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  1. Article: Why Me? To Be an Ultra-Responder to Antiplatelet Therapy: A Case Report.

    Rosafio, Francesca / Bigliardi, Guido / Lelli, Nicoletta / Vandelli, Laura / Naldi, Federica / Ciolli, Ludovico / Meletti, Stefano / Zini, Andrea

    Frontiers in neurology

    2021  Volume 12, Page(s) 663308

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2021-08-10
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2021.663308
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Proposal of a "gradient model" to evaluate residual platelet activity on antiplatelet therapy: A pilot study.

    Lelli, Nicoletta / Rizkallah, Rima / Ferrari, Patrizia / Pedretti, Simona / Cariani, Elisabetta / Trenti, Tommaso

    Thrombosis research

    2017  Volume 150, Page(s) 19–21

    MeSH term(s) Aged ; Aged, 80 and over ; Aspirin/pharmacology ; Aspirin/therapeutic use ; Blood Platelets/cytology ; Blood Platelets/drug effects ; Drug Resistance ; Electric Impedance ; Female ; Humans ; Male ; Middle Aged ; Pilot Projects ; Platelet Activation/drug effects ; Platelet Aggregation/drug effects ; Platelet Aggregation Inhibitors/pharmacology ; Platelet Aggregation Inhibitors/therapeutic use ; Platelet Function Tests/methods ; Ticlopidine/analogs & derivatives ; Ticlopidine/pharmacology ; Ticlopidine/therapeutic use
    Chemical Substances Platelet Aggregation Inhibitors ; clopidogrel (A74586SNO7) ; Ticlopidine (OM90ZUW7M1) ; Aspirin (R16CO5Y76E)
    Language English
    Publishing date 2017-02
    Publishing country United States
    Document type Letter
    ZDB-ID 121852-9
    ISSN 1879-2472 ; 0049-3848
    ISSN (online) 1879-2472
    ISSN 0049-3848
    DOI 10.1016/j.thromres.2016.12.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 863: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Platelet Function Monitoring Performed after Carotid Stenting during Endovascular Stroke Treatment Predicts Outcome.

    Ciolli, Ludovico / Lelli, Nicoletta / Rosafio, Francesca / Maffei, Stefania / Sacchetti, Federico / Vandelli, Laura / Dell'Acqua, Maria Luisa / Picchetto, Livio / Borzì, Giuseppe Maria / Ricceri, Riccardo / Pentore, Roberta / Tondelli, Manuela / Vandelli, Gabriele / Rodríguez-Villatoro, Noelia / Meletti, Stefano / Zini, Andrea / Vallone, Stefano / Bigliardi, Guido

    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association

    2021  Volume 30, Issue 7, Page(s) 105800

    Abstract: Objectives: Many studies showed that platelet reactivity testing can predict ischemic events after carotid stenting or ischemic stroke. The aim of our study was to assess the role of early platelet function monitoring in predicting 90-days functional ... ...

    Abstract Objectives: Many studies showed that platelet reactivity testing can predict ischemic events after carotid stenting or ischemic stroke. The aim of our study was to assess the role of early platelet function monitoring in predicting 90-days functional outcome, stent thrombosis and hemorrhagic transformation in patients with ischemic stroke treated with endovascular procedures requiring emergent extracranial stenting.
    Materials and methods: We performed a retrospective study on consecutive patients with acute anterior circulation stroke admitted to our hospital between January 2015 and March 2020, in whom platelet reactivity testing was performed within 10 days from stenting. Patients were divided according to validated cutoffs in acetylsalicylic acid and Clopidogrel responders and not responders. Group comparison and regression analyses were performed to identify differences between groups and outcome predictors.
    Results: We included in the final analysis 54 patients. Acetylsalicylic acid resistance was an independent predictor of poor 90 days outcome (OR for modified Rankin scale (mRS) ≤ 2: 0.10 95% CI: 0.02 - 0.69) whereas Clopidogrel resistance was an independent predictor of good outcome (OR for mRS ≤ 2: 7.09 95%CI: 1.33 - 37.72). Acetylsalicylic acid resistance was also associated with increased 90-days mortality (OR: 18.42; 95% CI: 1.67 - 203.14).
    Conclusion: We found a significant association between resistance to acetylsalicylic acid and poor 90-days functional outcome and between resistance to Clopidogrel and good 90-days functional outcome. If confirmed, our results might improve pharmacological management after acute carotid stenting.
    MeSH term(s) Aged ; Aspirin/therapeutic use ; Carotid Stenosis/blood ; Carotid Stenosis/diagnosis ; Carotid Stenosis/therapy ; Clopidogrel/therapeutic use ; Databases, Factual ; Disability Evaluation ; Drug Monitoring ; Endovascular Procedures/adverse effects ; Endovascular Procedures/instrumentation ; Female ; Humans ; Intracranial Hemorrhages/chemically induced ; Ischemic Stroke/blood ; Ischemic Stroke/diagnosis ; Ischemic Stroke/therapy ; Male ; Middle Aged ; Platelet Aggregation/drug effects ; Platelet Aggregation Inhibitors/adverse effects ; Platelet Aggregation Inhibitors/therapeutic use ; Platelet Function Tests ; Predictive Value of Tests ; Registries ; Retrospective Studies ; Risk Assessment ; Risk Factors ; Stents ; Thrombosis/blood ; Thrombosis/etiology ; Thrombosis/prevention & control ; Time Factors ; Treatment Outcome
    Chemical Substances Platelet Aggregation Inhibitors ; Clopidogrel (A74586SNO7) ; Aspirin (R16CO5Y76E)
    Language English
    Publishing date 2021-05-05
    Publishing country United States
    Document type Journal Article ; Multicenter Study
    ZDB-ID 1131675-5
    ISSN 1532-8511 ; 1052-3057
    ISSN (online) 1532-8511
    ISSN 1052-3057
    DOI 10.1016/j.jstrokecerebrovasdis.2021.105800
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3519: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Role of cerebrospinal fluid biomarkers to predict conversion to dementia in patients with mild cognitive impairment: a clinical cohort study.

    Tondelli, Manuela / Bedin, Roberta / Chiari, Annalisa / Molinari, Maria Angela / Bonifacio, Guendalina / Lelli, Nicoletta / Trenti, Tommaso / Nichelli, Paolo

    Clinical chemistry and laboratory medicine

    2015  Volume 53, Issue 3, Page(s) 453–460

    Abstract: Background: Cerebrospinal fluid (CSF) levels assessment of Aβ1-42 and Tau proteins may be accurate diagnostic biomarkers for the differentiation of preclinical Alzheimer's disease (AD) from age-associated memory impairment, depression and other forms of ...

    Abstract Background: Cerebrospinal fluid (CSF) levels assessment of Aβ1-42 and Tau proteins may be accurate diagnostic biomarkers for the differentiation of preclinical Alzheimer's disease (AD) from age-associated memory impairment, depression and other forms of dementia in patients with mild cognitive impairment (MCI). The aim of our study was to explore the utility of CSF biomarkers in combination with common cognitive markers as predictors for the risk of AD development, and other forms of dementia, and the time to conversion in community patients with MCI.
    Methods: A group of 71 MCI patients underwent neurological assessment, extended neuropsychological evaluation, routine blood tests, ApoE determination, and lumbar puncture to dose t-tau, p-tau181, Aβ1-42. We investigated baseline CSF and neuropsychological biomarker patterns according to groups stratified with later diagnoses of AD conversion (MCI-AD), other dementia (MCI-NAD) conversion, or clinical stability (sMCI).
    Results: Baseline Aβ1-42 CSF levels were significantly lower in MCI-AD patients compared to both sMCI and MCI-NAD. Additionally, p-tau181 was higher in the MCI-AD group compared to sMCI. The MCI-AD subgroup analysis confirmed the role of Aβ1-42 in its predictive role of time to conversion: rapid converters had lower Aβ1-42 levels compared to slow converters. Logistic regression and survival analysis further supported the key predictive role of baseline Aβ1-42 for incipient AD and dementia-free survival.
    Conclusions: Our results confirm the key role of CSF biomarkers in predicting patient conversion from MCI to dementia. The study suggests that CSF biomarkers may also be reliable in a real world clinical setting.
    MeSH term(s) Aged ; Biomarkers/analysis ; Cerebrospinal Fluid/chemistry ; Cognitive Dysfunction/cerebrospinal fluid ; Cognitive Dysfunction/diagnosis ; Cohort Studies ; Dementia/cerebrospinal fluid ; Dementia/diagnosis ; Disease Progression ; Female ; Humans ; Male ; Predictive Value of Tests ; Regression Analysis
    Chemical Substances Biomarkers
    Language English
    Publishing date 2015-02
    Publishing country Germany
    Document type Clinical Trial ; Journal Article
    ZDB-ID 1418007-8
    ISSN 1437-4331 ; 1434-6621 ; 1437-8523
    ISSN (online) 1437-4331
    ISSN 1434-6621 ; 1437-8523
    DOI 10.1515/cclm-2014-0414
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 121: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Platelet Function Testing in Patients with Acute Ischemic Stroke: An Observational Study.

    Rosafio, Francesca / Lelli, Nicoletta / Mimmi, Stefano / Vandelli, Laura / Bigliardi, Guido / Dell'Acqua, Maria Luisa / Picchetto, Livio / Pentore, Roberta / Ferraro, Diana / Trenti, Tommaso / Nichelli, Paolo / Zini, Andrea

    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association

    2017  Volume 26, Issue 8, Page(s) 1864–1873

    Abstract: Background: The measurement of platelet reactivity in patients with stroke undergoing antiplatelet therapies is not commonly performed in clinical practice. We assessed the prevalence of therapy responsiveness in patients with stroke and further ... ...

    Abstract Background: The measurement of platelet reactivity in patients with stroke undergoing antiplatelet therapies is not commonly performed in clinical practice. We assessed the prevalence of therapy responsiveness in patients with stroke and further investigated differences between patients on prevention therapy at stroke onset and patients naive to antiplatelet medications. We also sought differences in responsiveness between etiological subtypes and correlations between Clopidogrel responsiveness and genetic polymorphisms.
    Methods: A total of 624 stroke patients on antiplatelet therapy were included. Two different groups were identified: "non-naive patients", and "naive patients". Platelet function was measured with multiple electrode aggregometry, and genotyping assays were used to determine CYP2C19 polymorphisms.
    Results: Aspirin (ASA) responsiveness was significantly more frequent in naive patients compared with non-naive patients (94.9% versus 82.6%, P < .0010). A better responsiveness to ASA compared with Clopidogrel or combination therapy was found in the entire population (P < .0010), in non-naive patients (P < .0253), and in naive patients (P < .0010). Multivariate analysis revealed a strong effect of Clopidogrel as a possible "risk factor" for unresponsiveness (odds ratio 3.652, P < .0001). No difference between etiological subgroups and no correlations between responsiveness and CYP2C19 polymorphisms were found.
    Conclusion: In our opinion, platelet function testing could be potentially useful in monitoring the biological effect of antiplatelet agents. A substantial proportion of patients with stroke on ASA were "resistant", and the treatment with Clopidogrel was accompanied by even higher rates of unresponsiveness. Longitudinal studies are needed to assess whether aggregometry might supply individualized prognostic information and whether it can be considered a valid tool for future prevention strategies.
    Language English
    Publishing date 2017-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1131675-5
    ISSN 1532-8511 ; 1052-3057
    ISSN (online) 1532-8511
    ISSN 1052-3057
    DOI 10.1016/j.jstrokecerebrovasdis.2017.04.023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3519: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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