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  1. Article ; Online: Roadmap to improve the organized cancer screening programs - The case of colorectal cancer screening in Montenegro.

    Kovačević, Ivana Nikčević / Vujović, Adrijana / Stanišić, Milica / Vuković-Leković, Jovana / Lansdorp-Vogelaar, Iris / Mlakar, Dominika Novak / Senore, Carlo / Józwiak-Hagymásy, Judit / Széles, György / Vokó, Zoltán / Csanádi, Marcell

    Journal of cancer policy

    2023  Volume 39, Page(s) 100464

    Abstract: Background: Implementation of organized cancer screening programs comes with many challenges and barriers, which may inhibit the achievement of the screening activities' desired benefits. In this paper we outline a plan for improving the colorectal ... ...

    Abstract Background: Implementation of organized cancer screening programs comes with many challenges and barriers, which may inhibit the achievement of the screening activities' desired benefits. In this paper we outline a plan for improving the colorectal cancer (CRC) screening system in Montenegro.
    Methods: We formulated a roadmap, which was generally defined as a country-specific strategic plan to improve cancer screening programs. The roadmap development was an iterative, step-by-step process. First, we described the current screening program, then identified and described key barriers, and finally proposed actions to overcome them. Multiple sources of information (e.g., documents, expert opinions) were collected and processed by local and international stakeholders.
    Results: The CRC screening program was implemented between 2013-2019 by gradually increasing the invitation of the target population. Key barriers of the implementation were defined: 1) Lack of colonoscopy capacity in the northern part of the country; 2) Inadequate information technology systems; 3) Inadequate public promotion of screening. The defined actions were related to overcoming lack of available resources (e.g., financial, human and technological), to improve the policy environment and the knowledge, and to facilitate information sharing.
    Conclusion: The collaboration between local stakeholders of CRC screening and researchers experienced in planning and evaluating screening programs resulted in the first comprehensive description of CRC screening in Montenegro, detailed understanding of key barriers that emerged during implementation and a carefully designed list of actions. The implementation of these actions and the evaluation of whether barriers were solved will be captured in the upcoming period by maintaining this collaboration.
    MeSH term(s) Humans ; Montenegro ; Early Detection of Cancer/methods ; Colorectal Neoplasms/diagnosis ; Colonoscopy ; Health Services Needs and Demand
    Language English
    Publishing date 2023-12-15
    Publishing country England
    Document type Journal Article
    ISSN 2213-5383
    ISSN (online) 2213-5383
    DOI 10.1016/j.jcpo.2023.100464
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Clostridium perfringens sepsis following a molar pregnancy.

    Adams, Brandi N / Lekovic, Jovana P / Robinson, Suzzette

    American journal of obstetrics and gynecology

    2014  Volume 210, Issue 1, Page(s) e13–4

    Abstract: Clostridium perfringens sepsis is rare since the legalization of abortion in 1973. This is a 49 year old female who developed clostridial sepsis after suction dilation and curettage for a molar pregnancy. A hysterectomy was performed after prompt ... ...

    Abstract Clostridium perfringens sepsis is rare since the legalization of abortion in 1973. This is a 49 year old female who developed clostridial sepsis after suction dilation and curettage for a molar pregnancy. A hysterectomy was performed after prompt recognition, and the patient survived.
    MeSH term(s) Anti-Bacterial Agents/therapeutic use ; Bacteremia/diagnosis ; Bacteremia/drug therapy ; Bacteremia/etiology ; Carbapenems/therapeutic use ; Clostridium Infections/diagnosis ; Clostridium Infections/drug therapy ; Clostridium Infections/etiology ; Clostridium perfringens/isolation & purification ; Dilatation and Curettage ; Female ; Humans ; Hydatidiform Mole/complications ; Hydatidiform Mole/surgery ; Hysterectomy/methods ; Middle Aged ; Pregnancy ; Pregnancy Complications, Infectious/diagnosis ; Pregnancy Complications, Infectious/drug therapy ; Pregnancy Complications, Infectious/etiology ; Suction
    Chemical Substances Anti-Bacterial Agents ; Carbapenems
    Language English
    Publishing date 2014-01
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 80016-8
    ISSN 1097-6868 ; 0002-9378
    ISSN (online) 1097-6868
    ISSN 0002-9378
    DOI 10.1016/j.ajog.2013.09.045
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Lingual thrombosis in a woman with antiphospholipid syndrome.

    Lekovic, Jovana P / Friedman, Constantin M / Desancho, Maria T

    American journal of obstetrics and gynecology

    2013  Volume 208, Issue 4, Page(s) e3–4

    Abstract: A 28-year-old woman, 34 weeks pregnant, with previously diagnosed antiphospholipid syndrome, presents with vesicular tongue lesions treated as herpes outbreak and new onset of preeclampsia. Tongue biopsy preformed postpartum after induction of labor for ... ...

    Abstract A 28-year-old woman, 34 weeks pregnant, with previously diagnosed antiphospholipid syndrome, presents with vesicular tongue lesions treated as herpes outbreak and new onset of preeclampsia. Tongue biopsy preformed postpartum after induction of labor for preeclampsia reveals tongue infarction.
    MeSH term(s) Adult ; Antiphospholipid Syndrome/complications ; Female ; Humans ; Infarction/etiology ; Pregnancy ; Pregnancy Complications ; Thrombosis/etiology ; Tongue/blood supply
    Language English
    Publishing date 2013-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80016-8
    ISSN 1097-6868 ; 0002-9378
    ISSN (online) 1097-6868
    ISSN 0002-9378
    DOI 10.1016/j.ajog.2013.01.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Complement factor B activation in patients with preeclampsia.

    Velickovic, Ivan / Dalloul, Mudar / Wong, Karen A / Bakare, Olufunke / Schweis, Franz / Garala, Maya / Alam, Amit / Medranda, Giorgio / Lekovic, Jovana / Shuaib, Waqas / Tedjasukmana, Andreas / Little, Perry / Hanono, Daniel / Wijetilaka, Ruvini / Weedon, Jeremy / Lin, Jun / Toledano, Roulhac d'Arby / Zhang, Ming

    Journal of reproductive immunology

    2015  Volume 109, Page(s) 94–100

    Abstract: Preeclampsia is a leading cause of maternal and fetal morbidity and mortality. Bb, the active fragment of complement factor B (fB), has been reported to be a predictor of preeclampsia. However, conflicting results have been found by some investigators. ... ...

    Abstract Preeclampsia is a leading cause of maternal and fetal morbidity and mortality. Bb, the active fragment of complement factor B (fB), has been reported to be a predictor of preeclampsia. However, conflicting results have been found by some investigators. We hypothesized that the disagreement in findings may be due to the racial/ethnic differences among various study groups, and that fB activation is significant in women of an ethnic minority with preeclampsia. We investigated the maternal and fetal levels of Bb (the activated fB fragment) in pregnant women of an ethnic minority with or without preeclampsia. We enrolled 291 pregnant women (96% of an ethnic minority, including 78% African-American). Thirteen percent of these were diagnosed with preeclampsia. Maternal venous blood was collected from all participants together with fetal umbilical cord blood samples from 154 deliveries in the 291 women. The results were analyzed using the Mann-Whitney U test and multivariate analyses. Maternal Bb levels were significantly higher in the preeclamptic group than in the nonpreeclamptic group. Levels of Bb in fetal cord blood were similar in both groups. Subgroup analyses of African-American patients' results confirmed the study hypothesis that there would be a significant increase in Bb in the maternal blood of the preeclamptic group and no increase in Bb in the fetal cord blood of this group. These results suggest that a maternal immune response through complement fB might play a role in the development of preeclampsia, particularly in African-American patients.
    MeSH term(s) Adult ; African Americans ; Complement Activation/immunology ; Complement Factor B/immunology ; Complement Factor B/metabolism ; Female ; Fetal Blood/immunology ; Fetal Blood/metabolism ; Humans ; Pre-Eclampsia/blood ; Pre-Eclampsia/ethnology ; Pre-Eclampsia/immunology ; Pre-Eclampsia/mortality ; Pregnancy
    Chemical Substances Complement Factor B (EC 3.4.21.47)
    Language English
    Publishing date 2015-06
    Publishing country Ireland
    Document type Clinical Trial ; Journal Article ; Multicenter Study ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 424421-7
    ISSN 1872-7603 ; 0165-0378
    ISSN (online) 1872-7603
    ISSN 0165-0378
    DOI 10.1016/j.jri.2014.12.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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