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  1. Article ; Online: Clinical Significance of Circulating Tumor Cells in Gastrointestinal Carcinomas

    Leonie Konczalla / Anna Wöstemeier / Marius Kemper / Karl-Frederik Karstens / Jakob Izbicki / Matthias Reeh

    Diagnostics, Vol 10, Iss 192, p

    2020  Volume 192

    Abstract: The idea of a liquid biopsy to screen, surveil and treat cancer patients is an intensively discussed and highly awaited tool in the field of oncology. Despite intensive research in this field, the clinical application has not been implemented yet and ... ...

    Abstract The idea of a liquid biopsy to screen, surveil and treat cancer patients is an intensively discussed and highly awaited tool in the field of oncology. Despite intensive research in this field, the clinical application has not been implemented yet and further research has to be conducted. However, one component of the liquid biopsy is circulating tumor cells (CTCs) whose potential for clinical application is evaluated in the following. CTCs can shed from primary tumors to the peripheral blood at any time point during the progress of a malignant disease. Following, one single CTC can be the origin for distant metastasis at later cancer stage. Thus, CTCs have great potential to either be used in cancer diagnostics and patient stratification or to function as a target for new therapeutic approaches to stop tumor dissemination and metastasis at the very early beginning. Due to the biological fundamental role of CTCs in tumor progression, here, we provide an overview of CTCs in gastrointestinal cancers and their potential use in the clinical setting. In particular, we discuss the usage of CTC for screening and stratifying patients’ risk. Moreover, we will discuss the potential role of CTCs for treatment specification and treatment monitoring.
    Keywords liquid biopsy ; cancer diagnosis ; solid cancer/tumor ; circulating tumor cells ; free DNA ; Medicine (General) ; R5-920
    Subject code 610
    Language English
    Publishing date 2020-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Multicytokine-producing CD4+ T cells characterize the livers of patients with NASH

    Anna Woestemeier / Pasquale Scognamiglio / Yu Zhao / Jonas Wagner / Franziska Muscate / Christian Casar / Francesco Siracusa / Filippo Cortesi / Theodora Agalioti / Simone Müller / Adrian Sagebiel / Leonie Konczalla / Ramez Wahib / Karl-Frederick Karstens / Anastasios D. Giannou / Anna Duprée / Stefan Wolter / Milagros N. Wong / Anne K. Mühlig /
    Agata A. Bielecka / Vikas Bansal / Tianran Zhang / Oliver Mann / Victor G. Puelles / Tobias B. Huber / Ansgar W. Lohse / Jakob R. Izbicki / Noah W. Palm / Stefan Bonn / Samuel Huber / Nicola Gagliani

    JCI Insight, Vol 8, Iss

    2023  Volume 1

    Abstract: A role of CD4+ T cells during the progression from nonalcoholic fatty liver disease (NAFLD) to nonalcoholic steatohepatitis (NASH) has been suggested, but which polarization state of these cells characterizes this progression and the development of ... ...

    Abstract A role of CD4+ T cells during the progression from nonalcoholic fatty liver disease (NAFLD) to nonalcoholic steatohepatitis (NASH) has been suggested, but which polarization state of these cells characterizes this progression and the development of fibrosis remain unclear. In addition, a gut-liver axis has been suggested to play a role in NASH, but the role of CD4+ T cells in this axis has just begun to be investigated. Combining single-cell RNA sequencing and multiple-parameter flow cytometry, we provide the first cell atlas to our knowledge focused on liver-infiltrating CD4+ T cells in patients with NAFLD and NASH, showing that NASH is characterized by a population of multicytokine-producing CD4+ T cells. Among these cells, only those with a Th17 polarization state were enriched in patients with advanced fibrosis. In parallel, we observed that Bacteroides appeared to be enriched in the intestine of NASH patients and to correlate with the frequency of multicytokine-producing CD4+ T cells. In short, we deliver a CD4+ T cell atlas of NAFLD and NASH, providing the rationale to target CD4+ T cells with a Th17 polarization state to block fibrosis development. Finally, our data offer an early indication to test whether multicytokine-producing CD4+ T cells are part of the gut-liver axis characterizing NASH.
    Keywords Hepatology ; Immunology ; Medicine ; R
    Subject code 570
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher American Society for Clinical investigation
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Publisher Correction

    Laura Garcia Perez / Jan Kempski / Heather M. McGee / Penelope Pelzcar / Theodora Agalioti / Anastasios Giannou / Leonie Konczalla / Leonie Brockmann / Ramez Wahib / Hao Xu / Maria Carolina Amezcua Vesely / Shiwa Soukou / Babett Steglich / Tanja Bedke / Carolin Manthey / Oliver Seiz / Björn-Philipp Diercks / Stylianos Gnafakis / Andreas H. Guse /
    Daniel Perez / Jakob R. Izbicki / Nicola Gagliani / Richard A. Flavell / Samuel Huber

    Nature Communications, Vol 11, Iss 1, Pp 1-

    TGF-β signaling in Th17 cells promotes IL-22 production and colitis-associated colon cancer

    2020  Volume 2

    Abstract: An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    Abstract An amendment to this paper has been published and can be accessed via a link at the top of the paper.
    Keywords Science ; Q
    Language English
    Publishing date 2020-11-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: TGF-β signaling in Th17 cells promotes IL-22 production and colitis-associated colon cancer

    Laura Garcia Perez / Jan Kempski / Heather M. McGee / Penelope Pelzcar / Theodora Agalioti / Anastasios Giannou / Leonie Konczalla / Leonie Brockmann / Ramez Wahib / Hao Xu / Maria Carolina Amezcua Vesely / Shiwa Soukou / Babett Steglich / Tanja Bedke / Carolin Manthey / Oliver Seiz / Björn-Philipp Diercks / Stylianos Gnafakis / Andreas H. Guse /
    Daniel Perez / Jakob R. Izbicki / Nicola Gagliani / Richard A. Flavell / Samuel Huber

    Nature Communications, Vol 11, Iss 1, Pp 1-

    2020  Volume 14

    Abstract: Poly-functional helper T cells can have a stronger effect than mono-functional T cells, but whether the response is qualitatively different is not clear. Here the authors show that a population of IL-17+IL-22+, but not single IL-22+, CD4+ T cells are ... ...

    Abstract Poly-functional helper T cells can have a stronger effect than mono-functional T cells, but whether the response is qualitatively different is not clear. Here the authors show that a population of IL-17+IL-22+, but not single IL-22+, CD4+ T cells are induced by TGF-β, enriched in patients with colorectal cancer (CRC) and drive CRC progression in mice.
    Keywords Science ; Q
    Language English
    Publishing date 2020-05-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  5. Article ; Online: Publisher Correction

    Laura Garcia Perez / Jan Kempski / Heather M. McGee / Penelope Pelzcar / Theodora Agalioti / Anastasios Giannou / Leonie Konczalla / Leonie Brockmann / Ramez Wahib / Hao Xu / Maria Carolina Amezcua Vesely / Shiwa Soukou / Babett Steglich / Tanja Bedke / Carolin Manthey / Oliver Seiz / Björn-Philipp Diercks / Stylianos Gnafakis / Andreas H. Guse /
    Daniel Perez / Jakob R. Izbicki / Nicola Gagliani / Richard A. Flavell / Samuel Huber

    Nature Communications, Vol 11, Iss 1, Pp 1-

    TGF-β signaling in Th17 cells promotes IL-22 production and colitis-associated colon cancer

    2020  Volume 2

    Abstract: An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    Abstract An amendment to this paper has been published and can be accessed via a link at the top of the paper.
    Keywords Science ; Q
    Language English
    Publishing date 2020-11-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  6. Article ; Online: TGF-β signaling in Th17 cells promotes IL-22 production and colitis-associated colon cancer

    Laura Garcia Perez / Jan Kempski / Heather M. McGee / Penelope Pelzcar / Theodora Agalioti / Anastasios Giannou / Leonie Konczalla / Leonie Brockmann / Ramez Wahib / Hao Xu / Maria Carolina Amezcua Vesely / Shiwa Soukou / Babett Steglich / Tanja Bedke / Carolin Manthey / Oliver Seiz / Björn-Philipp Diercks / Stylianos Gnafakis / Andreas H. Guse /
    Daniel Perez / Jakob R. Izbicki / Nicola Gagliani / Richard A. Flavell / Samuel Huber

    Nature Communications, Vol 11, Iss 1, Pp 1-

    2020  Volume 14

    Abstract: Poly-functional helper T cells can have a stronger effect than mono-functional T cells, but whether the response is qualitatively different is not clear. Here the authors show that a population of IL-17+IL-22+, but not single IL-22+, CD4+ T cells are ... ...

    Abstract Poly-functional helper T cells can have a stronger effect than mono-functional T cells, but whether the response is qualitatively different is not clear. Here the authors show that a population of IL-17+IL-22+, but not single IL-22+, CD4+ T cells are induced by TGF-β, enriched in patients with colorectal cancer (CRC) and drive CRC progression in mice.
    Keywords Science ; Q
    Language English
    Publishing date 2020-05-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

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