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Article ; Online: Serum Levels of Copper and Zinc and Survival in Breast Cancer Patients.

Szwiec, Marek / Marciniak, Wojciech / Derkacz, Róża / Huzarski, Tomasz / Gronwald, Jacek / Cybulski, Cezary / Dębniak, Tadeusz / Jakubowska, Anna / Lener, Marcin R / Falco, Michał / Kładny, Józef / Baszuk, Piotr / Kotsopoulos, Joanne / Narod, Steven A / Lubiński, Jan

Nutrients

2024 Volume 16, Issue 7

Abstract: There is emerging interest in the relationship between several serum micronutrients and the prognosis of patients with breast cancer. The relationship between serum zinc and copper levels and breast cancer prognosis is unclear. In our study, we included ... ...

Abstract	There is emerging interest in the relationship between several serum micronutrients and the prognosis of patients with breast cancer. The relationship between serum zinc and copper levels and breast cancer prognosis is unclear. In our study, we included 583 patients with breast cancer diagnosed between 2008 and 2015 in the region of Szczecin, Poland. In a blood sample obtained before treatment, serum zinc and copper levels were quantified by mass spectroscopy. Each patient was assigned to one of four categories (quartiles) based on the distribution of the elements in the entire cohort. Patients were followed from diagnosis to death over a mean of 10.0 years. The 10-year overall survival was 58.3% for women in the highest and 82.1% for those in the lowest quartile of serum copper/zinc ratio (
MeSH term(s)	Humans ; Female ; Breast Neoplasms ; Copper ; Zinc ; Breast ; Mass Spectrometry
Chemical Substances	Copper (789U1901C5) ; Zinc (J41CSQ7QDS)
Language	English
Publishing date	2024-03-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu16071000
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Article ; Online: Correlation between Selenium and Zinc Levels and Survival among Prostate Cancer Patients.

Pietrzak, Sandra / Marciniak, Wojciech / Derkacz, Róża / Matuszczak, Milena / Kiljańczyk, Adam / Baszuk, Piotr / Bryśkiewicz, Marta / Sikorski, Andrzej / Gronwald, Jacek / Słojewski, Marcin / Cybulski, Cezary / Gołąb, Adam / Huzarski, Tomasz / Dębniak, Tadeusz / Lener, Marcin R / Jakubowska, Anna / Kluz, Tomasz / Scott, Rodney J / Lubiński, Jan

Nutrients

2024 Volume 16, Issue 4

Abstract: The most prevalent type of cancer among males is prostate cancer. Survival is considered quite good, but it can be further improved when risk factors are optimized. One of these factors is micronutrients, including Se and Zn. To our knowledge, the ... ...

Abstract	The most prevalent type of cancer among males is prostate cancer. Survival is considered quite good, but it can be further improved when risk factors are optimized. One of these factors is micronutrients, including Se and Zn. To our knowledge, the interaction between Se and Zn and prostate cancer remains undescribed. This study aimed to investigate the optimal levels of selenium (Se) and zinc (Zn) and their impact on the survival of individuals diagnosed with prostate cancer. A total of 338 prostate cancer patients were enrolled in this study, which was conducted in Poland between 2009 and 2015. Mass spectrometry, which uses inductively coupled plasma mass, was used to assess serum element levels before treatment. The study participants were categorized into quartiles (QI-QIV) based on the distributions of Se and Zn levels observed among surviving participants. Cox regression was used to assess the association between serum Se and Zn levels and the survival of prostate cancer patients. Our results reveal the effect of combined Se and Zn levels on survival in prostate cancer patients (SeQI-ZnQI vs. SeQIV-ZnQIV; HR = 20.9). These results need further research to establish Se/Zn norms for different populations.
MeSH term(s)	Male ; Humans ; Selenium ; Zinc ; Prostatic Neoplasms ; Micronutrients/analysis ; Mass Spectrometry/methods ; Copper
Chemical Substances	Selenium (H6241UJ22B) ; Zinc (J41CSQ7QDS) ; Micronutrients ; Copper (789U1901C5)
Language	English
Publishing date	2024-02-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu16040527
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Article ; Online: Serum Essential Elements and Survival after Cancer Diagnosis.

Lubiński, Jan / Lener, Marcin R / Marciniak, Wojciech / Pietrzak, Sandra / Derkacz, Róża / Cybulski, Cezary / Gronwald, Jacek / Dębniak, Tadeusz / Jakubowska, Anna / Huzarski, Tomasz / Matuszczak, Milena / Pullella, Katherine / Sun, Ping / Narod, Steven A

Nutrients

2023 Volume 15, Issue 11

Abstract: In a prospective study, we measured the associations between three serum elements (Se, Zn and Cu) and the prognosis of 1475 patients with four different types of cancer (breast, prostate, lung and larynx) from University Hospitals in Szczecin, Poland. ... ...

Abstract	In a prospective study, we measured the associations between three serum elements (Se, Zn and Cu) and the prognosis of 1475 patients with four different types of cancer (breast, prostate, lung and larynx) from University Hospitals in Szczecin, Poland. The elements were measured in serum taken after diagnosis and prior to treatment. Patients were followed from the date of diagnosis until death from any cause or until the last follow-up date (mean years of follow-up: 6.0-9.8 years, according to site). Kaplan-Meier curves were constructed for all cancers combined and for each cancer separately. Age-adjusted hazard ratios (HRs) were estimated using Cox regression. The outcome was all-cause mortality. A Se level in the highest quartile was also associated with a reduced mortality (HR = 0.66; 95%CI 0.49-0.88;
MeSH term(s)	Male ; Humans ; Copper ; Prospective Studies ; Selenium ; Zinc ; Prognosis ; Trace Elements ; Neoplasms/diagnosis
Chemical Substances	Copper (789U1901C5) ; Selenium (H6241UJ22B) ; Zinc (J41CSQ7QDS) ; Trace Elements
Language	English
Publishing date	2023-06-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu15112611
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Article: Blood Copper Levels and the Occurrence of Colorectal Cancer in Poland.

Baszuk, Piotr / Marciniak, Wojciech / Derkacz, Róża / Jakubowska, Anna / Cybulski, Cezary / Gronwald, Jacek / Dębniak, Tadeusz / Huzarski, Tomasz / Białkowska, Katarzyna / Pietrzak, Sandra / Muszyńska, Magdalena / Kładny, Józef / Narod, Steven A / Lubiński, Jan / Lener, Marcin R

Biomedicines

2021 Volume 9, Issue 11

Abstract: There is a need for sensitive and specific biomarkers for the early detection of colorectal cancer. In this retrospective study, we assessed whether a high blood copper level was associated with the presence of colorectal cancer. The blood copper level ... ...

Abstract	There is a need for sensitive and specific biomarkers for the early detection of colorectal cancer. In this retrospective study, we assessed whether a high blood copper level was associated with the presence of colorectal cancer. The blood copper level was measured among 187 colorectal cancer patients and 187 matched controls. Cases and controls were matched for sex, smoking status (yes/no) and year of birth. Among the cases, the mean blood copper level was 1031 µg/L (range 657 µg/L to 2043 µg/L) and among the controls, the mean blood copper level was 864 µg/L (range 589 µg/L to 1433 µg/L). The odds ratio for colorectal cancer for those in the highest quartile of copper level (versus the lowest) was 12.7 (95% CI: 4.98-32.3;
Language	English
Publishing date	2021-11-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines9111628
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Article: Low Blood-As Levels and Selected Genotypes Appears to Be Promising Biomarkers for Occurrence of Colorectal Cancer in Women.

Baszuk, Piotr / Stadnik, Paulina / Marciniak, Wojciech / Derkacz, Róża / Jakubowska, Anna / Cybulski, Cezary / Huzarski, Tomasz / Gronwald, Jacek / Dębniak, Tadeusz / Białkowska, Katarzyna / Pietrzak, Sandra / Kładny, Józef / Scott, Rodney J / Lubiński, Jan / Lener, Marcin R

Biomedicines

2021 Volume 9, Issue 9

Abstract: In following study we examined whether blood arsenic (As) levels combined with specific polymorphisms ... ...

Abstract	In following study we examined whether blood arsenic (As) levels combined with specific polymorphisms in
Language	English
Publishing date	2021-08-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines9091105
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Article ; Online: Blood Lead Level as Marker of Increased Risk of Ovarian Cancer in BRCA1 Carriers.

Kiljańczyk, Adam / Matuszczak, Milena / Marciniak, Wojciech / Derkacz, Róża / Stempa, Klaudia / Baszuk, Piotr / Bryśkiewicz, Marta / Lubiński, Krzysztof / Cybulski, Cezary / Dębniak, Tadeusz / Gronwald, Jacek / Huzarski, Tomasz / Lener, Marcin R / Jakubowska, Anna / Szwiec, Marek / Stawicka-Niełacna, Małgorzata / Godlewski, Dariusz / Prusaczyk, Artur / Jasiewicz, Andrzej /

Kluz, Tomasz / Tomiczek-Szwiec, Joanna / Kilar-Kobierzycka, Ewa / Siołek, Monika / Wiśniowski, Rafał / Posmyk, Renata / Jarkiewicz-Tretyn, Joanna / Sun, Ping / Scott, Rodney J / Narod, Steven A / Lubiński, Jan

Nutrients

2024 Volume 16, Issue 9

Abstract: BRCA1 mutations substantially elevate the risks of breast and ovarian cancer. Various modifiers, including environmental factors, can influence cancer risk. Lead, a known carcinogen, has been associated with various cancers, but its impact on BRCA1 ... ...

Abstract	BRCA1 mutations substantially elevate the risks of breast and ovarian cancer. Various modifiers, including environmental factors, can influence cancer risk. Lead, a known carcinogen, has been associated with various cancers, but its impact on BRCA1 carriers remains unexplored. A cohort of 989 BRCA1 mutation carriers underwent genetic testing at the Pomeranian Medical University, Poland. Blood lead levels were measured using inductively coupled plasma mass spectrometry. Each subject was assigned to a category based on their tertile of blood lead. Cox regression analysis was used to assess cancer risk associations. Elevated blood lead levels (>13.6 μg/L) were associated with an increased risk of ovarian cancer (univariable: HR = 3.33; 95% CI: 1.23-9.00;
MeSH term(s)	Humans ; Female ; Ovarian Neoplasms/blood ; Ovarian Neoplasms/genetics ; Lead/blood ; Adult ; Middle Aged ; BRCA1 Protein/genetics ; Risk Factors ; Poland ; Heterozygote ; Mutation ; Biomarkers, Tumor/blood ; Biomarkers, Tumor/genetics ; Genetic Predisposition to Disease ; Aged ; Proportional Hazards Models
Chemical Substances	Lead (2P299V784P) ; BRCA1 Protein ; BRCA1 protein, human ; Biomarkers, Tumor
Language	English
Publishing date	2024-04-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu16091370
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Article ; Online: Influence of the Levels of Arsenic, Cadmium, Mercury and Lead on Overall Survival in Lung Cancer.

Pietrzak, Sandra / Wójcik, Janusz / Baszuk, Piotr / Marciniak, Wojciech / Wojtyś, Małgorzata / Dębniak, Tadeusz / Cybulski, Cezary / Gronwald, Jacek / Alchimowicz, Jacek / Masojć, Bartłomiej / Waloszczyk, Piotr / Gajić, Darko / Grodzki, Tomasz / Jakubowska, Anna / Scott, Rodney J / Lubiński, Jan / Lener, Marcin R

Biomolecules

2021 Volume 11, Issue 8

Abstract: The effects of heavy metals on cancer risk have been widely studied in recent decades, but there is limited data on the effects of these elements on cancer survival. In this research, we examined whether blood concentrations of the heavy metals arsenic, ... ...

Abstract	The effects of heavy metals on cancer risk have been widely studied in recent decades, but there is limited data on the effects of these elements on cancer survival. In this research, we examined whether blood concentrations of the heavy metals arsenic, cadmium, mercury and lead were associated with the overall survival of lung cancer patients. The study group consisted of 336 patients with lung cancer who were prospectively observed. Blood concentrations of heavy metals were measured to study the relationship between their levels and overall survival using Cox proportional hazards analysis. The hazard ratio of death from all causes was 0.99 (
MeSH term(s)	Adenocarcinoma/blood ; Adenocarcinoma/drug therapy ; Adenocarcinoma/mortality ; Adenocarcinoma/pathology ; Aged ; Aged, 80 and over ; Antineoplastic Agents/therapeutic use ; Arsenic/blood ; Cadmium/blood ; Carcinoma, Non-Small-Cell Lung/blood ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/mortality ; Carcinoma, Non-Small-Cell Lung/pathology ; Carcinoma, Squamous Cell/blood ; Carcinoma, Squamous Cell/drug therapy ; Carcinoma, Squamous Cell/mortality ; Carcinoma, Squamous Cell/pathology ; Female ; Humans ; Lead/blood ; Lung Neoplasms/blood ; Lung Neoplasms/drug therapy ; Lung Neoplasms/mortality ; Lung Neoplasms/pathology ; Male ; Mercury/blood ; Middle Aged ; Neoplasm Staging ; Proportional Hazards Models ; Prospective Studies
Chemical Substances	Antineoplastic Agents ; Cadmium (00BH33GNGH) ; Lead (2P299V784P) ; Mercury (FXS1BY2PGL) ; Arsenic (N712M78A8G)
Language	English
Publishing date	2021-08-05
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2701262-1
ISSN	2218-273X ; 2218-273X
ISSN (online)	2218-273X
ISSN	2218-273X
DOI	10.3390/biom11081160
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Article ; Online: The Prevalence of Founder Mutations among Individuals from Families with Familial Pancreatic Cancer Syndrome.

Lener, Marcin R / Kashyap, Aniruddh / Kluźniak, Wojciech / Cybulski, Cezary / Soluch, Agnieszka / Pietrzak, Sandra / Huzarski, Tomasz / Gronwald, Jacek / Lubiński, Jan

Cancer research and treatment : official journal of Korean Cancer Association

2017 Volume 49, Issue 2, Page(s) 430–436

Abstract: Purpose: Familial pancreatic cancer describes families with at least two first-degree relatives with pancreatic cancer that do not fulfil the criteria of other inherited tumor syndromes with increased risks of pancreatic cancer. Although much has been ... ...

Abstract	Purpose: Familial pancreatic cancer describes families with at least two first-degree relatives with pancreatic cancer that do not fulfil the criteria of other inherited tumor syndromes with increased risks of pancreatic cancer. Although much has been learned regarding the aggregation of pancreatic cancer in some families, the genetic basis for this familial aggregation is poorly understood. This study evaluated the prevalence of 10 Polish founder mutations in four genes among individuals from families with diagnosed familial pancreatic cancer syndrome and assessed their possible association with the familial pancreatic cancer (FPC) risk in Poland. Materials and methods: In this study, 400 FPC individuals and 4,000 control subjects were genotyped for founder mutations in Results: A statistically significant association was observed between the 172_175delTTGT mutation of the Conclusion: The founder mutations in the genes,
Language	English
Publishing date	2017-04
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2133613-1
ISSN	2005-9256 ; 1598-2998
ISSN (online)	2005-9256
ISSN	1598-2998
DOI	10.4143/crt.2016.217
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Article: Blood Arsenic Levels as a Marker of Breast Cancer Risk among

Cancers

2021 Volume 13, Issue 13

Abstract: An important group of breast cancers is those associated with inherited susceptibility. In women, several predisposing mutations in genes involved in DNA repair have been discovered. Women with a germline pathogenic variant ... ...

Abstract	An important group of breast cancers is those associated with inherited susceptibility. In women, several predisposing mutations in genes involved in DNA repair have been discovered. Women with a germline pathogenic variant in
Language	English
Publishing date	2021-07-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers13133345
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Article ; Online: Lung Cancer Occurrence-Correlation with Serum Chromium Levels and Genotypes.

Baszuk, Piotr / Janasik, Beata / Pietrzak, Sandra / Marciniak, Wojciech / Reszka, Edyta / Białkowska, Katarzyna / Jabłońska, Ewa / Muszyńska, Magdalena / Lesicka, Monika / Derkacz, Róża / Grodzki, Tomasz / Wójcik, Janusz / Wojtyś, Małgorzata / Dębniak, Tadeusz / Cybulski, Cezary / Gronwald, Jacek / Kubisa, Bartosz / Wójcik, Norbert / Pieróg, Jarosław /

Gajić, Darko / Waloszczyk, Piotr / Scott, Rodney J / Wąsowicz, Wojciech / Jakubowska, Anna / Lubiński, Jan / Lener, Marcin R

Biological trace element research

2020 Volume 199, Issue 4, Page(s) 1228–1236

Abstract: Lung cancer is the leading cause of cancer-related death worldwide. Exposure to environmental and occupational carcinogens is an important cause of lung cancer. One of these substances is chromium, which is found ubiquitously across the planet. The ... ...

Abstract	Lung cancer is the leading cause of cancer-related death worldwide. Exposure to environmental and occupational carcinogens is an important cause of lung cancer. One of these substances is chromium, which is found ubiquitously across the planet. The International Agency for Research on Cancer has classified chromium(VI) as a human carcinogen. The aim of this study was to assess whether serum chromium levels, as well as DNA variants in selected genes involved in carcinogenesis, xenobiotic-metabolism, and oxidative stress could be helpful in the detection of lung cancer. We conducted a study using 218 lung cancer patients and 218 matched healthy controls. We measured serum chromium levels and genotyped ten genetic variants in ERCC2, XRCC1, MT1B, GSTP1, ABCB1, NQ01, CRTC3, GPX1, SOD2 and CAT. The odds ratios of being diagnosed with lung cancer were calculated using conditional logistic regression with respect to serum chromium level and genotypes. The odds ratio for the occurrence of lung cancer increased with increasing serum chromium levels. The difference between the quartiles with the lowest vs. highest chromium level was more than fourfold in the entire group (OR 4.52, CI 2.17-9.42, p < 0.01). This correlation was significantly increased by more than twice when specific genotypes were taken into consideration (ERCC-rs12181 TT, OR 12.34, CI 1.17-130.01, p = 0.04; CRTC3-rs12915189 non GG, OR 9.73, CI 1.58-60.10, p = 0.01; GSTP1-rs1695 non AA, OR 9.47, CI 2.06-43.49, p = < 0.01; CAT-rs1001179 non CC, OR 9.18, CI 1.64-51.24, p = 0.01). Total serum chromium levels > 0.1 μg/L were correlated with 73% (52/71) of lung cancers diagnosed with stage I disease. Our findings support the role of chromium and the influence of key proteins on lung cancer burden in the general population.
MeSH term(s)	Carcinogens ; Chromium/blood ; Female ; Genotype ; Glutathione S-Transferase pi ; Humans ; Lung Neoplasms/genetics ; Male ; X-ray Repair Cross Complementing Protein 1 ; Xeroderma Pigmentosum Group D Protein
Chemical Substances	Carcinogens ; X-ray Repair Cross Complementing Protein 1 ; XRCC1 protein, human ; Chromium (0R0008Q3JB) ; Glutathione S-Transferase pi (EC 2.5.1.18) ; Xeroderma Pigmentosum Group D Protein (EC 3.6.4.12) ; ERCC2 protein, human (EC 5.99.-)
Language	English
Publishing date	2020-07-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	445336-0
ISSN	1559-0720 ; 0163-4984
ISSN (online)	1559-0720
ISSN	0163-4984
DOI	10.1007/s12011-020-02240-6
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