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  1. AU="Leroy, J"
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  1. Article ; Online: A silicone-based slippery polymer coating with humidity-dependent nanoscale topography.

    Callau, M / Fajolles, C / Leroy, J / Verneuil, E / Guenoun, P

    Journal of colloid and interface science

    2023  Volume 642, Page(s) 724–735

    Abstract: Hypothesis: Slippery Omniphobic Covalently Attached Liquids (SOCAL) have been proposed for making omnirepellent thin films of self-assembled dimethylsiloxane polymer brushes grafted from silica surfaces. Smooth and flat at very small scale, these fluid ... ...

    Abstract Hypothesis: Slippery Omniphobic Covalently Attached Liquids (SOCAL) have been proposed for making omnirepellent thin films of self-assembled dimethylsiloxane polymer brushes grafted from silica surfaces. Smooth and flat at very small scale, these fluid surfaces could exhibit a more complex multiscale structure though showing very weak contact angle hysteresis (less than 5°).
    Experiment: In this work, coatings were deposited on glass surfaces from an acidic dimethoxydimethylsilane solution under carefully controlled relative humidity. Ellipsometry mapping was used to analyze the surface structuration with nanometric thickness sensitivity. The sliding properties were determined using a drop shape analyzer with a tilting device, and chemical analyses of the coatings were performed using on-surface techniques (XPS, ATR-FTIR spectroscopy).
    Findings: Coated materials possessed an unexpected surface structure with multiscale semispherical-like features, which surprisingly, did not increase the contact angle hysteresis. A careful study of some parameters of the coating process and the related evolution of the surface properties allowed us to propose a new model of the chemical organization of the polymer to support this remarkable liquid-like behavior. These structures are made of end-grafted strongly adsorbed Guiselin brushes with humidity-dependent thickness: the higher the humidity, the thinner and the more slippery the coating.
    Language English
    Publishing date 2023-04-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 241597-5
    ISSN 1095-7103 ; 0021-9797
    ISSN (online) 1095-7103
    ISSN 0021-9797
    DOI 10.1016/j.jcis.2023.03.198
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  2. Conference proceedings ; Online: Nombres irrationnels

    Leroy, Julien

    représentations périodiques et géométriques

    2020  

    Keywords Physical ; chemical ; mathematical & earth Sciences :: Mathematics ; Physique ; chimie ; mathématiques & sciences de la terre :: Mathématiques ; covid19
    Language English
    Publishing country be
    Document type Conference proceedings ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Conference proceedings ; Online: Factor complexity of minimal S-adic subshifts

    Leroy, Julien

    2020  

    Keywords Physical ; chemical ; mathematical & earth Sciences :: Mathematics ; Physique ; chimie ; mathématiques & sciences de la terre :: Mathématiques ; covid19
    Language English
    Publishing country be
    Document type Conference proceedings ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Conference proceedings ; Online: Minimal dendric subshifts

    Leroy, Julien

    2020  

    Keywords Physical ; chemical ; mathematical & earth Sciences :: Mathematics ; Physique ; chimie ; mathématiques & sciences de la terre :: Mathématiques ; covid19
    Language English
    Publishing country be
    Document type Conference proceedings ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Book ; Online: Sous-shifts dendriques et automorphismes du groupe libre

    Leroy, Julien

    2020  

    Keywords Physical ; chemical ; mathematical & earth Sciences :: Mathematics ; Physique ; chimie ; mathématiques & sciences de la terre :: Mathématiques ; covid19
    Language French
    Publishing date 2020-03-20
    Publishing country be
    Document type Book ; Online
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  6. Article ; Online: The Human Affectome Project: A dedication to Jaak Panksepp.

    Cromwell, Howard C / Lowe, Leroy J

    Neuroscience and biobehavioral reviews

    2022  Volume 138, Page(s) 104693

    Abstract: Mapping the neural basis of the Affectome was certainly the goal of Jaak Panksepp as he extended the work of a long line of thinkers from William James to Paul Maclean. Jaak's contribution was not just an incremental step, but a move to embrace feelings ... ...

    Abstract Mapping the neural basis of the Affectome was certainly the goal of Jaak Panksepp as he extended the work of a long line of thinkers from William James to Paul Maclean. Jaak's contribution was not just an incremental step, but a move to embrace feelings as a key component of affective science. His goal was to develop objective behavioral measures as he identified the neural substrates associated with affective states. He dedicated his career to studying the biological roots of emotional operating systems and his 1998 book "Affective Neuroscience" stands as a seminal accomplishment that provided a foundation for a field of research that has flourished since. His influences can be seen in many of the reviews created for this project and his early references to comfort zones are central to the human affectome. Indeed, Jaak was a tireless investigator who challenged our thinking, and he gave us many insights and gifts. We are immensely grateful for his contributions and this special issue is dedicated to his memory.
    MeSH term(s) Anniversaries and Special Events ; Emotions ; History, 20th Century ; Humans ; Male ; Motivation ; Neurosciences
    Language English
    Publishing date 2022-05-11
    Publishing country United States
    Document type Historical Article ; Journal Article ; Review
    ZDB-ID 282464-4
    ISSN 1873-7528 ; 0149-7634
    ISSN (online) 1873-7528
    ISSN 0149-7634
    DOI 10.1016/j.neubiorev.2022.104693
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    In stock of ZB MED Cologne/Königswinter

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  7. Article ; Online: Sensitivity of extreme precipitation to climate change inferred using artificial intelligence shows high spatial variability

    Leroy J. Bird / Gregory E. Bodeker / Kyle R. Clem

    Communications Earth & Environment, Vol 4, Iss 1, Pp 1-

    2023  Volume 14

    Abstract: Abstract Evaluating how extreme precipitation changes with climate is challenged by the paucity, brevity and inhomogeneity of observational records. Even when aggregating precipitation observations over large regions (obscuring potentially important ... ...

    Abstract Abstract Evaluating how extreme precipitation changes with climate is challenged by the paucity, brevity and inhomogeneity of observational records. Even when aggregating precipitation observations over large regions (obscuring potentially important spatial heterogeneity) the statistics describing extreme precipitation are often too uncertain to be of any practical value. Here we present an approach where a convolutional neural network (an artificial intelligence model) is trained on precipitation measurements from 10,000 stations to learn the spatial structure of the parameters of a generalised extreme value model, and the sensitivity of those parameters to the annual mean, global mean, surface temperature. The method is robust against the limitations of the observational record and avoids the short-comings of regional and global climate models in simulating the sensitivity of extreme precipitation to climate change. The maps of the sensitivity of extreme precipitation to climate change, on ~1.5 km × 1.5 km grids over North America, Europe, Australia and New Zealand, derived using the successfully trained convolutional neural network, show high spatial variability.
    Keywords Geology ; QE1-996.5 ; Environmental sciences ; GE1-350
    Subject code 910
    Language English
    Publishing date 2023-12-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Book ; Online: $\mathcal{S}$-adic characterization of minimal dendric shifts

    Gheeraert, France / Leroy, Julien

    2022  

    Abstract: Dendric shifts are defined by combinatorial restrictions of the extensions of the words in their languages. This family generalizes well-known families of shifts such as Sturmian shifts, Arnoux-Rauzy shifts and codings of interval exchange ... ...

    Abstract Dendric shifts are defined by combinatorial restrictions of the extensions of the words in their languages. This family generalizes well-known families of shifts such as Sturmian shifts, Arnoux-Rauzy shifts and codings of interval exchange transformations. It is known that any minimal dendric shift has a primitive $\mathcal{S}$-adic representation where the morphisms in $\mathcal{S}$ are positive tame automorphisms of the free group generated by the alphabet. In this paper we give an $\mathcal{S}$-adic characterization of this family by means of two finite graphs.

    Comment: 31 pages
    Keywords Mathematics - Dynamical Systems ; Computer Science - Discrete Mathematics ; 68R15 ; 37B10
    Publishing date 2022-06-01
    Publishing country us
    Document type Book ; Online
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  9. Article ; Online: Cyclic nucleotide phosphodiesterases as therapeutic targets in cardiac hypertrophy and heart failure.

    Kamel, Rima / Leroy, Jérôme / Vandecasteele, Grégoire / Fischmeister, Rodolphe

    Nature reviews. Cardiology

    2022  Volume 20, Issue 2, Page(s) 90–108

    Abstract: Cyclic nucleotide phosphodiesterases (PDEs) modulate the neurohormonal regulation of cardiac function by degrading cAMP and cGMP. In cardiomyocytes, multiple PDE isozymes with different enzymatic properties and subcellular localization regulate local ... ...

    Abstract Cyclic nucleotide phosphodiesterases (PDEs) modulate the neurohormonal regulation of cardiac function by degrading cAMP and cGMP. In cardiomyocytes, multiple PDE isozymes with different enzymatic properties and subcellular localization regulate local pools of cyclic nucleotides and specific functions. This organization is heavily perturbed during cardiac hypertrophy and heart failure (HF), which can contribute to disease progression. Clinically, PDE inhibition has been considered a promising approach to compensate for the catecholamine desensitization that accompanies HF. Although PDE3 inhibitors, such as milrinone or enoximone, have been used clinically to improve systolic function and alleviate the symptoms of acute HF, their chronic use has proved to be detrimental. Other PDEs, such as PDE1, PDE2, PDE4, PDE5, PDE9 and PDE10, have emerged as new potential targets to treat HF, each having a unique role in local cyclic nucleotide signalling pathways. In this Review, we describe cAMP and cGMP signalling in cardiomyocytes and present the various PDE families expressed in the heart as well as their modifications in pathological cardiac hypertrophy and HF. We also appraise the evidence from preclinical models as well as clinical data pointing to the use of inhibitors or activators of specific PDEs that could have therapeutic potential in HF.
    MeSH term(s) Humans ; Phosphodiesterase Inhibitors/therapeutic use ; Phosphodiesterase Inhibitors/pharmacology ; Phosphoric Diester Hydrolases/metabolism ; Heart Failure/drug therapy ; Cardiomegaly/drug therapy ; Nucleotides, Cyclic/metabolism ; Cyclic GMP/metabolism ; Myocytes, Cardiac/metabolism
    Chemical Substances Phosphodiesterase Inhibitors ; diethylstilbestrol monophosphate (47341-71-9) ; Phosphoric Diester Hydrolases (EC 3.1.4.-) ; Nucleotides, Cyclic ; Cyclic GMP (H2D2X058MU)
    Language English
    Publishing date 2022-09-01
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2490375-9
    ISSN 1759-5010 ; 1759-5002
    ISSN (online) 1759-5010
    ISSN 1759-5002
    DOI 10.1038/s41569-022-00756-z
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    Zs.A 6019: Show issues Location:
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  10. Article ; Online: [β-adrenergic regulation of the L-type Ca

    Leroy, Jérôme / Fischmeister, Rodolphe

    Medecine sciences : M/S

    2020  Volume 36, Issue 6-7, Page(s) 569–572

    Title translation Contrôle β-adrénergique du courant calcique de type L cardiaque - Le chaînon manquant enfin découvert.
    MeSH term(s) Action Potentials/drug effects ; Action Potentials/physiology ; Adrenergic Agents/pharmacology ; Animals ; Calcium/metabolism ; Calcium Channels, L-Type/drug effects ; Calcium Channels, L-Type/metabolism ; Calcium Signaling/drug effects ; Humans ; Myocytes, Cardiac/drug effects ; Myocytes, Cardiac/metabolism
    Chemical Substances Adrenergic Agents ; Calcium Channels, L-Type ; Calcium (SY7Q814VUP)
    Language French
    Publishing date 2020-07-02
    Publishing country France
    Document type News
    ZDB-ID 632733-3
    ISSN 1958-5381 ; 0767-0974
    ISSN (online) 1958-5381
    ISSN 0767-0974
    DOI 10.1051/medsci/2020104
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    Zs.B 2872: Show issues Location:
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