory regions, repeats, semi-degraded repeats, and 'dark matter'. The latter represents repeats so degraded that they can no longer be recognised as repetitive. In exploring ... ...

    Abstract Angiosperm genome sizes (GS) range ~2400-fold and comprise genes and their regulatory regions, repeats, semi-degraded repeats, and 'dark matter'. The latter represents repeats so degraded that they can no longer be recognised as repetitive. In exploring whether the histone modifications associated with chromatin packaging of these contrasting genomic components are conserved across the diversity of GS in angiosperms, we compared immunocytochemistry data for two species whose GS differ ~286-fold. We compared published data for
    Language English
    Publishing date 2023-05-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704341-1
    ISSN 2223-7747
    ISSN 2223-7747
    DOI 10.3390/plants12112159
    Database MEDical Literature Analysis and Retrieval System OnLINE

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