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  1. Article: Sonorheometry Device Thresholds in Liver Transplantation: An Observational Retrospective Study.

    Soucy-Proulx, Maxim / Kato, Hiromi / Coeckelenbergh, Sean / Naili Kortaia, Salima / Herboulier, Laurence / Pittau, Gabriella / Pham, Patrick / Lemoine, Antoinette / Duranteau, Jacques / Roullet, Stéphanie

    Journal of clinical medicine

    2024  Volume 13, Issue 3

    Abstract: Background: Liver transplantation (LT) remains a potentially haemorrhagic procedure whose perioperative bleeding and transfusion could be better monitored using point-of-care devices. Quantra: Methods: In 34 patients undergoing LT, blood samples were ...

    Abstract Background: Liver transplantation (LT) remains a potentially haemorrhagic procedure whose perioperative bleeding and transfusion could be better monitored using point-of-care devices. Quantra
    Methods: In 34 patients undergoing LT, blood samples were collected before surgical incision, 15 min after the beginning of the anhepatic phase, and 15 min after arterial revascularization of the graft.
    Results: Clotting time (CT) was well correlated with prothrombin (PT) ratio and activated partial thromboplastin time (aPTT) ratio. Platelet contribution to clot stiffness (PCS) was correlated with platelets (ρ = 0.82,
    Conclusion: Quantra
    Language English
    Publishing date 2024-01-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13030696
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  2. Article: Redox signaling in the pathogenesis of human disease and the regulatory role of autophagy.

    Pervaiz, Shazib / Bellot, Gregory L / Lemoine, Antoinette / Brenner, Catherine

    International review of cell and molecular biology

    2020  Volume 352, Page(s) 189–214

    Abstract: Aberrant cell death signaling and oxidative stress are implicated in myriad of human pathological states such as neurodegenerative, cardiovascular, metabolic and liver diseases, as well as drug-induced toxicities. While regulated cell death and mild ... ...

    Abstract Aberrant cell death signaling and oxidative stress are implicated in myriad of human pathological states such as neurodegenerative, cardiovascular, metabolic and liver diseases, as well as drug-induced toxicities. While regulated cell death and mild oxidative stress are essential during normal tissue homeostasis, deregulated signaling can trigger massive depletion in a particular cell type and/or damage tissues and impair organ function with deleterious consequences that manifest as disease states. If regeneration cannot restore tissue homeostasis, the severity of the disease correlates with the extent of cell loss. Cell death can be executed via multiple modalities such as apoptosis, necrosis, pyroptosis, necroptosis and ferroptosis, depending on cell autonomous mechanisms (e.g., reactive oxygen species production, calcium overload and altered proteostasis) and/or non-cell autonomous processes (e.g., environmental stress, irradiation, chemotherapeutic agents, inflammation and pathogens). Accordingly, the inhibition of aberrant cell death and oxidative stress together with activation of autophagy, a regulated self-degradation process, are progressively emerging as relevant cytoprotective strategies to sustain homeostasis. In this review, we summarize the current literature on the crosstalk between cellular redox state and cell fate signaling, specifically from the standpoint of autophagy and its role in the maintenance of tissue/organ homeostasis via regulating oxidative stress and the potential implications for the design of novel therapeutic strategies.
    MeSH term(s) Animals ; Autophagy ; Humans ; Neurodegenerative Diseases/metabolism ; Oxidation-Reduction ; Reactive Oxygen Species/metabolism ; Signal Transduction
    Chemical Substances Reactive Oxygen Species
    Language English
    Publishing date 2020-04-01
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2427220-6
    ISSN 1937-6448 ; 0074-7696
    ISSN 1937-6448 ; 0074-7696
    DOI 10.1016/bs.ircmb.2020.03.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Reply to P. Gazzaniga et al.

    Bouchahda, Mohamed / Saffroy, Raphael / Karaboué, Abdoulaye / Hamelin, Jocelyne / Innominato, Pasquale / Saliba, Faouzi / Bosselut, Nelly / Lemoine, Antoinette / Lévi, Francis

    JCO precision oncology

    2022  Volume 5, Page(s) 391–392

    Language English
    Publishing date 2022-01-07
    Publishing country United States
    Document type Letter ; Comment
    ISSN 2473-4284
    ISSN (online) 2473-4284
    DOI 10.1200/PO.20.00465
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  4. Article: Mitochondrial Proteins (e.g., VDAC, Bcl-2, HK, ANT) as Major Control Points in Oncology.

    Brenner, Catherine / Lemoine, Antoinette

    Frontiers in oncology

    2014  Volume 4, Page(s) 365

    Language English
    Publishing date 2014-12-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2014.00365
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  5. Article: Mutations at the splice sites of exon 14 of MET gene: a new target for sarcomatoid carcinomas?

    Wislez, Marie / Domblides, Charlotte / Cortot, Alexis / Lemoine, Antoinette

    Annals of translational medicine

    2016  Volume 4, Issue 5, Page(s) 96

    Language English
    Publishing date 2016-03-22
    Publishing country China
    Document type Journal Article
    ZDB-ID 2893931-1
    ISSN 2305-5847 ; 2305-5839
    ISSN (online) 2305-5847
    ISSN 2305-5839
    DOI 10.21037/atm.2016.01.12
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  6. Article ; Online: La publication au JO de nouveaux règlements européens sur les dispositifs médicaux pourrait-elle changer la pratique du diagnostic oncogénétique en France ?

    Robinet, Alison / Aljhni, Rania / Fouassier, Éric / Pham, Patrick / Bosselut, Nelly / Bergouin, Emilie / Lemoine, Antoinette

    Annales de biologie clinique

    2019  Volume 77, Issue 5, Page(s) 505–513

    Abstract: The use of predictive biomarkers in the diagnosis and prediction of the efficacy of targeted therapies for the individualized management of patients is generally based on the use of in vitro medical diagnosis devices that are now covered by the ... ...

    Title translation Could the publication of new european guidelines change practices in France?
    Abstract The use of predictive biomarkers in the diagnosis and prediction of the efficacy of targeted therapies for the individualized management of patients is generally based on the use of in vitro medical diagnosis devices that are now covered by the guidelines 90/385/EEC, 93/42/EEC and 98/42/EEC. On 25 May 2017, the European Parliament and Council Regulations 2017/745 and 2017/746 of 5 April 2017, related to medical devices and in vitro medical diagnosis devices, respectively, were published, disrupting years of practices based on European directives. They tend to bring the in vitro diagnosis in Europe closer to the American regulation in order to improve the use of safety diagnosis tests, while the United States have been changing their practices in the face of biomedical, technological and digital evolutions. We will describe the different regulations of diagnostic tests and discuss their applications in the field of oncology.
    MeSH term(s) Chemistry, Clinical/methods ; Chemistry, Clinical/standards ; Chemistry, Clinical/trends ; Clinical Laboratory Techniques/methods ; Clinical Laboratory Techniques/standards ; Clinical Laboratory Techniques/trends ; Europe ; France ; Humans ; Medical Oncology/standards ; Medical Oncology/trends ; Neoplasms/diagnosis ; Practice Guidelines as Topic ; Publications ; Reagent Kits, Diagnostic/standards ; United States
    Chemical Substances Reagent Kits, Diagnostic
    Language French
    Publishing date 2019-08-29
    Publishing country France
    Document type Journal Article ; Review
    ZDB-ID 418098-7
    ISSN 1950-6112 ; 0003-3898
    ISSN (online) 1950-6112
    ISSN 0003-3898
    DOI 10.1684/abc.2019.1477
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.203: Show issues Location:
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  7. Article ; Online: Retrospective analysis of real-world data to evaluate actionability of a comprehensive molecular profiling panel in solid tumor tissue samples (REALM study).

    Leroy, Karen / Audigier Valette, Clarisse / Alexandre, Jérôme / Boussemart, Lise / Chiesa, Jean / Deldycke, Clotilde / Gomez-Rocca, Carlos / Hollebecque, Antoine / Lehmann-Che, Jacqueline / Lemoine, Antoinette / Mansard, Sandrine / Medioni, Jacques / Monnet, Isabelle / Mourah, Samia / Pierret, Thomas / Spaëth, Dominique / Civet, Alexandre / Galoin, Sandrine / Italiano, Antoine

    PloS one

    2023  Volume 18, Issue 9, Page(s) e0291495

    Abstract: Introduction: Considering the growing interest in matched cancer treatment, our aim was to evaluate the ability of a comprehensive genomic profiling (CGP) assay to propose at least one targeted therapy given an identified genomic alteration or signature ...

    Abstract Introduction: Considering the growing interest in matched cancer treatment, our aim was to evaluate the ability of a comprehensive genomic profiling (CGP) assay to propose at least one targeted therapy given an identified genomic alteration or signature (actionability), and to collect the treatment modifications based on the CGP test results in clinical practise for solid tumors.
    Methods: This retrospective, multicentre French study was conducted among 25 centres that participated in a free of charge program between 2017 and 2019 for a tissue CGP test. Data were collected on the patient, disease, tumor genomic profile, treatment suggested in the report (related to the genomic profile results) and subsequent therapeutic decisions according to the physician's declaration.
    Results: Among the 416 patients, most had lung cancer (35.6%), followed by biliary tract cancer (11.5%) or rare cancers (11.1%); 75% had a metastatic disease. The actionability was 75.0% (95% CI [70.6%-78.9%]) for all patients, 85.1% and 78.4%, respectively in lung cancer and metastatic patients. After exclusion of clinical trial suggestions, the actionability decreased to 62.3% (95% CI [57.5%-66.8%]). Treatment modification based on the test results was observed in 17.3% of the patients and was more frequent in metastatic disease (OR = 2.73, 95% CI [1.31-5.71], p = 0.007). The main reasons for no treatment modification were poor general condition (33.2%) and stable disease or remission (30.2%). The genomic-directed treatment changes were performed mostly during the first six months after the CGP test, and interestingly a substantial part was observed from six to 24 months after the genomic profiling.
    Conclusion: This French study provides information on the real-life actionability of a CGP test based on tissue samples, and trends to confirm its utility in clinical practice across the course of the disease, in particularly for patients with lung cancer and/or advanced disease.
    MeSH term(s) Humans ; Retrospective Studies ; Lung Neoplasms/genetics ; Neoplasms, Second Primary ; Biological Assay ; Genetic Profile
    Language English
    Publishing date 2023-09-14
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0291495
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  8. Article ; Online: Human enhancer of filamentation 1-induced colorectal cancer cell migration: Role of serine phosphorylation and interaction with the breast cancer anti-estrogen resistance 3 protein.

    Ibrahim, Rama / Lemoine, Antoinette / Bertoglio, Jacques / Raingeaud, Joël

    The international journal of biochemistry & cell biology

    2015  Volume 64, Page(s) 45–57

    Abstract: Human enhancer of filamentation 1 (HEF1) is a member of the p130Cas family of docking proteins involved in integrin-mediated cytoskeleton reorganization associated with cell migration. Elevated expression of HEF1 promotes invasion and metastasis in ... ...

    Abstract Human enhancer of filamentation 1 (HEF1) is a member of the p130Cas family of docking proteins involved in integrin-mediated cytoskeleton reorganization associated with cell migration. Elevated expression of HEF1 promotes invasion and metastasis in multiple cancer cell types. To date, little is known on its role in CRC tumor progression. HEF1 is phosphorylated on several Ser/Thr residues but the effects of these post-translational modifications on the functions of HEF1 are poorly understood. In this manuscript, we investigated the role of HEF1 in migration of colorectal adeno-carcinoma cells. First, we showed that overexpression of HEF1 in colo-carcinoma cell line HCT116 increases cell migration. Moreover, in these cells, HEF1 increases Src-mediated phosphorylation of FAK on Tyr-861 and 925. We then showed that HEF1 mutation on Ser-369 enhances HEF1-induced migration and FAK phosphorylation as a result of protein stabilization. We also, for the first time characterized a functional mutation of HEF1 on Arg-367 which mimics the effect of Ser-369 to Ala mutation. Finally through mass spectrometry experiments, we identified BCAR3 as an essential interactor and mediator of HEF1-induced migration. We demonstrated that single amino acid mutations that prevent formation of the HEF1-BCAR3 complex impair HEF1-mediated migration. Therefore, amino-acid substitutions that impede Ser-369 phosphorylation stabilize HEF1 which increases the migration of CRC cells and this latter effect requires the interaction of HEF1 with the NSP family adaptor protein BCAR3. Collectively, these data reveal the importance of HEF1 expression level in cancer cell motility and then support the utilization of HEF1 as a biomarker of tumor progression.
    MeSH term(s) Adaptor Proteins, Signal Transducing/physiology ; Cell Movement ; HCT116 Cells ; Humans ; Phosphoproteins/physiology ; Phosphorylation ; Protein Processing, Post-Translational
    Chemical Substances Adaptor Proteins, Signal Transducing ; BCAR3 protein, human ; NEDD9 protein, human ; Phosphoproteins
    Language English
    Publishing date 2015-07
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1228429-4
    ISSN 1878-5875 ; 1357-2725
    ISSN (online) 1878-5875
    ISSN 1357-2725
    DOI 10.1016/j.biocel.2015.03.014
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  9. Article ; Online: Undetectable

    Bouchahda, Mohamed / Saffroy, Raphael / Karaboué, Abdoulaye / Hamelin, Jocelyne / Innominato, Pasquale / Saliba, Faouzi / Lévi, Francis / Bosselut, Nelly / Lemoine, Antoinette

    JCO precision oncology

    2020  Volume 4

    Abstract: Purpose: Combining cetuximab with chemotherapy provides clinical benefit to 60% of the patients with : Materials and methods: The occurrence of Kirsten rat sarcoma viral oncogene homolog (: Results: Of 16 registered patients, 11 were male and five ...

    Abstract Purpose: Combining cetuximab with chemotherapy provides clinical benefit to 60% of the patients with
    Materials and methods: The occurrence of Kirsten rat sarcoma viral oncogene homolog (
    Results: Of 16 registered patients, 11 were male and five female. They were age 48 to 81 years, and they had unresectable metastatic adenocarcinoma from the colon (n = 11) or rectum (n = 5), with a median of two metastatic sites. They had received a median number of three previous chemotherapy protocols. Plasma genotyping identified
    Conclusion: Patients with
    Language English
    Publishing date 2020-09-16
    Publishing country United States
    Document type Journal Article
    ISSN 2473-4284
    ISSN (online) 2473-4284
    DOI 10.1200/PO.19.00400
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  10. Article ; Online: Endothelin-1 Exhibiting Pro-Nociceptive and Pro-Peristaltic Activities Is Increased in Peritoneal Carcinomatosis.

    Greco, Céline / Basso, Lilian / Désormeaux, Cléo / Fournel, Audren / Demuynck, Benedicte / Lafendi, Leila / Chapiro, Sylvie / Lemoine, Antoinette / Zhu, Ying-Ying / Knauf, Claude / Cenac, Nicolas / Boucheix, Claude / Dietrich, Gilles

    Frontiers in pain research (Lausanne, Switzerland)

    2021  Volume 2, Page(s) 613187

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2021-02-11
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2673-561X
    ISSN (online) 2673-561X
    DOI 10.3389/fpain.2021.613187
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