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  1. Article: An Atypical Presentation of Childhood Paraganglioma with Seizures: A Case Report and Review of the Literature.

    Oyenusi, Elizabeth Eberechi / Nwigbo, Uzoamaka Felicia / Oladipo, Oluwadamilola Moromoke / Kene-Udemezue, Blessing Ebele / Akowundu, Kasarachi Pauline / Oleolo-Ayodeji, Khadijah Omobusola / Afoke, Oluwaseun Adunni / Babatunde, Funmilayo Oluwatoyin / Alakaloko, Felix Makinde / Asiyanbi, Gabriel Kolawole / Ogunleye, Ezekiel Olayiwola / Oduwole, Abiola Olufunmilayo / Lesi, Foluso Ebun Afolabi

    Case reports in endocrinology

    2023  Volume 2023, Page(s) 6637802

    Abstract: Introduction: A paraganglioma (PGL) is a tumour derived from extra-adrenal chromaffin cells of the sympathetic paravertebral ganglia of the thorax, abdomen, and pelvis. Cardiovascular manifestations predominate but neurological symptoms like seizures ... ...

    Abstract Introduction: A paraganglioma (PGL) is a tumour derived from extra-adrenal chromaffin cells of the sympathetic paravertebral ganglia of the thorax, abdomen, and pelvis. Cardiovascular manifestations predominate but neurological symptoms like seizures can occur requiring a high index of suspicion for prompt diagnosis and treatment.
    Conclusion: In evaluating aetiology of childhood hypertension, endocrine causes must be considered though they are rare. The occurrence of paraganglioma is uncommon and can present in unusual ways such as seizures. Measurement of blood pressure in children is advocated as part of routine health care. Clinicians must explore the aetiology of seizures and not merely control them with anticonvulsant therapy.
    Language English
    Publishing date 2023-11-27
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2627633-1
    ISSN 2090-651X ; 2090-6501
    ISSN (online) 2090-651X
    ISSN 2090-6501
    DOI 10.1155/2023/6637802
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Paediatric acute kidney injury in a tertiary hospital in Nigeria: prevalence, causes and mortality rate.

    Esezobor, Christopher Imokhuede / Ladapo, Taiwo Augustina / Osinaike, Babayemi / Lesi, Foluso Ebun Afolabi

    PloS one

    2012  Volume 7, Issue 12, Page(s) e51229

    Abstract: Background: The modest decline in child mortality in Africa raises the question whether the pattern of diseases associated with acute kidney injury (AKI) in children in Nigeria has changed.: Methods: A database of children, aged between one month and ...

    Abstract Background: The modest decline in child mortality in Africa raises the question whether the pattern of diseases associated with acute kidney injury (AKI) in children in Nigeria has changed.
    Methods: A database of children, aged between one month and 16 years, with AKI (using modified pediatric RIFLE criteria) was reviewed. The cause of AKI was defined as the major underlying disease. The clinical and laboratory features of children with AKI who survived were compared to those who died.
    Results: Of the 4 015 children admitted into Lagos University Teaching Hospital between July 2010 and July 2012, 70 episodes of AKI were recorded equalling 17.4 cases per 1000 children. The median age of the children with AKI was 4.8 (range 0.1-14.4) years and 68.6% were males. Acute kidney injury was present in 58 (82.9%) children at admission with 70% in 'failure' category. Primary kidney disease (38.6%), sepsis (25.7%) and malaria (11.4%) were the commonest causes. The primary kidney diseases were acute glomerulonephritis (11) and nephrotic syndrome (8). Nineteen (28.4%) children with AKI died. Need for dialysis [odds ratio: 10.04 (2.94-34.33)], white cell >15 000/mm(3) [odds ratio: 5.72 (1.65-19.89)] and platelet <100 000/mm(3) [odds ratio: 9.56 (2.63-34.77)] were associated with death.
    Conclusion: Acute kidney injury is common in children admitted to hospitals. The common causes remain primary kidney diseases, sepsis and malaria but the contribution of sepsis is rising while malaria and gastroenteritis are declining. Acute kidney injury-related mortality remains high.
    MeSH term(s) Acute Kidney Injury/epidemiology ; Acute Kidney Injury/etiology ; Acute Kidney Injury/mortality ; Acute Kidney Injury/therapy ; Adolescent ; Child ; Child, Preschool ; Female ; Humans ; Infant ; Male ; Nigeria/epidemiology ; Prevalence ; Renal Dialysis ; Tertiary Care Centers/organization & administration
    Language English
    Publishing date 2012-12-10
    Publishing country United States
    Document type Journal Article
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0051229
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Wilson disease in a Nigerian child: a case report.

    Esezobor, Christopher Imokhuede / Banjoko, Nora / Rotimi-Samuel, Adekunle / Lesi, Foluso Ebun Afolabi

    Journal of medical case reports

    2012  Volume 6, Page(s) 200

    Abstract: Introduction: Wilson disease is rarely reported among African children. This report describes the second case report of a Nigerian child with Wilson disease in three decades.: Case presentation: An eight-year-old African boy presented with ... ...

    Abstract Introduction: Wilson disease is rarely reported among African children. This report describes the second case report of a Nigerian child with Wilson disease in three decades.
    Case presentation: An eight-year-old African boy presented with generalized oedema and ascites and proteinuria. Over the next three weeks he developed conjugated hyperbilirubinaemia, severe coagulopathy and prominent extrapyramidal features consisting of rigidity, tremors at rest and in action, shuffling gait, slurred speech and emotional lability. Slit-lamp examination of his eyes revealed Kayser-Fleischer rings and sunflower cataracts. His serum caeruloplasmin level was 5mg/dL. Using the scoring system proposed by the 8th International Meeting of Wilson Disease and Menkes Disease, a diagnosis of Wilson disease was made.
    Conclusions: Wilson disease does occur in African children, although the diagnosis is rarely made. A diagnosis of Wilson disease should be entertained in the evaluation of African children presenting with liver dysfunction and/or extrapyramidal neurological features.
    Language English
    Publishing date 2012-07-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 2269805-X
    ISSN 1752-1947 ; 1752-1947
    ISSN (online) 1752-1947
    ISSN 1752-1947
    DOI 10.1186/1752-1947-6-200
    Database MEDical Literature Analysis and Retrieval System OnLINE

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