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Article ; Online: Rosai-Dorfman Disease in a Pediatric Patient: Imaging Findings and Pathology with a brief review of the Literature.

Hartmann, Thomas / Solomon, Nadia / Lerner, Gabriel / Ehrlich, Lauren

2023 Volume 17, Issue 9, Page(s) 1–14

Abstract: Rosai-Dorfman Disease, otherwise known as sinus histiocytosis with massive lymphadenopathy, is a rare form of non-Langerhans cell histiocytosis with an estimated incidence of 100 cases per year in the United States. Due to its variable presentation and ... ...

Abstract	Rosai-Dorfman Disease, otherwise known as sinus histiocytosis with massive lymphadenopathy, is a rare form of non-Langerhans cell histiocytosis with an estimated incidence of 100 cases per year in the United States. Due to its variable presentation and nonspecific clinical findings, it is particularly difficult to diagnose in pediatric patients. We report a case of an 11-month-old male who presented with a 4-day history of a right groin mass. Ultrasound of the groin and pelvis demonstrated, and MRI of the abdomen and pelvis confirmed an inguinal mass with surrounding lymphadenopathy. Pathology confirmed Rosai-Dorfman Disease and the patient improved after starting oral steroid therapy. To the best of our knowledge, this is the first case of Rosai-Dorfman Disease involving the inguinal region in an infant under 1 year of age reported in the literature. In this case report, we discuss the imaging and histology findings as well as provide a brief literature review for this diagnosis.
MeSH term(s)	Humans ; Male ; Child ; Infant ; Histiocytosis, Sinus/diagnostic imaging ; Histiocytosis, Sinus/drug therapy ; Pelvis/pathology ; Lymphadenopathy/diagnosis ; Diagnosis, Differential ; Magnetic Resonance Imaging
Language	English
Publishing date	2023-08-01
Publishing country	United States
Document type	Review ; Case Reports
ZDB-ID	2586384-8
ISSN	1943-0922 ; 1943-0922
ISSN (online)	1943-0922
ISSN	1943-0922
DOI	10.3941/jrcr.v17i8.4873
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Incorporation of the HIV-1 envelope glycoprotein into viral particles is regulated by the tubular recycling endosome in a cell type-specific manner.

Lerner, Grigoriy / Ding, Lingmei / Candor, Kathleen / Spearman, Paul

bioRxiv : the preprint server for biology

2023

Abstract: The HIV-1 envelope glycoprotein (Env) is incorporated into particles during assembly on the plasma membrane (PM). Env initially reaches the PM through the secretory pathway, after which it is rapidly endocytosed via an AP-2- and clathrin-dependent ... ...

Abstract	The HIV-1 envelope glycoprotein (Env) is incorporated into particles during assembly on the plasma membrane (PM). Env initially reaches the PM through the secretory pathway, after which it is rapidly endocytosed via an AP-2- and clathrin-dependent mechanism. Here we show that endocytosed cell surface Env enters the tubular recycling endosome compartment (TRE). Trafficking to the TRE was dependent upon motifs within the CT previously implicated in Env recycling and particle incorporation. Depletion of TRE components MICAL-L1 or EHD1 led to defects in Env incorporation, particle infectivity, and viral replication. Remarkably, defects were limited to cell types defined as nonpermissive for incorporation of CT-deleted Env, including monocyte-derived macrophages, and not observed in 293T, HeLa, or MT-4 cells. This work identifies the TRE as an essential component of Env trafficking and particle incorporation, and provides evidence that the cell type-dependent incorporation of Env is defined by interactions with components of the TRE.
Language	English
Publishing date	2023-12-17
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.12.17.572063
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Tryptophan-based motifs in the LLP3 region of the HIV-1 envelope glycoprotein cytoplasmic tail direct trafficking to the endosomal recycling compartment and mediate particle incorporation.

Lerner, Grigoriy / Ding, Lingmei / Spearman, Paul

Journal of virology

2023 Volume 97, Issue 10, Page(s) e0063123

Abstract: Importance: The HIV-1 envelope glycoprotein (Env) is an essential component of the virus and has an exceedingly long cytoplasmic tail (CT). Previous studies have suggested that trafficking signals in the CT interact with host factors to regulate the ... ...

Abstract	Importance: The HIV-1 envelope glycoprotein (Env) is an essential component of the virus and has an exceedingly long cytoplasmic tail (CT). Previous studies have suggested that trafficking signals in the CT interact with host factors to regulate the incorporation of Env into particles. One particular area of interest is termed lentiviral lytic peptide 3 (LLP3), as small deletions in this region have been shown to disrupt Env incorporation. In this study, we identify a small region within LLP3 that regulates how Env associates with cellular recycling compartments. Mutants that reduced or eliminated Env from the recycling compartment also reduced Env incorporation into particles. These findings emphasize the importance of two tryptophan motifs in LLP3 for the incorporation of Env into particles and provide additional support for the idea that the CT interacts with host recycling pathways to determine particle incorporation.
MeSH term(s)	Endosomes/metabolism ; env Gene Products, Human Immunodeficiency Virus/chemistry ; env Gene Products, Human Immunodeficiency Virus/metabolism ; Glycoproteins/chemistry ; Glycoproteins/metabolism ; HIV-1/physiology ; Peptides/chemistry ; Peptides/metabolism ; Tryptophan/metabolism ; Cytoplasm/metabolism ; Humans ; Host Microbial Interactions ; Virus Assembly ; Amino Acid Motifs ; Protein Transport
Chemical Substances	env Gene Products, Human Immunodeficiency Virus ; Glycoproteins ; Peptides ; Tryptophan (8DUH1N11BX)
Language	English
Publishing date	2023-10-05
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	80174-4
ISSN	1098-5514 ; 0022-538X
ISSN (online)	1098-5514
ISSN	0022-538X
DOI	10.1128/jvi.00631-23
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Article: Tryptophan-based motifs in the LLP3 Region of the HIV-1 envelope glycoprotein cytoplasmic tail direct trafficking to the endosomal recycling compartment and mediate particle incorporation.

Lerner, Grigoriy / Ding, Lingmei / Spearman, Paul

bioRxiv : the preprint server for biology

2023

Abstract: The HIV-1 envelope glycoprotein complex (Env) is incorporated into developing particles at the plasma membrane (PM). The cytoplasmic tail (CT) of Env is known to play an essential role in particle incorporation, while the exact mechanisms underlying this ...

Abstract	The HIV-1 envelope glycoprotein complex (Env) is incorporated into developing particles at the plasma membrane (PM). The cytoplasmic tail (CT) of Env is known to play an essential role in particle incorporation, while the exact mechanisms underlying this function of the CT remain uncertain. Upon reaching the PM, trafficking signals in the CT interact with host cell endocytic machinery, directing Env into endosomal compartments within the cell. Prior studies have suggested that Env must traffic through the endosomal recycling compartment (ERC) in order for Env to return to the plasma membrane (PM) site of particle assembly. Expression of a truncated form of the ERC-resident trafficking adaptor Rab11-Family Interacting Proteins C (FIP1C) resulted in CT-dependent sequestration of Env in the condensed ERC, preventing recycling of Env to the PM. In this work, the motifs within the CT responsible for ERC localization of Env were systematically mapped. A small deletion encompassing the N-terminal portion of LLP3 eliminated ERC localization. Site-directed mutagenesis identified two tryptophan-based motifs (WE Importance: The HIV-1 envelope glycoprotein (Env) is an essential component of the virus, and has an exceedingly long cytoplasmic tail (CT). Previous studies have suggested that trafficking signals in the CT interact with host factors to regulate the incorporation of Env into particles. One particular area of interest is termed lentiviral lytic peptide 3 (LLP3), as small deletions in this region have been shown to disrupt Env incorporation. In this study, we identify a small region within LLP3 that regulates how Env associates with cellular recycling compartments. Mutants that reduced or eliminated Env from the recycling compartment also reduced Env incorporation into particles. These findings emphasize the importance of two tryptophan motifs in LLP3 to the incorporation of Env into particles, and provide additional support for the idea that the CT interacts with host recycling pathways to determine particle incorporation.
Language	English
Publishing date	2023-04-28
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.04.28.538708
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Conference proceedings ; Online: Whose history? Inclusion in volcanological publishing

Lerner, G. / Williams, G. / Meredith, E. / Jenkins, S. / Barclay, J.

XXVIII General Assembly of the International Union of Geodesy and Geophysics (IUGG)

2023

Abstract: Historical studies are heavily impacted by whose stories are told, who writes them, and how much local perspectives are included. This is true in volcanology as well, where analysis of historical sources and data related to eruptions may be impacted by ... ...

Abstract	Historical studies are heavily impacted by whose stories are told, who writes them, and how much local perspectives are included. This is true in volcanology as well, where analysis of historical sources and data related to eruptions may be impacted by the perspective and lived experience of the authors. As such, it is important to understand where the authors of volcanological studies are from and what perspectives they have. We used bibliometric methods to assess the way in which local researchers are included in volcanological publications by comparing the affiliation of authors with the country in which researched volcanoes are located. Globally, 40% of articles about a specific volcano do not include an author whose affiliation is based in the country where the volcano is located (a locally domiciled author), while 56% are led by authors not based in the country of the volcano. Over the past three decades, first authorship rates among local researchers have not increased. However, local researchers have become more frequently included as co-authors in research led by researchers domiciled elsewhere. The results of these analyses suggest that there is room for improvement in inclusivity in volcanological research and cause for reflection on how we collaborate with international partners. Improved collaboration and inclusion in publishing could result in better consideration of local knowledge and perspectives when analyzing historical information related to volcanic eruptions.
Subject code	001
Language	English
Publishing country	de
Document type	Conference proceedings ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Advances in HIV-1 Assembly.

Lerner, Grigoriy / Weaver, Nicholas / Anokhin, Boris / Spearman, Paul

Viruses

2022 Volume 14, Issue 3

Abstract: The assembly of HIV-1 particles is a concerted and dynamic process that takes place on the plasma membrane of infected cells. An abundance of recent discoveries has advanced our understanding of the complex sequence of events leading to HIV-1 particle ... ...

Abstract	The assembly of HIV-1 particles is a concerted and dynamic process that takes place on the plasma membrane of infected cells. An abundance of recent discoveries has advanced our understanding of the complex sequence of events leading to HIV-1 particle assembly, budding, and release. Structural studies have illuminated key features of assembly and maturation, including the dramatic structural transition that occurs between the immature Gag lattice and the formation of the mature viral capsid core. The critical role of inositol hexakisphosphate (IP6) in the assembly of both the immature and mature Gag lattice has been elucidated. The structural basis for selective packaging of genomic RNA into virions has been revealed. This review will provide an overview of the HIV-1 assembly process, with a focus on recent advances in the field, and will point out areas where questions remain that can benefit from future investigation.
MeSH term(s)	HIV-1/genetics ; Virion/metabolism ; Virus Assembly ; gag Gene Products, Human Immunodeficiency Virus/metabolism
Chemical Substances	gag Gene Products, Human Immunodeficiency Virus
Language	English
Publishing date	2022-02-26
Publishing country	Switzerland
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v14030478
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Advances in HIV-1 Assembly

Lerner, Grigoriy / Weaver, Nicholas / Anokhin, Boris / Spearman, Paul

Viruses. 2022 Feb. 26, v. 14, no. 3

2022

Abstract	The assembly of HIV-1 particles is a concerted and dynamic process that takes place on the plasma membrane of infected cells. An abundance of recent discoveries has advanced our understanding of the complex sequence of events leading to HIV-1 particle assembly, budding, and release. Structural studies have illuminated key features of assembly and maturation, including the dramatic structural transition that occurs between the immature Gag lattice and the formation of the mature viral capsid core. The critical role of inositol hexakisphosphate (IP6) in the assembly of both the immature and mature Gag lattice has been elucidated. The structural basis for selective packaging of genomic RNA into virions has been revealed. This review will provide an overview of the HIV-1 assembly process, with a focus on recent advances in the field, and will point out areas where questions remain that can benefit from future investigation.
Keywords	RNA ; capsid ; genomics ; inositols ; plasma membrane
Language	English
Dates of publication	2022-0226
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2516098-9
ISSN	1999-4915
ISSN	1999-4915
DOI	10.3390/v14030478
Database	NAL-Catalogue (AGRICOLA)

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Conference proceedings ; Online: Using impact assessment to classify unconfined pyroclastic density currents and what it means for hazard assessment at stratovolcanoes

Lerner, G. / Jenkins, S. / Charbonnier, S. / Komorowski, J. / Baxter, P. / Tennant, E.

XXVIII General Assembly of the International Union of Geodesy and Geophysics (IUGG)

2023

Abstract: Pyroclastic density currents (PDCs) that escape their confining channels are among the most dangerous of volcanic hazards. These unconfined PDCs are capable of inundating inhabited areas that may be unprepared for these hazards, resulting in significant ... ...

Abstract	Pyroclastic density currents (PDCs) that escape their confining channels are among the most dangerous of volcanic hazards. These unconfined PDCs are capable of inundating inhabited areas that may be unprepared for these hazards, resulting in significant loss of life and damage to infrastructure. Unconfined PDCs can be categorized based on some of their primary dynamic characteristics (e.g., velocity, concentration, dynamic pressure, temperature), which also determine the impacts that they have on humans and infrastructure. Here, we used impact assessments following eruptions at Merapi (Indonesia) in 2010 and Fuego (Guatemala) in 2018 to better understand the dynamics of the PDCs during the eruptions. By analyzing these and similar events, we identified four main categories of unconfined PDC based on their dynamic characteristics: 1. fast overspill flows, 2. slow overspill flows, 3. high-energy surges, and 4. low-energy detached surges (LEDS). How we treat the uncertainty associated with forecasting the inundation area of these PDCs (e.g., in modelling) significantly impacts hazard planning for areas prone to volcanic eruptions. We provide an example of this using hazard modelling of lava dome collapse PDCs from several high-risk volcanoes in Southeast Asia, which show a difference in the projected impacts depending on the overspill buffer with which the PDC is modelled.
Language	English
Publishing country	de
Document type	Conference proceedings ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: KIF16B Mediates Anterograde Transport and Modulates Lysosomal Degradation of the HIV-1 Envelope Glycoprotein.

Weaver, Nicholas / Hammonds, Jason / Ding, Lingmei / Lerner, Grigoriy / Dienger-Stambaugh, Krista / Spearman, Paul

Journal of virology

2023 Volume 97, Issue 7, Page(s) e0025523

Abstract: The human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein (Env) is incorporated into virions at the site of particle assembly on the plasma membrane (PM). The route taken by Env to reach the site of assembly and particle incorporation remains ...

Abstract	The human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein (Env) is incorporated into virions at the site of particle assembly on the plasma membrane (PM). The route taken by Env to reach the site of assembly and particle incorporation remains incompletely understood. Following initial delivery to the PM through the secretory pathway, Env is rapidly endocytosed, suggesting that recycling is required for particle incorporation. Endosomes marked by the small GTPase Rab14 have been previously shown to play a role in Env trafficking. Here, we examined the role of KIF16B, the molecular motor protein that directs outward movement of Rab14-dependent cargo, in Env trafficking. Env colocalized extensively with KIF16B
MeSH term(s)	Humans ; HIV-1/physiology ; Protein Transport ; Cell Membrane/metabolism ; Lysosomes/metabolism ; Glycoproteins/metabolism ; Kinesins/genetics ; Kinesins/metabolism ; rab GTP-Binding Proteins/metabolism
Chemical Substances	Glycoproteins ; KIF16B protein, human ; Kinesins (EC 3.6.4.4) ; Rab14 protein, human (EC 3.6.1.-) ; rab GTP-Binding Proteins (EC 3.6.5.2)
Language	English
Publishing date	2023-06-26
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	80174-4
ISSN	1098-5514 ; 0022-538X
ISSN (online)	1098-5514
ISSN	0022-538X
DOI	10.1128/jvi.00255-23
Database	MEDical Literature Analysis and Retrieval System OnLINE

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ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Multiscale dynamical symmetries and selection rules in nonlinear optics.

Lerner, Gavriel / Neufeld, Ofer / Hareli, Liran / Shoulga, Georgiy / Bordo, Eliayu / Fleischer, Avner / Podolsky, Daniel / Bahabad, Alon / Cohen, Oren

Science advances

2023 Volume 9, Issue 15, Page(s) eade0953

Abstract: Symmetries and their associated selection rules are extremely useful in many fields of science. For systems of electromagnetic (EM) fields interacting with matter, the symmetries of matter and the EM fields' time-dependent polarization determine the ... ...

Abstract	Symmetries and their associated selection rules are extremely useful in many fields of science. For systems of electromagnetic (EM) fields interacting with matter, the symmetries of matter and the EM fields' time-dependent polarization determine the properties of the nonlinear responses, and they can be facilitated for controlling light emission and enabling ultrafast symmetry breaking spectroscopy of various properties. Here, we formulate a general theory that describes the macroscopic and microscopic dynamical symmetries (including quasicrystal-like symmetries) of EM vector fields, revealing many previously unidentified symmetries and selection rules in light-matter interactions. We demonstrate an example of multiscale selection rules experimentally in the framework of high harmonic generation. This work paves the way for novel spectroscopic techniques in multiscale systems and for imprinting complex structures in extreme ultraviolet-x-ray beams, attosecond pulses, or the interacting medium itself.
Language	English
Publishing date	2023-04-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	2810933-8
ISSN	2375-2548 ; 2375-2548
ISSN (online)	2375-2548
ISSN	2375-2548
DOI	10.1126/sciadv.ade0953
Database	MEDical Literature Analysis and Retrieval System OnLINE

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