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  1. AU="Lesage, C"
  2. AU=Kim Donghyun AU=Kim Donghyun
  3. AU="Weisburd, Ben"
  4. AU="van den Berg, Linda M"
  5. AU="Kurochkina, Yu D"
  6. AU="H Cao"
  7. AU="Elias, Rui"
  8. AU="Hofstaedter, Ferdinand"
  9. AU="Ross, Ashley E"
  10. AU="Luque Alarcón, Mónica"

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  1. Artikel: Posterior cord syndrome associated with immune checkpoint inhibitors for metastatic melanoma.

    Secco, L-P / Lesage, C / Lippi, A / Maria, A

    Annales de dermatologie et de venereologie

    2021  Band 148, Heft 3, Seite(n) 193–194

    Mesh-Begriff(e) Humans ; Immune Checkpoint Inhibitors ; Melanoma/drug therapy ; Skin Neoplasms/drug therapy
    Chemische Substanzen Immune Checkpoint Inhibitors
    Sprache Englisch
    Erscheinungsdatum 2021-02-04
    Erscheinungsland France
    Dokumenttyp Letter
    ZDB-ID 391805-1
    ISSN 2214-5451 ; 0151-9638
    ISSN (online) 2214-5451
    ISSN 0151-9638
    DOI 10.1016/j.annder.2020.11.008
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  2. Artikel ; Online: Association inhabituelle d’inhibiteurs de BRAF et de MEK : réponse clinique d’un mélanome métastatique traité par dabrafénib–cobimétinib.

    Leenhardt, Fanny / Mbatchi, Litaty / Evrard, Alexandre / Cupissol, Didier / Lesage, Candice

    Bulletin du cancer

    2023  Band 110, Heft 7-8, Seite(n) 865–868

    Abstract: Despite the efficacy of targeted therapies in melanoma, the management of adverse events with BRAFi and MEKi (inhibitors) is one of the limits of these treatments. Close monitoring is required to ensure efficacy and patient safety. In this case study, we ...

    Titelübersetzung Unusual association of BRAF and MEK inhibitors: Clinical response of metastatic melanoma treated with dabrafenib-cobimetinib.
    Abstract Despite the efficacy of targeted therapies in melanoma, the management of adverse events with BRAFi and MEKi (inhibitors) is one of the limits of these treatments. Close monitoring is required to ensure efficacy and patient safety. In this case study, we report a patient treated for metastatic melanoma with an unusual and innovative combination of dabrafenib (BRAFi) and cobimetinib (MEKi), to manage pyrexia, and lead to complete remission for 19 months. This is the first case ever reported of metastatic melanoma treated with this off-label combination and characterized by the use of therapeutic drug monitoring.
    Mesh-Begriff(e) Humans ; Proto-Oncogene Proteins B-raf/genetics ; Melanoma/drug therapy ; Melanoma/pathology ; Protein Kinase Inhibitors/adverse effects ; Mitogen-Activated Protein Kinase Kinases ; Skin Neoplasms/drug therapy ; Skin Neoplasms/pathology ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Mutation
    Chemische Substanzen dabrafenib (QGP4HA4G1B) ; cobimetinib (ER29L26N1X) ; Proto-Oncogene Proteins B-raf (EC 2.7.11.1) ; Protein Kinase Inhibitors ; Mitogen-Activated Protein Kinase Kinases (EC 2.7.12.2) ; BRAF protein, human (EC 2.7.11.1)
    Sprache Französisch
    Erscheinungsdatum 2023-03-23
    Erscheinungsland France
    Dokumenttyp Case Reports ; English Abstract ; Letter
    ZDB-ID 213270-9
    ISSN 1769-6917 ; 0007-4551
    ISSN (online) 1769-6917
    ISSN 0007-4551
    DOI 10.1016/j.bulcan.2023.02.019
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  3. Artikel: Angiosarcomes cutanés de la tête et du cou inopérables traités par bevacizumab et paclitaxel.

    Becquart, O / Girard, C / Lesage, C / Guillot, B

    Annales de dermatologie et de venereologie

    2018  Band 145, Heft 6-7, Seite(n) 451–453

    Titelübersetzung Angiosarcoma of the head and neck treated with bevacizumab and paclitaxel.
    Mesh-Begriff(e) Aged ; Aged, 80 and over ; Antineoplastic Agents, Immunological/administration & dosage ; Antineoplastic Agents, Phytogenic/administration & dosage ; Bevacizumab/administration & dosage ; Drug Therapy, Combination ; Fatal Outcome ; Female ; Head and Neck Neoplasms/drug therapy ; Hemangiosarcoma/drug therapy ; Humans ; Male ; Paclitaxel/administration & dosage ; Skin Neoplasms/drug therapy
    Chemische Substanzen Antineoplastic Agents, Immunological ; Antineoplastic Agents, Phytogenic ; Bevacizumab (2S9ZZM9Q9V) ; Paclitaxel (P88XT4IS4D)
    Sprache Französisch
    Erscheinungsdatum 2018-04-24
    Erscheinungsland France
    Dokumenttyp Case Reports ; Letter
    ZDB-ID 391805-1
    ISSN 2214-5451 ; 0151-9638
    ISSN (online) 2214-5451
    ISSN 0151-9638
    DOI 10.1016/j.annder.2018.02.008
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  4. Artikel ; Online: Melanoma and intellectual disability: do prognostic factors at diagnosis differ from general population?

    Lesage, C / Habib-Hadef, S / Trétarre, B / Lesage, F-X / Bessaoud, F / Varey, E / Guillot, B / Satgé, D

    Journal of intellectual disability research : JIDR

    2022  Band 66, Heft 4, Seite(n) 392–398

    Abstract: Background: Few melanoma cases are reported in individuals with intellectual disability (ID), and prognostic factors at diagnosis are unknown in this population. This work was designed to investigate whether prognostic factors at diagnostic are ... ...

    Abstract Background: Few melanoma cases are reported in individuals with intellectual disability (ID), and prognostic factors at diagnosis are unknown in this population. This work was designed to investigate whether prognostic factors at diagnostic are different in patients with ID compared with a general population.
    Methods: Melanoma cases retrieved from Hérault's Tumour Registry (HTR) from 1995 to 2015 were cross-referenced against a list of adult patients with ID, living in Hérault. Major prognostic factors were compared with those in non-ID melanoma patients included in HTR and in patients followed by Montpellier University Hospital and included in the Réseau pour la Recherche et l'Investigation Clinique sur le Mélanome (RIC-Mel) database.
    Results: Ten melanoma cases in individuals with ID were identified and compared with 3804 non-ID melanoma cases in HTR and 1024 non-ID melanoma cases included in RIC-Mel. Mean Breslow thickness at diagnosis was 4.6 mm in melanoma cases among those with ID versus 1.89 mm in HTR (P = 0.109) and 2.36 mm in RIC-Mel (P = 0.156). Stage at diagnosis was superior to stage IIB in 42.9% of ID cases versus 11.4% of non-ID cases in HTR (P < 0.05) and 8.5% in RIC-Mel (P < 0.05).
    Conclusions: Melanomas in patients with ID had less favourable prognostic factors at diagnosis, including higher Breslow thickness and more advanced stage, than melanomas in non-ID patients. These adverse prognostic factors indicate a later diagnosis in this population, leading to a poorer prognosis. This work underlines the need to improve melanoma screening among individuals with ID.
    Mesh-Begriff(e) Adult ; Humans ; Intellectual Disability/diagnosis ; Intellectual Disability/epidemiology ; Melanoma/diagnosis ; Melanoma/epidemiology ; Melanoma/pathology ; Prognosis ; Registries ; Skin Neoplasms/diagnosis ; Skin Neoplasms/epidemiology ; Skin Neoplasms/pathology
    Sprache Englisch
    Erscheinungsdatum 2022-02-08
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1103832-9
    ISSN 1365-2788 ; 0964-2633
    ISSN (online) 1365-2788
    ISSN 0964-2633
    DOI 10.1111/jir.12915
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  5. Artikel ; Online: Efficiency and tolerance of second-line triple BRAF inhibitor/MEK inhibitor/anti-PD1 combined therapy in BRAF mutated melanoma patients with central nervous system metastases occurring during first-line combined targeted therapy: a real-life survey.

    Fabre, Marie / Lamoureux, Anouck / Meunier, Laurent / Samaran, Quentin / Lesage, Candice / Girard, Céline / Du Thanh, Aurélie / Moulis, Lionel / Dereure, Olivier

    Melanoma research

    2024  Band 34, Heft 3, Seite(n) 241–247

    Abstract: Although current systemic therapies significantly improved the outcome of advanced melanoma, the prognosis of patient with central nervous system (CNS) metastases remains poor especially when clinically symptomatic. We aimed to investigate the efficiency ...

    Abstract Although current systemic therapies significantly improved the outcome of advanced melanoma, the prognosis of patient with central nervous system (CNS) metastases remains poor especially when clinically symptomatic. We aimed to investigate the efficiency of CNS targets and tolerance of second-line combined anti-PD1/dual-targeted anti-BRAF/anti-MEK therapy implemented in patients with CNS progression after initially efficient first-line combined targeted therapy in patients with BRAF-mutated melanoma in a real-life setting. A monocentric retrospective analysis including all such patients treated from January 2017 to January 2022 was conducted in our tertiary referral center. The response of CNS lesions to second-line triple therapy was assessed through monthly clinical and at least quarterly morphological (according to RECIST criteria) evaluation. Tolerance data were also collected. Seventeen patients were included with a mean follow-up of 2.59 (±2.43) months. Only 1 patient displayed a significant clinical and morphological response. No statistically significant difference was observed between patients receiving or not additional local therapy (mainly radiotherapy) as to response achievement. Immunotherapy was permanently discontinued in 1 patient owing to grade 4 toxicity. Mean PFS and OS after CNS progression were 2.59 and 4.12 months, respectively. In this real-life survey, the subsequent addition of anti-PD1 to combined targeted therapy in melanoma patients with upfront CNS metastases did not result in significant response of CNS targets in most BRAF mutated melanoma patients with secondary CNS progression after initially successful first-line combined targeted therapy.
    Mesh-Begriff(e) Humans ; Melanoma/drug therapy ; Melanoma/genetics ; Melanoma/pathology ; Female ; Male ; Proto-Oncogene Proteins B-raf/genetics ; Middle Aged ; Aged ; Retrospective Studies ; Central Nervous System Neoplasms/secondary ; Central Nervous System Neoplasms/drug therapy ; Adult ; Skin Neoplasms/drug therapy ; Skin Neoplasms/genetics ; Skin Neoplasms/pathology ; Protein Kinase Inhibitors/therapeutic use ; Protein Kinase Inhibitors/pharmacology ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Immune Checkpoint Inhibitors/therapeutic use ; Immune Checkpoint Inhibitors/pharmacology ; Mutation ; Programmed Cell Death 1 Receptor/antagonists & inhibitors ; Aged, 80 and over
    Chemische Substanzen Proto-Oncogene Proteins B-raf (EC 2.7.11.1) ; BRAF protein, human (EC 2.7.11.1) ; Protein Kinase Inhibitors ; Immune Checkpoint Inhibitors ; Programmed Cell Death 1 Receptor
    Sprache Englisch
    Erscheinungsdatum 2024-03-28
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 1095779-0
    ISSN 1473-5636 ; 0960-8931
    ISSN (online) 1473-5636
    ISSN 0960-8931
    DOI 10.1097/CMR.0000000000000963
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  6. Artikel ; Online: Material-Assisted Strategies for Osteochondral Defect Repair.

    Lesage, Constance / Lafont, Marianne / Guihard, Pierre / Weiss, Pierre / Guicheux, Jérôme / Delplace, Vianney

    Advanced science (Weinheim, Baden-Wurttemberg, Germany)

    2022  Band 9, Heft 16, Seite(n) e2200050

    Abstract: The osteochondral (OC) unit plays a pivotal role in joint lubrication and in the transmission of constraints to bones during movement. The OC unit does not spontaneously heal; therefore, OC defects are considered to be one of the major risk factors for ... ...

    Abstract The osteochondral (OC) unit plays a pivotal role in joint lubrication and in the transmission of constraints to bones during movement. The OC unit does not spontaneously heal; therefore, OC defects are considered to be one of the major risk factors for developing long-term degenerative joint diseases such as osteoarthritis. Yet, there is currently no curative treatment for OC defects, and OC regeneration remains an unmet medical challenge. In this context, a plethora of tissue engineering strategies have been envisioned over the last two decades, such as combining cells, biological molecules, and/or biomaterials, yet with little evidence of successful clinical transfer to date. This striking observation must be put into perspective with the difficulty in comparing studies to identify overall key elements for success. This systematic review aims to provide a deeper insight into the field of material-assisted strategies for OC regeneration, with particular considerations for the therapeutic potential of the different approaches (with or without cells or biological molecules), and current OC regeneration evaluation methods. After a brief description of the biological complexity of the OC unit, the recent literature is thoroughly analyzed, and the major pitfalls, emerging key elements, and new paths to success are identified and discussed.
    Mesh-Begriff(e) Biocompatible Materials ; Bone and Bones ; Cartilage, Articular/surgery ; Tissue Engineering/methods ; Tissue Scaffolds
    Chemische Substanzen Biocompatible Materials
    Sprache Englisch
    Erscheinungsdatum 2022-03-24
    Erscheinungsland Germany
    Dokumenttyp Journal Article ; Review ; Systematic Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2808093-2
    ISSN 2198-3844 ; 2198-3844
    ISSN (online) 2198-3844
    ISSN 2198-3844
    DOI 10.1002/advs.202200050
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  7. Artikel ; Online: Can postoperative calcemia kinetics predict the risk of hypocalcemia for the management of parathyroid adenoma in ambulatory surgery?

    Duplay, Q / Riou, J / Lesage, C / Legrand, E / Rodien, P / Mucci, S / Hamy, A

    Journal of visceral surgery

    2019  Band 157, Heft 3, Seite(n) 175–182

    Abstract: Introduction: The goal of this study was to analyse the kinetics of corrected calcemia levels (Cac) after parathyroid excision and to determine the percentage of variation (ΔCa) in the initial hours after surgery, in order to entertain an early ... ...

    Abstract Introduction: The goal of this study was to analyse the kinetics of corrected calcemia levels (Cac) after parathyroid excision and to determine the percentage of variation (ΔCa) in the initial hours after surgery, in order to entertain an early discharge.
    Population and methods: Were included in this study, patients undergoing operation for parathyroid adenoma responsible for primary hyperparathyroidism (PHP). The Cac was measure preoperatively and four hours after surgery, and then every day until patient discharge. Group A included patients for whom the Cac was inferior to 2.2mmol/L at least once postoperatively while group B included patients for whom the Cac was always equal or superior to 2.2mmol/L. The ΔCa represented the percentage of the fall in postoperative Cac with respect to preoperative Cac.
    Results: Between 2010 and 2017, 156 patients fulfilled the inclusion criteria (women 80.8%, [sex ratio 1:4], median age 64 years old). Preoperative Cac was statistically significantly lower in group A compared to group B (2.67 vs. 2.82mmol/L; P<0.0001). In total, 9.6% of patients had calcium supplementation for hypocalcemia, symptomatic or not. Postoperative Cac reached its nadir value on postoperative day 2. At four hours postoperative, the risk of postoperative calcelmia falling below 2.2mmol/L appeared when the ΔCa was superior to 6% with a sensitivity of 92.9% and a negative predictive value of 97.4%.
    Conclusion: After excision of a parathyroid adenoma for PHP, the Cac falls rapidly and reaches its nadir value on day 2. If the fall in calcemia is less than 6% four hours after surgery (vs. preoperative level), early discharge within the framework of ambulatory surgery is possible.
    Mesh-Begriff(e) Adenoma/metabolism ; Adenoma/surgery ; Aged ; Ambulatory Surgical Procedures ; Calcium/metabolism ; Female ; Humans ; Hypocalcemia/epidemiology ; Kinetics ; Male ; Middle Aged ; Parathyroid Neoplasms/metabolism ; Parathyroid Neoplasms/surgery ; Parathyroidectomy ; Postoperative Complications/epidemiology ; Postoperative Period ; Risk Assessment
    Chemische Substanzen Calcium (SY7Q814VUP)
    Sprache Englisch
    Erscheinungsdatum 2019-12-19
    Erscheinungsland France
    Dokumenttyp Journal Article ; Observational Study
    ISSN 1878-7886
    ISSN (online) 1878-7886
    DOI 10.1016/j.jviscsurg.2019.12.001
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  8. Artikel: Femmes de lettres a venise aux XVIe et XVIIe siecles: Moderata Fonte, Lucrezia Marinella, Arcangela Tarabotti.

    Lesage, C

    Clio (Toulouse, France)

    2001  , Heft 13, Seite(n) 135–144

    Titelübersetzung Women of letters in 16th- and 17th-century Venice: Moderata Fonte, Lucrezia Marinella, Arcangela Tarabotti.
    Mesh-Begriff(e) Authorship ; Correspondence as Topic/history ; Education/economics ; Education/history ; Education/legislation & jurisprudence ; History, 16th Century ; History, 17th Century ; Hostility ; Intelligence/physiology ; Italy/ethnology ; Power (Psychology) ; Prejudice ; Social Behavior ; Social Class ; Social Conditions/economics ; Social Conditions/history ; Social Conditions/legislation & jurisprudence ; Social Dominance ; Women/education ; Women/history ; Women/psychology ; Women's Health/economics ; Women's Health/ethnology ; Women's Health/history ; Women's Health/legislation & jurisprudence ; Women's Rights/economics ; Women's Rights/education ; Women's Rights/history ; Women's Rights/legislation & jurisprudence
    Sprache Französisch
    Erscheinungsdatum 2001
    Erscheinungsland France
    Dokumenttyp Historical Article ; Journal Article
    ISSN 1252-7017
    ISSN 1252-7017
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  9. Artikel: Fréquence des sensibilisations de contact aux pansements modernes utilisés sur les ulcères de jambe.

    Garval, E / Plee, J / Lesage, C / Grange-Prunier, A / Bernard, P / Perceau, G

    Annales de dermatologie et de venereologie

    2018  Band 145, Heft 5, Seite(n) 339–346

    Abstract: Introduction: Allergic contact dermatitis around chronic leg ulcers (CLU) is a common complication in patients presenting CLU and prolongs healing times. The aim of this study was to describe the rate of sensitization to modern dressings (MD) used in ... ...

    Titelübersetzung Frequency of contact sensitization to modern dressings used to treat chronic leg ulcer.
    Abstract Introduction: Allergic contact dermatitis around chronic leg ulcers (CLU) is a common complication in patients presenting CLU and prolongs healing times. The aim of this study was to describe the rate of sensitization to modern dressings (MD) used in these patients and to assess whether there is a relation between the number of sensitizations and ulcer type, the time from onset of the ulcer, and patient age and gender.
    Patients and methods: We conducted a retrospective study at Reims University Hospital between 2010 and 2014 that included all patients with CLU of vascular etiology surrounded by eczematous lesions, and who had one of the patch-tests in the following 3 series: European baseline±leg ulcers±corticosteroids.
    Results: Among the 73 patients included, 43 % were polysensitized. Thirty-three patients (45 %) were sensitized to MD (38 % to hydrocolloids, 18 % to hydrogels, 7 % to hydrocellular dressings, 7 % to hydrofiber dressings, 5 % to contact layers and 3 % to alginates). Median age and sex did not differ between "polysensitized" patients and "non-polysensitized" patients (P=0.84 and P=0.25, respectively). Polysensitization was more frequent among patients presenting ulcers for more than 5 years (P=0.032).
    Conclusion: Practically half of all patients presenting CLU with surrounding contact dermatitis had sensitization to modern dressings (mostly hydrocolloids and hydrogels). The rate of sensitization increased with the length of presence of CLU.
    Mesh-Begriff(e) Adult ; Aged ; Aged, 80 and over ; Bandages/adverse effects ; Chronic Disease ; Dermatitis, Allergic Contact/diagnosis ; Dermatitis, Allergic Contact/epidemiology ; Dermatitis, Allergic Contact/etiology ; Female ; France/epidemiology ; Humans ; Leg Ulcer/therapy ; Male ; Middle Aged ; Patch Tests ; Retrospective Studies
    Sprache Französisch
    Erscheinungsdatum 2018-04-17
    Erscheinungsland France
    Dokumenttyp Journal Article
    ZDB-ID 391805-1
    ISSN 2214-5451 ; 0151-9638
    ISSN (online) 2214-5451
    ISSN 0151-9638
    DOI 10.1016/j.annder.2018.01.048
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  10. Artikel: ASAXS study of the influence of sulfidation conditions and organic additives on sulfide slabs multiscale organization

    Humbert, S. / Devers, E. / Lesage, C. / Legens, C. / Lemaitre, L. / Sorbier, L. / De Geuser, F. / Briois, V.

    Journal of catalysis. 2021 Mar., v. 395

    2021  

    Abstract: One of the ways to improve the activity of the sulfide catalysts is to increase the quantity of molybdenum up to contents greater than 15 wt%. For such high Mo contents, the distribution of MoS₂ particles is suspected to play an important role in the ... ...

    Abstract One of the ways to improve the activity of the sulfide catalysts is to increase the quantity of molybdenum up to contents greater than 15 wt%. For such high Mo contents, the distribution of MoS₂ particles is suspected to play an important role in the catalytic activity. A complete description of the active phase is thus required and implies measuring i) the size and stacking distribution of the isolated slabs, ii) the proportion of Mo involved in aggregates or individual slabs, iii) the size of the aggregates. These steps are essential to deeply explain the intrinsic activity of the catalysts. To address this challenge, Anomalous Small-Angle X-ray Scattering (ASAXS) analyses have been performed on different sets of catalysts, prepared with various organic additives and activated either by a gas sulfidation (1 bar, 350 °C,15%H₂S/H₂) or by real industrial liquid sulfidation (30 bar, 350 °C, H₂/gas oil/DMDS). Furthermore, the spent catalysts were also characterized after HDS catalytic test on a real feedstock. The aim of this study was not to elucidate in detail the chemical mechanisms involved when using additives or different sulfidation conditions, but rather to better understand the impact of the microstructural organization on catalytic performances and demonstrate the potential of the ASAXS technique to give new insights on the multi-scale organization of the molybdenum active phase. We thus demonstrate that ASAXS allows to obtain a more detailed description of the slabs compared to TEM and, simultaneously, to identify and quantify the aggregation state of the particles which occurs on high loaded catalysts. The role of the additives is clearly highlighted after liquid sulfidation, as we demonstrate the dispersive effect of triethylene glycol and thioglycolic acid and to a lower extent of citric acid. The slab length and stacking are decreased, as well as the aggregate amount and size. The analysis of the spent catalysts have also revealed the significant evolution of the active phase under HDS reaction conditions. Among other parameters, the aggregate amount appears as a relevant descriptor since a correlation is found with the intrinsic catalytic performances, which suggests an issue of active sites accessibility.
    Schlagwörter catalytic activity ; citric acid ; evolution ; feedstocks ; liquids ; molybdenum ; small-angle X-ray scattering ; triethylene glycol
    Sprache Englisch
    Erscheinungsverlauf 2021-03
    Umfang p. 412-424.
    Erscheinungsort Elsevier Inc.
    Dokumenttyp Artikel
    ZDB-ID 1468993-5
    ISSN 1090-2694 ; 0021-9517
    ISSN (online) 1090-2694
    ISSN 0021-9517
    DOI 10.1016/j.jcat.2021.01.033
    Datenquelle NAL Katalog (AGRICOLA)

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