Article ; Online: Non-Haemodynamic Mechanisms Underlying Hypertension-Associated Damage in Target Kidney Components.
International journal of molecular sciences
2023 Volume 24, Issue 11
Abstract: Arterial hypertension (AH) is a global challenge that greatly impacts cardiovascular morbidity and mortality worldwide. AH is a major risk factor for the development and progression of kidney disease. Several antihypertensive treatment options are ... ...
| Abstract | Arterial hypertension (AH) is a global challenge that greatly impacts cardiovascular morbidity and mortality worldwide. AH is a major risk factor for the development and progression of kidney disease. Several antihypertensive treatment options are already available to counteract the progression of kidney disease. Despite the implementation of the clinical use of renin-angiotensin aldosterone system (RAAS) inhibitors, gliflozins, endothelin receptor antagonists, and their combination, the kidney damage associated with AH is far from being resolved. Fortunately, recent studies on the molecular mechanisms of AH-induced kidney damage have identified novel potential therapeutic targets. Several pathophysiologic pathways have been shown to play a key role in AH-induced kidney damage, including inappropriate tissue activation of the RAAS and immunity system, leading to oxidative stress and inflammation. Moreover, the intracellular effects of increased uric acid and cell phenotype transition showed their link with changes in kidney structure in the early phase of AH. Emerging therapies targeting novel disease mechanisms could provide powerful approaches for hypertensive nephropathy management in the future. In this review, we would like to focus on the interactions of pathways linking the molecular consequences of AH to kidney damage, suggesting how old and new therapies could aim to protect the kidney. |
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| MeSH term(s) | Humans ; Hypertension ; Kidney/metabolism ; Renin-Angiotensin System ; Antihypertensive Agents/pharmacology ; Antihypertensive Agents/therapeutic use ; Antihypertensive Agents/metabolism ; Hypertension, Renal/metabolism |
| Chemical Substances | Antihypertensive Agents |
| Language | English |
| Publishing date | 2023-05-29 |
| Publishing country | Switzerland |
| Document type | Journal Article ; Review |
| ZDB-ID | 2019364-6 |
| ISSN | 1422-0067 ; 1422-0067 ; 1661-6596 |
| ISSN (online) | 1422-0067 |
| ISSN | 1422-0067 ; 1661-6596 |
| DOI | 10.3390/ijms24119422 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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