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Article ; Online: Postintubation tracheal injuries: which criteria to guide non-surgical treatment?

Leoncini, Giacomo

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery

2011 Volume 39, Issue 3, Page(s) 424; author reply 425

MeSH term(s)	Humans ; Intubation, Intratracheal/adverse effects ; Trachea/injuries ; Trauma Severity Indices
Language	English
Publishing date	2011-03
Publishing country	Germany
Document type	Comment ; Letter
ZDB-ID	639293-3
ISSN	1873-734X ; 1010-7940 ; 1567-4258
ISSN (online)	1873-734X
ISSN	1010-7940 ; 1567-4258
DOI	10.1016/j.ejcts.2010.05.041
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Article: Temporal trend, geographic distribution, and publication quality in asbestos research

Ugolini, Donatella / Bonassi, Stefano / Cristaudo, Alfonso / Leoncini, Giacomo / Ratto, Giovanni Battista / Neri, Monica

Environmental science and pollution research international. 2015 May, v. 22, no. 9

2015

Abstract: Asbestos is a well-known cause of cancer and respiratory diseases. The aim of the current study was to investigate the scientific production in asbestos research evaluating temporal trend, geographic distribution, impact factor (IF) of published ... ...

Abstract	Asbestos is a well-known cause of cancer and respiratory diseases. The aim of the current study was to investigate the scientific production in asbestos research evaluating temporal trend, geographic distribution, impact factor (IF) of published literature, and taking into account socioeconomic variables. The PubMed database was searched starting from 1970. Publication numbers and IF were evaluated as absolute values and after standardization by population and gross domestic product (GDP). Six thousand nine hundred seven articles related to asbestos were retrieved. Publications grew steeply in the 1970s, leveled off in the 1980s, decreased in the 1990s, and then increased again. Mesothelioma, lung neoplasms, and occupational diseases are the most commonly used keywords. In the period of 1988–2011, 4220 citations were retrieved, 3187 of whom had an impact factor. The US, Italy, and the UK were the most productive countries. European countries published about 20 % more asbestos-related articles than the US, although the latter reached a higher mean IF, ranking second after Australia. When the national scientific production (sum of IF) was compared taking into account socioeconomic variables, Australia and Scandinavian countries performed very well, opposite to all main asbestos producers like Russia, China, and Brazil (except for Canada). The American Journal of Industrial Medicine and the Italian La Medicina del Lavoro published the highest numbers of articles. This study provides the first bibliometric analysis of scientific production in asbestos research. Interest appears to be higher in selected countries, with strong national features, and is growing again in the new millennium.
Keywords	asbestos ; databases ; geographical distribution ; gross domestic product ; lung neoplasms ; medicine ; mesothelioma ; occupational diseases ; socioeconomic factors ; Australia ; Brazil ; Canada ; China ; Italy ; Russia ; United Kingdom ; United States
Language	English
Dates of publication	2015-05
Size	p. 6957-6967.
Publishing place	Springer-Verlag
Document type	Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-014-3925-1
Database	NAL-Catalogue (AGRICOLA)

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Article: Successful primary staple-repair of thoracic oesophagus after delayed presentation of a spontaneous perforation.

Leoncini, Giacomo / Novello, Luca / Denegri, Andrea / Morelli, Lucia / Ratto, Giovanni B

International journal of surgery case reports

2015 Volume 14, Page(s) 167–171

Abstract: Introduction: Spontaneous perforation of the oesophagus is diagnosed late in over 50% of cases. Misdiagnosis may be due to atypical presentations. Primary repair is technically demanding in this setting and the risk of failure is high.: Presentation ... ...

Abstract	Introduction: Spontaneous perforation of the oesophagus is diagnosed late in over 50% of cases. Misdiagnosis may be due to atypical presentations. Primary repair is technically demanding in this setting and the risk of failure is high. Presentation of case: An 85 year-old lady presented with an atypical cohort of mild nonspecific symptoms in spite of a pleuro-mediastinal purulent collection secondary to an undiagnosed spontaneous perforation of the oesophagus occurred seven days before. Despite the extent of perforation (3cm in length), the late diagnosis and the necrosis of the muscular wall, the oesophagus was successfully repaired by means of a stapler. Discussion: The mechanism of the atypical presentation is discussed and possible modalities of treatment of delayed oesophageal perforations are reviewed, with particular reference to primary repair and to the possible use of staplers within this setting. Conclusion: Even large spontaneous perforations of the oesophagus can result in a contained abscess, with no frank sepsis. Diagnosis can be missed for days in these cases. The attempt at primary repair of the oesophagus is still indicated. The use of a stapler is preferable in such cases as a perfect mucosal approximation is provided with minimal manipulation and with the use of inert, well tolerated material, which does not tend to become infected.
Language	English
Publishing date	2015-07-31
Publishing country	Netherlands
Document type	Journal Article
ISSN	2210-2612
ISSN	2210-2612
DOI	10.1016/j.ijscr.2015.07.032
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Article ; Online: Temporal trend, geographic distribution, and publication quality in asbestos research.

Ugolini, Donatella / Bonassi, Stefano / Cristaudo, Alfonso / Leoncini, Giacomo / Ratto, Giovanni Battista / Neri, Monica

Environmental science and pollution research international

2015 Volume 22, Issue 9, Page(s) 6957–6967

Abstract	Asbestos is a well-known cause of cancer and respiratory diseases. The aim of the current study was to investigate the scientific production in asbestos research evaluating temporal trend, geographic distribution, impact factor (IF) of published literature, and taking into account socioeconomic variables. The PubMed database was searched starting from 1970. Publication numbers and IF were evaluated as absolute values and after standardization by population and gross domestic product (GDP). Six thousand nine hundred seven articles related to asbestos were retrieved. Publications grew steeply in the 1970s, leveled off in the 1980s, decreased in the 1990s, and then increased again. Mesothelioma, lung neoplasms, and occupational diseases are the most commonly used keywords. In the period of 1988-2011, 4220 citations were retrieved, 3187 of whom had an impact factor. The US, Italy, and the UK were the most productive countries. European countries published about 20 % more asbestos-related articles than the US, although the latter reached a higher mean IF, ranking second after Australia. When the national scientific production (sum of IF) was compared taking into account socioeconomic variables, Australia and Scandinavian countries performed very well, opposite to all main asbestos producers like Russia, China, and Brazil (except for Canada). The American Journal of Industrial Medicine and the Italian La Medicina del Lavoro published the highest numbers of articles. This study provides the first bibliometric analysis of scientific production in asbestos research. Interest appears to be higher in selected countries, with strong national features, and is growing again in the new millennium.
MeSH term(s)	Asbestos ; Australia ; Bibliometrics ; Brazil ; Canada ; China ; Europe ; Humans ; Italy ; Journal Impact Factor ; Lung Neoplasms ; Neoplasms ; Occupational Diseases ; Publishing ; Research
Chemical Substances	Asbestos (1332-21-4)
Language	English
Publishing date	2015-05
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-014-3925-1
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Article ; Online: Endovascular treatment of pulmonary sequestration in adults using Amplatzer® vascular plugs.

Leoncini, Giacomo / Rossi, Umberto G / Ferro, Carlo / Chessa, Leonardo

Interactive cardiovascular and thoracic surgery

2011 Volume 12, Issue 1, Page(s) 98–100

Abstract: Two adult patients were diagnosed with extralobar and intralobar pulmonary sequestration. One patient presented with haemoptysis. Both patients suffered from recurrent episodes of severe pulmonary infections. Both patients were treated by means of ... ...

Abstract	Two adult patients were diagnosed with extralobar and intralobar pulmonary sequestration. One patient presented with haemoptysis. Both patients suffered from recurrent episodes of severe pulmonary infections. Both patients were treated by means of endovascular embolization using Amplatzer(®) vascular plugs (AVPs). They were discharged from hospital after 48 and 24 h and then followed up for 24 and six months, respectively. No recurrence of symptoms was observed. Computed tomography scans were obtained every six months. Persistent occlusion of vascular supply and moderate regression of the sequestered lung tissue are evident after 24 and six months in both patients. Just one case of an adult patient affected by pulmonary sequestration and treated by endovascular embolization has been reported to date. The present report is the first on the use of the AVPs in adults for this condition. The potential advantages and drawbacks of this treatment modality in adults are discussed, as well the specific benefit represented by the AVPs.
MeSH term(s)	Adult ; Angiography, Digital Subtraction ; Aortography/methods ; Bronchopulmonary Sequestration/complications ; Bronchopulmonary Sequestration/diagnostic imaging ; Bronchopulmonary Sequestration/therapy ; Embolization, Therapeutic/instrumentation ; Endovascular Procedures/instrumentation ; Equipment Design ; Hemoptysis/etiology ; Humans ; Male ; Middle Aged ; Time Factors ; Tomography, X-Ray Computed ; Treatment Outcome
Language	English
Publishing date	2011-01
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	2095298-3
ISSN	1569-9285 ; 1569-9293
ISSN (online)	1569-9285
ISSN	1569-9293
DOI	10.1510/icvts.2010.246546
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Article ; Online: Primary and secondary purulent pericarditis in otherwise healthy adults.

Leoncini, Giacomo / Iurilli, Luciano / Queirolo, Augusto / Catrambone, Giuseppe

Interactive cardiovascular and thoracic surgery

2006 Volume 5, Issue 5, Page(s) 652–654

Abstract: The records of five previously healthy adult patients with primary and secondary purulent pericarditis are reported, in order to review the literature about such a rare condition and to discuss the options for treatment. Primary purulent pericarditis ... ...

Abstract	The records of five previously healthy adult patients with primary and secondary purulent pericarditis are reported, in order to review the literature about such a rare condition and to discuss the options for treatment. Primary purulent pericarditis occurred in a five months pregnant woman and in a lady who had experienced a serous pericarditis two months before. A man presented with pyo-pneumo-pericardium. He had an episode of acute prostatitis 30 days before. Two further patients had purulent pericarditis secondary to pulmonary and mediastinal infections. The diagnosis was made late in all cases, after tamponade and shock occurred. Pre-operative catheter drainage failed to prevent recurrent tamponade and sepsis in two patients. All patients underwent thoracotomy and partial pericardiectomy. A downward transdiaphragmatic spreading collection was evident in one patient and laparotomy was needed. The mean postoperative stay was 30.4 days (20-48 days). All patients were discharged home in good health. The lady who was pregnant experienced an uncomplicated vaginal delivery. The follow-up time ranged between 5 months to 12 years. No patient has signs of pericardial constriction. We conclude that effective control of sepsis and prevention of possible further constriction are achieved safely by open surgical drainage and partial pericardiectomy.
Language	English
Publishing date	2006-10
Publishing country	England
Document type	Journal Article
ZDB-ID	2095298-3
ISSN	1569-9285 ; 1569-9293
ISSN (online)	1569-9285
ISSN	1569-9293
DOI	10.1510/icvts.2006.131912
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Article ; Online: Chemoprevention of asbestos-linked cancers: a systematic review.

Neri, Monica / Ugolini, Donatella / Boccia, Stefania / Canessa, Pier Aldo / Cesario, Alfredo / Leoncini, Giacomo / Mutti, Luciano / Bonassi, Stefano

Anticancer research

2012 Volume 32, Issue 3, Page(s) 1005–1013

Abstract: Asbestos has been used extensively and, in spite of many countries having banned most of its uses, professional, domestic and environmental exposure has not ceased worldwide. Inhaled asbestos fibers can lead to malignant mesothelioma, lung cancer and non- ...

Abstract	Asbestos has been used extensively and, in spite of many countries having banned most of its uses, professional, domestic and environmental exposure has not ceased worldwide. Inhaled asbestos fibers can lead to malignant mesothelioma, lung cancer and non-cancerous conditions, while the substance persists indefinitely in the lung and pleural tissue, resulting in continuous damage. Exposed individuals may be offered medical surveillance or compensation, but nothing is currently being done to lower their specific cancer risk: chemoprevention seems a promising approach. A web search and a PubMed review of the literature on chemoprevention trials in individuals exposed to asbestos have been conducted. Forty-six articles on five projects were found and newly reviewed but, surprisingly, no novel trials have been set up for twenty years, although considerable advances have been gained in cancer chemoprevention. A re-consideration of possibilities offered by chemoprevention should be encouraged. New trials based on the most recently characterized molecules should be planned, taking into account specific issues such as the need for a very large number of participants and a long follow up or, alternatively, the use of biomarkers as surrogate endpoints. The long latency of asbestos related diseases may offer delayed intervention opportunities. The lack of chemoprevention trials for asbestos exposure highlights the urgent need for research in this field.
MeSH term(s)	Asbestos/toxicity ; Carcinogens/toxicity ; Chemoprevention ; Humans ; Neoplasms/chemically induced ; Neoplasms/prevention & control
Chemical Substances	Carcinogens ; Asbestos (1332-21-4)
Language	English
Publishing date	2012-03
Publishing country	Greece
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	604549-2
ISSN	1791-7530 ; 0250-7005
ISSN (online)	1791-7530
ISSN	0250-7005
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Article ; Online: Pleurectomy-decortication in malignant pleural mesothelioma: are different surgical techniques associated with different outcomes? Results from a multicentre study.

Marulli, Giuseppe / Breda, Cristiano / Fontana, Paolo / Ratto, Giovanni Battista / Leoncini, Giacomo / Alloisio, Marco / Infante, Maurizio / Luzzi, Luca / Paladini, Piero / Oliaro, Alberto / Ruffini, Enrico / Benvenuti, Mauro Roberto / Pariscenti, Gianluca / Spaggiari, Lorenzo / Casiraghi, Monica / Rusca, Michele / Carbognani, Paolo / Ampollini, Luca / Facciolo, Francesco /

Leuzzi, Giovanni / Mucilli, Felice / Camplese, Pierpaolo / Romanello, Paola / Perissinotto, Egle / Rea, Federico

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery

2017 Volume 52, Issue 1, Page(s) 63–69

Abstract: Objectives: The potential benefit of surgery for malignant pleural mesothelioma (MPM), especially concerning pleurectomy/decortication (P/D), is unclear from the literature. The aim of this study was to evaluate the outcome after multimodality treatment ...

Abstract	Objectives: The potential benefit of surgery for malignant pleural mesothelioma (MPM), especially concerning pleurectomy/decortication (P/D), is unclear from the literature. The aim of this study was to evaluate the outcome after multimodality treatment of MPM involving different types of P/D and to analyse the prognostic factors. Methods: We reviewed 314 patients affected by MPM who were operated on in 11 Italian centres from 1 January 2007 to 11 October 2014. Results: The characteristics of the population were male/female ratio: 3.7/1, and median age at operation was 67.8 years. The epithelioid histotype was observed in 79.9% of patients; neoadjuvant chemotherapy was given to 57% of patients and Stage III disease was found following a pathological analysis in 62.3% of cases. A total of 162 (51.6%) patients underwent extended P/D (EP/D); 115 (36.6%) patients had P/D and 37 (11.8%) received only a partial pleurectomy. Adjuvant radiotherapy was delivered in 39.2% of patients. Median overall survival time after surgery was 23.0 [95% confidence interval (CI): 19.6-29.1] months. On multivariable (Cox) analysis, pathological Stage III-IV [ P = 0.004, hazard ratio (HR):1.34; 95% CI: 1.09-1.64], EP/D and P/D ( P = 0.006, HR for EP/D: 0.46; 95% CI: 0.29-0.74; HR for P/D: 0.52; 95% CI: 0.31-0.87), left-sided disease ( P = 0.01, HR: 1.52; 95% CI: 1.09-2.12) and pathological status T4 ( P = 0.0003, HR: 1.38; 95% CI: 1.14-1.66) were found to be independent significant predictors of overall survival. Conclusions: Whether the P/D is extended or not, it shows similarly good outcomes in terms of early results and survival rate. In contrast, a partial pleurectomy, which leaves gross tumour behind, has no impact on survival.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Female ; Humans ; Italy/epidemiology ; Kaplan-Meier Estimate ; Lung Neoplasms/diagnosis ; Lung Neoplasms/mortality ; Lung Neoplasms/surgery ; Male ; Mesothelioma/diagnosis ; Mesothelioma/mortality ; Mesothelioma/surgery ; Mesothelioma, Malignant ; Middle Aged ; Pleura/pathology ; Pleura/surgery ; Pleural Neoplasms/diagnosis ; Pleural Neoplasms/mortality ; Pleural Neoplasms/surgery ; Positron Emission Tomography Computed Tomography/methods ; Survival Rate/trends ; Thoracic Surgical Procedures/methods ; Treatment Outcome
Language	English
Publishing date	2017-04-12
Publishing country	Germany
Document type	Journal Article ; Multicenter Study
ZDB-ID	639293-3
ISSN	1873-734X ; 1010-7940 ; 1567-4258
ISSN (online)	1873-734X
ISSN	1010-7940 ; 1567-4258
DOI	10.1093/ejcts/ezx079
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Article ; Online: Prognostic Score of Long-Term Survival After Surgery for Malignant Pleural Mesothelioma: A Multicenter Analysis.

The Annals of thoracic surgery

2015 Volume 100, Issue 3, Page(s) 890–897

Abstract: Background: Despite ongoing efforts to improve therapy in malignant pleural mesothelioma, few patients undergoing extrapleural pneumonectomy experience long-term survival (LTS). This study aims to explore predictors of LTS after extrapleural ... ...

Abstract	Background: Despite ongoing efforts to improve therapy in malignant pleural mesothelioma, few patients undergoing extrapleural pneumonectomy experience long-term survival (LTS). This study aims to explore predictors of LTS after extrapleural pneumonectomy and to define a prognostic score. Methods: From January 2000 to December 2010, we retrospectively reviewed clinicopathologic and oncological factors in a multicenter cohort of 468 malignant pleural mesothelioma patients undergoing extrapleural pneumonectomy. LTS was defined as survival longer than 3 years. Associations were evaluated using χ(2), Student's t, and Mann-Whitney U tests. Logistic regression, Cox regression hazard model, and bootstrap analysis were applied to identify outcome predictors. Survival curves were calculated by the Kaplan-Meier method. Receiver operating characteristic analyses were used to estimate optimal cutoff and area under the curve for accuracy of the model. Results: Overall, 107 patients (22.9%) survived at least 3 years. Median overall, cancer-specific, and disease-free survival times were 60 (95% confidence interval [CI], 51 to 69), 63 (95% CI, 54 to 72), and 49 months (95% CI, 39 to 58), respectively. At multivariate analysis, age (odds ratio, 0.51; 95% CI, 0.31 to 0.82), epithelioid histology (odds ratio, 7.07; 95% CI, 1.56 to 31.93), no history of asbestos exposure (odds ratio, 3.13; 95% CI, 1.13 to 8.66), and the ratio between metastatic and resected lymph nodes less than 22% (odds ratio, 4.12; 95% CI, 1.68 to 10.12) were independent predictors of LTS. According to these factors, we created a scoring system for LTS that allowed us to correctly predict overall, cancer-specific, and disease-free survival in the total sample, obtaining two different groups with favorable or poor prognosis (area under the curve, 0.74; standard error, 0.04; p < 0.0001). Conclusions: Our prognostic model facilitates the prediction of LTS after surgery for malignant pleural mesothelioma and can help to stratify the outcome and, eventually, tailor postoperative treatment.
MeSH term(s)	Adult ; Aged ; Female ; Humans ; Male ; Mesothelioma/mortality ; Mesothelioma/surgery ; Middle Aged ; Pleural Neoplasms/mortality ; Pleural Neoplasms/surgery ; Pneumonectomy/methods ; Prognosis ; Retrospective Studies ; Survival Rate ; Time Factors
Language	English
Publishing date	2015-09
Publishing country	Netherlands
Document type	Journal Article ; Multicenter Study
ZDB-ID	211007-6
ISSN	1552-6259 ; 0003-4975
ISSN (online)	1552-6259
ISSN	0003-4975
DOI	10.1016/j.athoracsur.2015.04.087
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Article ; Online: Extrapleural pneumonectomy for malignant mesothelioma: an Italian multicenter retrospective study.

The Annals of thoracic surgery

2014 Volume 97, Issue 6, Page(s) 1859–1865

Abstract: Background: This study assessed perioperative outcome and long-term survival in a large series of patients with malignant pleural mesothelioma who underwent extrapleural pneumonectomy (EPP) to identify prognostic factors allowing better patient ... ...

Abstract	Background: This study assessed perioperative outcome and long-term survival in a large series of patients with malignant pleural mesothelioma who underwent extrapleural pneumonectomy (EPP) to identify prognostic factors allowing better patient selection. Methods: We retrospectively collected data from nine referral centers for thoracic surgery in Italy. Perioperative outcome and survival data were available for 518 malignant pleural mesothelioma patients (84.4% with epithelial tumors, 68.0% with pathologic stage 3 disease) who underwent EPP with intention-to-treat (R0/R1) between 2000 and 2010. Induction chemotherapy was administered in 271 patients (52.3%) and adjuvant therapy in 373 patients (72.0%), including radiotherapy in 213 patients (41.1%), adjuvant chemotherapy in 43 patients (8.3%), and both in 117 patients (22.6%). Results: In all, 136 patients (26.3%) had major complications after EPP, and 36 (6.9%) died within 90 days after surgery. The median overall survival was 18 months, with a 1-, 2-, and 3-year overall survival of 65%, 41%, and 27%, respectively. At multivariable analysis adjusted for age and disease stage, male sex (hazard ratio [HR] 1.47, 95% confidence interval [CI]: 1.12 to 1.92), nonepithelial histology (HR 1.96, 95% CI: 1.48 to 2.58), and trimodality treatment using induction chemotherapy (HR 0.61, 95% CI: 0.43 to 0.85) were significantly associated with survival. Development of a major complication also significantly worsened outcome (HR 1.85, 95% CI: 1.37 to 2.50). Conclusions: The success of EPP in the context of a multimodality treatment depends on a series of patient characteristics. Female patients, patients with epithelial tumors, and patients who received induction chemotherapy will best benefit from EPP.
MeSH term(s)	Adult ; Aged ; Female ; Humans ; Lung Neoplasms/mortality ; Lung Neoplasms/pathology ; Lung Neoplasms/surgery ; Male ; Mesothelioma/mortality ; Mesothelioma/pathology ; Mesothelioma/surgery ; Mesothelioma, Malignant ; Middle Aged ; Pleural Neoplasms/mortality ; Pleural Neoplasms/pathology ; Pleural Neoplasms/surgery ; Pneumonectomy/adverse effects ; Pneumonectomy/methods ; Proportional Hazards Models ; Retrospective Studies
Language	English
Publishing date	2014-04-14
Publishing country	Netherlands
Document type	Journal Article ; Multicenter Study
ZDB-ID	211007-6
ISSN	1552-6259 ; 0003-4975
ISSN (online)	1552-6259
ISSN	0003-4975
DOI	10.1016/j.athoracsur.2014.01.050
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