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  1. Article ; Online: Relationship between obstructive sleep apnea and pulmonary hypertension: past, present and future.

    Lenka, Jyotirmayee / Foley, Raymond / Metersky, Mark / Salmon, Adrian

    Expert review of respiratory medicine

    2024  , Page(s) 1–13

    Abstract: Introduction: Obstructive sleep apnea (OSA) is a widely prevalent condition with consequent multiple organ systems complications. There is consensus that OSA is associated with negative effects on pulmonary hemodynamics but whether it contributes to ... ...

    Abstract Introduction: Obstructive sleep apnea (OSA) is a widely prevalent condition with consequent multiple organ systems complications. There is consensus that OSA is associated with negative effects on pulmonary hemodynamics but whether it contributes to development of clinical pulmonary hypertension (PH) is unclear.
    Areas covered: In this review, we (1) highlight previous studies looking into the possible bidirectional association of OSA and PH, focusing on those that explore clinical prognostic implications, (2) explore potential pathophysiology, (3) discuss the new metrics in OSA, (4) describe endo-phenotyping of OSA, (5) recommend possible risk assessment and screening pathways.
    Expert opinion: Relying only on symptoms to consider a sleep study in PH patients is a missed opportunity to detect OSA, which, if present and not treated, can worsen outcomes. The potential prognostic role of sleep study metrics such as oxygen desaturation index (ODI), hypoxic burden (HB) and ventilatory burden (VB) in OSA should be studied in prospective trials to identify patients at risk for PH. AHI alone has not provided clarity. In those with PH, we should consider replacing ambulatory overnight pulse oximetry (OPO) with home sleep studies (HST). In PH patients, mild OSA should be sufficient to consider PAP therapy.
    Language English
    Publishing date 2024-04-24
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2479146-5
    ISSN 1747-6356 ; 1747-6348
    ISSN (online) 1747-6356
    ISSN 1747-6348
    DOI 10.1080/17476348.2024.2345684
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  2. Article ; Online: Quality of content reporting on two major oncology media websites: OncLive and Targeted Oncology.

    Sharma, Naman / Wayant, Cole / Neupane, Karun / Lenka, Jyotirmayee / Berger, Katherine / Goodman, Aaron M / Booth, Christopher M / Prasad, Vinay / Mohyuddin, Ghulam Rehman

    Journal of cancer policy

    2023  Volume 36, Page(s) 100411

    Abstract: Introduction: Oncology media websites such as Oncology Live (OncLive) and Targeted Oncology (TargetedOnc) play an important role in the dissemination of oncology news to patients and clinicians; however, the quality of the content on these websites has ... ...

    Abstract Introduction: Oncology media websites such as Oncology Live (OncLive) and Targeted Oncology (TargetedOnc) play an important role in the dissemination of oncology news to patients and clinicians; however, the quality of the content on these websites has not been assessed. Our study aimed to analyze content from these websites and assess financial conflicts of interest (FCOI) amongst speakers interviewed on these websites.
    Methods: Articles published on OncLive and TargetedOnc during October 2021, were prospectively captured and analyzed. The primary outcome of our study was the quality of oncology news reporting in OncLive and TargetedOnc. We assessed the FCOI amongst speakers using data from Open Payments.
    Results: We examined 196 articles (OncLive 108, TargetedOnc 88). Limitations of cited research were reported in 7% (7/105) of OncLive and zero TargetedOnc articles. Benefit and risks in absolute numbers were reported in 28% (28/99) of OncLive and 16% (7/45) of TargetedOnc articles. Independent experts were quoted in 47% (51/108) and 51% (44/86) of the OncLive and TargetedOnc articles, respectively (Table 3). Pharmaceutical executives were quoted in 18% (20/108) and 11% (10/88) of OncLive and TargetedOnc articles, respectively. No FCOI disclosures were listed or reported for any articles. The mean general payment received from industry by United States physicians was $63,861 in 2019 and $39,639 in 2020.
    Conclusion: Our study demonstrates low quality and potentially biased reporting of oncology news on OncLive and TargetedOnc. Careful safeguards, oversight and reporting of relevant FCOI are needed to maintain the quality and transparency of content being provided.
    MeSH term(s) Humans ; United States ; Disclosure ; Industry ; Conflict of Interest ; Medical Oncology ; Physicians
    Language English
    Publishing date 2023-02-10
    Publishing country England
    Document type Journal Article
    ISSN 2213-5383
    ISSN (online) 2213-5383
    DOI 10.1016/j.jcpo.2023.100411
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  3. Article: Clinical characteristics and outcomes of critically ill patients with COVID-19 in a tertiary community hospital in upstate New York.

    Lenka, Jyotirmayee / Chhabria, Mamta S / Sharma, Naman / Tan, Bryan E-Xin / Boppana, Leela Krishna Teja / Venugopal, Sharini / Sondhi, Damanpaul S

    Journal of community hospital internal medicine perspectives

    2020  Volume 10, Issue 6, Page(s) 491–500

    Abstract: ... ...

    Abstract Background
    Keywords covid19
    Language English
    Publishing date 2020-10-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2616884-4
    ISSN 2000-9666
    ISSN 2000-9666
    DOI 10.1080/20009666.2020.1811070
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  4. Article: Clinical characteristics and outcomes of critically ill patients with COVID-19 in a tertiary community hospital in upstate New York

    Lenka, Jyotirmayee Chhabria Mamta S. / Sharma, Naman Tan Bryan E. Xin Boppana Leela Krishna Teja Venugopal Sharini Sondhi Damanpaul S.

    Journal of Community Hospital Internal Medicine Perspectives

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #900304
    Database COVID19

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  5. Article ; Online: Clinical characteristics and outcomes of critically ill patients with COVID-19 in a tertiary community hospital in upstate New York

    Lenka, Jyotirmayee / Chhabria, Mamta S / Sharma, Naman / Tan, Bryan E-Xin / Boppana, Leela Krishna Teja / Venugopal, Sharini / Sondhi, Damanpaul S

    medRxiv

    Abstract: Background: There are limited reports describing critically ill COVID-19 patients in New York. Methods: We conducted a retrospective analysis of 32 adult critically ill patients admitted to a tertiary community hospital in upstate NY, between March 14th ... ...

    Abstract Background: There are limited reports describing critically ill COVID-19 patients in New York. Methods: We conducted a retrospective analysis of 32 adult critically ill patients admitted to a tertiary community hospital in upstate NY, between March 14th and April 12th, 2020. We collected demographic, laboratory, ventilator, and treatment data, which were analyzed and clinical outcomes tabulated. Results: 32 patients admitted to the ICU were included, with mean (±SD) follow-up duration 21 ± 7 days. Mean (±SD) age was 62.2 ± 11.2 years, and 62.5% were men. 27 (84.4%) of patients had one or more medical co-morbidities and 50% of the patients were current or former smokers. The mean (±SD) duration of symptoms was 6.6 (±4.4) days before presentation, with cough (81.3%), dyspnea (68.7%), and fever (65.6%) being most common. 23 (71.9%) patients received invasive mechanical ventilation. 5 (15.6%) had died, 11 (34.4%) had been discharged home, and 16 (50%) remained hospitalized, 8 (25%) of which were still in ICU. Mean (±SD) length of ICU stay was 10.2 (±7.7) days, and mean (±SD) length of hospital stay was 14.8 (±7.7) days. Conclusion: Majority of patients were of older age and with medical co-morbidities. With adequate resource utilization, mortality of critically ill COVID-19 patients may not be as high as previously suggested.
    Keywords covid19
    Language English
    Publishing date 2020-06-22
    Publisher Cold Spring Harbor Laboratory Press
    Document type Article ; Online
    DOI 10.1101/2020.06.18.20135046
    Database COVID19

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  6. Article ; Online: Clinical characteristics and outcomes of critically ill patients with COVID-19 in a tertiary community hospital in upstate New York

    Lenka, Jyotirmayee / Chhabria, Mamta S. / Sharma, Naman / Tan, Bryan E-Xin / Boppana, Leela Krishna Teja / Venugopal, Sharini / Sondhi, Damanpaul S.

    Journal of Community Hospital Internal Medicine Perspectives

    2020  Volume 10, Issue 6, Page(s) 491–500

    Keywords covid19
    Language English
    Publisher Informa UK Limited
    Publishing country uk
    Document type Article ; Online
    ZDB-ID 2616884-4
    ISSN 2000-9666
    ISSN 2000-9666
    DOI 10.1080/20009666.2020.1811070
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: SINGLE CENTER CRITICAL CARE EXPERIENCE WITH A FOCUS ON VENTILATOR SETTINGS IN 32 CRITICALLY ILL PATIENTS WITH COVID-19

    Lenka, Jyotirmayee / Chhabria, Mamta / Sharma, Naman / E-Xin Tan, Bryan / Teja Boppana, Leela Krishna / Venugopal, Sharini / Sondhi, Damanpaul

    Chest

    2020  Volume 158, Issue 4, Page(s) A2633

    Keywords Critical Care and Intensive Care Medicine ; Pulmonary and Respiratory Medicine ; Cardiology and Cardiovascular Medicine ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2020.09.219
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    Ui III Zs.45: Show issues Location:
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  8. Article ; Online: National Trends and Outcomes of Percutaneous Coronary Intervention in Patients ≥70 Years of Age With Acute Coronary Syndrome (from the National Inpatient Sample Database).

    Elbadawi, Ayman / Elgendy, Islam Y / Ha, Le Dung / Mahmoud, Karim / Lenka, Jyotirmayee / Olorunfemi, Odunayo / Reyes, Amy / Ogunbayo, Gbolahan O / Saad, Marwan / Abbott, J Dawn

    The American journal of cardiology

    2018  Volume 123, Issue 1, Page(s) 25–32

    Abstract: Several randomized trials have demonstrated the benefits of an invasive strategy for older patients with acute coronary syndromes (ACS); however, there are limited real-world data of the temporal trends in the use of percutaneous coronary intervention ( ... ...

    Abstract Several randomized trials have demonstrated the benefits of an invasive strategy for older patients with acute coronary syndromes (ACS); however, there are limited real-world data of the temporal trends in the use of percutaneous coronary intervention (PCI) in this population. This was a retrospective observational analysis. We queried the National Inpatient Sample database from 1998 to 2013 for patients aged ≥70 years who had non-ST-elevation acute coronary syndrome (NSTE-ACS) or ST-elevation myocardial infarction (STEMI). We reported the temporal trends of PCI and in-hospital mortality. A total of 6,720,281 hospitalizations with ACS were identified in advanced age patients, 18.3% of whom also underwent PCI. There was an upward trend in the rate of PCI in older adults ≥70 years with any ACS from 9.4% in 1998 to 28.3% in 2013 (p <0.001), as well as in cases of PCI for NSTE-ACS (7.3% in 1998 vs 24.9% in 2013, p <0.001) and PCI for STEMI (11% in 1998 vs 35.7% in 2013, p = 0.002). This upward trend was consistent in all age categories (70 to 79), (80 to 89) and ≥90 years. Despite an increase in the prevalence of comorbidities for ACS hospitalizations aged ≥70 years who received PCI, the in-hospital mortality rate showed a downward trend (p <0.001). Multivariate analysis adjusting for various comorbidities showed that PCI was associated with lower in-hospital mortality and length of hospital stay among elderly with NSTE-ACS and STEMI. In conclusion, in this 16-year analysis there was an increase in the rate of PCI procedures among older adults with ACS. PCI was independently associated with lower mortality in elderly patients with ACS.
    MeSH term(s) Acute Coronary Syndrome/mortality ; Acute Coronary Syndrome/surgery ; Aged ; Aged, 80 and over ; Comorbidity ; Female ; Hospital Mortality/trends ; Humans ; Length of Stay/statistics & numerical data ; Male ; Percutaneous Coronary Intervention ; Retrospective Studies ; Risk Factors ; United States
    Language English
    Publishing date 2018-09-27
    Publishing country United States
    Document type Journal Article ; Observational Study
    ZDB-ID 80014-4
    ISSN 1879-1913 ; 0002-9149
    ISSN (online) 1879-1913
    ISSN 0002-9149
    DOI 10.1016/j.amjcard.2018.09.030
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  9. Article ; Online: A novel luciferase-based assay for the detection of Chimeric Antigen Receptors.

    Gopalakrishnan, Ramakrishnan / Matta, Hittu / Choi, Sunju / Natarajan, Venkatesh / Prins, Ruben / Gong, Songjie / Zenunovic, Arta / Narasappa, Nell / Patel, Fatima / Prakash, Rekha / Chaudhary, Vishan / Sikri, Varun / Chitnis, Saurabh Deepak / Kochegarov, Andrei / Wang, Dan / Falat, Magdalena / Kahn, Michael / Keerthipati, Pooja Smruthi / Sharma, Naman /
    Lenka, Jyotirmayee / Stieben, Tomas Meza / Braun, Jason / Batra, Ankita / Purvis, Katelyn / Ito, Kenta / Lee, Jae Han / Jeronimo, Alberto / Zamora, Hannalei Mae / Membreno, Allen / Qiu, Queenie / Peshin, Supriya / Namburu, Lalith / Chaudhary, Preet M

    Scientific reports

    2019  Volume 9, Issue 1, Page(s) 1957

    Abstract: Chimeric Antigen Receptor-T (CAR-T) cell immunotherapy has produced dramatic responses in hematologic malignancies. One of the challenges in the field is the lack of a simple assay for the detection of CARs on the surface of immune effector cells. In ... ...

    Abstract Chimeric Antigen Receptor-T (CAR-T) cell immunotherapy has produced dramatic responses in hematologic malignancies. One of the challenges in the field is the lack of a simple assay for the detection of CARs on the surface of immune effector cells. In this study, we describe a novel luciferase-based assay, termed Topanga Assay, for the detection of CAR expression. The assay utilizes a recombinant fusion protein, called Topanga reagent, generated by joining the extra-cellular domain of a CAR-target in frame with one of the marine luciferases or their engineered derivatives. The assay involves incubation of CAR expressing cells with the Topanga reagent, a few washes and measurement of luminescence. The assay can detect CARs comprising either immunoglobulin- or non-immunoglobulin-based antigen binding domains. We further demonstrate that addition of epitope tags to the Topanga reagent not only allows its convenient one step purification but also extends its use for detection of CAR cells using flow cytometry. However, crude supernatant containing the secreted Topanga reagent can be directly used in both luminescence and flow-cytometry based assays without prior protein purification. Our results demonstrate that the Topanga assay is a highly sensitive, specific, convenient, economical and versatile assay for the detection of CARs.
    MeSH term(s) Cell Line ; Flow Cytometry/methods ; Humans ; Immunotherapy, Adoptive/methods ; Luciferases/metabolism ; Lymphocytes/metabolism ; Receptors, Antigen/metabolism ; Receptors, Antigen, T-Cell/metabolism ; Receptors, Chimeric Antigen/analysis ; Receptors, Chimeric Antigen/metabolism ; Recombinant Fusion Proteins/metabolism ; T-Lymphocytes/immunology
    Chemical Substances Receptors, Antigen ; Receptors, Antigen, T-Cell ; Receptors, Chimeric Antigen ; Recombinant Fusion Proteins ; Luciferases (EC 1.13.12.-)
    Language English
    Publishing date 2019-02-13
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-018-38258-z
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