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Article ; Online: Left Axilla Adenocarcinoma of Unknown Origin.

Jiang, Heng / Lele, Subodh M / Santamaria-Barria, Juan A

JAMA oncology

2023 Volume 9, Issue 5, Page(s) 710–711

MeSH term(s)	Humans ; Female ; Axilla/pathology ; Breast/pathology ; Lymph Nodes/pathology ; Adenocarcinoma/pathology ; Breast Neoplasms/pathology
Language	English
Publishing date	2023-03-16
Publishing country	United States
Document type	Journal Article
ISSN	2374-2445
ISSN (online)	2374-2445
DOI	10.1001/jamaoncol.2022.7858
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Article ; Online: Epithelial ovarian carcinoma - a perspective.

Renavikar, Pranav S / Chen, Jie / Lele, Subodh M

Journal of histotechnology

2023 Volume 46, Issue 2, Page(s) 55–56

MeSH term(s)	Female ; Humans ; Carcinoma, Ovarian Epithelial ; Ovarian Neoplasms ; Neoplasms, Glandular and Epithelial
Language	English
Publishing date	2023-04-26
Publishing country	England
Document type	Editorial
ZDB-ID	604634-4
ISSN	2046-0236 ; 0147-8885
ISSN (online)	2046-0236
ISSN	0147-8885
DOI	10.1080/01478885.2023.2204609
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Zs.A 1701: Show issues

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Article ; Online: A case of metastatic adenoid cystic (basal cell) carcinoma of the prostate: Systemic therapy for a rare disease.

Trinh, Jonathan Q / Lele, Subodh M / Teply, Benjamin A

The Prostate

2023 Volume 83, Issue 8, Page(s) 814–819

Abstract: Background: Metastatic adenoid cystic (basal cell) carcinoma of the prostate is an exceedingly rare disease entity. As a result, no current consensus exists for optimal systemic therapy.: Methods: We present a patient with metastatic adenoid cystic ( ... ...

Abstract	Background: Metastatic adenoid cystic (basal cell) carcinoma of the prostate is an exceedingly rare disease entity. As a result, no current consensus exists for optimal systemic therapy. Methods: We present a patient with metastatic adenoid cystic (basal cell) carcinoma of the prostate who subsequently received systemic treatment, including chemotherapy and immunotherapy. We comprehensively reviewed all published data on therapy outcomes in advanced disease. Results: Our patient benefited from combination chemotherapy (carboplatin and paclitaxel), with objective radiographic response and reduction in cancer-related pain. However, chemotherapy was stopped due to cumulative neurotoxicity, and subsequent immunotherapy with atezolizumab did not produce any response. Our literature review revealed inconsistent outcomes with various treatments but showed most promise with chemotherapy. Targeted therapy and immunotherapy seem to benefit specific cases, and androgen deprivation therapy had minimal evidence of benefit. Conclusion: Based on the findings of our case report and literature review, we suggest platinum-based chemotherapy doublets as first-line treatment for metastatic cases of adenoid cystic (basal cell) carcinoma of the prostate, reserving targeted therapy or immunotherapy for select cases based upon molecular profiles.
MeSH term(s)	Male ; Humans ; Prostate/pathology ; Androgen Antagonists ; Rare Diseases ; Adenoids/pathology ; Prostatic Neoplasms/drug therapy ; Prostatic Neoplasms/pathology ; Carcinoma, Adenoid Cystic/diagnostic imaging ; Carcinoma, Adenoid Cystic/drug therapy ; Carcinoma, Basal Cell/pathology ; Skin Neoplasms
Chemical Substances	Androgen Antagonists
Language	English
Publishing date	2023-03-26
Publishing country	United States
Document type	Review ; Case Reports ; Journal Article
ZDB-ID	604707-5
ISSN	1097-0045 ; 0270-4137
ISSN (online)	1097-0045
ISSN	0270-4137
DOI	10.1002/pros.24521
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Zs.A 1608: Show issues

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Article ; Online: Mucin-producing urothelial-type adenocarcinoma of the prostate with sarcomatoid features and novel molecular phenotype.

Renavikar, Pranav S / Auen, Thomas J / Wagner, David G / Lele, Subodh M

IJU case reports

2023 Volume 7, Issue 1, Page(s) 77–82

Abstract: Introduction: Mucin-producing urothelial-type adenocarcinoma of the prostate is a rare tumor that may not elevate serum prostate-specific antigen, creating significant diagnostic and monitoring challenges. We evaluate our case in detail and review prior ...

Abstract	Introduction: Mucin-producing urothelial-type adenocarcinoma of the prostate is a rare tumor that may not elevate serum prostate-specific antigen, creating significant diagnostic and monitoring challenges. We evaluate our case in detail and review prior studies to demonstrate that the pathologic and molecular features of this tumor are distinct from conventional prostate adenocarcinoma. Case presentation: Our patient had a remote history of radiation-treated conventional prostate adenocarcinoma and presented many years later with an abscess-like prostate mass leading to urinary obstruction and hematuria. Biopsy revealed mucin-producing urothelial-type adenocarcinoma of the prostate with concurrent sarcomatoid features. Molecular studies showed a unique phenotype involving alterations in the Conclusions: To our knowledge, this is the first report that describes sarcomatoid features and molecular mutations in mucin-producing urothelial-type adenocarcinoma of the prostate.
Language	English
Publishing date	2023-11-20
Publishing country	Australia
Document type	Case Reports
ISSN	2577-171X
ISSN (online)	2577-171X
DOI	10.1002/iju5.12672
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Article ; Online: Pathology Data-Based Risk Group Stratification Is Equivalent to That Obtained by Oncotype DX Testing in Prostatic Adenocarcinoma.

Renavikar, Pranav S / LaGrange, Chad A / Lele, Subodh M

Archives of pathology & laboratory medicine

2023 Volume 147, Issue 10, Page(s) 1158–1163

Abstract: Context.—: Low-risk (Gleason score 3 + 3 = 6) and intermediate-risk (Gleason score 3 + 4 = 7) prostate carcinoma cases diagnosed on needle biopsies are frequently referred for gene expression studies such as Oncotype DX to help validate the risk. Risk ... ...

Abstract	Context.—: Low-risk (Gleason score 3 + 3 = 6) and intermediate-risk (Gleason score 3 + 4 = 7) prostate carcinoma cases diagnosed on needle biopsies are frequently referred for gene expression studies such as Oncotype DX to help validate the risk. Risk assessment helps in determining prognosis and therapeutic decision making. Objective.—: To determine if addition of molecular testing is necessary, by evaluating its correlation with risk stratification provided by pathology report (Gleason score, Grade Group, proportion of positive cores) and serum prostate-specific antigen (PSA) level. Design.—: Our institutional database was searched for cases that had Oncotype DX testing after prostate biopsy. The final risk category determined by molecular testing was compared to the risk stratification predicted by the pathology report and serum PSA levels. Cases were classified as concordant if they fell under the same National Comprehensive Cancer Network risk and recommended initial therapy group. Follow-up information on discordant cases was obtained and used to determine if risk stratification by molecular testing was superior to that obtained from the clinicopathologic data. Results.—: A total of 4967 prostate biopsies (2015-2020) were screened. Of these, 131 prostate carcinoma cases (2.6%) had Oncotype DX testing and 111 of 131 cases (85%) had follow-up information. There was risk stratification concordance in 93 of 111 cases (84%). All 18 of 111 cases (16%) that were discordant had a follow-up course that matched the risk predicted by pathology data and serum PSA. Conclusions.—: Risk stratification provided by information in the pathology report on routine biopsy assessment coupled with the serum PSA level is equivalent to that obtained by Oncotype DX testing.
MeSH term(s)	Male ; Humans ; Prostate-Specific Antigen ; Prostatic Neoplasms/diagnosis ; Prostatic Neoplasms/genetics ; Prostatic Neoplasms/pathology ; Risk Factors ; Prognosis ; Carcinoma ; Adenocarcinoma/diagnosis ; Adenocarcinoma/genetics
Chemical Substances	Prostate-Specific Antigen (EC 3.4.21.77)
Language	English
Publishing date	2023-01-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	194119-7
ISSN	1543-2165 ; 0363-0153 ; 0096-8528 ; 0003-9985
ISSN (online)	1543-2165
ISSN	0363-0153 ; 0096-8528 ; 0003-9985
DOI	10.5858/arpa.2022-0225-OA
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Ud II Zs.36: Show issues

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Article: Unusual Clinical Presentation of Clear Cell Sarcoma in a Young Woman.

Asif, Samia / Hurley, Brendan J / Haroon, Sehr / Lele, Subodh / Sharma, Bhavina

Oncology (Williston Park, N.Y.)

2023 Volume 37, Issue 10, Page(s) 412–416

Abstract: Clear cell sarcoma (CCS) is a rare but aggressive malignancy that typically occurs in young adults and is characterized by soft tissue tumors of the extremities. CCS can be difficult to distinguish from metastatic melanoma based solely on histology and ... ...

Abstract	Clear cell sarcoma (CCS) is a rare but aggressive malignancy that typically occurs in young adults and is characterized by soft tissue tumors of the extremities. CCS can be difficult to distinguish from metastatic melanoma based solely on histology and immunohistochemistry (IHC) because of the significant overlap between them. However, it is imperative to get an accurate clinical diagnosis, as it informs disease staging and treatment options for patient care. Present in approximately 75% of CCS cases, the EWSR1 gene rearrangement detected by fluorescence in situ hybridization (FISH) can help with establishing a diagnosis; the underlying reciprocal translocation has never been reported in cutaneous melanoma. We reviewed a case of a young woman who presented with a confusing picture of widespread lymphadenopathy, cutaneous metastases, and electrolyte derangements and was subsequently diagnosed with metastatic CCS.This case suggests possible value in performing molecular testing when a clinical picture does not correspond with what is expected for melanoma. It also raises the question of whether CCS cases may be underreported. This case highlights an uncommon presentation that may not be recognized as a manifestation of CCS by an oncologist who is not a sarcoma specialist. It is unclear how COVID-19 vaccination contributed to her clinical presentation, and it is also unclear whether an early diagnosis would have changed her clinical outcome.
MeSH term(s)	Female ; Young Adult ; Humans ; Sarcoma, Clear Cell/diagnosis ; Sarcoma, Clear Cell/genetics ; Melanoma ; Skin Neoplasms/diagnosis ; Skin Neoplasms/genetics ; COVID-19 Vaccines ; In Situ Hybridization, Fluorescence ; Soft Tissue Neoplasms
Chemical Substances	COVID-19 Vaccines
Language	English
Publishing date	2023-10-24
Publishing country	United States
Document type	Case Reports ; Review ; Journal Article
ZDB-ID	1067950-9
ISSN	0890-9091
ISSN	0890-9091
DOI	10.46883/2023.25921005
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Zs.A 3168: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article: Robot-Assisted Laparoscopic Removal of a Large Primary Retroperitoneal Mature Cystic Teratoma in an Adult.

Blazek, Andrew / Plambeck, Benjamin / Lele, Subodh / Hill, Brett C

Cureus

2021 Volume 13, Issue 7, Page(s) e16329

Abstract: Mature teratomas are unique and generally benign neoplasms. They are derived from embryonic tissues and typically located within the gonadal region. Primary retroperitoneal teratomas are uncommon in adults and often challenging to treat, given their ... ...

Abstract	Mature teratomas are unique and generally benign neoplasms. They are derived from embryonic tissues and typically located within the gonadal region. Primary retroperitoneal teratomas are uncommon in adults and often challenging to treat, given their location and size. Here, we offer a rare case of a large primary retroperitoneal mature cystic teratoma, detected on abdominal ultrasound during the work-up of abdominal bloating and nausea and treated with robot-assisted laparoscopic excision in a 58-year-old male. In this report, we sought to describe the evaluation, treatment, and follow-up of this condition, as well as review the associated literature.
Language	English
Publishing date	2021-07-12
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.16329
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Article ; Online: The Development of Thermoresponsive Polymeric Simvastatin Prodrug for the Treatment of Experimental Periodontitis in Rats.

Xu, Xiaoke / Jia, Zhenshan / Chen, Ningrong / Lele, Subodh M / Arash, Shabnam / Reinhardt, Richard A / Killeen, Amy C / Wang, Dong

Molecular pharmaceutics

2023 Volume 20, Issue 11, Page(s) 5631–5645

Abstract: Periodontitis (PD) is a severe inflammatory gum pathology that damages the periodontal soft tissue and bone. It is highly prevalent in the US, affecting more than 47% of adults. Besides routine scaling and root planing, there are few effective treatments ...

Abstract	Periodontitis (PD) is a severe inflammatory gum pathology that damages the periodontal soft tissue and bone. It is highly prevalent in the US, affecting more than 47% of adults. Besides routine scaling and root planing, there are few effective treatments for PD. Developed as an effective treatment for hyperlipidemia, simvastatin (SIM) is also known for its well-established anti-inflammatory and osteogenic properties, suggesting its potential utility in treating PD. Its clinical translation, however, has been impeded by its poor water-solubility, lack of osteotropicity, and side effects (e.g., hepatoxicity) associated with systemic exposure. To address these challenges, an
MeSH term(s)	Rats ; Animals ; Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Prodrugs/chemistry ; Simvastatin/chemistry ; Polymers ; Periodontitis/drug therapy
Chemical Substances	Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Prodrugs ; Simvastatin (AGG2FN16EV) ; Polymers
Language	English
Publishing date	2023-09-29
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	2138405-8
ISSN	1543-8392 ; 1543-8384
ISSN (online)	1543-8392
ISSN	1543-8384
DOI	10.1021/acs.molpharmaceut.3c00508
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Article: APE1 and SSRP1 is overexpressed in muscle invasive bladder cancer and associated with poor survival

Song, Heyu / Zeng, Jiping / Lele, Subodh / LaGrange, Chad A / Bhakat, Kishor K

Heliyon. 2021 Apr., v. 7, no. 4

2021

Abstract: Human apurinic/apyrimidinic (AP) endonuclease 1 (APE1) plays a critical role in DNA base excision repair (BER) pathway and has been reported to be overexpressed in multiple cancers. Previously, we have shown that histone chaperone FACT complex ( ... ...

Abstract	Human apurinic/apyrimidinic (AP) endonuclease 1 (APE1) plays a critical role in DNA base excision repair (BER) pathway and has been reported to be overexpressed in multiple cancers. Previously, we have shown that histone chaperone FACT complex (Facilitates Chromatin Transcription, a heterodimer of SSRP1 and SPT16 proteins) facilitates the chromatin access and DNA repair function of APE1, and their expression levels are correlated with promoting drug resistance in cancer. FACT inhibitor has been introduced in phase I and II clinical trials for chemosensitization of advanced solid cancers. However, the expression profile and prognostic significance of APE1 and FACT complex in bladder cancer remains largely unknown.Retrospectively, 69 bladder cancer samples were retrieved and submitted for immunohistochemical staining of APE1 and SSRP1. Expression profile including cytoplasmic and nuclear staining of APE1 and expression level of SSRP1 was examined and semi-quantified to render a H-score. The prognostic significance of APE1 and SSRP1 was evaluated by Kaplan-Meier survival analysis in our cohort and R2 database.APE1 expression is elevated in bladder cancer compared to normal adjacent tissues. Compared with low grade tumors, high grade tumors show a shift in the staining pattern including higher intensity and positive cytoplasmic staining. Carcinoma in situ has a similar staining pattern to high grade tumors. APE1 and SSRP1 staining intensity increases as tumor progresses with stage. There is a correlation between APE1 and SSRP1 staining in invasive bladder cancer (Spearman r = 0.5466, p < 0.0001). The increased expression of APE1 and SSRP1 is associated with poor survival in Kaplan-Meier analysis in our cohort and in R2-TCGA bladder cancer database.The expression levels of APE1 and SSRP1 are significantly elevated in bladder cancer as compared to normal adjacent tissues. APE1 correlates with SSRP1 expression in high grade tumors. Overexpression of APE1 and SSRP1 is associated with poor survival in bladder cancer. This suggests the usage of FACT inhibitor curaxins in muscle invasive bladder cancer to target FACT complex and APE1 to improve chemosensitization after further validation.
Keywords	DNA repair ; carcinoma ; chemosensitization ; chromatin ; drug resistance ; histones ; humans ; immunohistochemistry ; muscles ; nucleobases ; urinary bladder neoplasms
Language	English
Dates of publication	2021-04
Publishing place	Elsevier Ltd
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2021.e06756
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: First report of Sarcina ventriculi in a pyloric and duodenal brushing specimen.

Rohr, Joseph M / Eidem, Megan E / Lele, Subodh M

Cytopathology : official journal of the British Society for Clinical Cytology

2019 Volume 30, Issue 5, Page(s) 563–564

MeSH term(s)	Adult ; Duodenum/microbiology ; Duodenum/pathology ; Gastric Mucosa/microbiology ; Gastric Mucosa/pathology ; Humans ; Male ; Sarcina/physiology ; Ulcer/microbiology ; Ulcer/pathology
Language	English
Publishing date	2019-06-26
Publishing country	England
Document type	Case Reports ; Letter
ZDB-ID	1034190-0
ISSN	1365-2303 ; 0956-5507 ; 1350-4037
ISSN (online)	1365-2303
ISSN	0956-5507 ; 1350-4037
DOI	10.1111/cyt.12735
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