Article ; Online: Circulating cellular clusters are associated with thrombotic complications and clinical outcomes in COVID-19
iScience, Vol 26, Iss 7, Pp 107202- (2023)
2023
Abstract: Summary: We sought to study the role of circulating cellular clusters (CCC) –such as circulating leukocyte clusters (CLCs), platelet-leukocyte aggregates (PLA), and platelet-erythrocyte aggregates (PEA)– in the immunothrombotic state induced by COVID-19. ...
| Abstract | Summary: We sought to study the role of circulating cellular clusters (CCC) –such as circulating leukocyte clusters (CLCs), platelet-leukocyte aggregates (PLA), and platelet-erythrocyte aggregates (PEA)– in the immunothrombotic state induced by COVID-19. Forty-six blood samples from 37 COVID-19 patients and 12 samples from healthy controls were analyzed with imaging flow cytometry. Patients with COVID-19 had significantly higher levels of PEAs (p value<0.001) and PLAs (p value = 0.015) compared to healthy controls. Among COVID-19 patients, CLCs were correlated with thrombotic complications (p value = 0.016), vasopressor need (p value = 0.033), acute kidney injury (p value = 0.027), and pneumonia (p value = 0.036), whereas PEAs were associated with positive bacterial cultures (p value = 0.033). In predictive in silico simulations, CLCs were more likely to result in microcirculatory obstruction at low flow velocities (≤1 mm/s) and at higher branching angles. Further studies on the cellular component of hyperinflammatory prothrombotic states may lead to the identification of novel biomarkers and drug targets for inflammation-related thrombosis. |
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| Keywords | Cell biology ; Health sciences ; Immunology ; Microbiology ; Science ; Q |
| Subject code | 610 |
| Language | English |
| Publishing date | 2023-07-01T00:00:00Z |
| Publisher | Elsevier |
| Document type | Article ; Online |
| Database | BASE - Bielefeld Academic Search Engine (life sciences selection) |
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