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Artikel ; Online: Multiphase Kinetic Modeling of Air Pollutant Effects on Protein Modification and Nitrotyrosine Formation in Epithelial Lining Fluid.

Mishra, Ashmi / Lelieveld, Steven / Pöschl, Ulrich / Berkemeier, Thomas

Environmental science & technology

2023 Band 57, Heft 34, Seite(n) 12642–12653

Abstract: Exposure to ambient air pollution is a major risk factor for human health. Inhalation of air pollutants can enhance the formation of reactive species in the epithelial lining fluid (ELF) of the respiratory tract and can lead to oxidative stress and ... ...

Abstract	Exposure to ambient air pollution is a major risk factor for human health. Inhalation of air pollutants can enhance the formation of reactive species in the epithelial lining fluid (ELF) of the respiratory tract and can lead to oxidative stress and oxidative damage. Here, we investigate the chemical modification of proteins by reactive species from air pollution and endogenous biological sources using an extended version of the multiphase chemical kinetic model KM-SUB-ELF 2.0 with a detailed mechanism of protein modification. Fine particulate matter (PM
Mesh-Begriff(e)	Humans ; Air Pollutants ; Tyrosine ; Oxidative Stress ; Air Pollution
Chemische Substanzen	Air Pollutants ; 3-nitrotyrosine (3604-79-3) ; Tyrosine (42HK56048U)
Sprache	Englisch
Erscheinungsdatum	2023-08-17
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1520-5851
ISSN (online)	1520-5851
DOI	10.1021/acs.est.3c03556
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Endogenous Nitric Oxide Can Enhance Oxidative Stress Caused by Air Pollutants and Explain Higher Susceptibility of Individuals with Inflammatory Disorders.

Lelieveld, Steven / Lelieveld, Jos / Mishra, Ashmi / Daiber, Andreas / Pozzer, Andrea / Pöschl, Ulrich / Berkemeier, Thomas

Environmental science & technology

2024 Band 58, Heft 4, Seite(n) 1823–1831

Abstract: Air pollution causes morbidity and excess mortality. In the epithelial lining fluid of the respiratory tract, air pollutants trigger a chemical reaction sequence that causes the formation of noxious hydroxyl radicals that drive oxidative stress. For ... ...

Abstract	Air pollution causes morbidity and excess mortality. In the epithelial lining fluid of the respiratory tract, air pollutants trigger a chemical reaction sequence that causes the formation of noxious hydroxyl radicals that drive oxidative stress. For hitherto unknown reasons, individuals with pre-existing inflammatory disorders are particularly susceptible to air pollution. Through detailed multiphase chemical kinetic analysis, we show that the commonly elevated concentrations of endogenous nitric oxide in diseased individuals can increase the production of hydroxyl radicals via peroxynitrite formation. Our findings offer a molecular rationale of how adverse health effects and oxidative stress caused by air pollutants may be exacerbated by inflammatory disorders.
Mesh-Begriff(e)	Humans ; Air Pollutants/analysis ; Nitric Oxide/analysis ; Nitric Oxide/pharmacology ; Particulate Matter/analysis ; Kinetics ; Oxidative Stress ; Air Pollution/analysis ; Hydroxyl Radical/analysis ; Hydroxyl Radical/pharmacology
Chemische Substanzen	Air Pollutants ; Nitric Oxide (31C4KY9ESH) ; Particulate Matter ; Hydroxyl Radical (3352-57-6)
Sprache	Englisch
Erscheinungsdatum	2024-01-18
Erscheinungsland	United States
Dokumenttyp	Journal Article
ISSN	1520-5851
ISSN (online)	1520-5851
DOI	10.1021/acs.est.3c07010
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Influence of aerosol acidity and organic ligands on transition metal solubility and oxidative potential of fine particulate matter in urban environments.

Shahpoury, Pourya / Lelieveld, Steven / Johannessen, Cassandra / Berkemeier, Thomas / Celo, Valbona / Dabek-Zlotorzynska, Ewa / Harner, Tom / Lammel, Gerhard / Nenes, Athanasios

The Science of the total environment

2023 Band 906, Seite(n) 167405

Abstract: The adverse health effects of air pollution around the world have been associated with the inhalation of fine particulate matter ( ... ...

Abstract	The adverse health effects of air pollution around the world have been associated with the inhalation of fine particulate matter (PM
Sprache	Englisch
Erscheinungsdatum	2023-09-29
Erscheinungsland	Netherlands
Dokumenttyp	Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2023.167405
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Is the oxidative potential of components of fine particulate matter surface-mediated?

Baumann, Karsten / Wietzoreck, Marco / Shahpoury, Pourya / Filippi, Alexander / Hildmann, Stefanie / Lelieveld, Steven / Berkemeier, Thomas / Tong, Haijie / Pöschl, Ulrich / Lammel, Gerhard

Environ Sci Pollut Res. 2023 Feb., v. 30, no. 6 p.16749-16755

2023

Abstract: Redox-active substances in fine particulate matter (PM) contribute to inhalation health risks through their potential to generate reactive oxygen species in epithelial lung lining fluid (ELF). The ELF’s air–liquid interface (ALI) can play an important ... ...

Abstract	Redox-active substances in fine particulate matter (PM) contribute to inhalation health risks through their potential to generate reactive oxygen species in epithelial lung lining fluid (ELF). The ELF’s air–liquid interface (ALI) can play an important role in the phase transfer and multi-phase reactions of redox-active PM constituents. We investigated the influence of interfacial processes and properties by scrubbing of coated nano-particles with simulated ELF in a nebulizing mist chamber. Weakly water-soluble redox-active organics abundant in ambient fine PM were reproducibly loaded into ELF via ALI mixing. The resulting oxidative potential (OP) of selected quinones and other PAH derivatives were found to exceed the OP resulting from bulk mixing of the same amounts of redox-active substances and ELF. Our results indicate that the OP of PM components depends not only on the PM substance properties but also on the ELF interface properties and uptake mechanisms. OP measurements based on bulk mixing of phases may not represent the effective OP in the human lung.
Schlagwörter	breathing ; epithelium ; humans ; liquid-air interface ; lungs ; mists ; nanoparticles ; particulates ; quinones ; reactive oxygen species ; water solubility
Sprache	Englisch
Erscheinungsverlauf	2023-02
Umfang	p. 16749-16755.
Erscheinungsort	Springer Berlin Heidelberg
Dokumenttyp	Artikel ; Online
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-022-24897-3
Datenquelle	NAL Katalog (AGRICOLA)

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Artikel: Hydroxyl Radical Production by Air Pollutants in Epithelial Lining Fluid Governed by Interconversion and Scavenging of Reactive Oxygen Species

Lelieveld, Steven / Wilson, Jake / Dovrou, Eleni / Mishra, Ashmi / Lakey, Pascale S. J. / Shiraiwa, Manabu / Pöschl, Ulrich / Berkemeier, Thomas

Environmental science & technology. 2021 Oct. 05, v. 55, no. 20

2021

Abstract: Air pollution is a major risk factor for human health. Chemical reactions in the epithelial lining fluid (ELF) of the human respiratory tract result in the formation of reactive oxygen species (ROS), which can lead to oxidative stress and adverse health ... ...

Abstract	Air pollution is a major risk factor for human health. Chemical reactions in the epithelial lining fluid (ELF) of the human respiratory tract result in the formation of reactive oxygen species (ROS), which can lead to oxidative stress and adverse health effects. We use kinetic modeling to quantify the effects of fine particulate matter (PM2.5), ozone (O₃), and nitrogen dioxide (NO₂) on ROS formation, interconversion, and reactivity, and discuss different chemical metrics for oxidative stress, such as cumulative production of ROS and hydrogen peroxide (H₂O₂) to hydroxyl radical (OH) conversion. All three air pollutants produce ROS that accumulate in the ELF as H₂O₂, which serves as reservoir for radical species. At low PM2.5 concentrations (<10 μg m–³), we find that less than 4% of all produced H₂O₂ is converted into highly reactive OH, while the rest is intercepted by antioxidants and enzymes that serve as ROS buffering agents. At elevated PM2.5 concentrations (>10 μg m–³), however, Fenton chemistry overwhelms the ROS buffering effect and leads to a tipping point in H₂O₂ fate, causing a strong nonlinear increase in OH production. This shift in ROS chemistry and the enhanced OH production provide a tentative mechanistic explanation for how the inhalation of PM2.5 induces oxidative stress and adverse health effects.
Schlagwörter	air ; air pollution ; breathing ; epithelium ; human health ; humans ; hydrogen peroxide ; hydroxyl radicals ; nitrogen dioxide ; oxidative stress ; ozone ; particulates ; respiratory system ; risk factors ; technology
Sprache	Englisch
Erscheinungsverlauf	2021-1005
Umfang	p. 14069-14079.
Erscheinungsort	American Chemical Society
Dokumenttyp	Artikel
ISSN	1520-5851
DOI	10.1021/acs.est.1c03875
Datenquelle	NAL Katalog (AGRICOLA)

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Artikel ; Online: Is the oxidative potential of components of fine particulate matter surface-mediated?

Baumann, Karsten / Wietzoreck, Marco / Shahpoury, Pourya / Filippi, Alexander / Hildmann, Stefanie / Lelieveld, Steven / Berkemeier, Thomas / Tong, Haijie / Pöschl, Ulrich / Lammel, Gerhard

Environmental science and pollution research international

2022 Band 30, Heft 6, Seite(n) 16749–16755

Abstract: Redox-active substances in fine particulate matter (PM) contribute to inhalation health risks through their potential to generate reactive oxygen species in epithelial lung lining fluid (ELF). The ELF's air-liquid interface (ALI) can play an important ... ...

Abstract	Redox-active substances in fine particulate matter (PM) contribute to inhalation health risks through their potential to generate reactive oxygen species in epithelial lung lining fluid (ELF). The ELF's air-liquid interface (ALI) can play an important role in the phase transfer and multi-phase reactions of redox-active PM constituents. We investigated the influence of interfacial processes and properties by scrubbing of coated nano-particles with simulated ELF in a nebulizing mist chamber. Weakly water-soluble redox-active organics abundant in ambient fine PM were reproducibly loaded into ELF via ALI mixing. The resulting oxidative potential (OP) of selected quinones and other PAH derivatives were found to exceed the OP resulting from bulk mixing of the same amounts of redox-active substances and ELF. Our results indicate that the OP of PM components depends not only on the PM substance properties but also on the ELF interface properties and uptake mechanisms. OP measurements based on bulk mixing of phases may not represent the effective OP in the human lung.
Mesh-Begriff(e)	Humans ; Particulate Matter/analysis ; Air Pollutants/analysis ; Reactive Oxygen Species ; Oxidation-Reduction ; Oxidative Stress
Chemische Substanzen	Particulate Matter ; Air Pollutants ; Reactive Oxygen Species
Sprache	Englisch
Erscheinungsdatum	2022-12-23
Erscheinungsland	Germany
Dokumenttyp	Journal Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-022-24897-3
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Hydroxyl Radical Production by Air Pollutants in Epithelial Lining Fluid Governed by Interconversion and Scavenging of Reactive Oxygen Species.

Lelieveld, Steven / Wilson, Jake / Dovrou, Eleni / Mishra, Ashmi / Lakey, Pascale S J / Shiraiwa, Manabu / Pöschl, Ulrich / Berkemeier, Thomas

Environmental science & technology

2021 Band 55, Heft 20, Seite(n) 14069–14079

Abstract	Air pollution is a major risk factor for human health. Chemical reactions in the epithelial lining fluid (ELF) of the human respiratory tract result in the formation of reactive oxygen species (ROS), which can lead to oxidative stress and adverse health effects. We use kinetic modeling to quantify the effects of fine particulate matter (PM2.5), ozone (O
Mesh-Begriff(e)	Air Pollutants ; Humans ; Hydrogen Peroxide ; Hydroxyl Radical ; Particulate Matter ; Reactive Oxygen Species
Chemische Substanzen	Air Pollutants ; Particulate Matter ; Reactive Oxygen Species ; Hydroxyl Radical (3352-57-6) ; Hydrogen Peroxide (BBX060AN9V)
Sprache	Englisch
Erscheinungsdatum	2021-10-05
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1520-5851
ISSN (online)	1520-5851
DOI	10.1021/acs.est.1c03875
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Antioxidant activity of cerium dioxide nanoparticles and nanorods in scavenging hydroxyl radicals.

Filippi, Alexander / Liu, Fobang / Wilson, Jake / Lelieveld, Steven / Korschelt, Karsten / Wang, Ting / Wang, Yueshe / Reich, Tobias / Pöschl, Ulrich / Tremel, Wolfgang / Tong, Haijie

RSC advances

2019 Band 9, Heft 20, Seite(n) 11077–11081

Abstract: Cerium oxide nanoparticles (CeNPs) have been shown to exhibit antioxidant capabilities, but their efficiency in scavenging reactive oxygen species (ROS) and the underlying mechanisms are not yet well understood. In this study, cerium dioxide ... ...

Abstract	Cerium oxide nanoparticles (CeNPs) have been shown to exhibit antioxidant capabilities, but their efficiency in scavenging reactive oxygen species (ROS) and the underlying mechanisms are not yet well understood. In this study, cerium dioxide nanoparticles (CeNPs) and nanorods (CeNRs) were found to exhibit much stronger scavenging activity than ·OH generation in phosphate buffered saline (PBS) and surrogate lung fluid (SLF). The larger surface area and higher defect density of CeNRs may lead to higher ·OH scavenging activity than for CeNPs. These insights are important to understand the redox activity of cerium nanomaterials and provide clues to the role of CeNPs in biological and environmental processes.
Sprache	Englisch
Erscheinungsdatum	2019-04-09
Erscheinungsland	England
Dokumenttyp	Journal Article
ISSN	2046-2069
ISSN (online)	2046-2069
DOI	10.1039/c9ra00642g
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Buch ; Online: Aqueous-phase reactive species formed by fine particulate matter from remote forests and polluted urban air

eISSN: 1680-7324

2021

Abstract: In the aqueous phase, fine particulate matter can form reactive species (RS) that influence the aging, properties, and health effects of atmospheric aerosols. In this study, we explore the RS yields of aerosol samples from a remote forest (Hyytiälä, ... ...

Abstract	In the aqueous phase, fine particulate matter can form reactive species (RS) that influence the aging, properties, and health effects of atmospheric aerosols. In this study, we explore the RS yields of aerosol samples from a remote forest (Hyytiälä, Finland) and polluted urban locations (Mainz, Germany; Beijing, China), and we relate the RS yields to different chemical constituents and reaction mechanisms. Ultra-high-resolution mass spectrometry was used to characterize organic aerosol composition, electron paramagnetic resonance (EPR) spectroscopy with a spin-trapping technique was applied to determine the concentrations of ⚫ OH, O <math xmlns="http://www.w3.org/1998/Math/MathML" id="M2" display="inline" overflow="scroll" dspmath="mathml"><mrow><msubsup><mi/><mn mathvariant="normal">2</mn><mrow><mi class="Radical" mathvariant="normal">⚫</mi><mo>-</mo></mrow></msubsup></mrow></math> <svg:svg xmlns:svg="http://www.w3.org/2000/svg" width="12pt" height="16pt" class="svg-formula" dspmath="mathimg" md5hash="0745b536dd0e5fe0f2cc8f1f9cffd00f"><svg:image xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="acp-21-10439-2021-ie00001.svg" width="12pt" height="16pt" src="acp-21-10439-2021-ie00001.png"/></svg:svg> , and carbon- or oxygen-centered organic radicals, and a fluorometric assay was used to quantify H 2 O 2 . The aqueous H 2 O 2 -forming potential per mass unit of ambient PM 2.5 (particle diameter < 2.5 µm ) was roughly the same for all investigated samples, whereas the mass-specific yields of radicals were lower for sampling sites with higher concentrations of PM 2.5 . The abundances of water-soluble transition metals and aromatics in ambient PM 2.5 were positively correlated with the relative fraction of ⚫ OH and negatively correlated with the relative fraction of carbon-centered radicals. In contrast, highly oxygenated organic molecules (HOM) were positively correlated with the relative fraction of carbon-centered radicals and negatively correlated with the relative fraction of ⚫ OH. Moreover, we found that the relative fractions of different types of radicals formed by ambient PM 2.5 were comparable to surrogate mixtures comprising transition metal ions, organic hydroperoxide, H 2 O 2 , and humic or fulvic acids. The interplay of transition metal ions (e.g., iron and copper ions), highly oxidized organic molecules (e.g., hydroperoxides), and complexing or scavenging agents (e.g., humic or fulvic acids) leads to nonlinear concentration dependencies in aqueous-phase RS production. A strong dependence on chemical composition was also observed for the aqueous-phase radical yields of laboratory-generated secondary organic aerosols (SOA) from precursor mixtures of naphthalene and β -pinene. Our findings show how the composition of PM 2.5 can influence the amount and nature of aqueous-phase RS, which may explain differences in the chemical reactivity and health effects of particulate matter in clean and polluted air.
Thema/Rubrik (Code)	511 ; 333
Sprache	Englisch
Erscheinungsdatum	2021-07-09
Erscheinungsland	de
Dokumenttyp	Buch ; Online
Datenquelle	BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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