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Article ; Online: First report of Acinetobacter pittii acute community-acquired pneumonia in an immunocompetent patient in France following a heat wave.

Souhail, Bérénice / Danjean, Maxime / Mercier-Darty, Mélanie / Amaddeo, Giuliana / Sessa, Anna / Fihman, Vincent / Galy, Adrien / Woerther, Paul Louis / Lepeule, Raphaël

BMC infectious diseases

2024 Volume 24, Issue 1, Page(s) 35

Abstract: Background: In recent years, Acinetobacter baumannii-calcoaceticus complex (ABC) infections have attracted attention, mainly because of the impact of carbapenem-resistant isolates in hospital-acquired infections. However, acute community-acquired ABC ... ...

Abstract	Background: In recent years, Acinetobacter baumannii-calcoaceticus complex (ABC) infections have attracted attention, mainly because of the impact of carbapenem-resistant isolates in hospital-acquired infections. However, acute community-acquired ABC infections are not uncommon in warm and humid countries, where they are responsible for community-acquired infections with specific clinical features. To date, such infection has not been reported in France. Case presentation: We report the case of a 55-year-old non-immunocompromised patient living in France with no known risk factors for community-acquired ABC infections who presented pneumonia with bloodstream infection due to wild-type A. pittii. The outcome was favorable after 7 days of antibiotic treatment with cefepime. We confirmed bacterial identification with whole-genome sequencing, and we examined the A. pitii core-genome phylogeny for genomic clusters. Conclusions: This situation is uncommon in Europe and occurred after a heat wave in France with temperatures above 38 °C. Herein, we discuss the possibility that this pneumonia may be emerging in the current context of global warming.
MeSH term(s)	Humans ; Middle Aged ; Community-Acquired Infections/diagnosis ; Community-Acquired Infections/drug therapy ; Hot Temperature ; Acinetobacter/genetics ; Anti-Bacterial Agents/therapeutic use ; Acinetobacter Infections/diagnosis ; Acinetobacter Infections/drug therapy ; Acinetobacter Infections/microbiology ; Pneumonia/diagnosis ; Pneumonia/drug therapy ; France ; Acinetobacter baumannii ; Microbial Sensitivity Tests
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2024-01-02
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	2041550-3
ISSN	1471-2334 ; 1471-2334
ISSN (online)	1471-2334
ISSN	1471-2334
DOI	10.1186/s12879-023-08945-y
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Article ; Online: Overly broad-spectrum antibiotic treatment of wild-type

Ourghanlian, Clément / Fihman, Vincent / Morel, Antoine / Lafont, Charlotte / Galy, Adrien / Calimouttoupoulle, Eimma / Woerther, Paul-Louis / Lepeule, Raphaël

JAC-antimicrobial resistance

2022 Volume 4, Issue 5, Page(s) dlac099

Abstract: Objectives: EUCAST changed the definition of the 'intermediate' (I) category in 2019, now defined as 'susceptible, increased exposure'. This new definition could lead to an increased prescription of antibiotics still reported as 'S', compared with those ...

Abstract	Objectives: EUCAST changed the definition of the 'intermediate' (I) category in 2019, now defined as 'susceptible, increased exposure'. This new definition could lead to an increased prescription of antibiotics still reported as 'S', compared with those now reported as 'I'. The objective of this study was to evaluate the influence of this definition on the use of overly broad-spectrum antibiotics for the treatment of infections caused by WT Methods: A retrospective observational multicentre study was conducted, involving five hospitals. Two 15 month study periods were defined, before and after the implementation of the new definition. All patients with an infection caused by WT Results: Two hundred and ninety-one patients were included. No difference between groups was found, in terms of infection, microbiology or demographic characteristics. Two overly broad-spectrum antibiotic treatments by meropenem or ceftolozane/tazobactam were observed in Period 1 (1.2%), versus 13 in Period 2 (10.8%; Conclusions: This new definition can cause a negative impact on the use of overly broad-spectrum antibiotic treatment due to misunderstanding by clinicians. Its successful implementation requires adaptation of software for reporting antibiotic susceptibility, a sustained strong information campaign by microbiologists and support by an antimicrobial stewardship team.
Language	English
Publishing date	2022-10-17
Publishing country	England
Document type	Journal Article
ISSN	2632-1823
ISSN (online)	2632-1823
DOI	10.1093/jacamr/dlac099
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Article ; Online: Emergence of Resistance to Carbapenems Should Not Be Considered the Only Marker of Good Practices in Antibiotic Stewardship.

Woerther, Paul-Louis / Royer, Guilhem / Decousser, Jean-Winoc / Fihman, Vincent / Lepeule, Raphaël

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

2020 Volume 71, Issue 9, Page(s) 2538–2539

MeSH term(s)	Anti-Bacterial Agents/therapeutic use ; Antimicrobial Stewardship ; Carbapenems/pharmacology ; Carbapenems/therapeutic use ; Humans ; Piperacillin, Tazobactam Drug Combination ; Pyelonephritis/drug therapy ; beta-Lactamases/genetics
Chemical Substances	Anti-Bacterial Agents ; Carbapenems ; Piperacillin, Tazobactam Drug Combination (157044-21-8) ; beta-Lactamases (EC 3.5.2.6)
Language	English
Publishing date	2020-02-04
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	1099781-7
ISSN	1537-6591 ; 1058-4838
ISSN (online)	1537-6591
ISSN	1058-4838
DOI	10.1093/cid/ciaa116
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Zs.A 1505: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Ampicillin-susceptible

Faury, Hélène / Le Guen, Ronan / Demontant, Vanessa / Rodriguez, Christophe / Souhail, Bérénice / Galy, Adrien / Jolivet, Sarah / Lepeule, Raphaël / Decousser, Jean-Winoc / Fihman, Vincent / Woerther, Paul-Louis / Royer, Guilhem

Microbiology spectrum

2023 , Page(s) e0454522

Abstract: Enterococcus faecium, ...

Abstract	Enterococcus faecium,
Language	English
Publishing date	2023-09-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	2807133-5
ISSN	2165-0497 ; 2165-0497
ISSN (online)	2165-0497
ISSN	2165-0497
DOI	10.1128/spectrum.04545-22
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Article ; Online: Defining standard and high dosages for β-lactam agents administered by intermittent, prolonged or continuous infusion: a PK/PD simulation study.

Goutelle, Sylvain / Jullien, Vincent / Bru, Jean-Pierre / Cattoir, Vincent / Gauzit, Rémy / Lesprit, Philippe / Lina, Gérard / Schramm, Frédéric / Canoui, Etienne / Lepeule, Raphael

The Journal of antimicrobial chemotherapy

2023 Volume 78, Issue 11, Page(s) 2762–2769

Abstract: Background: The new definitions of antimicrobial susceptibility categories proposed by EUCAST in 2020 require the definition of standard and high dosages of antibiotic. For injectable β-lactams, standard and high dosages have been proposed for short- ... ...

Abstract	Background: The new definitions of antimicrobial susceptibility categories proposed by EUCAST in 2020 require the definition of standard and high dosages of antibiotic. For injectable β-lactams, standard and high dosages have been proposed for short-infusion regimens only. Objectives: To evaluate dosages for β-lactams administered by prolonged infusion (PI) and continuous infusion (CI). Methods: Monte Carlo simulations were performed for seven injectable β-lactams: aztreonam, cefepime, cefotaxime, cefoxitin, ceftazidime, piperacillin and temocillin. Various dosage regimens based on short infusion, PI or CI were simulated in virtual patients. Pharmacokinetic (PK) profiles and PTAs were obtained based on reference population PK models, as well as PK/pharmacodynamic targets and MIC breakpoints proposed by EUCAST. Alternative dosage regimens associated with PTA values similar to those of recommended dosages up to the breakpoints were considered acceptable. Results: Adequate PTAs were confirmed for most EUCAST short-infusion dosage regimens. A total of 9 standard and 14 high dosages based on PI (3 to 4 h) or CI were identified as alternatives. For cefepime and aztreonam, only PI and CI regimens could achieve acceptable PTAs for infections caused by Pseudomonas spp.: 2 g q8h as PI of 4 h or 6 g/24 h CI for cefepime; 2 g q6h as PI of 3 h or 6 g/24 h CI for aztreonam. Conclusions: These alternative standard and high dosage regimens are expected to provide antibiotic exposure compatible with new EUCAST definitions of susceptibility categories and associated MIC breakpoints. However, further clinical evaluation is necessary.
MeSH term(s)	Humans ; Cefepime ; Aztreonam ; Anti-Bacterial Agents/pharmacology ; Ceftazidime ; Piperacillin ; Microbial Sensitivity Tests ; Monte Carlo Method
Chemical Substances	Cefepime (807PW4VQE3) ; Aztreonam (G2B4VE5GH8) ; Anti-Bacterial Agents ; Ceftazidime (9M416Z9QNR) ; Piperacillin (X00B0D5O0E)
Language	English
Publishing date	2023-10-09
Publishing country	England
Document type	Journal Article
ZDB-ID	191709-2
ISSN	1460-2091 ; 0305-7453
ISSN (online)	1460-2091
ISSN	0305-7453
DOI	10.1093/jac/dkad300
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Zs.A 1197: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 124: Show issues

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Article ; Online: Efficacy of vancomycin lock therapy for totally implantable venous access port-related infection due to coagulase-negative staphylococci in 100 patients with cancer.

Lafaurie, Matthieu / Montlahuc, Claire / Kerneis, Solen / de Lastours, Victoire / Abgrall, Sophie / Manceron, Véronique / Couzigou, Carine / Chabrol, Amélie / de Raigniac, Axelle / Lescure, Xavier / Longuet, Pascale / Lesprit, Philippe / Vanjak, Dominique / Lepeule, Raphael

The Journal of antimicrobial chemotherapy

2023 Volume 78, Issue 5, Page(s) 1253–1258

Abstract: Objectives: Data on the efficacy of vancomycin catheter lock therapy (VLT) for conservative treatment of totally implantable venous access port-related infections (TIVAP-RI) due to CoNS are scarce. The aim of this study was to evaluate the effectiveness ...

Abstract	Objectives: Data on the efficacy of vancomycin catheter lock therapy (VLT) for conservative treatment of totally implantable venous access port-related infections (TIVAP-RI) due to CoNS are scarce. The aim of this study was to evaluate the effectiveness of VLT in the treatment of TIVAP-RI due to CoNS in cancer patients. Methods: This prospective, observational, multicentre study included adults with cancer treated with VLT for a TIVAP-RI due to CoNS. The primary endpoint was the success of VLT, defined as no TIVAP removal nor TIVAP-RI recurrence within 3 months after initiation of VLT. The secondary endpoint was 3 month mortality. Risk factors for VLT failure were also analysed. Results: One hundred patients were included [men 53%, median age 63 years (IQR 53-72)]. Median duration of VLT was 12 days (IQR 9-14). Systemic antibiotic therapy was administered in 87 patients. VLT was successful in 44 patients. TIVAP could be reused after VLT in 51 patients. Recurrence of infection after completion of VLT occurred in 33 patients, among which TIVAP was removed in 27. Intermittent VLT (antibiotic solution left in place in the TIVAP lumen part of the time) was identified as a risk factor for TIVAP-RI recurrence. At 3 months, 26 deaths were reported; 1 (4%) was related to TIVAP-RI. Conclusions: At 3 months, success of VLT for TIVAP-RI due to CoNS was low. However, removing TIVAP was avoided in nearly half the patients. Continuous locks should be preferred to intermittent locks. Identifying factors of success is essential to select patients who may benefit from VLT.
MeSH term(s)	Male ; Adult ; Humans ; Middle Aged ; Vancomycin/therapeutic use ; Catheterization, Central Venous/adverse effects ; Coagulase ; Prospective Studies ; Catheters, Indwelling/adverse effects ; Catheter-Related Infections/drug therapy ; Catheter-Related Infections/complications ; Anti-Bacterial Agents/therapeutic use ; Neoplasms/drug therapy ; Staphylococcus
Chemical Substances	Vancomycin (6Q205EH1VU) ; Coagulase ; Anti-Bacterial Agents
Language	English
Publishing date	2023-04-10
Publishing country	England
Document type	Observational Study ; Multicenter Study ; Journal Article
ZDB-ID	191709-2
ISSN	1460-2091 ; 0305-7453
ISSN (online)	1460-2091
ISSN	0305-7453
DOI	10.1093/jac/dkad083
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Zs.A 1197: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 124: Show issues

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Article ; Online: PET/CT for osteoarticular septic grafts in endocarditis: A large monocentric cohort.

Hugues, Benjamin / Emsen, Berivan / Pina Vegas, Laura / Lepeule, Raphaël / Ternacle, Julien / Huguet, Raphaëlle / Decousser, Jean-Winoc / Fiore, Antonio / Lim, Pascal / Itti, Emmanuel / Chevalier, Xavier / Abulizi, Mukedaizi / Eymard, Florent

Joint bone spine

2023 Volume 90, Issue 5, Page(s) 105577

MeSH term(s)	Humans ; Positron Emission Tomography Computed Tomography ; Endocarditis ; Fluorodeoxyglucose F18 ; Radiopharmaceuticals ; Prosthesis-Related Infections
Chemical Substances	Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; Radiopharmaceuticals
Language	English
Publishing date	2023-04-17
Publishing country	France
Document type	Letter
ZDB-ID	2020487-5
ISSN	1778-7254 ; 1297-319X
ISSN (online)	1778-7254
ISSN	1297-319X
DOI	10.1016/j.jbspin.2023.105577
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Zs.A 4590: Show issues

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Article ; Online: First-year recurrence rate of skin and soft tissue infections following an initial necrotizing soft tissue infection of the lower extremities: A retrospective cohort study of 93 patients.

Traineau, Hélène / Charpentier, Chloé / Lepeule, Raphaël / Ingen-Housz-Oro, Saskia / Hersant, Barbara / Urbina, Tomas / de Prost, Nicolas / Hua, Camille / Chosidow, Olivier

Journal of the American Academy of Dermatology

2023 Volume 88, Issue 6, Page(s) 1360–1363

MeSH term(s)	Humans ; Soft Tissue Infections/epidemiology ; Retrospective Studies ; Cellulitis/drug therapy ; Skin ; Lower Extremity ; Fasciitis, Necrotizing/epidemiology ; Fasciitis, Necrotizing/drug therapy ; Anti-Bacterial Agents/therapeutic use
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2023-01-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	603641-7
ISSN	1097-6787 ; 0190-9622
ISSN (online)	1097-6787
ISSN	0190-9622
DOI	10.1016/j.jaad.2022.12.044
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Article: Blood Cultures for the Diagnosis of Infective Endocarditis: What Is the Benefit of Prolonged Incubation?

Fihman, Vincent / Faury, Hélène / Moussafeur, Amina / Huguet, Raphaelle / Galy, Adrien / Gallien, Sébastien / Lim, Pascal / Lepeule, Raphaël / Woerther, Paul-Louis

Journal of clinical medicine

2021 Volume 10, Issue 24

Abstract: To assess the need for prolonged incubation of blood culture bottles beyond five days for the diagnosis of infectious endocarditis (IE), we conducted a retrospective cohort study of 6109 sets of two blood culture bottles involving 1211 patients admitted ... ...

Abstract	To assess the need for prolonged incubation of blood culture bottles beyond five days for the diagnosis of infectious endocarditis (IE), we conducted a retrospective cohort study of 6109 sets of two blood culture bottles involving 1211 patients admitted to the Henri Mondor University Hospital for suspicion of IE between 1 January 2016 and 31 December 2019. Among the 322 patients with IE, 194 had positive blood cultures in our centre. Only one patient with a time-to-positivity blood culture of more than 120 h (5 days) was found. The main cause for the 22 patients with positive blood cultures after five days was contamination with
Language	English
Publishing date	2021-12-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm10245824
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Article: Antibiotics in Necrotizing Soft Tissue Infections.

Urbina, Tomas / Razazi, Keyvan / Ourghanlian, Clément / Woerther, Paul-Louis / Chosidow, Olivier / Lepeule, Raphaël / de Prost, Nicolas

Antibiotics (Basel, Switzerland)

2021 Volume 10, Issue 9

Abstract: Necrotizing soft tissue infections (NSTIs) are rare life-threatening bacterial infections characterized by an extensive necrosis of skin and subcutaneous tissues. Initial urgent management of NSTIs relies on broad-spectrum antibiotic therapy, rapid ... ...

Abstract	Necrotizing soft tissue infections (NSTIs) are rare life-threatening bacterial infections characterized by an extensive necrosis of skin and subcutaneous tissues. Initial urgent management of NSTIs relies on broad-spectrum antibiotic therapy, rapid surgical debridement of all infected tissues and, when present, treatment of associated organ failures in the intensive care unit. Antibiotic therapy for NSTI patients faces several challenges and should (1) carry broad-spectrum activity against gram-positive and gram-negative pathogens because of frequent polymicrobial infections, considering extended coverage for multidrug resistance in selected cases. In practice, a broad-spectrum beta-lactam antibiotic (e.g., piperacillin-tazobactam) is the mainstay of empirical therapy; (2) decrease toxin production, typically using a clindamycin combination, mainly in proven or suspected group A streptococcus infections; and (3) achieve the best possible tissue diffusion with regards to impaired regional perfusion, tissue necrosis, and pharmacokinetic and pharmacodynamic alterations. The best duration of antibiotic treatment has not been well established and is generally comprised between 7 and 15 days. This article reviews the currently available knowledge regarding antibiotic use in NSTIs.
Language	English
Publishing date	2021-09-13
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2681345-2
ISSN	2079-6382
ISSN	2079-6382
DOI	10.3390/antibiotics10091104
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