Article ; Online: Aurora-A kinase oncogenic signaling mediates TGF-β-induced triple-negative breast cancer plasticity and chemoresistance.
2021 Volume 40, Issue 14, Page(s) 2509–2523
Abstract: Triple-negative breast cancer (TNBCs) account for 15-20% of all breast cancers and represent the most aggressive subtype of this malignancy. Early tumor relapse and progression are linked to the enrichment of a sub-fraction of cancer cells, termed breast ...
| Abstract | Triple-negative breast cancer (TNBCs) account for 15-20% of all breast cancers and represent the most aggressive subtype of this malignancy. Early tumor relapse and progression are linked to the enrichment of a sub-fraction of cancer cells, termed breast tumor-initiating cells (BTICs), that undergo epithelial to mesenchymal transition (EMT) and typically exhibit a basal-like CD44 |
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| MeSH term(s) | Aurora Kinase A/metabolism ; Breast Neoplasms/genetics ; Breast Neoplasms/mortality ; Cell Plasticity/genetics ; Female ; Humans ; Signal Transduction ; Survival Analysis | |||||
| Chemical Substances | Aurora Kinase A (EC 2.7.11.1) | |||||
| Language | English | |||||
| Publishing date | 2021-03-05 | |||||
| Publishing country | England | |||||
| Document type | Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't | |||||
| ZDB-ID | 639046-8 | |||||
| ISSN | 1476-5594 ; 0950-9232 | |||||
| ISSN (online) | 1476-5594 | |||||
| ISSN | 0950-9232 | |||||
| DOI | 10.1038/s41388-021-01711-x | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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