Article ; Online: A case illustrating successful eradication of recurrent, aggressive basal cell carcinoma located in a scar with vismodegib.
2018 Volume 24, Issue 2
Abstract: Vismodegib is a small molecule inhibitor of the Hedgehog signaling pathway that has shown efficacy in the control of locally advanced or metastatic basal cell carcinoma, although proof of its effectiveness in the elimination of aggressive tumors is ... ...
| Abstract | Vismodegib is a small molecule inhibitor of the Hedgehog signaling pathway that has shown efficacy in the control of locally advanced or metastatic basal cell carcinoma, although proof of its effectiveness in the elimination of aggressive tumors is lacking. We report a case and provide complete histological evidence of a 69-year-old gentleman who presented with a recurrent, infiltrative, and sclerosing (morpheiform) basal cell carcinoma on his left upper lip that was entirely eradicated with a three-month course of vismodegib 150 mg daily. Complete histologic clearance of a tumor in a recurrent, infiltrative, and sclerosing basal cell carcinoma with vismodegib is uncommon. |
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| MeSH term(s) | Aged ; Anilides/therapeutic use ; Antineoplastic Agents/therapeutic use ; Carcinoma, Basal Cell/drug therapy ; Carcinoma, Basal Cell/pathology ; Carcinoma, Basal Cell/surgery ; Cicatrix ; Combined Modality Therapy ; Humans ; Male ; Mohs Surgery ; Neoplasm Recurrence, Local/drug therapy ; Neoplasm Recurrence, Local/pathology ; Neoplasm Recurrence, Local/surgery ; Pyridines/therapeutic use ; Skin/pathology ; Skin Neoplasms/drug therapy ; Skin Neoplasms/pathology ; Skin Neoplasms/surgery |
| Chemical Substances | Anilides ; Antineoplastic Agents ; HhAntag691 ; Pyridines |
| Language | English |
| Publishing date | 2018-02-15 |
| Publishing country | United States |
| Document type | Case Reports ; Journal Article |
| ZDB-ID | 2026239-5 |
| ISSN | 1087-2108 ; 1087-2108 |
| ISSN (online) | 1087-2108 |
| ISSN | 1087-2108 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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