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Article: Therapeutics to Treat Psychiatric and Neurological Disorders: A Promising Perspective from Algerian Traditional Medicine.

Larit, Farida / León, Francisco

2023 Volume 12, Issue 22

Abstract: Ancient people sought out drugs in nature to prevent, cure, and treat their diseases, including mental illnesses. Plants were their primary source for meeting their healthcare needs. In Algeria, folk medicine remains a fundamental part of the local ... ...

Abstract	Ancient people sought out drugs in nature to prevent, cure, and treat their diseases, including mental illnesses. Plants were their primary source for meeting their healthcare needs. In Algeria, folk medicine remains a fundamental part of the local intangible knowledge. This study aims to conduct a comprehensive ethnomedicinal investigation and documentation of medicinal plants and the different plant formulations traditionally used in Algeria for the treatment of pain, psychiatric, and neurological disorders. It also intends to improve the current knowledge of Algerian folk medicine. Several scientific databases were used to accomplish this work. Based on this investigation, we identified 82 plant species belonging to 69 genera and spanning 38 distinct botanical families used as remedies to treat various psychological and neurological conditions. Their traditional uses and methods of preparation, along with their phytochemical composition, main bioactive constituents, and toxicity were noted. Therefore, this review provides a new resource of information on Algerian medicinal plants used in the treatment and management of neurological and psychological diseases, which can be useful not only for the documentation and conservation of traditional knowledge, but also for conducting future phytochemical and pharmacological studies.
Language	English
Publishing date	2023-11-15
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2704341-1
ISSN	2223-7747
ISSN	2223-7747
DOI	10.3390/plants12223860
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Synthesis and Monoamine Oxidase Inhibitory Activity of Halogenated Flavones.

Castillo-Arellano, Jorge I / Stryker, Zachary / Wyatt, Michael D / León, Francisco

ACS medicinal chemistry letters

2024 Volume 15, Issue 5, Page(s) 610–618

Abstract: Small molecule neurotransmitters containing amines are metabolized by monoamine oxidase (MAO) in the nervous system. Monoamine oxidase inhibitors are a valuable class of drugs prescribed for the management of neurological disorders, including depression. ...

Abstract	Small molecule neurotransmitters containing amines are metabolized by monoamine oxidase (MAO) in the nervous system. Monoamine oxidase inhibitors are a valuable class of drugs prescribed for the management of neurological disorders, including depression. A series of halogenated flavonoids similar to the dietary flavonoid acacetin were designed as selective MAO-B inhibitors. MAO-A and -B inhibition of 36 halogenated flavones were tested. The halogens (fluorine and chlorine) were placed at positions 5 and 7 on ring A of the flavone scaffold. All compounds were selective MAO-B inhibitors with micro- and nanomolar IC
Language	English
Publishing date	2024-04-03
Publishing country	United States
Document type	Journal Article
ISSN	1948-5875
ISSN	1948-5875
DOI	10.1021/acsmedchemlett.3c00573
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Device implantation complicated by a retrosternal goiter.

Elshafie, Sally / Tariq, Abu Taher / Leon, Francisco Leyva

Pacing and clinical electrophysiology : PACE

2023 Volume 47, Issue 5, Page(s) 673–675

Abstract: Central venous obstruction in the cardiac implantable electronic devices (CIED) population is commonly due to thrombosis and fibrosis secondary to the passage of pre-existing leads. However, vein occlusion before CIED implantation is uncommon, and one ... ...

Abstract	Central venous obstruction in the cardiac implantable electronic devices (CIED) population is commonly due to thrombosis and fibrosis secondary to the passage of pre-existing leads. However, vein occlusion before CIED implantation is uncommon, and one cause is retrosternal goiters. We report a case where the failure of the initial implantation of a primary CIED led to an unusual implantation route without goiter excision. The patient had an indication for cardiac resynchronization therapy (CRT) given his left ventricular (LV) function was impaired and had second-degree heart block Mobitz Type II; however, he had occluded bilateral subclavian veins due to a sizeable retrosternal goiter. This obstruction led to the implantation of a single lead pacemaker via the right femoral vein after multiple failed attempts at CRT, dual chamber pacemaker and left bundle branch area pacing (LBBaP).
MeSH term(s)	Humans ; Male ; Pacemaker, Artificial ; Goiter, Substernal/surgery ; Goiter, Substernal/complications ; Prosthesis Implantation/methods ; Aged ; Subclavian Vein/surgery ; Subclavian Vein/diagnostic imaging
Language	English
Publishing date	2023-08-18
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	424437-0
ISSN	1540-8159 ; 0147-8389
ISSN (online)	1540-8159
ISSN	0147-8389
DOI	10.1111/pace.14806
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Zs.A 1466: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: PHYTOCHROME A controls the DNA damage response and cell death tolerance within the Arabidopsis root meristem.

Huerta-Venegas, Pedro Iván / Raya-González, Javier / Ruíz-Herrera, León Francisco / López-Bucio, José

Plant, cell & environment

2024 Volume 47, Issue 5, Page(s) 1513–1525

Abstract: The DNA damage response avoids mutations into dividing cells. Here, we analysed the role of photoreceptors on the restriction of root growth imposed by genotoxic agents and its relationship with cell viability and performance of meristems. Comparison of ... ...

Abstract	The DNA damage response avoids mutations into dividing cells. Here, we analysed the role of photoreceptors on the restriction of root growth imposed by genotoxic agents and its relationship with cell viability and performance of meristems. Comparison of root growth of Arabidopsis WT, phyA-211, phyB-9, and phyA-211phyB-9 double mutants unveiled a critical role for phytochrome A (PhyA) in protecting roots from genotoxic stress, regeneration and cell replenishment in the meristematic zone. PhyA was located on primary root tips, where it influences genes related to the repair of DNA, including ERF115 and RAD51. Interestingly, phyA-211 mutants treated with zeocin failed to induce the expression of the repressor of cell cycle MYB3R3, which correlated with expression of the mitotic cyclin CycB1, suggesting that PhyA is required for safeguarding the DNA integrity during cell division. Moreover, the growth of the primary roots of PhyA downstream component HY5 and root growth analyses in darkness suggest that cell viability and DNA damage responses within root meristems may act independently from light and photomorphogenesis. These data support novel roles for PhyA as a key player for stem cell niche maintenance and DNA damage responses, which are critical for proper root growth.
MeSH term(s)	Arabidopsis/metabolism ; Arabidopsis Proteins/genetics ; Arabidopsis Proteins/metabolism ; Cell Death ; DNA/metabolism ; DNA Repair/genetics ; Light ; Meristem/genetics ; Meristem/metabolism ; Mutation ; Phytochrome/metabolism ; Phytochrome A/genetics ; Phytochrome A/metabolism ; Phytochrome B/metabolism
Chemical Substances	Arabidopsis Proteins ; DNA (9007-49-2) ; Phytochrome (11121-56-5) ; Phytochrome A ; Phytochrome B (136250-22-1) ; PHYA protein, Arabidopsis
Language	English
Publishing date	2024-01-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	391893-2
ISSN	1365-3040 ; 0140-7791
ISSN (online)	1365-3040
ISSN	0140-7791
DOI	10.1111/pce.14831
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Article: Effects of Installing Different Types of Cooling Fins on the Cold Side of a Thermoelectric Power Generation Device on the Thermal Efficiency and Exergy Efficiency of Power Cable Surface Waste Heat Recovery.

Hu, Zihao / de León, Francisco / Wang, Rizhou / Li, Yanzhe

Micromachines

2023 Volume 14, Issue 8

Abstract: This study investigates the thermal efficiency and exergy efficiency of a thermoelectric power generation device for recovering power cable surface waste heat. Numerical simulations are conducted to analyze the impact of different types of cooling fins ... ...

Abstract	This study investigates the thermal efficiency and exergy efficiency of a thermoelectric power generation device for recovering power cable surface waste heat. Numerical simulations are conducted to analyze the impact of different types of cooling fins on the system's performance. The results demonstrate that the installation of cooling fins improves heat transfer efficiency and enhances the thermoelectric power generation device's output power. Among the various fin designs, the system equipped with cooling fins with 17 teeth exhibits the highest performance. These findings highlight the importance of fin design in optimizing the system's thermal efficiency and exergy efficiency. This study provides valuable insights for the development and improvement of thermoelectric power generation systems for power cable surface waste heat recovery applications.
Language	English
Publishing date	2023-08-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2620864-7
ISSN	2072-666X
ISSN	2072-666X
DOI	10.3390/mi14081591
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Article ; Online: Loss-of-function of MEDIATOR 12 or 13 subunits causes the swelling of root hairs in response to sucrose and abscisic acid in Arabidopsis

Javier Raya-González / José Carlos Prado-Rodríguez / León Francisco Ruiz-Herrera / José López-Bucio

Plant Signaling & Behavior, Vol 18, Iss

2023 Volume 1

Abstract: Root hairs are epidermal cell extensions that increase the root surface for water and nutrient acquisition. Thus, both the initiation and elongation of root hairs are critical for soil exploration and plant adaptation to ever changing growth conditions. ... ...

Abstract	Root hairs are epidermal cell extensions that increase the root surface for water and nutrient acquisition. Thus, both the initiation and elongation of root hairs are critical for soil exploration and plant adaptation to ever changing growth conditions. Here, we describe the critical roles of two subunits of the Mediator complex, MED12 and MED13, in root hair growth in response to sucrose and abscisic acid, which are tightly linked to abiotic stress resistance. When compared to the WT, med12 and med13 mutants showed increased sensitivity to sucrose and ABA treatments on root meristem and elongation zones that were accompanied with alterations in root hair length and morphology, leading to the isodiametric growth of these structures. The swollen root hair phenotype appeared to be specific, since med8 or med16 mutants did not develop rounded hairs when supplied with 4.8% sucrose. Under standard growth medium, MED12 and MED13 were mainly expressed in root vascular tissues and cotyledons, and their expression was repressed by sucrose or ABA. Interestingly, med12 and med13 mutants manifested exacerbated levels of nitric oxide under normal growth conditions, and upon sucrose supplementation in trichoblast cells, which coincided with root hair deformation. Our results indicate that MED12 and MED13 play non-redundant functions for maintenance of root hair integrity in response to sucrose and ABA and involve nitric oxide as a cellular messenger in Arabidopsis thaliana.
Keywords	arabidopsis thaliana ; root hair development ; abscisic acid ; sucrose ; mediator complex ; Plant ecology ; QK900-989 ; Biology (General) ; QH301-705.5
Subject code	580
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	Taylor & Francis Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Responses of population structure and genomic diversity to climate change and fishing pressure in a pelagic fish

Mendoza‐Portillo, Verónica / García‐De León, Francisco J. / Von der Heyden, Sophie

Global Change Biology. 2023 July, v. 29, no. 14 p.4107-4125

2023

Abstract: The responses of marine species to environmental changes and anthropogenic pressures (e.g., fishing) interact with ecological and evolutionary processes that are not well understood. Knowledge of changes in the distribution range and genetic diversity of ...

Abstract	The responses of marine species to environmental changes and anthropogenic pressures (e.g., fishing) interact with ecological and evolutionary processes that are not well understood. Knowledge of changes in the distribution range and genetic diversity of species and their populations into the future is essential for the conservation and sustainable management of resources. Almaco jack (Seriola rivoliana) is a pelagic fish with high importance to fisheries and aquaculture in the Pacific Ocean. In this study, we assessed contemporary genomic diversity and structure in loci that are putatively under selection (outlier loci) and determined their potential functions. Using a combination of genotype–environment association, spatial distribution models, and demogenetic simulations, we modeled the effects of climate change (under three different RCP scenarios) and fishing pressure on the species' geographic distribution and genomic diversity and structure to 2050 and 2100. Our results show that most of the outlier loci identified were related to biological and metabolic processes that may be associated with temperature and salinity. The contemporary genomic structure showed three populations—two in the Eastern Pacific (Cabo San Lucas and Eastern Pacific) and one in the Central Pacific (Hawaii). Future projections suggest a loss of suitable habitat and potential range contractions for most scenarios, while fishing pressure decreased population connectivity. Our results suggest that future climate change scenarios and fishing pressure will affect the genomic structure and genotypic composition of S. rivoliana and lead to loss of genomic diversity in populations distributed in the eastern‐central Pacific Ocean, which could have profound effects on fisheries that depend on this resource.
Keywords	Hawaii ; Seriola rivoliana ; aquaculture ; climate change ; genetic variation ; genomics ; genotype-environment interaction ; geographical distribution ; habitats ; pelagic fish ; population structure ; salinity ; species diversity ; temperature ; Pacific Ocean
Language	English
Dates of publication	2023-07
Size	p. 4107-4125.
Publishing place	John Wiley & Sons, Ltd
Document type	Article ; Online
Note	JOURNAL ARTICLE
ZDB-ID	1281439-8
ISSN	1365-2486 ; 1354-1013
ISSN (online)	1365-2486
ISSN	1354-1013
DOI	10.1111/gcb.16732
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Molecular Characterization of Peronospora variabilis Isolates Infecting Chenopodium quinoa and Chenopodium album in Spain

Fondevilla, Sara / Arias-Giraldo, Luis F. / García-León, Francisco Javier / Landa, Blanca B.

Plant Disease. 2023 Apr. 03, v. 107, no. 4 p.999-1004

2023

Abstract: Quinoa is an expanding crop in southern Spain. Downy mildew, caused by Peronospora variabilis, is the most important quinoa disease in Spain and worldwide. In Spain, this disease has also been observed on the weed Chenopodium album. The objectives of ... ...

Abstract	Quinoa is an expanding crop in southern Spain. Downy mildew, caused by Peronospora variabilis, is the most important quinoa disease in Spain and worldwide. In Spain, this disease has also been observed on the weed Chenopodium album. The objectives of this study were to unravel the origin of the P. variabilis isolates currently infecting quinoa in southern Spain and to study their genetic diversity. We hypothesized that P. variabilis isolates infecting quinoa in Spain could have been introduced through the seeds of the quinoa varieties currently grown in the country or, alternatively, that these isolates are endemic isolates, originally infecting C. album, that jumped to quinoa. In order to test these hypotheses, we sequenced the internal transcribed spacer (ITS), cytochrome c oxidase subunit 1 (cox1), and cox2 regions of 33 P. variabilis isolates infecting C. quinoa and C. album in southern Spain and analyzed their phylogenetic relationship with isolates present in other countries infecting Chenopodium spp. cox1 gene sequences from all of the Spanish P. variabilis isolates were identical and exhibited nine single-nucleotide polymorphisms (SNPs) compared with a single P. variabilis cox1 sequence found at GenBank. Phylogenetic analyses based on the ITS ribosomal DNA region were not suitable to differentiate isolates according to their geographical origin or host. The cox2 sequences from P. variabilis Spanish isolates collected from C. quinoa and C. album were all identical and had a distinctive SNP in the last of four polymorphic sites that distinguished Spanish isolates from isolates from other countries. These results suggest that P. variabilis infecting quinoa in southern Spain could be native isolates that originally infected C. album. Copyright © 2023 The Author(s). This is an open access article distributed under the CC BY 4.0 International license.
Keywords	Chenopodium album ; Chenopodium quinoa ; Peronospora ; downy mildew ; genes ; genetic variation ; internal transcribed spacers ; oxidoreductases ; phylogeny ; provenance ; ribosomal DNA ; weeds ; Spain ; genetic diversity ; Peronospora variabilis ; quinoa downy mildew
Language	English
Dates of publication	2023-0403
Size	p. 999-1004.
Publishing place	The American Phytopathological Society
Document type	Article ; Online
ZDB-ID	754182-x
ISSN	0191-2917
ISSN	0191-2917
DOI	10.1094/PDIS-05-22-1198-SC
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: The Polypharmacological Effects of Cannabidiol.

Castillo-Arellano, Jorge / Canseco-Alba, Ana / Cutler, Stephen J / León, Francisco

Molecules (Basel, Switzerland)

2023 Volume 28, Issue 7

Abstract: Cannabidiol (CBD) is a major phytocannabinoid present ... ...

Abstract	Cannabidiol (CBD) is a major phytocannabinoid present in
MeSH term(s)	Animals ; Humans ; Cannabidiol/pharmacology ; Cannabidiol/metabolism ; Cannabis/metabolism ; Epilepsy/drug therapy ; Cannabinoid Receptor Agonists ; Pain ; Dronabinol/pharmacology
Chemical Substances	Cannabidiol (19GBJ60SN5) ; Cannabinoid Receptor Agonists ; Dronabinol (7J8897W37S)
Language	English
Publishing date	2023-04-06
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules28073271
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Article ; Online: Natural Products Inhibitors of Monoamine Oxidases-Potential New Drug Leads for Neuroprotection, Neurological Disorders, and Neuroblastoma.

Chaurasiya, Narayan D / Leon, Francisco / Muhammad, Ilias / Tekwani, Babu L

Molecules (Basel, Switzerland)

2022 Volume 27, Issue 13

Abstract: Monoamine oxidase inhibitors (MAOIs) are an important class of drugs prescribed for treatment of depression and other neurological disorders. Evidence has suggested that patients with atypical depression preferentially respond to natural product MAOIs. ... ...

Abstract	Monoamine oxidase inhibitors (MAOIs) are an important class of drugs prescribed for treatment of depression and other neurological disorders. Evidence has suggested that patients with atypical depression preferentially respond to natural product MAOIs. This review presents a comprehensive survey of the natural products, predominantly from plant sources, as potential new MAOI drug leads. The psychoactive properties of several traditionally used plants and herbal formulations were attributed to their MAOI constituents. MAO inhibitory constituents may also be responsible for neuroprotective effects of natural products. Different classes of MAOIs were identified from the natural product sources with non-selective as well as selective inhibition of MAO-A and -B. Selective reversible natural product MAOIs may be safer alternatives to the conventional MAOI drugs. Characterization of MAO inhibitory constituents of natural products traditionally used as psychoactive preparations or for treatment of neurological disorders may help in understanding the mechanism of action, optimization of these preparations for desired bioactive properties, and improvement of the therapeutic potential. Potential therapeutic application of natural product MAOIs for treatment of neuroblastoma is also discussed.
MeSH term(s)	Biological Products/pharmacology ; Biological Products/therapeutic use ; Humans ; Monoamine Oxidase ; Monoamine Oxidase Inhibitors/pharmacology ; Monoamine Oxidase Inhibitors/therapeutic use ; Nervous System Diseases/drug therapy ; Neuroblastoma/drug therapy ; Neuroprotection
Chemical Substances	Biological Products ; Monoamine Oxidase Inhibitors ; Monoamine Oxidase (EC 1.4.3.4)
Language	English
Publishing date	2022-07-04
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules27134297
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