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  1. AU="Leonor C Guedes"
  2. AU="Otón, Teresa"
  3. AU=Gurrapu Sreeharsha
  4. AU="Senbet, Lemma W"
  5. AU="Chi, Ching-Chi" AU="Chi, Ching-Chi"
  6. AU="Jiang, Man-Jing"
  7. AU="Ren, Jia"
  8. AU="Sumpio, B. E."
  9. AU="Schneider, Lynda"

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  1. Artikel ; Online: Correction

    Raquel Pinho / Leonor C Guedes / Lilach Soreq / Patrícia P Lobo / Tiago Mestre / Miguel Coelho / Mário M Rosa / Nilza Gonçalves / Pauline Wales / Tiago Mendes / Ellen Gerhardt / Christiane Fahlbusch / Vincenzo Bonifati / Michael Bonin / Gabriel Miltenberger-Miltényi / Fran Borovecki / Hermona Soreq / Joaquim J Ferreira / Tiago F Outeiro

    PLoS ONE, Vol 12, Iss 12, p e

    Gene Expression Differences in Peripheral Blood of Parkinson's Disease Patients with Distinct Progression Profiles.

    2017  Band 0190552

    Abstract: This corrects the article DOI:10.1371/journal.pone.0157852.]. ...

    Abstract [This corrects the article DOI:10.1371/journal.pone.0157852.].
    Schlagwörter Medicine ; R ; Science ; Q
    Sprache Englisch
    Verlag Public Library of Science (PLoS)
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: Gene Expression Differences in Peripheral Blood of Parkinson's Disease Patients with Distinct Progression Profiles.

    Raquel Pinho / Leonor C Guedes / Lilach Soreq / Patrícia P Lobo / Tiago Mestre / Miguel Coelho / Mário M Rosa / Nilza Gonçalves / Pauline Wales / Tiago Mendes / Ellen Gerhardt / Christiane Fahlbusch / Vincenzo Bonifati / Michael Bonin / Gabriel Miltenberger-Miltényi / Fran Borovecki / Hermona Soreq / Joaquim J Ferreira / Tiago F Outeiro

    PLoS ONE, Vol 11, Iss 6, p e

    2016  Band 0157852

    Abstract: The prognosis of neurodegenerative disorders is clinically challenging due to the inexistence of established biomarkers for predicting disease progression. Here, we performed an exploratory cross-sectional, case-control study aimed at determining whether ...

    Abstract The prognosis of neurodegenerative disorders is clinically challenging due to the inexistence of established biomarkers for predicting disease progression. Here, we performed an exploratory cross-sectional, case-control study aimed at determining whether gene expression differences in peripheral blood may be used as a signature of Parkinson's disease (PD) progression, thereby shedding light into potential molecular mechanisms underlying disease development. We compared transcriptional profiles in the blood from 34 PD patients who developed postural instability within ten years with those of 33 patients who did not develop postural instability within this time frame. Our study identified >200 differentially expressed genes between the two groups. The expression of several of the genes identified was previously found deregulated in animal models of PD and in PD patients. Relevant genes were selected for validation by real-time PCR in a subset of patients. The genes validated were linked to nucleic acid metabolism, mitochondria, immune response and intracellular-transport. Interestingly, we also found deregulation of these genes in a dopaminergic cell model of PD, a simple paradigm that can now be used to further dissect the role of these molecular players on dopaminergic cell loss. Altogether, our study provides preliminary evidence that expression changes in specific groups of genes and pathways, detected in peripheral blood samples, may be correlated with differential PD progression. Our exploratory study suggests that peripheral gene expression profiling may prove valuable for assisting in prediction of PD prognosis, and identifies novel culprits possibly involved in dopaminergic cell death. Given the exploratory nature of our study, further investigations using independent, well-characterized cohorts will be essential in order to validate our candidates as predictors of PD prognosis and to definitively confirm the value of gene expression analysis in aiding patient stratification and therapeutic ...
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2016-01-01T00:00:00Z
    Verlag Public Library of Science (PLoS)
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: Convergence of miRNA expression profiling, α-synuclein interacton and GWAS in Parkinson's disease.

    Madalena Martins / Alexandra Rosa / Leonor C Guedes / Benedita V Fonseca / Kristina Gotovac / Sara Violante / Tiago Mestre / Miguel Coelho / Mário M Rosa / Eden R Martin / Jeffery M Vance / Tiago F Outeiro / Liyong Wang / Fran Borovecki / Joaquim J Ferreira / Sofia A Oliveira

    PLoS ONE, Vol 6, Iss 10, p e

    2011  Band 25443

    Abstract: miRNAs were recently implicated in the pathogenesis of numerous diseases, including neurological disorders such as Parkinson's disease (PD). miRNAs are abundant in the nervous system, essential for efficient brain function and play important roles in ... ...

    Abstract miRNAs were recently implicated in the pathogenesis of numerous diseases, including neurological disorders such as Parkinson's disease (PD). miRNAs are abundant in the nervous system, essential for efficient brain function and play important roles in neuronal patterning and cell specification. To further investigate their involvement in the etiology of PD, we conducted miRNA expression profiling in peripheral blood mononuclear cells (PBMCs) of 19 patients and 13 controls using microarrays. We found 18 miRNAs differentially expressed, and pathway analysis of 662 predicted target genes of 11 of these miRNAs revealed an over-representation in pathways previously linked to PD as well as novel pathways. To narrow down the genes for further investigations, we undertook a parallel approach using chromatin immunoprecipitation-sequencing (ChIP-seq) analysis to uncover genome-wide interactions of α-synuclein, a molecule with a central role in both monogenic and idiopathic PD. Convergence of ChIP-seq and miRNomics data highlighted the glycosphingolipid biosynthesis and the ubiquitin proteasome system as key players in PD. We then tested the association of target genes belonging to these pathways with PD risk, and identified nine SNPs in USP37 consistently associated with PD susceptibility in three genome-wide association studies (GWAS) datasets (0.46≤OR≤0.63) and highly significant in the meta-dataset (3.36×10⁻⁴
    Schlagwörter Medicine ; R ; Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2011-01-01T00:00:00Z
    Verlag Public Library of Science (PLoS)
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

    Volltext online

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    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

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