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  1. Article ; Online: The striplastron: A new circular stripline microwave launcher for plasma generation in capillary tubes.

    Leroy, O

    The Review of scientific instruments

    2022  Volume 93, Issue 7, Page(s) 73508

    Abstract: Until now, microwave plasmas could be ignited in small capillary tubes (inner diameter less than 1 mm) by generating surface waves propagating along their dielectric surfaces using mainly surfatron launchers or stripline-based launchers, such as "split- ... ...

    Abstract Until now, microwave plasmas could be ignited in small capillary tubes (inner diameter less than 1 mm) by generating surface waves propagating along their dielectric surfaces using mainly surfatron launchers or stripline-based launchers, such as "split-ring resonators." This work presents a novel launcher, which is called the "striplastron," because it is halfway between surfatrons and stripline launchers. It is a circular stripline directly excitated by a microcoaxial cable. Compared with the surfatron, it is smaller and the part of the plasma hidden by the launcher is limited to its thickness (∼1-2 cm). Moreover, its frequency response presents an intense and large resonance. Eventually, its geometry could allow the simultaneous ignition of several microplasmas in capillaries arranged in parallel, which could be very interesting for applications, such as the use of multi-tube microplasmas as metamaterials.
    Language English
    Publishing date 2022-08-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 209865-9
    ISSN 1089-7623 ; 0034-6748
    ISSN (online) 1089-7623
    ISSN 0034-6748
    DOI 10.1063/5.0084832
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: 04--apport des explorations microbiologiques au diagnostic des infections des voies respiratoires basses.

    Leroy, O

    Medecine et maladies infectieuses

    2006  Volume 36, Issue 11-12, Page(s) 570–598

    Abstract: The diagnosis of community-acquired pneumonia is usually based on clinical and radiological criteria. The identification of a causative organism is not required for the diagnosis. Although numerous microbiological techniques are available, their ... ...

    Title translation Contribution of microbiological investigations to the diagnosis of lower respiratory tract infections.
    Abstract The diagnosis of community-acquired pneumonia is usually based on clinical and radiological criteria. The identification of a causative organism is not required for the diagnosis. Although numerous microbiological techniques are available, their sensitivity and specificity are not high enough to guide first-line antimicrobial therapy. Consequently, this treatment remains most often empiric. If the causative organism is identified, the antimicrobial treatment is adapted. Sputum analysis may be proposed as a diagnostic tool for patients with an acute exacerbation of chronic obstructive pulmonary disease, in specific cases (prior antibiotherapy, hospitalization, failure of the empiric antimicrobial treatment).
    MeSH term(s) Acute Disease ; Animals ; Community-Acquired Infections/diagnosis ; Community-Acquired Infections/epidemiology ; Diagnosis, Differential ; Humans ; Legionnaires' Disease/epidemiology ; Pneumonia/diagnosis ; Pneumonia/epidemiology ; Respiratory Tract Infections/diagnosis ; Respiratory Tract Infections/epidemiology ; Respiratory Tract Infections/transmission
    Keywords covid19
    Language French
    Publishing date 2006-11-13
    Publishing country France
    Document type English Abstract ; Journal Article ; Review
    ZDB-ID 423536-8
    ISSN 0399-077X ; 1166-8237
    ISSN 0399-077X ; 1166-8237
    DOI 10.1016/j.medmal.2006.07.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1410: Show issues Location:
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  3. Article ; Online: Questions for European Vaccine Initiative.

    Leroy, Odile

    Human vaccines

    2010  Volume 6, Issue 6, Page(s) 435

    MeSH term(s) Clinical Trials as Topic ; Drug Design ; Europe ; Fund Raising ; Humans ; Malaria/prevention & control ; Vaccines/economics ; Vaccines/immunology ; Vaccines/therapeutic use
    Chemical Substances Vaccines
    Language English
    Publishing date 2010-06
    Publishing country United States
    Document type Journal Article
    ISSN 1554-8619
    ISSN (online) 1554-8619
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Comparison of Anodic and Au-Au Thermocompression Si-Wafer Bonding Methods for High-Pressure Microcooling Devices.

    Bargiel, Sylwester / Cogan, Julien / Queste, Samuel / Oliveri, Stefania / Gauthier-Manuel, Ludovic / Raschetti, Marina / Leroy, Olivier / Beurthey, Stéphan / Perrin-Terrin, Mathieu

    Micromachines

    2023  Volume 14, Issue 7

    Abstract: Silicon-based microchannel technology offers unmatched performance in the cooling of silicon pixel detectors in high-energy physics. Although Si-Si direct bonding, used for the fabrication of cooling plates, also meets the stringent requirements of this ... ...

    Abstract Silicon-based microchannel technology offers unmatched performance in the cooling of silicon pixel detectors in high-energy physics. Although Si-Si direct bonding, used for the fabrication of cooling plates, also meets the stringent requirements of this application (its high-pressure resistance of ~200 bar, in particular), its use is reported to be a challenging and expensive process. In this study, we evaluated two alternative bonding methods, aiming toward a more cost-effective fabrication process: Si-Glass-Si anodic bonding (AB) with a thin-film glass, and Au-Au thermocompression (TC). The bonding strengths of the two methods were evaluated with destructive pressure burst tests (0-690 bar) on test structures, each made of a 1 × 2 cm
    Language English
    Publishing date 2023-06-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2620864-7
    ISSN 2072-666X
    ISSN 2072-666X
    DOI 10.3390/mi14071297
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Pneumonies communautaires graves.

    Leroy, O

    La Revue du praticien

    2001  Volume 51, Issue 6, Page(s) 614–619

    Abstract: Community-acquired pneumonia is severe when hospitalisation is required. The diagnosis is based on pulmonary involvement (chest radiography) associated with vital signs abnormalities (mental status, temperature, blood pressure and ventilatory rate) or ... ...

    Title translation Severe community-acquired pneumonia.
    Abstract Community-acquired pneumonia is severe when hospitalisation is required. The diagnosis is based on pulmonary involvement (chest radiography) associated with vital signs abnormalities (mental status, temperature, blood pressure and ventilatory rate) or immunosuppression (neoplastic diseases). No specific causative pathogen could be incriminated. S. pneumoniae is the main causative pathogen. Prognosis-related factors are numerous. Among them, the effectiveness of the initial antimicrobial therapy appears as the main factor directly related to the medical intervention. First-line antimicrobial therapy, instituted as soon as possible, is empirical and must, always, be effective against S. pneumoniae. For pneumonia requiring admission into ICU, a wider antimicrobial spectrum based on antimicrobial combination is used. Mortality rates varying from 3 to 30% could be early predicted by specific prognostic indices.
    MeSH term(s) Anti-Bacterial Agents/therapeutic use ; Community-Acquired Infections ; Hospitalization ; Humans ; Pneumococcal Infections/diagnosis ; Pneumococcal Infections/drug therapy ; Pneumococcal Infections/pathology ; Pneumonia/diagnosis ; Pneumonia/drug therapy ; Pneumonia/pathology ; Prognosis
    Chemical Substances Anti-Bacterial Agents
    Language French
    Publishing date 2001-03-31
    Publishing country France
    Document type English Abstract ; Journal Article
    ZDB-ID 205365-2
    ISSN 2101-017X ; 0035-2640
    ISSN (online) 2101-017X
    ISSN 0035-2640
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.433: Show issues Location:
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  6. Article ; Online: Burden of Candida-related vascular graft infection: a nested-case control study.

    Caulier, Thomas / Senneville, Eric / Sobocinski, Jonathan / Leroy, Olivier / Patoz, Pierre / Blondiaux, Nicolas / Georges, Hugues / Pierre-Yves, Delannoy / d'Elia, PierVito / Robineau, Olivier

    Infection

    2024  

    Abstract: Purpose: We aimed to assess risk factors of candida-related Vascular Graft Infections (VGIs).: Methods: We did a case-control study (1:4) matched by age and year of infection, nested in a cohort of patient with a history of VGIs. Cases were defined ... ...

    Abstract Purpose: We aimed to assess risk factors of candida-related Vascular Graft Infections (VGIs).
    Methods: We did a case-control study (1:4) matched by age and year of infection, nested in a cohort of patient with a history of VGIs. Cases were defined by a positive culture for Candida spp. in biological samples and controls were defined by a positive culture for bacterial strains only in biological samples. Risk factors for Candida-related VGIs were investigated using multivariate logistic regression. Mortality were compared using survival analysis.
    Results: 16 Candida-related VGIs were matched to 64 bacterial-related VGIs. The two groups were comparable regarding medical history and clinical presentation. Candida-related VGIs were associated with bacterial strains in 88% (14/16). Gas/fluid-containing collection on abdominal CT scan and the presence of an aortic endoprosthesis were risk factors for Candida spp.-related VGIs [RRa 10.43 [1.81-60.21] p = 0.009 RRa and 6.46 [1.17-35.73] p = 0.03, respectively]. Candida-related VGIs were associated with a higher mortality when compared to bacterial-related VGIs (p = 0.002).
    Conclusions: Candida-related VGIs are severe. Early markers of Candida spp. infection are needed to improve their outcome. The suspicion of aortic endoprosthesis infection may necessitate probabilistic treatment with antifungal agents.
    Language English
    Publishing date 2024-02-08
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 185104-4
    ISSN 1439-0973 ; 0300-8126 ; 0173-2129
    ISSN (online) 1439-0973
    ISSN 0300-8126 ; 0173-2129
    DOI 10.1007/s15010-023-02172-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 881: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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    Zs.MO 528: Show issues

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  7. Article: Quels prélèvements aux urgences pour le diagnostic microbiologique d’une infection pulmonaire communautaire grave du sujet immunocompétent ?

    Thellier, D / Georges, H / Leroy, O

    Reanimation : journal de la Societe de reanimation de langue francaise

    2014  Volume 23, Issue 5, Page(s) 490–497

    Abstract: Current diagnostic methods allow microbial identification in 50% of patients admitted with severe community-acquired pneumonia (CAP). Guidelines derived from epidemiological data help physicians to start empirical antimicrobial therapy. Definitive ... ...

    Title translation Which samples to obtain in the emergency department for the microbiological diagnosis of community-acquired pneumonia in the immunocompetent patient?
    Abstract Current diagnostic methods allow microbial identification in 50% of patients admitted with severe community-acquired pneumonia (CAP). Guidelines derived from epidemiological data help physicians to start empirical antimicrobial therapy. Definitive microbial diagnosis is useful to guide further pathogen-directed therapy. Blood cultures, cultures of respiratory specimens and urine antigen tests are recommended to determine the causative bacterial pathogen. Positive blood cultures range from 15 to 25% of CAP patients according to severity. Whether sputum specimens represent or not lower respiratory secretions determines its accuracy in CAP microbial diagnosis. In intubated patients, endotracheal aspirates are often of interest. Detection of positive pneumococcal or legionella urinary antigen is often associated with CAP severity. The sensitivity of this test is not decreased in patients who have received antibiotics prior to sampling. Viral pneumonia account for 10 to 40% of severe CAP. Nasal swabs are recommended for influenza identification using polymerase chain reaction (PCR) in order to deliver oseltamivir treatment. In the emergency department, atypical pneumonia serology is less useful than respiratory specimens obtained using fiberoptic bronchoscopy. Serum PCR to diagnose bacterial CAP is not superior to the other usual methods.
    Keywords covid19
    Language French
    Publishing date 2014-09-23
    Publishing country France
    Document type English Abstract ; Journal Article
    ZDB-ID 2046519-1
    ISSN 1951-6959 ; 1624-0693 ; 1164-6756
    ISSN (online) 1951-6959
    ISSN 1624-0693 ; 1164-6756
    DOI 10.1007/s13546-014-0923-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4839: Show issues Location:
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  8. Book: Key demographics in retirement risk management

    Stone, Leroy O

    2012  

    Author's details Leroy O. Stone (ed.)
    Keywords Retirement/Planning/Psychological aspects ; Retirement/Sociological aspects ; Altersvorsorge ; Sparen ; Anlageverhalten ; Privater Haushalt ; Lebensstandard ; Ältere Menschen
    Language English
    Size XVIII, 144 S., graph. Darst., 235 mm x 155 mm
    Publisher Springer
    Publishing place Dordrecht u.a.
    Document type Book
    Note Enth. 8 Beitr.
    ISBN 9400740433 ; 9789400740433
    Database ECONomics Information System

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  9. Article: Espoirs et enjeux des stratégies vaccinales contre le paludisme. Pourquoi nous devons faire mieux.

    Leroy, Odile

    Bulletin de l'Academie nationale de medecine

    2007  Volume 191, Issue 7, Page(s) 1249–59; discussion 1259–60

    Abstract: During the last 10 years the development of a malaria vaccine has attracted an increasing amount of attention both from the political sector and from financial investors. This has led to a number of major scientific and technological advances, but much ... ...

    Title translation Perspectives and challenges of malaria vaccine. Why we must do more.
    Abstract During the last 10 years the development of a malaria vaccine has attracted an increasing amount of attention both from the political sector and from financial investors. This has led to a number of major scientific and technological advances, but much remains to be done. Numerous potential target antigens are under investigation, and most research is focusing on a subunit vaccine. Irradiated attenuated sporozoites are also a promising approach, even if major technological and regulatory challenges remain to be overcome. Barriers to vaccine development include an inadequate understanding of certain aspects of host-parasite biology and protective immune responses. Other challenges are to increase the antigenicity of some antigens, and to optimize the quality of the immune response. However, research funding remains the main obstacle.
    MeSH term(s) Animals ; Anopheles/parasitology ; Forecasting ; Humans ; Insect Vectors/parasitology ; Life Cycle Stages ; Malaria/prevention & control ; Malaria Vaccines/immunology ; Malaria, Falciparum/prevention & control ; Plasmodium falciparum/immunology ; Plasmodium falciparum/physiology ; Plasmodium falciparum/radiation effects ; Vaccines, Attenuated ; Vaccines, Subunit/immunology
    Chemical Substances Malaria Vaccines ; Vaccines, Attenuated ; Vaccines, Subunit
    Language French
    Publishing date 2007-10
    Publishing country Netherlands
    Document type English Abstract ; Journal Article ; Review
    ZDB-ID 213227-8
    ISSN 0001-4079
    ISSN 0001-4079
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Continuous Infusion of High Doses of Cefepime in Intensive Care Unit: Assessment of Steady-State Plasma Level and Incidence on Neurotoxicity.

    Jean-Michel, Vanessa / Homey, Corentin / Devos, Patrick / Delannoy, Pierre-Yves / Boussekey, Nicolas / Caulier, Thomas / Leroy, Olivier / Georges, Hugues

    Antibiotics (Basel, Switzerland)

    2022  Volume 12, Issue 1

    Abstract: Continuous infusion (CI) with high doses of cefepime is recommended in the empirical antimicrobial regimen of critically ill patients with suspected Gram-negative sepsis. This study aimed to determine factors associated with cefepime overdosing and the ... ...

    Abstract Continuous infusion (CI) with high doses of cefepime is recommended in the empirical antimicrobial regimen of critically ill patients with suspected Gram-negative sepsis. This study aimed to determine factors associated with cefepime overdosing and the incidence of cefepime-induced neurotoxicity (CIN) in these patients. We performed a retrospective study including all patients receiving cefepime treatment between January 2019 and May 2022. The plasma level of cefepime defining overdosing was over 35 mg/L. Neurotoxicity was defined according to strict criteria and correlated with concomitant steady-state concentration of cefepime. Seventy-eight courses of cefepime treatment were analyzed. The mean cefepime plasma level at steady state was 59.8 ± 29.3 mg/L, and overdosing occurred in 80% of patients. Renal failure and a daily dose > 5 g were independently associated with overdosing. CIN was present in 30% of patients. In multivariate analysis, factors associated with CIN were chronic renal failure and a cefepime plasma concentration ≥ 60 mg/L. CIN was not associated with mortality. Overdosing is frequent in patients receiving high doses of cefepime by CI. Steady-state levels are higher than targeted therapeutic pharmacokinetic/pharmacodynamic objectives. The risk of CIN is important when the plasma concentration is ≥60 mg/L.
    Language English
    Publishing date 2022-12-30
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics12010069
    Database MEDical Literature Analysis and Retrieval System OnLINE

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