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  1. Article ; Online: Should we deny ICU admission to the elderly? Ethical considerations in times of COVID-19

    Lenneke E. M. Haas / Dylan W. de Lange / Diederik van Dijk / Johannes J. M. van Delden

    Critical Care, Vol 24, Iss 1, Pp 1-

    2020  Volume 3

    Keywords ICU ; Critical care ; Ethics ; Triage ; Age ; Elderly ; Medical emergencies. Critical care. Intensive care. First aid ; RC86-88.9 ; covid19
    Language English
    Publishing date 2020-06-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Selective Decontamination of the Digestive Tract Reduces Pneumonia and Mortality

    Lenneke E. M. Haas / Marcus J. Schultz

    Critical Care Research and Practice, Vol

    2010  Volume 2010

    Abstract: Selective decontamination of the digestive tract (SDD) has been subject of numerous randomized controlled trials in critically ill patients. Almost all clinical trials showed SDD to prevent pneumonia. Nevertheless, SDD has remained a controversial ... ...

    Abstract Selective decontamination of the digestive tract (SDD) has been subject of numerous randomized controlled trials in critically ill patients. Almost all clinical trials showed SDD to prevent pneumonia. Nevertheless, SDD has remained a controversial strategy. One reason for why clinicians remained reluctant to implement SDD into daily practice could be that mortality was reduced in only 2 trials. Another reason could be the heterogeneity of trials of SDD. Indeed, many different prophylactic antimicrobial regimes were tested, and dissimilar diagnostic criteria for pneumonia were applied amongst the trials. This heterogeneity impeded interpretation and comparison of trial results. Two other hampering factors for implementation of SDD have been concerns over the risk of antimicrobial resistance and fear for escalation of costs associated with the use of prophylactic antimicrobials. This paper describes the concept of SDD, summarizes the results of published trials of SDD in mixed medical-surgical intensive care units, and rationalizes the risk of antimicrobial resistance and rise of costs associated with this potentially life-saving preventive strategy.
    Keywords Internal medicine ; RC31-1245 ; Medical emergencies. Critical care. Intensive care. First aid ; RC86-88.9
    Subject code 610
    Language English
    Publishing date 2010-01-01T00:00:00Z
    Publisher Hindawi Publishing Corporation
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Inter-library loan at ZB MED

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  3. Article ; Online: Human Metapneumovirus in Adults

    Lenneke E. M. Haas / Steven F. T. Thijsen / Leontine van Elden / Karen A. Heemstra

    Viruses, Vol 5, Iss 1, Pp 87-

    2013  Volume 110

    Abstract: Human metapneumovirus (HMPV) is a relative newly described virus. It was first isolated in 2001 and currently appears to be one of the most significant and common human viral infections. Retrospective serologic studies demonstrated the presence of HMPV ... ...

    Abstract Human metapneumovirus (HMPV) is a relative newly described virus. It was first isolated in 2001 and currently appears to be one of the most significant and common human viral infections. Retrospective serologic studies demonstrated the presence of HMPV antibodies in humans more than 50 years earlier. Although the virus was primarily known as causative agent of respiratory tract infections in children, HMPV is an important cause of respiratory infections in adults as well. Almost all children are infected by HMPV below the age of five; the repeated infections throughout life indicate transient immunity. HMPV infections usually are mild and self-limiting, but in the frail elderly and the immunocompromised patients, the clinical course can be complicated. Since culturing the virus is relatively difficult, diagnosis is mostly based on a nucleic acid amplification test, such as reverse transcriptase polymerase chain reaction. To date, no vaccine is available and treatment is supportive. However, ongoing research shows encouraging results. The aim of this paper is to review the current literature concerning HMPV infections in adults, and discuss recent development in treatment and vaccination.
    Keywords human metapneumovirus ; HMPV ; respiratory tract infection ; adults ; intensive care ; diagnosis ; treatment ; vaccination ; Microbiology ; QR1-502 ; Science ; Q ; DOAJ:Microbiology ; DOAJ:Biology ; DOAJ:Biology and Life Sciences
    Subject code 610
    Language English
    Publishing date 2013-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: A Fatal Complication of A Peripheral Venous Catheter

    Sanjay U.C. Sankatsing / Jan-Willem Fijen / Steven F.T. Thijsen / Bart C. Kortlandt / Lenneke E.M. Haas

    International Journal of Clinical Medicine, Vol 03, Iss 05, Pp 433-

    2012  Volume 437

    Abstract: Peripheral venous catheters (PVC) are widely used in the hospital and seem to be innocent. However, complications can be devastating. We present a case of a fatal septic shock due to vertebral osteomyelitis after PVC-related Staphylococcus aureus ... ...

    Abstract Peripheral venous catheters (PVC) are widely used in the hospital and seem to be innocent. However, complications can be devastating. We present a case of a fatal septic shock due to vertebral osteomyelitis after PVC-related Staphylococcus aureus bacteremia (SAB). Staphylococcus aureus is a leading cause of bacteraemia in both the community and the hospital with a significantly increased incidence over the last several decades. Intravascular catheters are the most common cause of SAB. Morbidity and mortality are high, even with appropriate therapy. Although complications are known and common, they may be difficult to recognize. Vertebral osteomyelitis is one of these known severe complications.
    Keywords Staphylococcus Aureus Bacteraemia ; Vertebral Osteomyelitis ; Peripheral Venous Catheter ; Intensive Care ; Medicine (General) ; R5-920 ; Medicine ; R ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Language English
    Publishing date 2012-09-01T00:00:00Z
    Publisher Scientific Research Publishing
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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