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Book ; Online ; Thesis: Analyse und Charakterisierung des Woronin Körper-Proteins WscA, des Bindeproteins Lah und der Verankerung von Woronin Körpern am Hyphen-Septum im pathogenen Schimmelpilz Aspergillus fumigatus

Leonhardt, Yannik [Verfasser] / Ebel, Frank [Akademischer Betreuer]

2021

Author's details	Yannik Leonhardt ; Betreuer: Frank Ebel
Keywords	Medizin, Gesundheit ; Medicine, Health
Subject code	sg610
Language	German
Publisher	Universitätsbibliothek der Ludwig-Maximilians-Universität
Publishing place	München
Document type	Book ; Online ; Thesis
Database	Digital theses on the web

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Article ; Online: Evaluation of a deep learning-based reconstruction method for denoising and image enhancement of shoulder MRI in patients with shoulder pain.

Feuerriegel, Georg C / Weiss, Kilian / Kronthaler, Sophia / Leonhardt, Yannik / Neumann, Jan / Wurm, Markus / Lenhart, Nicolas S / Makowski, Marcus R / Schwaiger, Benedikt J / Woertler, Klaus / Karampinos, Dimitrios C / Gersing, Alexandra S

European radiology

2023 Volume 33, Issue 7, Page(s) 4875–4884

Abstract: Objectives: To evaluate the diagnostic performance of an automated reconstruction algorithm combining MR imaging acquired using compressed SENSE (CS) with deep learning (DL) in order to reconstruct denoised high-quality images from undersampled MR ... ...

Abstract	Objectives: To evaluate the diagnostic performance of an automated reconstruction algorithm combining MR imaging acquired using compressed SENSE (CS) with deep learning (DL) in order to reconstruct denoised high-quality images from undersampled MR images in patients with shoulder pain. Methods: Prospectively, thirty-eight patients (14 women, mean age 40.0 ± 15.2 years) with shoulder pain underwent morphological MRI using a pseudo-random, density-weighted k-space scheme with an acceleration factor of 2.5 using CS only. An automated DL-based algorithm (CS DL) was used to create reconstructions of the same k-space data as used for CS reconstructions. Images were analyzed by two radiologists and assessed for pathologies, image quality, and visibility of anatomical landmarks using a 4-point Likert scale. Results: Overall agreement for the detection of pathologies between the CS DL reconstructions and CS images was substantial to almost perfect (κ 0.95 (95% confidence interval 0.82-1.00)). Image quality and the visibility of the rotator cuff, articular cartilage, and axillary recess were overall rated significantly higher for CS DL images compared to CS (p < 0.03). Contrast-to-noise ratios were significantly higher for cartilage/fluid (CS DL 198 ± 24.3, CS 130 ± 32.2, p = 0.02) and ligament/fluid (CS DL 184 ± 17.3, CS 141 ± 23.5, p = 0.03) and SNR values were significantly higher for ligaments and muscle of the CS DL reconstructions (p < 0.04). Conclusion: Evaluation of shoulder pathologies was feasible using a DL-based algorithm for MRI reconstruction and denoising. In clinical routine, CS DL may be beneficial in particular for reducing image noise and may be useful for the detection and better discrimination of discrete pathologies. Assessment of shoulder pathologies was feasible with improved image quality as well as higher SNR using a compressed sensing deep learning-based framework for image reconstructions and denoising. Key points: • Automated deep learning-based reconstructions showed a significant increase in signal-to-noise ratio and contrast-to-noise ratio (p < 0.04) with only a slight increase of reconstruction time of 40 s compared to CS. • All pathologies were accurately detected with no loss of diagnostic information or prolongation of the scan time. • Significant improvements of the image quality as well as the visibility of the rotator cuff, articular cartilage, and axillary recess were detected.
MeSH term(s)	Humans ; Female ; Young Adult ; Adult ; Middle Aged ; Shoulder Pain/diagnostic imaging ; Shoulder/diagnostic imaging ; Deep Learning ; Magnetic Resonance Imaging/methods ; Image Enhancement/methods ; Signal-To-Noise Ratio ; Cartilage, Articular ; Image Processing, Computer-Assisted/methods
Language	English
Publishing date	2023-02-18
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1085366-2
ISSN	1432-1084 ; 0938-7994 ; 1613-3749
ISSN (online)	1432-1084
ISSN	0938-7994 ; 1613-3749
DOI	10.1007/s00330-023-09472-9
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Article ; Online: Evaluation of 3D MRI for early detection of bone edema associated with apical periodontitis.

Feuerriegel, Georg C / Burian, Egon / Sollmann, Nico / Leonhardt, Yannik / Burian, Gintare / Griesbauer, Magdalena / Bumm, Caspar / Makowski, Marcus R / Probst, Monika / Probst, Florian A / Karampinos, Dimitrios C / Folwaczny, Matthias

Clinical oral investigations

2023 Volume 27, Issue 9, Page(s) 5403–5412

Abstract: Objectives: To detect and evaluate early signs of apical periodontitis using MRI based on a 3D short-tau-inversion-recovery (STIR) sequence compared to conventional panoramic radiography (OPT) and periapical radiographs in patients with apical ... ...

Abstract	Objectives: To detect and evaluate early signs of apical periodontitis using MRI based on a 3D short-tau-inversion-recovery (STIR) sequence compared to conventional panoramic radiography (OPT) and periapical radiographs in patients with apical periodontitis. Materials and methods: Patients with clinical evidence of periodontal disease were enrolled prospectively and received OPT as well as MRI of the viscerocranium including a 3D-STIR sequence. The MRI sequences were assessed for the occurrence and extent of bone changes associated with apical periodontitis including bone edema, periradicular cysts, and dental granulomas. OPTs and intraoral periapical radiographs, if available, were assessed for corresponding periapical radiolucencies using the periapical index (PAI). Results: In total, 232 teeth of 37 patients (mean age 62±13.9 years, 18 women) were assessed. In 69 cases reactive bone edema was detected on MRI with corresponding radiolucency according to OPT. In 105 cases edema was detected without corresponding radiolucency on OPT. The overall extent of edema measured on MRI was significantly larger compared to the radiolucency on OPT (mean: STIR 2.4±1.4 mm, dental radiograph 1.3±1.2 mm, OPT 0.8±1.1 mm, P=0.01). The overall PAI score was significantly higher on MRI compared to OPT (mean PAI: STIR 1.9±0.7, dental radiograph 1.3±0.5, OPT 1.2±0.7, P=0.02). Conclusion: Early detection and assessment of bone changes of apical periodontitis using MRI was feasible while the extent of bone edema measured on MRI exceeded the radiolucencies measured on OPT. Clinical relevance: In clinical routine, dental MRI might be useful for early detection and assessment of apical periodontitis before irreversible bone loss is detected on conventional panoramic and intraoral periapical radiographs.
MeSH term(s)	Humans ; Female ; Middle Aged ; Aged ; Root Canal Therapy ; Periapical Periodontitis/complications ; Radiography ; Magnetic Resonance Imaging ; Tooth, Nonvital/diagnostic imaging
Language	English
Publishing date	2023-07-18
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1364490-7
ISSN	1436-3771 ; 1432-6981
ISSN (online)	1436-3771
ISSN	1432-6981
DOI	10.1007/s00784-023-05159-z
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Article ; Online: Deep-learning-based image quality enhancement of CT-like MR imaging in patients with suspected traumatic shoulder injury.

Feuerriegel, Georg C / Weiss, Kilian / Tu Van, Anh / Leonhardt, Yannik / Neumann, Jan / Gassert, Florian T / Haas, Yannick / Schwarz, Markus / Makowski, Marcus R / Woertler, Klaus / Karampinos, Dimitrios C / Gersing, Alexandra S

European journal of radiology

2023 Volume 170, Page(s) 111246

Abstract: Purpose: To evaluate the diagnostic performance of CT-like MR images reconstructed with an algorithm combining compressed sense (CS) with deep learning (DL) in patients with suspected osseous shoulder injury compared to conventional CS-reconstructed ... ...

Abstract	Purpose: To evaluate the diagnostic performance of CT-like MR images reconstructed with an algorithm combining compressed sense (CS) with deep learning (DL) in patients with suspected osseous shoulder injury compared to conventional CS-reconstructed images. Methods: Thirty-two patients (12 women, mean age 46 ± 14.9 years) with suspected traumatic shoulder injury were prospectively enrolled into the study. All patients received MR imaging of the shoulder, including a CT-like 3D T1-weighted gradient-echo (T1 GRE) sequence and in case of suspected fracture a conventional CT. An automated DL-based algorithm, combining CS and DL (CS DL) was used to reconstruct images of the same k-space data as used for CS reconstructions. Two musculoskeletal radiologists assessed the images for osseous pathologies, image quality and visibility of anatomical landmarks using a 5-point Likert scale. Moreover, signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) were calculated. Results: Compared to CT, all acute fractures (n = 23) and osseous pathologies were detected accurately on the CS only and CS DL images with almost perfect agreement between the CS DL and CS only images (κ 0.95 (95 %confidence interval 0.82-1.00). Image quality as well as the visibility of the fracture lines, bone fragments and glenoid borders were overall rated significantly higher for the CS DL reconstructions than the CS only images (CS DL range 3.7-4.9 and CS only range 3.2-3.8, P = 0.01-0.04). Significantly higher SNR and CNR values were observed for the CS DL reconstructions (P = 0.02-0.03). Conclusion: Evaluation of traumatic shoulder pathologies is feasible using a DL-based algorithm for reconstruction of high-resolution CT-like MR imaging.
MeSH term(s)	Humans ; Female ; Adult ; Middle Aged ; Shoulder ; Deep Learning ; Magnetic Resonance Imaging/methods ; Image Enhancement/methods ; Shoulder Injuries/diagnostic imaging ; Fractures, Bone/diagnostic imaging ; Tomography, X-Ray Computed/methods ; Imaging, Three-Dimensional/methods
Language	English
Publishing date	2023-12-02
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	138815-0
ISSN	1872-7727 ; 0720-048X
ISSN (online)	1872-7727
ISSN	0720-048X
DOI	10.1016/j.ejrad.2023.111246
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Article ; Online: Sparse-sampling computed tomography for detection of endoleak after endovascular aortic repair (EVAR).

Meurer, Felix / Kopp, Felix / Renz, Martin / Harder, Felix N / Leonhardt, Yannik / Bippus, Rolf / Noël, Peter B / Makowski, Markus R / Sauter, Andreas P

European journal of radiology

2021 Volume 142, Page(s) 109843

Abstract: Objectives: To evaluate sparse sampling computed tomography (SpSCT) for detection of endoleak after endovascular aortic repair (EVAR) at different dose levels in terms of subjective image criteria and diagnostic accuracy.: Methods: Twenty clinically ... ...

Abstract	Objectives: To evaluate sparse sampling computed tomography (SpSCT) for detection of endoleak after endovascular aortic repair (EVAR) at different dose levels in terms of subjective image criteria and diagnostic accuracy. Methods: Twenty clinically indicated computed tomography aortic angiography (CTA) scans were used to obtain simulated low-dose scans with 100%, 50%, 25%, 12.5% and 6.25% of the applicated clinical dose, resulting in five dose levels (DL). From full sampling (FS) data sets, every second (2-SpSCT) or fourth (4-SpSCT) projection was used to generate simulated sparse sampling scans. All examinations were evaluated by four blinded radiologists regarding subjective image criteria and diagnostic performance. Results: Sensitivity was higher than 93% in 4-SpSCT at the 25% DL which is the same as with FS at full dose (100% DL). High accuracies and relative high AUC-values were obtained for 2- and 4-SpSCT down to the 12.5% DL, while for FS similar values were shown down to 25% DL only. Subjective image quality was significantly higher for 4-SpSCT compared to FS at each dose level. More than 90% of all cases were rated with a high or medium confidence for FS and 2-SpSCT at the 50% DL and for 4-SpSCT at the 25% DL. At DL 25% and 12.5%, more cases showed a high confidence using 2- and 4-SpSCT compared with FS. Conclusions: Via SpSCT, a dose reduction down to a 25% dose level (mean effective dose of 1.49 mSv in the current study) for CTA is possible while maintaining high image quality and full diagnostic confidence.
MeSH term(s)	Aortic Aneurysm, Abdominal/surgery ; Aortography ; Blood Vessel Prosthesis Implantation/adverse effects ; Computed Tomography Angiography ; Endoleak/diagnostic imaging ; Endovascular Procedures/adverse effects ; Humans ; Retrospective Studies ; Tomography, X-Ray Computed ; Treatment Outcome
Language	English
Publishing date	2021-07-09
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	138815-0
ISSN	1872-7727 ; 0720-048X
ISSN (online)	1872-7727
ISSN	0720-048X
DOI	10.1016/j.ejrad.2021.109843
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Article ; Online: Functional characterization of the Woronin body protein WscA of the pathogenic mold Aspergillus fumigatus.

Leonhardt, Yannik / Beck, Julia / Ebel, Frank

International journal of medical microbiology : IJMM

2016 Volume 306, Issue 3, Page(s) 165–173

Abstract: Woronin bodies are fungal-specific organelles that seal damaged hyphal compartments and thereby contribute to the stress resistance and virulence of filamentous fungi. In this study, we have characterized the Aspergillus fumigatus Woronin body protein ... ...

Abstract	Woronin bodies are fungal-specific organelles that seal damaged hyphal compartments and thereby contribute to the stress resistance and virulence of filamentous fungi. In this study, we have characterized the Aspergillus fumigatus Woronin body protein WscA. WscA is homologous to Neurospora crassa WSC, a protein that was shown to be important for biogenesis, segregation and positioning of Woronin bodies. WscA and WSC both belong to the Mpv17/PMP22 family of peroxisomal membrane proteins. An A. fumigatus ΔwscA mutant is unable to form Woronin bodies, and HexA, the protein that forms the crystal-like core of Woronin bodies, accumulates in large peroxisomes instead. The ΔwscA mutant showed no defect in segregation of HexA containing organelles, as has been reported for the corresponding N. crassa mutant. In the peroxisomes of the A. fumigatus mutant, HexA assembles into compact, donut-shaped structures. Experiments with GFP fusion proteins revealed that WscA function is highly sensitive to these modifications, in particular to an N-terminal fusion of GFP. In N. crassa, WSC was shown to be essentially required for Woronin body positioning, but the respective domain is not conserved in most other Pezizomycotina, including A. fumigatus. We have recently found evidence that HexA may have a direct role in WB positioning, since a HexA-GFP fusion protein, lacking a functional PTS1 motif, is efficiently recruited to the septal pore. In the current study we show that this targeting of HexA-GFP is independent of WscA.
MeSH term(s)	Aspergillus fumigatus/genetics ; Aspergillus fumigatus/metabolism ; Fungal Proteins/genetics ; Fungal Proteins/metabolism ; Hyphae/metabolism ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Neurospora crassa/genetics ; Neurospora crassa/metabolism ; Peroxisomes/metabolism
Chemical Substances	Fungal Proteins ; Membrane Proteins ; Woronin body major protein, Neurospora crassa
Language	English
Publishing date	2016-05
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2006518-8
ISSN	1618-0607 ; 1438-4221
ISSN (online)	1618-0607
ISSN	1438-4221
DOI	10.1016/j.ijmm.2016.03.008
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Article ; Online: Lah is a transmembrane protein and requires Spa10 for stable positioning of Woronin bodies at the septal pore of Aspergillus fumigatus.

Leonhardt, Yannik / Kakoschke, Sara Carina / Wagener, Johannes / Ebel, Frank

Scientific reports

2017 Volume 7, Page(s) 44179

Abstract: Woronin bodies are specialized, fungal-specific organelles that enable an immediate closure of septal pores after injury to protect hyphae from excessive cytoplasmic bleeding. In most Ascomycetes, Woronin bodies are tethered at the septal pore by so- ... ...

Abstract	Woronin bodies are specialized, fungal-specific organelles that enable an immediate closure of septal pores after injury to protect hyphae from excessive cytoplasmic bleeding. In most Ascomycetes, Woronin bodies are tethered at the septal pore by so-called Lah proteins. Using the pathogenic mold Aspergillus fumigatus as a model organism, we show that the C-terminal 288 amino acids of Lah (LahC
MeSH term(s)	Aspergillus fumigatus/genetics ; Aspergillus fumigatus/metabolism ; Aspergillus fumigatus/ultrastructure ; Cell Membrane/genetics ; Cell Membrane/metabolism ; Cell Membrane/ultrastructure ; Fungal Proteins/genetics ; Fungal Proteins/metabolism ; Gene Deletion ; Hyphae/genetics ; Hyphae/metabolism ; Hyphae/ultrastructure ; Membrane Proteins/genetics ; Membrane Proteins/metabolism
Chemical Substances	Fungal Proteins ; Membrane Proteins
Language	English
Publishing date	2017-03-10
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/srep44179
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: X-ray dark-field chest radiography: a reader study to evaluate the diagnostic quality of attenuation chest X-rays from a dual-contrast scanning prototype.

Kattau, Margarete / Willer, Konstantin / Noichl, Wolfgang / Urban, Theresa / Frank, Manuela / De Marco, Fabio / Schick, Rafael / Koehler, Thomas / Maack, Hanns-Ingo / Renger, Bernhard / Renz, Martin / Sauter, Andreas / Leonhardt, Yannik / Fingerle, Alexander / Makowski, Marcus / Pfeiffer, Daniela / Pfeiffer, Franz

European radiology

2023 Volume 33, Issue 8, Page(s) 5549–5556

Abstract: Objectives: To compare the visibility of anatomical structures and overall quality of the attenuation images obtained with a dark-field X-ray radiography prototype with those from a commercial radiography system.: Methods: Each of the 65 patients ... ...

Abstract	Objectives: To compare the visibility of anatomical structures and overall quality of the attenuation images obtained with a dark-field X-ray radiography prototype with those from a commercial radiography system. Methods: Each of the 65 patients recruited for this study obtained a thorax radiograph at the prototype and a reference radiograph at the commercial system. Five radiologists independently assessed the visibility of anatomical structures, the level of motion artifacts, and the overall image quality of all attenuation images on a five-point scale, with 5 points being the highest rating. The average scores were compared between the two image types. The differences were evaluated using an area under the curve (AUC) based z-test with a significance level of p ≤ 0.05. To assess the variability among the images, the distributions of the average scores per image were compared between the systems. Results: The overall image quality was rated high for both devices, 4.2 for the prototype and 4.6 for the commercial system. The rating scores varied only slightly between both image types, especially for structures relevant to lung assessment, where the images from the commercial system were graded slightly higher. The differences were statistically significant for all criteria except for the bronchial structures, the cardiophrenic recess, and the carina. Conclusions: The attenuation images acquired with the prototype were assigned a high diagnostic quality despite a lower resolution and the presence of motion artifacts. Thus, the attenuation-based radiographs from the prototype can be used for diagnosis, eliminating the need for an additional conventional radiograph. Key points: • Despite a low tube voltage (70 kVp) and comparably long acquisition time, the attenuation images from the dark-field chest radiography system achieved diagnostic quality for lung assessment. • Commercial chest radiographs obtained a mean rating score regarding their diagnostic quality of 4.6 out of 5, and the grating-based images had a slightly lower mean rating score of 4.2 out of 5. • The difference in rating scores for anatomical structures relevant to lung assessment is below 5%.
MeSH term(s)	Humans ; X-Rays ; Radiography, Thoracic/methods ; Radiography ; Thorax ; Lung/diagnostic imaging
Language	English
Publishing date	2023-02-18
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1085366-2
ISSN	1432-1084 ; 0938-7994 ; 1613-3749
ISSN (online)	1432-1084
ISSN	0938-7994 ; 1613-3749
DOI	10.1007/s00330-023-09477-4
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Assessment of glenoid bone loss and other osseous shoulder pathologies comparing MR-based CT-like images with conventional CT.

Feuerriegel, Georg C / Kronthaler, Sophia / Weiss, Kilian / Haller, Bernhard / Leonhardt, Yannik / Neumann, Jan / Pfeiffer, Daniela / Hesse, Nina / Erber, Bernd / Schwaiger, Benedikt J / Makowski, Marcus R / Woertler, Klaus / Karampinos, Dimitrios C / Wurm, Markus / Gersing, Alexandra S

European radiology

2023 Volume 33, Issue 12, Page(s) 8617–8626

Abstract: Objectives: To evaluate and compare the diagnostic performance of CT-like images based on a 3D T1-weighted spoiled gradient-echo sequence (T1 GRE), an ultra-short echo time sequence (UTE), and a 3D T1-weighted spoiled multi-echo gradient-echo sequence ( ... ...

Abstract	Objectives: To evaluate and compare the diagnostic performance of CT-like images based on a 3D T1-weighted spoiled gradient-echo sequence (T1 GRE), an ultra-short echo time sequence (UTE), and a 3D T1-weighted spoiled multi-echo gradient-echo sequence (FRACTURE) with conventional CT in patients with suspected osseous shoulder pathologies. Materials and methods: Patients with suspected traumatic dislocation of the shoulder (n = 46, mean age 40 ± 14.5 years, 19 women) were prospectively recruited and received 3-T MR imaging including 3D T1 GRE, UTE, and 3D FRACTURE sequences. CT was performed in patients with acute fractures and served as standard of reference (n = 25). Agreement of morphological features between the modalities was analyzed including the glenoid bone loss, Hill-Sachs interval, glenoid track, and the anterior straight-line length. Agreement between the modalities was assessed using Bland-Altman plots, Student's t-test, and Pearson's correlation coefficient. Inter- and intrareader assessment was evaluated with weighted Cohen's κ and intraclass correlation coefficient. Results: All osseous pathologies were detected accurately on all three CT-like sequences (n = 25, κ = 1.00). No significant difference in the percentage of glenoid bone loss was found between CT (mean ± standard deviation, 20.3% ± 8.0) and CT-like MR images (FRACTURE 20.6% ± 7.9, T1 GRE 20.4% ± 7.6, UTE 20.3% ± 7.7, p > 0.05). When comparing the different measurements on CT-like images, measurements performed using the UTE images correlated best with CT. Conclusion: Assessment of bony Bankart lesions and other osseous pathologies was feasible and accurate using CT-like images based on 3-T MRI compared with conventional CT. Compared to the T1 GRE and FRACTURE sequence, the UTE measurements correlated best with CT. Clinical relevance statement: In an acute trauma setting, CT-like images based on a T1 GRE, UTE, or FRACTURE sequence might be a useful alternative to conventional CT scan sparing associated costs as well as radiation exposure. Key points: • No significant differences were found for the assessment of the glenoid bone loss when comparing measurements of CT-like MR images with measurements of conventional CT images. • Compared to the T1 GRE and FRACTURE sequence, the UTE measurements correlated best with CT whereas the FRACTURE sequence appeared to be the most robust regarding motion artifacts. • The T1 GRE sequence had the highest resolution with high bone contrast and detailed delineation of even small fractures but was more susceptible to motion artifacts.
MeSH term(s)	Humans ; Female ; Adult ; Middle Aged ; Shoulder ; Tomography, X-Ray Computed/methods ; Magnetic Resonance Imaging/methods ; Shoulder Joint/diagnostic imaging ; Fractures, Bone/diagnostic imaging ; Bone Diseases, Metabolic ; Imaging, Three-Dimensional/methods
Language	English
Publishing date	2023-07-15
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1085366-2
ISSN	1432-1084 ; 0938-7994 ; 1613-3749
ISSN (online)	1432-1084
ISSN	0938-7994 ; 1613-3749
DOI	10.1007/s00330-023-09939-9
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Article ; Online: Imaging of traumatic mandibular fractures in young adults using CT-like MRI: a feasibility study.

Feuerriegel, Georg C / Ritschl, Lucas M / Sollmann, Nico / Palla, Benjamin / Leonhardt, Yannik / Maier, Lisa / Gassert, Florian T / Karampinos, Dimitrios C / Makowski, Marcus R / Zimmer, Claus / Wolff, Klaus-Dietrich / Probst, Monika / Fichter, Andreas M / Burian, Egon

Clinical oral investigations

2022 Volume 27, Issue 3, Page(s) 1227–1233

Abstract: Objectives: To assess and compare the diagnostic performance of CT-like images based on a three- dimensional (3D) T1-weighted spoiled gradient-echo sequence (3D T1 GRE) with CT in patients with acute traumatic fractures of the mandible.: Materials and ...

Abstract	Objectives: To assess and compare the diagnostic performance of CT-like images based on a three- dimensional (3D) T1-weighted spoiled gradient-echo sequence (3D T1 GRE) with CT in patients with acute traumatic fractures of the mandible. Materials and methods: Subjects with acute mandibular fractures diagnosed on conventional CT were prospectively recruited and received an additional 3 T MRI with a CT-like 3D T1 GRE sequence. The images were assessed by two radiologists with regard to fracture localization, degree of dislocation, and number of fragments. Bone to soft tissue contrast, diagnostic confidence, artifacts, and overall image quality were rated using a five-point Likert-scale. Agreement of measurements was assessed using an independent t-test. Results: Fourteen subjects and 22 fracture sites were included (26 ± 3.9 years; 4 females, 10 males). All traumatic fractures were accurately detected on CT-like MRI (n = 22, κ 1.00 (95% CI 1.00-1.00)). There was no statistically significant difference in the assessment of the fracture dislocation (axial mean difference (MD) 0.06 mm, p = 0.93, coronal MD, 0.08 mm, p = 0.89 and sagittal MD, 0.04 mm, p = 0.96). The agreement for the fracture classification as well as the inter- and intra-rater agreement was excellent (range κ 0.92-0.98 (95% CI 0.96-0.99)). Conclusion: Assessment of mandibular fractures was feasible and accurate using CT-like MRI based on a 3D T1 GRE sequence and is comparable to conventional CT. Clinical relevance: For the assessment of acute mandibular fractures, CT-like MRI might become a useful alternative to CT in order to reduce radiation exposure particularly in young patients.
MeSH term(s)	Male ; Female ; Humans ; Young Adult ; Mandibular Fractures ; Feasibility Studies ; Imaging, Three-Dimensional/methods ; Magnetic Resonance Imaging/methods ; Tomography, X-Ray Computed
Language	English
Publishing date	2022-10-08
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1364490-7
ISSN	1436-3771 ; 1432-6981
ISSN (online)	1436-3771
ISSN	1432-6981
DOI	10.1007/s00784-022-04736-y
Database	MEDical Literature Analysis and Retrieval System OnLINE

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