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  1. Article ; Online: Svenskanpassad triage gav färre överprioriteringar på barnakut.

    Sjöstedt, Hannah / Leo Lemarquis, Andri / Klasson, Martin / Holmqvist, Lina

    Lakartidningen

    2022  Volume 119

    Abstract: Pediatric Priority Process (PEPP) is a triage system derived from the South African Triage Scale. It was developed by healthcare professionals at the Queen Silvia Children's hospital in Gothenburg. PEPP is a four-level triage system with two parts: vital ...

    Title translation Fewer overtriaged children with PEPP compared to RETTS-p at a Swedish pediatric emergency department.
    Abstract Pediatric Priority Process (PEPP) is a triage system derived from the South African Triage Scale. It was developed by healthcare professionals at the Queen Silvia Children's hospital in Gothenburg. PEPP is a four-level triage system with two parts: vital parameters and warning symptoms. The aim of the study was to compare the amount of overtriage and the specificity for children in need of hospitalization in PEPP compared to RETTS-p. Our study shows that PEPP yields significantly fewer children with a high priority and has a higher specificity than RETTS-p. Senior triage nurses judged PEPP to have a higher accuracy, and the system triages children in need of supplemental oxygen higher than RETTS-p. We conclude that PEPP has high patient safety, and the next step is to implement it at our pediatric emergency department and to continue research for further validation.
    MeSH term(s) Child ; Emergency Service, Hospital ; Hospitalization ; Humans ; Sweden ; Triage
    Language Swedish
    Publishing date 2022-07-06
    Publishing country Sweden
    Document type Journal Article
    ZDB-ID 391010-6
    ISSN 1652-7518 ; 0023-7205
    ISSN (online) 1652-7518
    ISSN 0023-7205
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  2. Article ; Online: Mapping of Signaling Pathways Linked to sIgAD Reveals Impaired IL-21 Driven STAT3 B-Cell Activation.

    Lemarquis, Andri L / Theodors, Fannar / Einarsdottir, Helga K / Ludviksson, Bjorn R

    Frontiers in immunology

    2019  Volume 10, Page(s) 403

    Abstract: Objectives: ...

    Abstract Objectives:
    MeSH term(s) B-Lymphocytes/immunology ; B-Lymphocytes/metabolism ; Humans ; IgA Deficiency/immunology ; IgA Deficiency/metabolism ; Interleukins/immunology ; Lymphocyte Activation/immunology ; Phosphorylation ; STAT3 Transcription Factor/immunology ; STAT3 Transcription Factor/metabolism ; Signal Transduction/immunology ; T-Lymphocytes/immunology ; T-Lymphocytes/metabolism
    Chemical Substances Interleukins ; STAT3 Transcription Factor ; STAT3 protein, human ; interleukin-21 (MKM3CA6LT1)
    Language English
    Publishing date 2019-03-18
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2019.00403
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: IL-18-secreting multi-antigen targeting CAR T-cells eliminate antigen-low myeloma in an immunocompetent mouse model.

    Ng, Brandon D / Rajagopalan, Adhithi / Kousa, Anastasia I / Fischman, Jacob S / Chen, Sophia / Massa, Alyssa Rae / Elias, Harold K / Manuele, Dylan / Galiano, Michael / Lemarquis, Andri L / Boardman, Alexander P / DeWolf, Susan / Pierce, Jonah Addison / Bogen, Bjarne / James, Scott E / van den Brink, Marcel R M

    Blood

    2024  

    Abstract: Multiple myeloma is a plasma cell malignancy that is currently incurable with conventional therapies. Following the success of CD19-targeted chimeric antigen receptor (CAR) T-cells in leukemia and lymphoma, CAR T-cells targeting B-cell maturation antigen ...

    Abstract Multiple myeloma is a plasma cell malignancy that is currently incurable with conventional therapies. Following the success of CD19-targeted chimeric antigen receptor (CAR) T-cells in leukemia and lymphoma, CAR T-cells targeting B-cell maturation antigen (BCMA) more recently demonstrated impressive activity in relapsed and refractory myeloma patients. However, BCMA-directed therapy can fail due to low expression of BCMA on myeloma cells, suggesting that novel approaches to better address antigen-low disease may improve patient outcomes. We hypothesized that engineered secretion of the pro-inflammatory cytokine interleukin-18 (IL-18) and multi-antigen targeting could improve CAR T-cell activity against BCMA-low myeloma. In a syngeneic murine model of myeloma, CAR T-cells targeting the myeloma-associated antigens BCMA and B-cell activating factor (BAFF-R) failed to eliminate myeloma when these antigens were weakly expressed, whereas IL-18-secreting CAR T-cells targeting these antigens promoted myeloma clearance. IL-18-secreting CAR T-cells developed an effector-like T-cell phenotype, promoted interferon-gamma production, reprogrammed the myeloma bone marrow microenvironment through type I/II interferon signaling, and activated macrophages to mediate anti-myeloma activity. Simultaneous targeting of weakly expressed BCMA and BAFF-R with dual-CAR T-cells enhanced T-cell:target cell avidity, increased overall CAR signal strength, and stimulated anti-myeloma activity. Dual-antigen targeting augmented CAR T-cell secretion of engineered IL-18 and facilitated elimination of larger myeloma burdens in vivo. Our results demonstrate that combination of engineered IL-18 secretion and multi-antigen targeting can eliminate myeloma with weak antigen expression through distinct mechanisms.
    Language English
    Publishing date 2024-04-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2023022293
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Transitional B Cells and TLR9 Responses Are Defective in Selective IgA Deficiency.

    Lemarquis, Andri L / Einarsdottir, Helga K / Kristjansdottir, Rakel N / Jonsdottir, Ingileif / Ludviksson, Bjorn R

    Frontiers in immunology

    2018  Volume 9, Page(s) 909

    Abstract: Selective IgA deficiency (IgAD) is the most common primary antibody deficiency in the western world with affected individuals suffering from an increased burden of autoimmunity, atopic diseases and infections. It has been shown that IgAD B cells can be ... ...

    Abstract Selective IgA deficiency (IgAD) is the most common primary antibody deficiency in the western world with affected individuals suffering from an increased burden of autoimmunity, atopic diseases and infections. It has been shown that IgAD B cells can be induced with germinal center mimicking reactions to produce IgA. However, IgA is the most prevalent antibody in mucosal sites, where antigen-independent responses are important. Much interest has recently focused on the role of TLR9 in both naïve and mature B cell differentiation into IgA secreting plasma cells. Here, we analyze the phenotype and function of T and B cells in individuals with IgAD following IgA-inducing CpG-TLR9 stimulations. The IgAD individuals had significantly lower numbers of transitional B cells (CD19
    MeSH term(s) Adult ; Aged ; B-Lymphocytes/pathology ; Cell Differentiation ; Female ; Humans ; IgA Deficiency/immunology ; Immunoglobulin A/biosynthesis ; Immunoglobulin Class Switching ; Interleukin-10/genetics ; Lymphocyte Activation ; Male ; Middle Aged ; Oligodeoxyribonucleotides ; Precursor Cells, B-Lymphoid/drug effects ; T-Lymphocytes, Regulatory/drug effects ; Toll-Like Receptor 9/immunology
    Chemical Substances IL10 protein, human ; Immunoglobulin A ; Oligodeoxyribonucleotides ; TLR9 protein, human ; Toll-Like Receptor 9 ; Interleukin-10 (130068-27-8)
    Language English
    Publishing date 2018-04-27
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2018.00909
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Severe COVID-19 in an APS1 patient with interferon autoantibodies treated with plasmapheresis.

    Lemarquis, Andri / Campbell, Tessa / Aranda-Guillén, Maribel / Hennings, Viktoria / Brodin, Petter / Kämpe, Olle / Blennow, Kaj / Zetterberg, Henrik / Wennerås, Christine / Eriksson, Kristina / Landegren, Nils / Bryceson, Yenan / Berg, Stefan / Ekwall, Olov

    The Journal of allergy and clinical immunology

    2021  Volume 148, Issue 1, Page(s) 96–98

    MeSH term(s) Adaptive Immunity ; Adrenal Cortex Hormones/therapeutic use ; Antibodies, Viral/blood ; Autoantibodies/blood ; COVID-19/immunology ; COVID-19/therapy ; Cells, Cultured ; Child ; Female ; Humans ; Immunoglobulins, Intravenous/therapeutic use ; Interferon Type I/immunology ; Interleukins/immunology ; Lymphocyte Activation ; Plasmapheresis/methods ; Polyendocrinopathies, Autoimmune/immunology ; Polyendocrinopathies, Autoimmune/therapy ; SARS-CoV-2/immunology ; Severity of Illness Index ; Transcription Factors/genetics ; AIRE Protein ; Interleukin-22
    Chemical Substances Adrenal Cortex Hormones ; Antibodies, Viral ; Autoantibodies ; Immunoglobulins, Intravenous ; Interferon Type I ; Interleukins ; Transcription Factors ; interferon omega 1
    Language English
    Publishing date 2021-04-16
    Publishing country United States
    Document type Case Reports ; Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 121011-7
    ISSN 1097-6825 ; 1085-8725 ; 0091-6749
    ISSN (online) 1097-6825 ; 1085-8725
    ISSN 0091-6749
    DOI 10.1016/j.jaci.2021.03.034
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Long-Term Follow-Up of Newborns with 22q11 Deletion Syndrome and Low TRECs.

    Framme, Jenny Lingman / Lundqvist, Christina / Lundell, Anna-Carin / van Schouwenburg, Pauline A / Lemarquis, Andri L / Thörn, Karolina / Lindgren, Susanne / Gudmundsdottir, Judith / Lundberg, Vanja / Degerman, Sofie / Zetterström, Rolf H / Borte, Stephan / Hammarström, Lennart / Telemo, Esbjörn / Hultdin, Magnus / van der Burg, Mirjam / Fasth, Anders / Oskarsdóttir, Sólveig / Ekwall, Olov

    Journal of clinical immunology

    2022  Volume 42, Issue 3, Page(s) 618–633

    Abstract: Background: Population-based neonatal screening using T-cell receptor excision circles (TRECs) identifies infants with profound T lymphopenia, as seen in cases of severe combined immunodeficiency, and in a subgroup of infants with 22q11 deletion ... ...

    Abstract Background: Population-based neonatal screening using T-cell receptor excision circles (TRECs) identifies infants with profound T lymphopenia, as seen in cases of severe combined immunodeficiency, and in a subgroup of infants with 22q11 deletion syndrome (22q11DS).
    Purpose: To investigate the long-term prognostic value of low levels of TRECs in newborns with 22q11DS.
    Methods: Subjects with 22q11DS and low TRECs at birth (22q11Low, N=10), matched subjects with 22q11DS and normal TRECs (22q11Normal, N=10), and matched healthy controls (HC, N=10) were identified. At follow-up (median age 16 years), clinical and immunological characterizations, covering lymphocyte subsets, immunoglobulins, TRECs, T-cell receptor repertoires, and relative telomere length (RTL) measurements were performed.
    Results: At follow-up, the 22q11Low group had lower numbers of naïve T-helper cells, naïve T-regulatory cells, naïve cytotoxic T cells, and persistently lower TRECs compared to healthy controls. Receptor repertoires showed skewed V-gene usage for naïve T-helper cells, whereas for naïve cytotoxic T cells, shorter RTL and a trend towards higher clonality were found. Multivariate discriminant analysis revealed a clear distinction between the three groups and a skewing towards Th17 differentiation of T-helper cells, particularly in the 22q11Low individuals. Perturbations of B-cell subsets were found in both the 22q11Low and 22q11Normal group compared to the HC group, with larger proportions of naïve B cells and lower levels of memory B cells, including switched memory B cells.
    Conclusions: This long-term follow-up study shows that 22q11Low individuals have persistent immunologic aberrations and increased risk for immune dysregulation, indicating the necessity of lifelong monitoring.
    Clinical implications: This study elucidates the natural history of childhood immune function in newborns with 22q11DS and low TRECs, which may facilitate the development of programs for long-term monitoring and therapeutic choices.
    MeSH term(s) 22q11 Deletion Syndrome ; Adolescent ; DNA ; Follow-Up Studies ; Humans ; Infant, Newborn ; Lymphopenia/diagnosis ; Neonatal Screening ; Receptors, Antigen, T-Cell/genetics ; Severe Combined Immunodeficiency/diagnosis
    Chemical Substances Receptors, Antigen, T-Cell ; DNA (9007-49-2)
    Language English
    Publishing date 2022-01-26
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 779361-3
    ISSN 1573-2592 ; 0271-9142
    ISSN (online) 1573-2592
    ISSN 0271-9142
    DOI 10.1007/s10875-021-01201-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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