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  1. Article ; Online: Influence of hydroxyurea on tubular phosphate handling in sickle cell nephropathy.

    de Abreu, Gabriela Araujo / de Sousa, Duaran Lopes / Dantas, Suzzy Maria Carvalho / Martins, Alice Maria Costa / Sampaio, Tiago Lima / Lemes, Romélia Pinheiro Gonçalves

    Hematology, transfusion and cell therapy

    2024  

    Abstract: Objective: This study aims to evaluate the markers of tubular phosphate handling in adults with sickle cell anemia (SCA) and the influence of hydroxyurea (HU), the degree of anemia and Hb F concentration on these markers.: Methods: Eighty-eight ... ...

    Abstract Objective: This study aims to evaluate the markers of tubular phosphate handling in adults with sickle cell anemia (SCA) and the influence of hydroxyurea (HU), the degree of anemia and Hb F concentration on these markers.
    Methods: Eighty-eight steady state SCA patients in outpatient follow-up in Fortaleza, Ceara, Brazil and 31 healthy individuals were included in this study. Vitamin D (25OHD) was measured by enzyme-bound fluorescence assay, intact parathyroid hormone (iPTH) by electrochemiluminescence, and serum and urinary phosphate and creatinine by colorimetric methods. Details of Hb F and HU use were obtained from clinical records. Tubular reabsorption of phosphate (TRP) and maximum tubular reabsorption of phosphate (MTRP) were calculated. SCA patients were stratified according to the use of HU, degree of anemia and percentage of Hb F. The significance level was set for p-values <0.05.
    Results: Compared to controls the 25OHD level (25 ± 11 vs. 30 ± 9 pg/mL) was lower in SCA, while serum phosphate and MTRP were higher (3.86 ± 0.94 vs. 3.46 ± 0.72 and 3.6 ± 1.21 vs. 3.21 ± 0.53, respectively). There was no significant difference in iPTH, TRP and phosphaturia. Serum phosphate showed correlation with TRP (r = 0.32; p-value = 0.008) and MTRP (r = 0.9; p-value <0.001) in SCA. Patients taking HU, especially those with Hb F >10 % presented reduced serum phosphate levels, and TRP and MTRP rates. Those with mild anemia presented reduced serum phosphate levels and MTRP rates.
    Conclusion: Serum phosphate levels and renal phosphate reabsorption rate were increased in SCA. HU use, high Hb F concentration and total Hb were associated with better control of tubular phosphate handling markers.
    Language English
    Publishing date 2024-02-14
    Publishing country Brazil
    Document type Journal Article
    ISSN 2531-1387
    ISSN (online) 2531-1387
    DOI 10.1016/j.htct.2023.11.015
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  2. Article: Comments on the clinical and laboratory characteristics of patients with dengue hemorrhagic fever manifestations and their transfusion profile.

    Lemes, Romélia Pinheiro Gonçalves

    Revista brasileira de hematologia e hemoterapia

    2014  Volume 36, Issue 2, Page(s) 100–101

    Language English
    Publishing date 2014-03-26
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 2105177-X
    ISSN 1806-0870 ; 1516-8484
    ISSN (online) 1806-0870
    ISSN 1516-8484
    DOI 10.5581/1516-8484.20140022
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  3. Article ; Online: Sickle Cell Disease and the Kidney: Pathophysiology and Novel Biomarkers.

    Lemes, Romélia Pinheiro Gonçalves / Rocha Laurentino, Marilia / Castelo, Luan Rebouças / Silva Junior, Geraldo

    Contributions to nephrology

    2021  Volume 199, Page(s) 114–121

    Abstract: Clinical Background: Renal involvement in sickle cell disease (SCD), called sickle cell nephropathy (SCN), includes several renal manifestations, such as renal acidification defect, distal nephron dysfunction, renal papillary necrosis, and proteinuria ... ...

    Abstract Clinical Background: Renal involvement in sickle cell disease (SCD), called sickle cell nephropathy (SCN), includes several renal manifestations, such as renal acidification defect, distal nephron dysfunction, renal papillary necrosis, and proteinuria related to glomerular injury, leading to end-stage renal disease. Epidemiology: Many patients with SCD have a defect in urinary concentration, a problem caused by the destruction of the renal medulla that initiates in childhood. The presence of proteinuria in SCD is age-related and starts as microalbuminuria in adolescence and progresses to macroalbuminuria. Proteinuria is responsible for the progression to chronic kidney disease in some patients with SCD with glomerular filtration rate (GFR) decreased due to interactions between various processes involving the vascular, glomerular, tubular, and interstitial compartments of the kidney. Challenges: Renal complications are hardly identifiable in the early stages, as serum creatinine increases only in the final stages of SCN. Subnormal GFR and elevated serum creatinine levels develop only when there is significant proteinuria. Prevention and Treatment: The identification of biomarkers of early, non-invasive kidney injury, and their inclusion in clinical practice will contribute to the identification of the mechanisms involved in the development of renal syndromes, facilitating the development of more effective strategies in the prevention and treatment of SCD.
    MeSH term(s) Adolescent ; Anemia, Sickle Cell/complications ; Biomarkers ; Glomerular Filtration Rate ; Humans ; Kidney ; Kidney Diseases/etiology ; Renal Insufficiency, Chronic/complications
    Chemical Substances Biomarkers
    Language English
    Publishing date 2021-08-03
    Publishing country Switzerland
    Document type Journal Article ; Review
    ISSN 1662-2782 ; 0302-5144
    ISSN (online) 1662-2782
    ISSN 0302-5144
    DOI 10.1159/000517703
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  4. Article ; Online: Hematological changes in Covid-19 infections.

    Duarte, Fernando Barroso / Lemes, Romélia Pinheiro Gonçalves / Duarte, Isabella Araujo / Duarte, Beatrice Araújo / Duarte, João Vitor Araujo

    Revista da Associacao Medica Brasileira (1992)

    2020  Volume 66, Issue 2, Page(s) 99

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections/blood ; Coronavirus Infections/diagnosis ; Hematologic Diseases/diagnosis ; Humans ; Pandemics ; Pneumonia, Viral/blood ; Pneumonia, Viral/diagnosis ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-05-15
    Publishing country Brazil
    Document type Letter
    ZDB-ID 731969-1
    ISSN 1806-9282 ; 0104-4230 ; 0004-5241 ; 0102-843X
    ISSN (online) 1806-9282
    ISSN 0104-4230 ; 0004-5241 ; 0102-843X
    DOI 10.1590/1806-9282.66.2.99
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  5. Book ; Online: Hematological changes in Covid-19 infections

    Duarte, Fernando Barroso / Lemes, Romélia Pinheiro Gonçalves / Duarte, Isabella Araujo / Duarte, Beatrice Araújo / Duarte, João Vitor Araujo

    Revista da Associação Médica Brasileira v.66 n.2 2020

    2020  

    Keywords covid19
    Language English
    Publishing date 2020-02-01
    Publisher Associação Médica Brasileira
    Publishing country br
    Document type Book ; Online
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  6. Article: Hematological changes in Covid-19 infections

    Duarte, Fernando Barroso / Lemes, Romélia Pinheiro Gonçalves / Duarte, Isabella Araujo / Duarte, Beatrice Araújo / Duarte, João Vitor Araujo

    Rev Assoc Med Bras (1992)

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #32428139
    Database COVID19

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  7. Article ; Online: Prolonged response to recombinant human erythropoietin treatment in patients with myelodysplastic syndrome at a single referral centre in Brazil.

    Moura, Anna Thawanny Gadelha / Duarte, Fernando Barroso / Barbosa, Maritza Cavalcante / Santos, Talyta Ellen de Jesus Dos / Lemes, Romélia Pinheiro Gonçalves

    Clinics (Sao Paulo, Brazil)

    2019  Volume 74, Page(s) e771

    Abstract: Objectives: To evaluate the effects of epoetin (EPO) alfa treatment on overall survival, event-free survival and response duration in patients with myelodysplastic syndrome (MDS) who were treated at a haematological referral centre in northeastern ... ...

    Abstract Objectives: To evaluate the effects of epoetin (EPO) alfa treatment on overall survival, event-free survival and response duration in patients with myelodysplastic syndrome (MDS) who were treated at a haematological referral centre in northeastern Brazil.
    Methods: This was a retrospective cohort study of 36 patients diagnosed with MDS and treated with EPO alfa at 30,000 to 60,000 IU per week. Clinical data were collected from medical records. The events assessed were non-response to treatment and progression to acute myeloid leukaemia (AML). Statistical analyses were performed using GraphPad Prism 7 and SPSS 24 software.
    Results: The overall survival of patients who received EPO alfa treatment was 51.64%, with a median of 65 months of treatment, and the overall survival of this group was 100% during the first 24 months. We detected a 43.5-month median event-free survival, with a response rate of 80.5%. We observed responses from 25 to 175 months. Patients with transfusion dependence and those with a high-risk stratification, as determined by the International Prognostic Scoring System (IPSS), the Revised International Prognostic Scoring System (IPSS-R), the WHO classification-based Prognostic Scoring System (WPSS) and the WHO 2016, had a lower event-free survival than other patients.
    Conclusions: Despite the wide use of EPO alfa in the treatment of anaemia in patients with MDS, the median response duration is approximately only 24 months. Our data provide encouraging results concerning the benefits of using EPO alfa for the improvement of the quality of life, as patients treated with EPO showed higher overall survival, event-free survival rates and longer response durations than have been previously described in the literature.
    MeSH term(s) Aged ; Aged, 80 and over ; Blood Transfusion ; Brazil ; Disease Progression ; Epoetin Alfa/therapeutic use ; Female ; Hematinics/therapeutic use ; Hemoglobins/analysis ; Humans ; Kaplan-Meier Estimate ; Karyotype ; Male ; Middle Aged ; Myelodysplastic Syndromes/drug therapy ; Myelodysplastic Syndromes/mortality ; Platelet Count ; Progression-Free Survival ; Reference Values ; Retrospective Studies ; Risk Factors ; Time Factors ; Treatment Outcome
    Chemical Substances Hematinics ; Hemoglobins ; Epoetin Alfa (64FS3BFH5W)
    Language English
    Publishing date 2019-09-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2182801-5
    ISSN 1980-5322 ; 1807-5932
    ISSN (online) 1980-5322
    ISSN 1807-5932
    DOI 10.6061/clinics/2019/e771
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  8. Article ; Online: Non-invasive urinary biomarkers of renal function in sickle cell disease: an overview.

    Laurentino, Marília Rocha / Parente Filho, Sérgio Luiz Arruda / Parente, Lívia Leal Chagas / da Silva Júnior, Geraldo Bezerra / Daher, Elizabeth De Francesco / Lemes, Romélia Pinheiro Gonçalves

    Annals of hematology

    2019  Volume 98, Issue 12, Page(s) 2653–2660

    Abstract: Sickle cell disease (SCD) is a hereditary condition characterized by homozygosis of the hemoglobin S (HbS) gene. Marked morbimortality is observed due to chronic hemolysis, endothelial injury, and episodes of vaso-occlusion, which leads to multi-organ ... ...

    Abstract Sickle cell disease (SCD) is a hereditary condition characterized by homozygosis of the hemoglobin S (HbS) gene. Marked morbimortality is observed due to chronic hemolysis, endothelial injury, and episodes of vaso-occlusion, which leads to multi-organ damage. Renal impairment is common and may have different presentations, such as deficiency in urinary acidification or concentration, glomerulopathies, proteinuria, and hematuria, frequently resulting in end-stage renal disease (ESRD). Novel biomarkers of renal function, such as kidney injury molecule 1 (KIM-1), and neutrophil gelatinase-associated lipocalin (NGAL) and monocyte chemoattractant protein 1 (MCP-1) are being studied in order to enable early diagnosis of kidney damage in SCD.
    MeSH term(s) Anemia, Sickle Cell/complications ; Anemia, Sickle Cell/urine ; Biomarkers/urine ; Chemokine CCL2/urine ; Hepatitis A Virus Cellular Receptor 1/metabolism ; Humans ; Kidney/metabolism ; Kidney Failure, Chronic/etiology ; Kidney Failure, Chronic/urine ; Lipocalin-2/urine
    Chemical Substances Biomarkers ; CCL2 protein, human ; Chemokine CCL2 ; HAVCR1 protein, human ; Hepatitis A Virus Cellular Receptor 1 ; LCN2 protein, human ; Lipocalin-2
    Language English
    Publishing date 2019-10-23
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 1064950-5
    ISSN 1432-0584 ; 0939-5555 ; 0945-8077
    ISSN (online) 1432-0584
    ISSN 0939-5555 ; 0945-8077
    DOI 10.1007/s00277-019-03813-9
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  9. Article ; Online: Use of non-conventional biomarkers in the early diagnosis of acute kidney injury in preterm newborns with sepsis.

    Barbosa, Joycilene da Silva / Silva Júnior, Geraldo Bezerra da / Meneses, Gdayllon Cavalcante / Martins, Alice Maria Costa / Daher, Elizabeth De Francesco / Machado, Rosângela Pinheiro Gonçalves / Lemes, Romélia Pinheiro Gonçalves

    Jornal brasileiro de nefrologia

    2021  Volume 44, Issue 1, Page(s) 97–108

    Abstract: Acute kidney injury (AKI) is a common finding in Neotatal Intensive Care Units (NICU). Sepsis is one the main causes of AKI in preterm newborns. AKI has been associated with significant death rates. Early detection of the condition is the first step to ... ...

    Abstract Acute kidney injury (AKI) is a common finding in Neotatal Intensive Care Units (NICU). Sepsis is one the main causes of AKI in preterm newborns. AKI has been associated with significant death rates. Early detection of the condition is the first step to improving prevention, treatment, and outcomes, while decreasing length of hospitalization, care costs, and morbimortality. AKI may progress to chronic kidney disease (CKD), a condition linked with dialysis and greater risk of cardiovascular disease. This review article aims to discuss cases of AKI in preterm newborns with sepsis, the use of biomarkers in lab workup, and the use of non-conventional biomarkers for the early identification of AKI.
    MeSH term(s) Acute Kidney Injury/diagnosis ; Acute Kidney Injury/etiology ; Biomarkers ; Early Diagnosis ; Humans ; Infant, Newborn ; Intensive Care Units ; Renal Dialysis/adverse effects ; Risk Factors ; Sepsis/complications ; Sepsis/diagnosis
    Chemical Substances Biomarkers
    Language Portuguese
    Publishing date 2021-11-29
    Publishing country Brazil
    Document type Journal Article ; Review
    ZDB-ID 2057873-8
    ISSN 2175-8239 ; 2175-8239
    ISSN (online) 2175-8239
    ISSN 2175-8239
    DOI 10.1590/2175-8239-JBN-2020-0222
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  10. Article ; Online: Obliterans With Organizing Pneumonia: A Possible Misdiagnosis of Lung Graft-Versus-Host Disease in Posttransplant Patients With COVID-19.

    Duarte, Fernando Barroso / Lemes, Romélia Pinheiro Gonçalves / Barroso, Karine Sampaio Nunes / Vasconcelos, João Paulo / Pitombeira, Beatriz Stela Gomes de Souza / Gurgel, Lívia Andrade / Viana, Thaísa Marjore Menezes / Duarte, Beatrice Araújo / Duarte, Isabella Araujo / Moura, Anna Thawanny Gadelha

    Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation

    2021  Volume 19, Issue 4, Page(s) 393–395

    MeSH term(s) Aged ; COVID-19/complications ; COVID-19/diagnosis ; COVID-19/virology ; COVID-19 Serological Testing ; Cryptogenic Organizing Pneumonia/diagnosis ; Cryptogenic Organizing Pneumonia/virology ; Diagnostic Errors ; Graft vs Host Disease/diagnosis ; Graft vs Host Disease/etiology ; Hematopoietic Stem Cell Transplantation/adverse effects ; Humans ; Male ; Myelodysplastic Syndromes/diagnosis ; Myelodysplastic Syndromes/surgery ; Predictive Value of Tests ; Tomography, X-Ray Computed ; Transplantation, Homologous ; Treatment Outcome
    Language English
    Publishing date 2021-02-01
    Publishing country Turkey
    Document type Case Reports ; Letter
    ZDB-ID 2396778-X
    ISSN 2146-8427 ; 1304-0855
    ISSN (online) 2146-8427
    ISSN 1304-0855
    DOI 10.6002/ect.2020.0360
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