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  1. Book: Perspektiven der pharmakologischen Behandlung von Epilepsien

    Lerche, Holger

    (UNI-MED science)

    2013  

    Author's details [Holger Lerche ... Unter Mitarb. von Albert J. Becker ...]
    Series title UNI-MED science
    Keywords Antiepileptikum
    Subject Antikonvulsivum ; Anticonvulsivum ; Antiepileptika
    Subject code 615.784
    Language German
    Size 125 S. : Ill., graph. Darst., 25 cm
    Edition 1. Aufl.
    Publisher UNI-MED-Verl
    Publishing place Bremen u.a.
    Publishing country Germany
    Document type Book
    Note Literaturangaben
    HBZ-ID HT018199259
    ISBN 978-3-8374-2128-6 ; 3-8374-2128-7
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2014 A 1047 available for loan (reading room) Lesesaal EG

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  2. Article ; Online: Retigabine and gabapentin restore channel function and neuronal firing in a cellular model of an epilepsy-associated dominant-negative KCNQ5 variant.

    Krüger, Johanna / Lerche, Holger

    Neuropharmacology

    2024  Volume 250, Page(s) 109892

    Abstract: KCNQ5 encodes the voltage-gated potassium channel ... ...

    Abstract KCNQ5 encodes the voltage-gated potassium channel K
    MeSH term(s) Humans ; Gabapentin/pharmacology ; KCNQ2 Potassium Channel/genetics ; KCNQ2 Potassium Channel/metabolism ; Epilepsy/drug therapy ; Epilepsy/genetics ; Carbamates/pharmacology ; Carbamates/therapeutic use ; Phenylenediamines
    Chemical Substances Gabapentin (6CW7F3G59X) ; ezogabine (12G01I6BBU) ; KCNQ2 Potassium Channel ; Carbamates ; Phenylenediamines
    Language English
    Publishing date 2024-02-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 218272-5
    ISSN 1873-7064 ; 0028-3908
    ISSN (online) 1873-7064
    ISSN 0028-3908
    DOI 10.1016/j.neuropharm.2024.109892
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Drug-resistant epilepsy - time to target mechanisms.

    Lerche, Holger

    Nature reviews. Neurology

    2020  Volume 16, Issue 11, Page(s) 595–596

    MeSH term(s) Animals ; Anticonvulsants/administration & dosage ; Drug Resistant Epilepsy/diagnostic imaging ; Drug Resistant Epilepsy/genetics ; Drug Resistant Epilepsy/therapy ; Genetic Therapy/methods ; Genetic Therapy/trends ; Humans
    Chemical Substances Anticonvulsants
    Language English
    Publishing date 2020-10-07
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2491514-2
    ISSN 1759-4766 ; 1759-4758
    ISSN (online) 1759-4766
    ISSN 1759-4758
    DOI 10.1038/s41582-020-00419-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Gentherapien für Epilepsie: Klinische Studien sind auf dem Weg.

    Müller, Peter / Lerche, Holger

    Fortschritte der Neurologie-Psychiatrie

    2023  Volume 91, Issue 4, Page(s) 135–140

    Abstract: For more than 10 years, research has been conducted on gene therapies for the most severe forms of epilepsy, which until now have proven resistant to treatment. First gene therapies are now in clinical trials for pharmacoresistant focal epilepsies and ... ...

    Title translation Gene Therapy for Epilepsy: Clinical Studies are on the Road.
    Abstract For more than 10 years, research has been conducted on gene therapies for the most severe forms of epilepsy, which until now have proven resistant to treatment. First gene therapies are now in clinical trials for pharmacoresistant focal epilepsies and Dravet syndrome. In this article, we describe how these and many more gene therapies work and what they target.
    MeSH term(s) Humans ; Epilepsy/therapy ; Epilepsy/drug therapy ; Epilepsies, Myoclonic/therapy ; Epilepsies, Myoclonic/drug therapy ; Anticonvulsants/therapeutic use
    Chemical Substances Anticonvulsants
    Language German
    Publishing date 2023-01-30
    Publishing country Germany
    Document type English Abstract ; Journal Article
    ZDB-ID 625328-3
    ISSN 1439-3522 ; 0720-4299
    ISSN (online) 1439-3522
    ISSN 0720-4299
    DOI 10.1055/a-1995-5405
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Voltage-gated calcium channels in genetic epilepsies.

    Lauerer, Robert J / Lerche, Holger

    Journal of neurochemistry

    2023  

    Abstract: Voltage-gated calcium channels (VGCC) are abundant in the central nervous system and serve a broad spectrum of functions, either directly in cellular excitability or indirectly to regulate ... ...

    Abstract Voltage-gated calcium channels (VGCC) are abundant in the central nervous system and serve a broad spectrum of functions, either directly in cellular excitability or indirectly to regulate Ca
    Language English
    Publishing date 2023-10-11
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 80158-6
    ISSN 1471-4159 ; 0022-3042 ; 1474-1644
    ISSN (online) 1471-4159
    ISSN 0022-3042 ; 1474-1644
    DOI 10.1111/jnc.15983
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Book ; Thesis: Über die Pathophysiologie von Ionenkanalerkrankungen und den Mechanismus der schnellen Natriumkanalinaktivierung

    Lerche, Holger

    1999  

    Author's details vorgelegt von Holger Lerche
    Language German ; English
    Size 94 S. in getr. Zählung, graph. Darst., 30 cm
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Ulm, Univ., Habil.-Schr., 1999
    Note Enth. 9 Sonderabdr. aus verschiedenen Zeitschr.
    HBZ-ID HT012961380
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2001 E 761 order to use in reading room Magazin

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  7. Article ; Online: Synaptic or ion channel modifier? PRRT2 is a chameleon-like regulator of neuronal excitability.

    Lerche, Holger

    Brain : a journal of neurology

    2018  Volume 141, Issue 4, Page(s) 938–941

    MeSH term(s) Animals ; Ion Channels ; Lizards ; Neurons
    Chemical Substances Ion Channels
    Language English
    Publishing date 2018-03-29
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 80072-7
    ISSN 1460-2156 ; 0006-8950
    ISSN (online) 1460-2156
    ISSN 0006-8950
    DOI 10.1093/brain/awy073
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: [No title information]

    Müller, Peter / Lerche, Holger

    Fortschritte der Neurologie · Psychiatrie

    2023  Volume 91, Issue 04, Page(s) 135–140

    Abstract: Seit über 10 Jahren wird an Gentherapien für die schwersten Formen von Epilepsie geforscht, die bis jetzt therapieresistent sind. Nun ergeben sich für fokale pharmakoresistente Epilepsien und für ...

    Abstract Seit über 10 Jahren wird an Gentherapien für die schwersten Formen von Epilepsie geforscht, die bis jetzt therapieresistent sind. Nun ergeben sich für fokale pharmakoresistente Epilepsien und für das Dravet Syndrom Gentherapieansätze in ersten klinischen Studien. In diesem Artikel beschreiben wir die Funktionsweise und Ziele dieser und weiterer Gentherapien.
    Keywords Epilepsie ; Gentherapie ; entwicklungsneurologische Störung ; entwicklungssassoziierte und epileptische Enzephalopathien ; Therapie-refraktäre Epilepsie ; epilepsy ; gene therapy ; neurodevelopmental disorder ; developmental and epileptic encephalopathy ; Refractory focal epilepsy
    Language German
    Publishing date 2023-01-30
    Publisher Georg Thieme Verlag
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 625328-3
    ISSN 1439-3522 ; 0720-4299
    ISSN (online) 1439-3522
    ISSN 0720-4299
    DOI 10.1055/a-1995-5405
    Database Thieme publisher's database

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  9. Book ; Online ; Thesis: Characterizations of a heterozygous Stx1b-knockout mouse model with fever associated epilepsy

    Meyer, Anjela [Verfasser] / Lerche, Holger [Akademischer Betreuer]

    2024  

    Author's details Anjela Catherine Meyer ; Betreuer: Holger Lerche
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language English
    Publisher Universitätsbibliothek Tübingen
    Publishing place Tübingen
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  10. Book ; Thesis: Charakterisierung des Calcium-aktivierten Kaliumkanals mit großer Leitfähigkeit und der Natriumkanalstörung bei Natriumkanal-Myotonie in adulter, menschlicher Skelettmuskulatur

    Lerche, Holger

    1995  

    Author's details vorgelegt von Holger Lerche
    Language German
    Size 93 S. : Ill., graph. Darst.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Ulm, Univ., Diss., 1996
    HBZ-ID HT007487430
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    97 E 726 order for loan Magazin

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