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  1. Article: Acquired facial lipoatrophy: pathogenesis and therapeutic options.

    Szczerkowska-Dobosz, Aneta / Olszewska, Barbara / Lemańska, Małgorzata / Purzycka-Bohdan, Dorota / Nowicki, Roman

    Postepy dermatologii i alergologii

    2015  Volume 32, Issue 2, Page(s) 127–133

    Abstract: Facial lipoatrophy refers to the loss of subcutaneous fat tissue presenting by flattening or indentation of convex contour of the face. Facial lipoatrophy is a feature of the normal ageing process. It may be also a manifestation of chronic diseases, most ...

    Abstract Facial lipoatrophy refers to the loss of subcutaneous fat tissue presenting by flattening or indentation of convex contour of the face. Facial lipoatrophy is a feature of the normal ageing process. It may be also a manifestation of chronic diseases, most frequently it affects HIV-infected individuals treated with highly active antiretroviral therapy (HAART) and may constitute a complication of connective tissue diseases, like lupus erythematosus profundus or morphea. Early recognition and treatment of the active stage of connective tissue diseases is of essential significance in prevention of subsequent scarring and atrophy lesions. In HIV-positive patients undergoing HAART therapy, the attempt to modify thetreatment scheme so it has a less lipemic effect seems to be justified. Esthetic correction of facial lipoatrophy in chronic diseases is a great challenge. Improvement of appearance is very important for affected individuals, because it diminishes their stigmatization and psychosocial dysfunction. Facial volumetric correction includes surgical and dermatological procedures such as adipose transfer and injectable dermal fillers.
    Language English
    Publishing date 2015-03-30
    Publishing country Poland
    Document type Journal Article ; Review
    ZDB-ID 2596142-1
    ISSN 1642-395X
    ISSN 1642-395X
    DOI 10.5114/pdia.2014.40971
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Ocena wartości energetycznej całodziennych racji pokarmowych osób dorosłych HIV-pozytywnych.

    Lebiedzińska, Anna / Bierzyńska, Natalia / Lemańska, Małgorzata / Jankowska, Maria / Trocha, Hanna / Smiatacz, Tomasz / Szefer, Piotr

    Roczniki Panstwowego Zakladu Higieny

    2009  Volume 60, Issue 2, Page(s) 191–194

    Abstract: The purpose of this study was to determine energy intake in HIV-positive adults. In the study participated 150 adults. Energy intake and percentage of energy from protein, carbohydrate and fat were measured using 24-hour dietary recalls and computer ... ...

    Title translation Assessment of energy intake in HIV--positive adults.
    Abstract The purpose of this study was to determine energy intake in HIV-positive adults. In the study participated 150 adults. Energy intake and percentage of energy from protein, carbohydrate and fat were measured using 24-hour dietary recalls and computer program Wikt 1.3. The results of the study showed that energy intakes were below the dietary reference values for HIV-positive. Moreover the analyzed diets contained too small protein and carbohydrate contents but too high level of fat. Despite of this fact, the majority of respondents had correct BMI value.
    MeSH term(s) Adult ; Body Mass Index ; Case-Control Studies ; Diet Surveys ; Dietary Carbohydrates/metabolism ; Dietary Fats/metabolism ; Dietary Proteins/metabolism ; Energy Intake ; Female ; HIV Seropositivity/physiopathology ; Humans ; Male ; Nutrition Assessment
    Chemical Substances Dietary Carbohydrates ; Dietary Fats ; Dietary Proteins
    Language Polish
    Publishing date 2009
    Publishing country Poland
    Document type English Abstract ; Journal Article
    ZDB-ID 421739-1
    ISSN 0035-7715
    ISSN 0035-7715
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 696: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Distribution and time trends of HIV-1 variants in Poland: Characteristics of non-B clades and recombinant viruses.

    Parczewski, Miłosz / Leszczyszyn-Pynka, Magdalena / Witak-Jędra, Magdalena / Rymer, Weronika / Zalewska, Małgorzata / Gąsiorowski, Jacek / Bociąga-Jasik, Monika / Kalinowska-Nowak, Anna / Garlicki, Aleksander / Grzeszczuk, Anna / Jankowska, Maria / Lemańska, Małgorzata / Barałkiewicz, Grażyna / Mozer-Lisewska, Iwona / Łojewski, Władysław / Grąbczewska, Edyta / Olczak, Anita / Jabłonowska, Elżbieta / Urbańska, Anna

    Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases

    2016  Volume 39, Page(s) 232–240

    Abstract: The spread of HIV-1 subtypes varies considerably both worldwide and within Europe, with non-B variants commonly found across various exposure groups. This study aimed to analyse the distribution and temporal trends in HIV-1 subtype variability across ... ...

    Abstract The spread of HIV-1 subtypes varies considerably both worldwide and within Europe, with non-B variants commonly found across various exposure groups. This study aimed to analyse the distribution and temporal trends in HIV-1 subtype variability across Poland. For analysis of the subtype distribution, 1219 partial pol sequences obtained from patients followed up in 9 of 17 Polish HIV treatment centres were used. Subtyping was inferred using the maximum likelihood method; recombination was assessed using the bootscanning and jumping profile hidden Markov model methods. Subtype B dominated in the studied group (n=1059, 86.9%); in 160 (13.1%) sequences, non-B variants were present [A1 (n=63, 5.2%), D (n=43, 3.5%), C (n=22, 1.8%), and F1 (n=2, 0.2%)]. In 25 (2.1%) cases circulating recombinant forms (CRFs) were found. Five A1 variants (0.4%) were unique AB recombinant forms (URF) not previously identified in Poland. Non-B clades were notably more common among females (n=73, 45.6%, p<0.001) and heterosexual individuals (n=103, 66.5%, p<0.001) and less frequent among men who have sex with men (MSM) (n=27, 17.42%, p<0.001). HIV-1 viral load at diagnosis was higher among non-B cases [median: 5.0 (IQR: 4.4-5.6)] vs. [median: 4.8 (IQR: 4.3-5.4) log copies/ml for subtype B (p<0.001)] with a lower CD4(+) lymphocyte count at baseline [median: 248 (IQR: 75-503) for non-B vs. median: 320 (IQR: 125-497) cells/μl for subtype B; p<0.001]. The frequency of the non-B subtypes proved stable from 2008 (11.5%) to 2014 (8.0%) [OR: 0.95 (95% CI: 0.84-1.07), p=0.4], with no temporal differences for exposure groups, gender, age and AIDS. Despite the predominance of subtype B, the variability of HIV in Poland is notable; both CRFs and URFs are present in the analysed population. Non-B variants are associated with heterosexual transmission, more advanced HIV disease and have stable temporal frequencies.
    MeSH term(s) Adult ; CD4 Lymphocyte Count ; Female ; Genetic Variation ; Genotype ; HIV Infections/epidemiology ; HIV Infections/immunology ; HIV Infections/virology ; HIV-1/genetics ; Humans ; Male ; Middle Aged ; Odds Ratio ; Phylogeny ; Poland/epidemiology ; Recombination, Genetic ; Viral Load
    Language English
    Publishing date 2016-04
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2037068-4
    ISSN 1567-7257 ; 1567-1348
    ISSN (online) 1567-7257
    ISSN 1567-1348
    DOI 10.1016/j.meegid.2016.02.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5645: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Transmitted HIV drug resistance in antiretroviral-treatment-naive patients from Poland differs by transmission category and subtype.

    Parczewski, Miłosz / Leszczyszyn-Pynka, Magdalena / Witak-Jędra, Magdalena / Maciejewska, Katarzyna / Rymer, Weronika / Szymczak, Aleksandra / Szetela, Bartosz / Gąsiorowski, Jacek / Bociąga-Jasik, Monika / Skwara, Paweł / Garlicki, Aleksander / Grzeszczuk, Anna / Rogalska, Magdalena / Jankowska, Maria / Lemańska, Małgorzata / Hlebowicz, Maria / Barałkiewicz, Grażyna / Mozer-Lisewska, Iwona / Mazurek, Renata /
    Lojewski, Władyslaw / Grąbczewska, Edyta / Olczak, Anita / Jabłonowska, Elżbieta / Clark, Jeremy / Urbańska, Anna

    The Journal of antimicrobial chemotherapy

    2015  Volume 70, Issue 1, Page(s) 233–242

    Abstract: Objectives: The surveillance of HIV-transmitted drug resistance mutations (t-DRMs), including temporal trends across subtypes and exposure groups, remains a priority in the current management of the epidemic worldwide.: Methods: A cross-sectional ... ...

    Abstract Objectives: The surveillance of HIV-transmitted drug resistance mutations (t-DRMs), including temporal trends across subtypes and exposure groups, remains a priority in the current management of the epidemic worldwide.
    Methods: A cross-sectional analysis of 833 treatment-naive patients from 9 of 17 Polish HIV treatment centres. Partial pol sequences were used to analyse drug resistance with a general time reversible (GTR)-based maximum likelihood algorithm used for cluster/pair identification. Mutation frequencies and temporal trends were investigated.
    Results: t-DRMs were observed in 9% of cases (5.8% for NRTI, 1.2% NNRTI and 2.0% PI mutations) and were more common among heterosexually infected (HET) individuals (13.4%) compared with MSM (8.3%, P = 0.03) or injection drug users (IDUs; 2.9%, P = 0.001) and in MSM compared with IDUs (P = 0.046). t-DRMs were more frequent in cases infected with the non-B variant (21.6%) compared with subtype B (6.6%, P < 0.001). With subtype B a higher mutation frequency was found in MSM compared with non-MSM cases (8.3% versus 1.8% for IDU + HET, P = 0.038), while non-B variants were associated with heterosexual exposure (30.4% for HET versus 4.8% for MSM, P = 0.019; versus 0 for IDU, P = 0.016). Trends in t-DRM frequencies were stable over time except for a decrease in NNRTI t-DRMs among MSM (P = 0.0662) and an NRTI t-DRM decrease in HET individuals (P = 0.077). With subtype B a higher frequency of sequence pairs/clusters in MSM (50.4%) was found compared with HET (P < 0.001) and IDUs (P = 0.015).
    Conclusions: Despite stable trends over time, patterns of t-DRMs differed notably between transmission categories and subtypes: subtype B was associated with MSM transmission and clustering while in non-B clades t-DRMs were more common and were associated with heterosexual infections.
    MeSH term(s) Adult ; Anti-HIV Agents/pharmacology ; Cross-Sectional Studies ; Drug Resistance, Viral ; Female ; Genotype ; HIV/classification ; HIV/drug effects ; HIV/genetics ; HIV Infections/epidemiology ; HIV Infections/transmission ; HIV Infections/virology ; Humans ; Male ; Middle Aged ; Mutation Rate ; Poland/epidemiology ; Prevalence ; Sequence Analysis, DNA ; pol Gene Products, Human Immunodeficiency Virus/genetics
    Chemical Substances Anti-HIV Agents ; pol Gene Products, Human Immunodeficiency Virus
    Language English
    Publishing date 2015-01
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 191709-2
    ISSN 1460-2091 ; 0305-7453
    ISSN (online) 1460-2091
    ISSN 0305-7453
    DOI 10.1093/jac/dku372
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1197: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 124: Show issues

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  5. Article ; Online: Meeting the WHO 90% target: antiretroviral treatment efficacy in Poland is associated with baseline clinical patient characteristics.

    Parczewski, Milosz / Siwak, Ewa / Leszczyszyn-Pynka, Magdalena / Cielniak, Iwona / Burkacka, Ewa / Pulik, Piotr / Witor, Adam / Muller, Karolina / Zasik, Ewelina / Grzeszczuk, Anna / Jankowska, Maria / Lemańska, Małgorzata / Olczak, Anita / Grąbczewska, Edyta / Szymczak, Aleksandra / Gąsiorowski, Jacek / Szetela, Bartosz / Bociąga-Jasik, Monika / Skwara, Paweł /
    Witak-Jędra, Magdalena / Jabłonowska, Elżbieta / Wójcik-Cichy, Kamila / Kamerys, Juliusz / Janczarek, Małgorzata / Krankowska, Dagny / Mikuła, Tomasz / Kozieł, Katarzyna / Bielec, Dariusz / Stempkowska, Justyna / Kocbach, Aleksandra / Błudzin, Wiesława / Horban, Andrzej

    Journal of the International AIDS Society

    2017  Volume 20, Issue 1, Page(s) 21847

    Abstract: Introduction: Modern combined antiretroviral therapies (cART) allow to effectively suppress HIV-1 viral load, with the 90% virologic success rate, meeting the WHO target in most clinical settings. The aim of this study was to analyse antiretroviral ... ...

    Abstract Introduction: Modern combined antiretroviral therapies (cART) allow to effectively suppress HIV-1 viral load, with the 90% virologic success rate, meeting the WHO target in most clinical settings. The aim of this study was to analyse antiretroviral treatment efficacy in Poland and to identify variables associated with virologic suppression.
    M: ethods
    Results: Virologic suppression rates of <50 copies/mL were observed in 4672 (90.68%) and <200 copies/mL in 4934 (95.77%) individuals. In univariate analyses, for the suppression threshold <50 copies/mL higher efficacy was noted for 2NRTI+NNRTI-based combinations (94.73%) compared to 2NRTI+PI (89.93%), 2NRTI+InI (90.61%), nucleos(t)ide sparing PI/r+InI (82.02%) and three drug class regimens (74.49%) (
    Conclusions: Proportion of virologically suppressed patients is in line with WHO treatment target confirming successful application of antiretroviral treatment strategy in Poland. Virological suppression rates depend on baseline patient characteristics, which should guide individualized antiretroviral tre0atment decisions.
    MeSH term(s) Adult ; Age Factors ; Anti-HIV Agents/therapeutic use ; CD4 Lymphocyte Count ; Cross-Sectional Studies ; Drug Therapy, Combination ; Female ; HIV Infections/drug therapy ; HIV-1 ; Health Planning ; Humans ; Male ; Middle Aged ; Poland ; Treatment Outcome ; Viral Load ; World Health Organization ; Young Adult
    Chemical Substances Anti-HIV Agents
    Language English
    Publishing date 2017-07-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2467110-1
    ISSN 1758-2652 ; 1758-2652
    ISSN (online) 1758-2652
    ISSN 1758-2652
    DOI 10.7448/IAS.20.1.21847
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Time trends in HIV-1 transmitted drug resistance mutation frequency in Poland.

    Parczewski, Milosz / Witak-Jedra, Magdalena / Maciejewska, Katarzyna / Bociaga-Jasik, Monika / Skwara, Pawel / Garlicki, Aleksander / Grzeszczuk, Anna / Rogalska, Magdalena / Jankowska, Maria / Lemanska, Malgorzata / Hlebowicz, Maria / Baralkiewicz, Grazyna / Mozer-Lisewska, Iwona / Mazurek, Renata / Lojewski, Wladyslaw / Grabczewska, Edyta / Olczak, Anita / Jablonowska, Elzbieta / Rymer, Weronika /
    Szymczak, Aleksandra / Szetela, Bartosz / Gasiorowski, Jacek / Knysz, Brygida / Urbanska, Anna / Leszczyszyn-Pynka, Magdalena

    Journal of the International AIDS Society

    2014  Volume 17, Issue 4 Suppl 3, Page(s) 19753

    Abstract: Introduction: In Poland, the HIV epidemic has shifted recently from being predominantly related to injection drug use (IDU) to being driven by transmissions among men-who-have-sex-with-men (MSM). The number of new HIV cases has increased in the recent ... ...

    Abstract Introduction: In Poland, the HIV epidemic has shifted recently from being predominantly related to injection drug use (IDU) to being driven by transmissions among men-who-have-sex-with-men (MSM). The number of new HIV cases has increased in the recent years, while no current data on the transmitted drug resistance associated mutations (tDRM) frequency trend over time are available from 2010. In this study, we analyze the temporal trends in the spread of tDRM from 2008 to 2013.
    Materials and methods: Partial pol sequences from 833 antiretroviral treatment-naive individuals of European descent (Polish origin) linked to care in 9 of 17 Polish HIV treatment centres were analyzed. Drug resistance interpretation was performed according to WHO surveillance recommendations, subtyping with REGA genotyping 2.0 tool. Time trends were examined for the frequency of t-DRM across subtypes and transmission groups using logistic regression (R statistical platform, v. 3.1.0).
    Results: Frequency of tDRM proved stable over time, with mutation frequency change from 11.3% in 2008 to 8.3% in 2013 [OR: 0.91 (95% CI 0.80-1,05), p=0.202] (Figure 1a). Also, no significant differences over time were noted for the subtype B (decrease from 8.4% 2008 to 6.2% in 2013 [OR: 0.94 (95% CI 0.79-1.11), p=0.45] and across non-B variants [change from 22.6% 2008 to 23.1% in 2013, OR: 0.94 (95% CI 0.75-1.19), p=0.62]. When patient groups were stratified according to transmission route, in MSM there was a trend for a NNRTI t-DRM decrease (from 6.8% 2008 to 1% in 2013, OR: 0.61 (95% CI 0.34-1.02), p=0.0655, slope -0.74%/year) (Figure 1b), related to the subtype B infected MSM (decrease from 7% 2008 to 1% in 2013, OR: 0.61 (95% CI 0.34-1.03), p=0.0662, slope -0.75%/year). Overall tDRM frequency decrease was also noted for the heterosexually infected patients [from 17.6% 2008 to 10.3% in 2013, OR: 0.83 (95% CI 0.67-1.02, p=0.077, slope -2.041%/year)] but did not associate with drug class (Figure 1c). In IDUs, the trends in t-DRM frequency were not significant over time (change from 1.9% in 2008 to 0 in 2013 [OR:1.24 (95% CI 0.73-2.26), p=0.4)].
    Conclusions: The frequency of t-DRM in Poland is generally stable over time. Decrease in the overall tDRM frequency in heterosexual infected cases and NNRTI resistance in subtype B infected MSM may be related to the higher treatment efficacy of current cART.
    Language English
    Publishing date 2014
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2467110-1
    ISSN 1758-2652 ; 1758-2652
    ISSN (online) 1758-2652
    ISSN 1758-2652
    DOI 10.7448/IAS.17.4.19753
    Database MEDical Literature Analysis and Retrieval System OnLINE

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