Article ; Online: Enantioselective Approach for Expanding the Three-Dimensional Space of Tetrahydroquinoline to Develop BET Bromodomain Inhibitors.
Chemistry (Weinheim an der Bergstrasse, Germany)
2022 Volume 28, Issue 64, Page(s) e202202293
Abstract: The pharmaceutical industry has a pervasive need for chiral specific molecules with optimal affinity for their biological targets. However, the mass production of such compounds is currently limited by conventional chemical routes, that are costly and ... ...
| Abstract | The pharmaceutical industry has a pervasive need for chiral specific molecules with optimal affinity for their biological targets. However, the mass production of such compounds is currently limited by conventional chemical routes, that are costly and have an environmental impact. Here, we propose an easy access to obtain new tetrahydroquinolines, a motif found in many bioactive compounds, that is rapid and cost effective. Starting from simple raw materials, the procedure uses a proline-catalyzed Mannich reaction followed by the addition of BF |
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| MeSH term(s) | Stereoisomerism ; Quinolines ; Antineoplastic Agents ; Catalysis |
| Chemical Substances | 1,2,3,4-tetrahydroquinoline (CCR50N1Z9G) ; Quinolines ; Antineoplastic Agents |
| Language | English |
| Publishing date | 2022-09-13 |
| Publishing country | Germany |
| Document type | Journal Article |
| ZDB-ID | 1478547-X |
| ISSN | 1521-3765 ; 0947-6539 |
| ISSN (online) | 1521-3765 |
| ISSN | 0947-6539 |
| DOI | 10.1002/chem.202202293 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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