Article ; Online: Laboratory monitoring of hemophilia A treatments: new challenges.
2020 Volume 4, Issue 9, Page(s) 2111–2118
Abstract: Monitoring factor VIII (FVIII) activity has traditionally been complicated by discrepancies between assays for the various sorts of FVIII molecules. The advent of novel nonfactor therapies (emicizumab, fitusiran, and anti-tissue factor pathway inhibitor ... ...
Abstract | Monitoring factor VIII (FVIII) activity has traditionally been complicated by discrepancies between assays for the various sorts of FVIII molecules. The advent of novel nonfactor therapies (emicizumab, fitusiran, and anti-tissue factor pathway inhibitor antibodies) in hemophilia A poses a new level of difficulty on the laboratory monitoring of these patients. To use the correct assays and for a proper interpretation of their results, it is pertinent to understand the mode of action of these nonfactor agents. Furthermore, the biochemical consequences for the different types of activity assays (whether it be specific FVIII activity assays or global coagulation assays) should be taken into account as well. In this review, these aspects will be discussed. In addition, the use of various animal models to estimate FVIII-equivalence of the nonfactor therapies will be presented. |
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MeSH term(s) | Animals ; Blood Coagulation ; Blood Coagulation Tests ; Hemophilia A/diagnosis ; Hemophilia A/drug therapy ; Hemostatics ; Humans ; Laboratories |
Chemical Substances | Hemostatics |
Language | English |
Publishing date | 2020-05-11 |
Publishing country | United States |
Document type | Journal Article ; Review |
ZDB-ID | 2915908-8 |
ISSN | 2473-9537 ; 2473-9529 |
ISSN (online) | 2473-9537 |
ISSN | 2473-9529 |
DOI | 10.1182/bloodadvances.2019000849 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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