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  1. Article ; Online: Response to Intermediate stage treatment: Is TACE enough?

    Pecorelli, Anna / Lenzi, Barbara / Trevisani, Franco

    Liver international : official journal of the International Association for the Study of the Liver

    2018  Volume 38, Issue 1, Page(s) 188–189

    MeSH term(s) Carcinoma, Hepatocellular ; Chemoembolization, Therapeutic ; Humans ; Liver Neoplasms ; Treatment Outcome
    Language English
    Publishing date 2018-01-16
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2102783-3
    ISSN 1478-3231 ; 1478-3223
    ISSN (online) 1478-3231
    ISSN 1478-3223
    DOI 10.1111/liv.13624
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Self-Reported Anxiety and Depression in a Monocentric Cohort of Patients With Systemic Lupus Erythematosus: Analysis of Prevalence, Main Determinants, and Impact on Quality of Life.

    Elefante, Elena / Tani, Chiara / Stagnaro, Chiara / Signorini, Viola / Lenzi, Beatrice / Zucchi, Dina / Trentin, Francesca / Carli, Linda / Ferro, Francesco / Mosca, Marta

    Frontiers in medicine

    2022  Volume 9, Page(s) 859840

    Abstract: Aims of the study: To analyze the prevalence of self-reported anxiety and depression in a monocentric cohort of patients with Systemic Lupus Erythematosus (SLE); to study the main determinants and the impact on quality of life (QoL).: Methods: A ... ...

    Abstract Aims of the study: To analyze the prevalence of self-reported anxiety and depression in a monocentric cohort of patients with Systemic Lupus Erythematosus (SLE); to study the main determinants and the impact on quality of life (QoL).
    Methods: A cross-sectional observational study including adult outpatients with SLE. Demographic and clinical data were analyzed: indices of disease activity (SELENA-SLEDAI); damage (SLICC-DI); comorbidities and concomitant therapies. The definitions for remission (DORIS) and "Lupus Low Disease Activity State" (LLDAS) were applied. At enrollment, each patient completed the following questionnaires: SF-36, FACIT-Fatigue, Lupus Impact Tracker (LIT), Systemic Lupus Activity Questionnaire (SLAQ), and the Hospital Anxiety and Depression Scale (HADS) in order to self-assess anxiety and depression symptoms. The Student
    Results: One hundred fifty-four consecutive patients with SLE were enrolled, the majority female and Caucasian with a mean age = 43.3 ± 13.7 years. 79.9% were in LLDAS or remission. 36.4% had a SDI > 1. 13.7% of patients had concomitant fibromyalgia. 37.4% had symptoms indicating anxiety and 25% of depression according to the HADS questionnaire. In the multivariate analysis, patients with active disease were significantly more anxious and depressed (
    Conclusion: Symptoms of anxiety and depression are frequent in SLE patients, including outpatients with mild/moderate disease. Such symptoms have a significant negative impact on QoL and perception of disease activity, regardless of other factors. Moreover, disease activity, advanced age and fibromyalgia appear to be significantly linked to mood disorders. Assessing symptoms of the anxious-depressive spectrum in patients with SLE could lead to improvement in patients' perception of health status and quality of life.
    Language English
    Publishing date 2022-03-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2022.859840
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Hyperammonemic encephalopathy during XELOX regimen. Is it capecitabine or oxaliplatin responsible?

    Di Federico, Alessandro / Nuvola, Giacomo / Sisi, Monia / Lenzi, Barbara / Nobili, Elisabetta / Campana, Davide

    Anti-cancer drugs

    2020  Volume 31, Issue 10, Page(s) 1103–1105

    Abstract: Hyperammonemic encephalopathy represents a rare adverse effect of several chemotherapeutic agents, occurring in about 0.7% of patients treated with fluoropyrimidines, and it is independent from dihydropyrimidine dehydrogenase deficiency. Instead, its ... ...

    Abstract Hyperammonemic encephalopathy represents a rare adverse effect of several chemotherapeutic agents, occurring in about 0.7% of patients treated with fluoropyrimidines, and it is independent from dihydropyrimidine dehydrogenase deficiency. Instead, its physiopathology is linked to the inhibition of Krebs cycle by fluoroacetate, leading to decreased ATP production, and to the inhibition of the urea cycle. Oxaliplatin seems to induce hyperammonemic encephalopathy in a similar way, acting on mitochondria. Here, we report the intriguing case of acute hyperammonemic encephalopathy in a 65-year-old patient with preserved liver function, who was treated with oxaliplatin and capecitabine for a metastatic, G1, atypical lung carcinoid. We reviewed the literature and found very few reports of oxaliplatin or capecitabine-induced hyperammonemic encephalopathy. Out of five cases of capecitabine-related hyperammonemic encephalopathy analyzed (four plus our case), median time to hyperammonemic encephalopathy onset was 6 days, with median serum ammonia levels of 213 μmol/L. Oxaliplatin-related hyperammonemic encephalopathy analyzed cases were three (two plus ours), with a median time to hyperammonemic encephalopathy of 11 days and median serum ammonia levels of 167 μmol/L. Identified predisposing factors for chemotherapy-induced hyperammonemia, such as dehydration, liver and renal impairment, infections, and sarcopenia were absent in our case. We hypothesize that the combination of a platinum-derivative and a fluoropyrimidine multiplies the risk of hyperammonemic encephalopathy, even in the absence of predisposing factors nor impaired liver function. We therefore suggest to always consider the risk of hyperammonemia when starting fluoropyrimidines-based chemotherapy, especially combined with platinum-derivatives, and to timely investigate neurologic symptoms monitoring ammonia serum levels.
    MeSH term(s) Aged ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Brain Diseases/chemically induced ; Brain Diseases/diagnosis ; Brain Diseases/drug therapy ; Capecitabine/administration & dosage ; Capecitabine/adverse effects ; Electroencephalography ; Humans ; Hyperammonemia/chemically induced ; Hyperammonemia/diagnosis ; Hyperammonemia/drug therapy ; Lactulose/therapeutic use ; Lung Neoplasms/diagnostic imaging ; Lung Neoplasms/drug therapy ; Lung Neoplasms/pathology ; Male ; Oxaliplatin/administration & dosage ; Oxaliplatin/adverse effects ; Oxaloacetates/adverse effects
    Chemical Substances Oxaloacetates ; Oxaliplatin (04ZR38536J) ; Lactulose (4618-18-2) ; Capecitabine (6804DJ8Z9U)
    Language English
    Publishing date 2020-08-18
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 1065301-6
    ISSN 1473-5741 ; 0959-4973
    ISSN (online) 1473-5741
    ISSN 0959-4973
    DOI 10.1097/CAD.0000000000000987
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Critical diagnostic delay associated with unusual presentation of hepatocellular carcinoma (HCC) with orbital metastases: a case report.

    Filippini, Daria M / Di Federico, Alessandro / Lenzi, Barbara / Nobili, Elisabetta / Brocchi, Stefano / Malvi, Deborah / Brandi, Giovanni

    Annals of palliative medicine

    2021  Volume 10, Issue 7, Page(s) 8474–8478

    Abstract: Orbital metastases are an extremely rare finding in patients with hepatocarcinoma (HCC), especially as its first presentation. Therefore, the risk of misdiagnosis is high, as well as that of drastic delays of the therapeutic algorithm. Here we report a ... ...

    Abstract Orbital metastases are an extremely rare finding in patients with hepatocarcinoma (HCC), especially as its first presentation. Therefore, the risk of misdiagnosis is high, as well as that of drastic delays of the therapeutic algorithm. Here we report a 71-year-old man presenting with orbital metastases as the initial sign of HCC, whose initial misdiagnosis led to the impossibility to start life-saving cancer treatment. The patient's history has begun on March 2018 with a growing tumefaction of the right orbit initially treted with antibiotics and corticosteroids without benefit. Subsequently, a facial CT scan showed a voluminous right intra-orbital mass, eroding the orbital roof. Tissue biopsy documented well differentiated malignant epithelial tumor cells. Under the suspect of primitive lachrymal gland tumor, the patient was admitted to the head and neck Unit with surgical intent. However, a subsequent 18F-FDG-PET documented the presence of liver lesions and multiple sites of metastasis. A new biopsy, this time on liver nodules, was carried out and the diagnosis of HCC was finally made. Samples from the first biopsy were then reviewed and judged consistent with HCC metastasis. Unfortunately, the initial misdiagnosis resulted in a six-month delay of the start of a therapeutic approach. During that time, patient's general conditions got extremely worse, making him unable to afford an antiblastic treatment. The patient died three months after the definitive diagnosis. This case suggests that the presence of intraorbital lesion requires a multimodal approach starting from the initial presentation. Performing a complete staging since tumor's clinical onset is mandatory, preferably before carrying out a tissue biopsy. Even though HCC represents a rare cause of intraocular metastasis, it needs to be ruled out when an orbital mass is documented, as the short median survival and the frequently poor conditions of HCC patients make a timely diagnosis crucial.
    MeSH term(s) Aged ; Carcinoma, Hepatocellular/diagnosis ; Delayed Diagnosis ; Humans ; Liver Neoplasms/diagnosis ; Male ; Orbital Neoplasms/diagnosis ; Tomography, X-Ray Computed
    Language English
    Publishing date 2021-05-11
    Publishing country China
    Document type Case Reports
    ZDB-ID 2828544-X
    ISSN 2224-5839 ; 2224-5839
    ISSN (online) 2224-5839
    ISSN 2224-5839
    DOI 10.21037/apm-20-2331
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Single-agent carboplatin in extensive disease small-cell lung cancer patient with liver failure: a case report within the experience of a single institution.

    Di Federico, Alessandro / Andrini, Elisa / Sisi, Monia / Nuvola, Giacomo / Lamberti, Giuseppe / Lenzi, Barbara / Nobili, Elisabetta / Gelsomino, Francesco / Ardizzoni, Andrea

    Anti-cancer drugs

    2021  Volume 32, Issue 7, Page(s) 755–757

    Abstract: Until recently, platinum-based chemotherapy has represented the benchmark for the treatment of extensive disease small-cell lung cancer (ED-SCLC). ED-SCLC patients are often diagnosed with poor performance status (PS ≥2) and/or compromised organ ... ...

    Abstract Until recently, platinum-based chemotherapy has represented the benchmark for the treatment of extensive disease small-cell lung cancer (ED-SCLC). ED-SCLC patients are often diagnosed with poor performance status (PS ≥2) and/or compromised organ functions. In fact, up to 63% of ED-SCLC has extensive liver involvement at diagnosis, which correlates with a poor prognosis. Whether to treat patients with tumor-related organ failure is still debated and the selection of those who could benefit from chemotherapy is crucial. Moreover, severe liver impairment contraindicates the administration of etoposide. Among 74 consecutive ED-SCLC patients followed at our institution from January 2017 to November 2019, three patients received single-agent carboplatin as a first-line treatment due to liver failure. We provide a brief description of a former heavy smoker 70-year-old man who was diagnosed with ED-SCLC and severe liver involvement leading to liver failure. The patient received a first-line treatment with single-agent carboplatin, obtaining a partial response, clinical benefit and the normalization of laboratory test, which documented the complete recovery of liver function. The intent of our work is to highlight the feasibility of single-agent carboplatin in ED-SCLC patients with tumor-related hepatic failure but preserved Eastern Cooperative Oncology Group PS, suggesting that this therapeutic option should not be discouraged a priori. Indeed, the identification of specific tools guiding physicians in the selection of patients who might benefit from the treatment is remarkably needed; meanwhile, the use of available prognostic score (e.g. Manchester score) might be of great value and should be considered in clinical practice.
    MeSH term(s) Aged ; Carboplatin/administration & dosage ; Carboplatin/therapeutic use ; Humans ; Liver Failure/complications ; Lung Neoplasms/complications ; Lung Neoplasms/drug therapy ; Male ; Small Cell Lung Carcinoma/complications ; Small Cell Lung Carcinoma/drug therapy ; Smokers
    Chemical Substances Carboplatin (BG3F62OND5)
    Language English
    Publishing date 2021-03-11
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 1065301-6
    ISSN 1473-5741 ; 0959-4973
    ISSN (online) 1473-5741
    ISSN 0959-4973
    DOI 10.1097/CAD.0000000000001057
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  6. Article: The Palliative Prognostic (PaP) Score without Clinical Evaluation Predicts Early Mortality among Advanced NSCLC Patients Treated with Immunotherapy.

    De Giglio, Andrea / Tassinari, Elisa / Zappi, Arianna / Di Federico, Alessandro / Lenzi, Barbara / Sperandi, Francesca / Melotti, Barbara / Gelsomino, Francesco / Maltoni, Marco / Ardizzoni, Andrea

    Cancers

    2022  Volume 14, Issue 23

    Abstract: Background: An acceptable risk-benefit ratio may encourage the prescription of immune checkpoint inhibitors (ICI) near the late stage of life. The lung immune prognostic index (LIPI) was validated in advanced non-small cell lung cancer (NSCLC) patients ... ...

    Abstract Background: An acceptable risk-benefit ratio may encourage the prescription of immune checkpoint inhibitors (ICI) near the late stage of life. The lung immune prognostic index (LIPI) was validated in advanced non-small cell lung cancer (NSCLC) patients treated with ICIs. The palliative prognostic (PaP) score without clinical prediction of survival (PaPwCPS) predicts early mortality probability in terminal cancer patients. Methods: We performed a retrospective study including 182 deceased advanced NSCLC patients, treated with single-agent ICI at our Institution. Two prognostic categories of high and low mortality risk were identified through ROC curve analysis for PaPwCPS and LIPI scores. Results: Most were >65 years of age (68.3%) and received second-line ICI (61.2%). A total of 29 (15.9%) and 131 (72.0%) patients died within 30 and 90 days from treatment start, respectively. A total of 81 patients (44.5%) received ICI during the last month of life. Baseline PaPwCPS and LIPI scores were assessable for 78 patients. The AUC of ROC curves was significantly increased for PaPwCPS as compared with LIPI score for both 30-day and 90-day mortality. A high PaPwCPS score was associated in multivariate analysis with increased 30-day (HR 2.69, p = 0.037) and 90-day (HR 4.01, p < 0.001) mortality risk. A high LIPI score was associated with increased 90-day mortality risk (p < 0.001). Conclusion: We found a tendency towards ICI prescription near the late stage of life. The PaPwCPS score was a reliable predictor of 30- and 90-day mortality.
    Language English
    Publishing date 2022-11-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers14235845
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  7. Article ; Online: Feasibility of Heart Rate and Respiratory Rate Estimation by Inertial Sensors Embedded in a Virtual Reality Headset.

    Floris, Claudia / Solbiati, Sarah / Landreani, Federica / Damato, Gianfranco / Lenzi, Bruno / Megale, Valentino / Caiani, Enrico Gianluca

    Sensors (Basel, Switzerland)

    2020  Volume 20, Issue 24

    Abstract: Virtual reality (VR) headsets, with embedded micro-electromechanical systems, have the potential to assess the mechanical heart's functionality and respiratory activity in a non-intrusive way and without additional sensors by utilizing the ... ...

    Abstract Virtual reality (VR) headsets, with embedded micro-electromechanical systems, have the potential to assess the mechanical heart's functionality and respiratory activity in a non-intrusive way and without additional sensors by utilizing the ballistocardiographic principle. To test the feasibility of this approach for opportunistic physiological monitoring, thirty healthy volunteers were studied at rest in different body postures (sitting (SIT), standing (STAND) and supine (SUP)) while accelerometric and gyroscope data were recorded for 30 s using a VR headset (Oculus Go, Oculus, Microsoft, USA) simultaneously with a 1-lead electrocardiogram (ECG) signal for mean heart rate (HR) estimation. In addition, longer VR acquisitions (50 s) were performed under controlled breathing in the same three postures to estimate the respiratory rate (RESP). Three frequency-based methods were evaluated to extract from the power spectral density the corresponding frequency. By the obtained results, the gyroscope outperformed the accelerometer in terms of accuracy with the gold standard. As regards HR estimation, the best results were obtained in SIT, with R
    MeSH term(s) Ballistocardiography ; Feasibility Studies ; Heart Rate ; Humans ; Respiratory Rate ; Virtual Reality ; Wearable Electronic Devices
    Language English
    Publishing date 2020-12-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s20247168
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  8. Article ; Online: De novo hepatocellular carcinoma of liver allograft: a neglected issue.

    Trevisani, Franco / Garuti, Francesca / Cucchetti, Alessandro / Lenzi, Barbara / Bernardi, Mauro

    Cancer letters

    2015  Volume 357, Issue 1, Page(s) 47–54

    Abstract: De novo hepatocellular carcinoma (HCC) is a rare neoplasm, ensuing after liver transplantation. Its definitive identification requires sophisticated molecular analyses. Hence, some cases, particularly those ensuing in patients who have been transplanted ... ...

    Abstract De novo hepatocellular carcinoma (HCC) is a rare neoplasm, ensuing after liver transplantation. Its definitive identification requires sophisticated molecular analyses. Hence, some cases, particularly those ensuing in patients who have been transplanted with HCC, are probably misclassified as recurrences of the primary tumor. Nevertheless, a tumor recurrence cannot be excluded in patients transplanted without apparent malignancy, because of an occult HCC. The main risk factor for de novo HCC is the recurrence of hepatitis/cirrhosis in the allograft. All the described de novo HCCs occurred at least 2 years after OLT, whereas most recurrent HCCs develop within 2 years from surgery. The treatment of this tumor can follow the recommendations of guidelines for primary HCC and, unlike recurrent HCC, re-transplant can be considered a therapeutic option for these patients. Prevention of this tumor relies on the prevention/cure of recurrent liver disease in the allograft and on judicious post-transplant immunosuppression. The present review analyzes this topic by addressing seven key questions. An algorithm based on clinical factors - regarding primary and secondary tumors - to trigger the suspicion of de novo origin of a post-transplant HCC is proposed.
    MeSH term(s) Aged ; Allografts ; Carcinoma, Hepatocellular/etiology ; Carcinoma, Hepatocellular/pathology ; Female ; Humans ; Liver Neoplasms/etiology ; Liver Neoplasms/pathology ; Liver Transplantation/adverse effects ; Liver Transplantation/methods ; Male ; Middle Aged ; Neoplasm Recurrence, Local/pathology ; Risk Factors
    Language English
    Publishing date 2015-02-01
    Publishing country Ireland
    Document type Journal Article ; Review
    ZDB-ID 195674-7
    ISSN 1872-7980 ; 0304-3835
    ISSN (online) 1872-7980
    ISSN 0304-3835
    DOI 10.1016/j.canlet.2014.11.032
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  9. Article ; Online: Integrated Method for Personal Thermal Comfort Assessment and Optimization through Users' Feedback, IoT and Machine Learning: A Case Study

    Salamone, Francesco / Belussi, Lorenzo / Currò, Cristian / Danza, Ludovico / Ghellere, Matteo / Guazzi, Giulia / Lenzi, Bruno / Megale, Valentino / Meroni, Italo

    Sensors (Basel, Switzerland)

    2018  Volume 18, Issue 5

    Abstract: Thermal comfort has become a topic issue in building performance assessment as well as energy efficiency. Three methods are mainly recognized for its assessment. Two of them based on standardized methodologies, face the problem by considering the indoor ... ...

    Abstract Thermal comfort has become a topic issue in building performance assessment as well as energy efficiency. Three methods are mainly recognized for its assessment. Two of them based on standardized methodologies, face the problem by considering the indoor environment in steady-state conditions (PMV and PPD) and users as active subjects whose thermal perception is influenced by outdoor climatic conditions (adaptive approach). The latter method is the starting point to investigate thermal comfort from an overall perspective by considering endogenous variables besides the traditional physical and environmental ones. Following this perspective, the paper describes the results of an in-field investigation of thermal conditions through the use of nearable and wearable solutions, parametric models and machine learning techniques. The aim of the research is the exploration of the reliability of IoT-based solutions combined with advanced algorithms, in order to create a replicable framework for the assessment and improvement of user thermal satisfaction. For this purpose, an experimental test in real offices was carried out involving eight workers. Parametric models are applied for the assessment of thermal comfort; IoT solutions are used to monitor the environmental variables and the users' parameters; the machine learning CART method allows to predict the users' profile and the thermal comfort perception respect to the indoor environment.
    Language English
    Publishing date 2018-05-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s18051602
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  10. Article ; Online: DUALarm: An open-source and 3D-printable device for upper limb neurorehabilitation.

    Dinon, Tito / Caimmi, Marco / Chiavenna, Andrea / Malosio, Matteo / Prini, Alessio / Scano, Alessandro / Molinari Tosatti, Lorenzo / Currò, Cristian / Lenzi, Bruno / Megale, Valentino

    Journal of rehabilitation and assistive technologies engineering

    2018  Volume 5, Page(s) 2055668317749989

    Abstract: Positively advocating that low-cost additive 3D-printing technologies and open-source licensed software/hardware platforms represent an optimal solution to realize low-cost equipment, a mechanical and 3D-printable device for bilateral upper-limb ... ...

    Abstract Positively advocating that low-cost additive 3D-printing technologies and open-source licensed software/hardware platforms represent an optimal solution to realize low-cost equipment, a mechanical and 3D-printable device for bilateral upper-limb rehabilitation is presented. The design and manufacturing process of this wheel-geared mechanism, enabling in-phase and anti-phase movements, will be openly provided online with the aim of making a set of customizable devices for neurorehabilitation exploitable all over the world even by people/countries with limited economical and technological resources. In order to characterize the interaction with the device, preliminary trials with EMG and kinematics recordings were performed on healthy subjects.
    Language English
    Publishing date 2018-01-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 2819384-2
    ISSN 2055-6683 ; 2055-6683
    ISSN (online) 2055-6683
    ISSN 2055-6683
    DOI 10.1177/2055668317749989
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