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  1. Article ; Online: VOSviewer and Bibliometrix.

    Arruda, Humberto / Silva, Edison Renato / Lessa, Marcus / Proença, Domício / Bartholo, Roberto

    Journal of the Medical Library Association : JMLA

    2023  Volume 110, Issue 3, Page(s) 392–395

    Abstract: VOSviewer (version 1.6.17, July 22, 2021). ...

    Abstract VOSviewer (version 1.6.17, July 22, 2021).
    MeSH term(s) Humans ; Italy ; Technology ; Universities
    Language English
    Publishing date 2023-01-15
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2072435-4
    ISSN 1558-9439 ; 1536-5050
    ISSN (online) 1558-9439
    ISSN 1536-5050
    DOI 10.5195/jmla.2022.1434
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Aeroallergen sensitization patterns among patients with chronic rhinitis with or without concomitant asthma.

    Souza, Tássia Milenna Oliveira de / Fernandes, Jamille Souza / Santana, Cinthia Vila Nova / Lessa, Marcus Miranda / Cruz, Álvaro A

    Brazilian journal of otorhinolaryngology

    2023  Volume 90, Issue 2, Page(s) 101351

    Abstract: Objectives: The aim of this study was to explore the differences in the pattern of allergen sensitization in CR individuals without or with asthma, according to asthma severity.: Methods: A total of 1066 adults were evaluated. Asthma and chronic⁄ ... ...

    Abstract Objectives: The aim of this study was to explore the differences in the pattern of allergen sensitization in CR individuals without or with asthma, according to asthma severity.
    Methods: A total of 1066 adults were evaluated. Asthma and chronic⁄allergic rhinits were identified by specialists, questionnaries and skin-prick test. The phenotypic characterization was avaliable from skin-prick test to an aeroallergen extended panel, total IgE and pulmonary function. Using questionnaires and clinical evaluation, participants were classified into the groups: chronic rhinitis alone (CRA) and chronic rhinitis + asthma, the latter subdivided into CR + mild asthma (CRMA) and CR + moderate to severe asthma (CRMSA). Aerollergen sensitization was defined by a positive prick test to one or more allergens associated with nasal symptoms and/or asthma. The association between CR and asthma was evaluated by multivariable logistic regression. The evidence of effect modification of pattern of sensitization in CR on the association with asthma severity and outcomes was examined by introducing interactions terms in the logistic regression models adjusting for confounders.
    Results: Frequency of sensitization to aeroallergens was higher in association with asthma in comparison to CRA (CRMA 70.4%; CRMSA 65.0%; CRA 47.0%; p = 0.000). Similarly, the presence of asthma was associated to aeroallergen multiple sensitization (51.5%) (OR = 2.10, 95% CI 1.27-3.50). Additionally, the sensitization to mites, cockroaches, animal epithelium, grasses, and molds, were higher in asthma (56.8%, 24.3%, 12%, 7.13% and 10.3%, respectively). Sensitization to Alternaria alternata, Cladosporium herbarum and dog epithelium was exclusive in asthma groups. A concomitant asthma diagnosis was directly associated with a positive allergen sensitization at least one allergen (62.7%, OR = 2.45, 95% CI 1.80-3.34) and polissensitization (51.5%, OR = 2.10, 95% CI 1.27-3.50).
    Conclusion: Asthma is associated with multiple allergen sensitization among patients with CR. Some unique profiles of aeroallergen sensitization were observed in patients with CR and asthma. Nevertheless, no difference was found in the sensitization in relation to asthma severity, which suggest atopy is not the main underlying mechanism for asthma severity among patients with CR.
    Level of evidence: Level 3.
    MeSH term(s) Adult ; Animals ; Dogs ; Humans ; Allergens ; Asthma/complications ; Rhinitis/complications ; Rhinitis/diagnosis ; Hypersensitivity ; Skin Tests
    Chemical Substances Allergens
    Language English
    Publishing date 2023-10-27
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 2428110-4
    ISSN 1808-8686 ; 1808-8694
    ISSN (online) 1808-8686
    ISSN 1808-8694
    DOI 10.1016/j.bjorl.2023.101351
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Brief communication: Vitamin D serum levels in American tegumentary leishmaniasis from an endemic area in Northeast Brazil.

    Figueiredo, Lorena Pinheiro / Cerqueira-Silva, Thiago / Magalhães, Andréa / Lago, Ednaldo Lima / Lessa, Marcus Miranda

    The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases

    2022  Volume 27, Issue 1, Page(s) 102720

    Abstract: Introduction: The pathogenesis of cutaneous and mucosal leishmaniasis is associated with different immune responses. Vitamin D may modulate the immune system. Here we evaluate the association of vitamin D levels with the severity of the clinical forms ... ...

    Abstract Introduction: The pathogenesis of cutaneous and mucosal leishmaniasis is associated with different immune responses. Vitamin D may modulate the immune system. Here we evaluate the association of vitamin D levels with the severity of the clinical forms of cutaneous and mucosal leishmaniasis.
    Methods: We conducted an observational study evaluating the association between vitamin D levels, disease severity and therapeutic response in patients with cutaneous and mucosal leishmaniasis. Additionally, we conducted a cross-sectional study to compare vitamin D levels in patients with leishmaniasis and healthy subjects. Hypovitaminosis D was defined as a serum level of 25 (OH) D < 30 ng/mL.
    Results: In patients with leishmaniasis, vitamin D serum levels were 38.5 ± 11.54 ng/mL, and 37.5 ± 10.43 ng/mL in healthy subjects The prevalence of hypovitaminosis D was 23.3% and 20.0%, respectively (p = 0.72). There was no correlation between vitamin D serum levels, disease severity, and healing time in the mucosal leishmaniasis group.
    Conclusion: Vitamin D levels are not associated with neither susceptibility nor severity of tegumentary leishmaniasis.
    MeSH term(s) Humans ; United States ; Vitamin D ; Brazil/epidemiology ; Cross-Sectional Studies ; Leishmaniasis, Cutaneous/epidemiology ; Leishmaniasis, Cutaneous/pathology ; Vitamin D Deficiency/epidemiology ; Communication
    Chemical Substances Vitamin D (1406-16-2)
    Language English
    Publishing date 2022-12-02
    Publishing country Brazil
    Document type Observational Study ; Journal Article
    ZDB-ID 2041400-6
    ISSN 1678-4391 ; 1413-8670
    ISSN (online) 1678-4391
    ISSN 1413-8670
    DOI 10.1016/j.bjid.2022.102720
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Alpha-lipoic acid does not improve olfactory training results in olfactory loss due to COVID-19: a double-blind randomized trial.

    Figueiredo, Lorena Pinheiro / Paim, Paulo Victor Dos Santos Lima / Cerqueira-Silva, Thiago / Barreto, Carolina Cincurá / Lessa, Marcus Miranda

    Brazilian journal of otorhinolaryngology

    2023  Volume 90, Issue 1, Page(s) 101356

    Abstract: Objectives: Olfactory loss is a recognized long-term dysfunction after Coronavirus Disease 2019 (COVID-19) infection. This investigation aimed to assess the effect of alpha-lipoic acid as an adjuvant treatment of olfactory training on the improvement of ...

    Abstract Objectives: Olfactory loss is a recognized long-term dysfunction after Coronavirus Disease 2019 (COVID-19) infection. This investigation aimed to assess the effect of alpha-lipoic acid as an adjuvant treatment of olfactory training on the improvement of smell loss in post-COVID-19 patients.
    Methods: This randomized controlled trial included 128 adult outpatients who had persistent smell loss for more than 3-months after COVID-19 infection. The participants were randomly allocated into two groups: the intervention treatment group, which received alpha-lipoic acid associated to olfactory training, and comparison treatment group, which received placebo pills associated to olfactory training. The participants were followed-up for 12-weeks. Olfactory dysfunction was assessed in terms of Visual Analog Scale (VAS), and the Connecticut Chemosensory Clinical Research Center (CCCRC) test for the Brazilian population.
    Results: A total of 100 participants completed the follow-up period and were analyzed in this study. Both groups have improved CCCRC score (p = 0.000), olfactory threshold (p = 0.000), identification score (p = 0.000) and VAS score (p = 0.000) after 12-weeks follow-up. No significant differences were determined between the intervention and comparison treatment groups in CCCRC score (p = 0.63), olfactory threshold (p = 0.50), identification score (p = 0.96) and VAS score (p = 0.97). In all these criteria, comparison treatment group went slightly worse. At the endpoint of the study, the frequency of anosmia reduced to 2% in the intervention treatment group and to 7.8% in the comparison treatment group. Also, 16.8% of the intervention group' subjects, and 15.7% of comparison treatment group's patients reached normosmia.
    Conclusions: Overall, there was a strongly significant difference in olfactory function between baseline and endpoint for both groups. However, based on the lack of significant difference between the intervention treatment and the comparison treatment groups in terms of olfactory changes, our study appoints that the alpha-lipoic acid is not better than olfactory training alone to treat olfactory loss after COVID-19.
    Level of evidence: Level 2.
    MeSH term(s) Adult ; Humans ; Anosmia/drug therapy ; COVID-19/complications ; Olfaction Disorders/drug therapy ; Olfaction Disorders/etiology ; Olfactory Training ; Smell ; Thioctic Acid/therapeutic use ; Double-Blind Method
    Chemical Substances Thioctic Acid (73Y7P0K73Y)
    Language English
    Publishing date 2023-10-30
    Publishing country Brazil
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 2428110-4
    ISSN 1808-8686 ; 1808-8694
    ISSN (online) 1808-8686
    ISSN 1808-8694
    DOI 10.1016/j.bjorl.2023.101356
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Association between Benign Paroxysmal Positional Vertigo and Thyroid Diseases: Systematic Review and Meta-analysis

    Lima, Cyntia Machado / Paiva, Daniel Felipe Fernandes / Corona, Ana Paula / Lessa, Marcus Miranda

    International Archives of Otorhinolaryngology

    2023  

    Abstract: Introduction: Benign paroxysmal positional vertigo (BPPV) is the peripheral vestibular dysfunction that most affects people worldwide, but its etiopathogenesis is still not fully understood. Considering the etiological diversity, some studies highlight ... ...

    Abstract Introduction: Benign paroxysmal positional vertigo (BPPV) is the peripheral vestibular dysfunction that most affects people worldwide, but its etiopathogenesis is still not fully understood. Considering the etiological diversity, some studies highlight the association between BPPV and thyroid diseases.
    Objective: To investigate the association between thyroid diseases and BPPV.
    Data Synthesis: Systematic review and meta-analysis of epidemiological studies searched in the PubMed, Web of Science, Embase, Cochrane Library, and Scopus databases. Studies that were fully available and investigated the association between BPPV and thyroid diseases were selected. The articles that composed the meta-analysis were analyzed using the dichotomous model, the Mantel-Haenszel statistical test, odds ratio (OR), and a 95% confidence interval (CI). Of the 67 articles retrieved from the databases, 7 met the eligibility criteria of the systematic review, and 4 had data necessary to perform the meta-analysis. Qualitative analysis revealed that the studies were conducted in the European and Asian continents. The predominant methodological design was the case-control type, and thyroid dysfunctions, hypothyroidism, and Hashimoto thyroiditis occurred more frequently. The meta-analysis showed no association between hypothyroidism and BPPV; however, there was a statistically significant relationship between Hashimoto thyroiditis and BPPV.
    Conclusion: The meta-analysis results suggest a possible association between BPPV and Hashimoto thyroiditis. Nevertheless, we emphasize the need for further studies to elucidate the evidence obtained.
    Keywords benign paroxysmal positional vertigo ; hypothyroidism ; hyperthyroidism ; hashimoto thyroiditis
    Language English
    Publishing date 2023-09-14
    Publisher Thieme Revinter Publicações Ltda.
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2578584-9
    ISSN 1809-4864 ; 1809-9777 ; 1809-4864
    ISSN (online) 1809-4864
    ISSN 1809-9777 ; 1809-4864
    DOI 10.1055/s-0043-1769496
    Database Thieme publisher's database

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  6. Article ; Online: Assessment of Immune and Clinical Response in Patients with Mucosal Leishmaniasis Treated with Pentavalent Antimony and Pentoxifylline.

    Cincura, Carolina / Costa, Rubia S / De Lima, Clara Monica F / Oliveira-Filho, Jamary / Rocha, Paulo Novis / Carvalho, Edgar M / Lessa, Marcus M

    Tropical medicine and infectious disease

    2022  Volume 7, Issue 11

    Abstract: Mucosal leishmaniasis (ML) is a severe form of tegumentary leishmaniasis associated with a persistent inflammatory response. High levels of TNF, IFN-γ, CXCL9 and CXCL10 are found in ML patients, and the association of pentoxifylline with antimony is more ...

    Abstract Mucosal leishmaniasis (ML) is a severe form of tegumentary leishmaniasis associated with a persistent inflammatory response. High levels of TNF, IFN-γ, CXCL9 and CXCL10 are found in ML patients, and the association of pentoxifylline with antimony is more effective in decreasing the healing time in ML patients when compared to antimony alone. The present study aimed to investigate the existence of a correlation between cytokine and chemokine production and ML severity and evaluate the potential value of cytokine and chemokine production as marker of therapeutic response in ML patients. This prospective study included 86 subjects in an area of endemic
    Language English
    Publishing date 2022-11-16
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2414-6366
    ISSN (online) 2414-6366
    DOI 10.3390/tropicalmed7110383
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Brazilian guideline for the use of immunobiologicals in chronic rhinosinusitis with nasal polyps ‒ 2024 update.

    Anselmo-Lima, Wilma T / Romano, Fabrizio R / Tamashiro, Edwin / Roithmann, Renato / Dinarte, Vanessa R P / Piltcher, Otavio B / Miyake, Marcel M / Fornazieri, Marco A / Nakanishi, Marcio / Bezerra, Thiago F P / Dolci, Ricardo L L / Mello, João F / Lessa, Marcus M / Voegels, Richard L / Kosugi, Eduardo M / Sakano, Eulalia / Valera, Fabiana C P

    Brazilian journal of otorhinolaryngology

    2024  Volume 90, Issue 3, Page(s) 101394

    Abstract: Introduction: Biologics targeting type 2 inflammation have revolutionized the way we treat patients with Chronic Rhinosinusitis with Nasal Polyps (CRSwNP). Particularly in severe and difficult-to-control cases, these drugs have provided a new reality ... ...

    Abstract Introduction: Biologics targeting type 2 inflammation have revolutionized the way we treat patients with Chronic Rhinosinusitis with Nasal Polyps (CRSwNP). Particularly in severe and difficult-to-control cases, these drugs have provided a new reality for these patients, allowing for the effective and safe treatment of extensive diseases that were not completely managed with the typical strategy of surgery and topical medications.
    Objectives: The experience achieved with the approval of these medications by ANVISA for use in CRSwNP and the knowledge obtained regarding outcomes, adverse effects, and the ideal patient profile prompted the update of the previously published guideline, with a detailed review of the most recent scientific literature, the personal experiences of experts, and the adaptation to the reality of the Brazilian healthcare system, both public and private.
    Results: We proposed a new eligibility criterion for biologics in patients with CRSwNP based on four pillars of indication: the impact of the disease on the patient's life, whether in the presence of specific symptoms or in overall quality of life; the extent of sinonasal disease; the presence of type 2 comorbidities, considering other associated diseases that may also benefit from anti-T2 biologics, and the presence of biomarkers to define type 2 inflammation, especially those associated with worse disease prognoses.
    Conclusions: This innovative and pioneering method has two major advantages. First, it ensures a comprehensive evaluation of patients; second, it is flexible, as advancements in our understanding of the disease and changes in cost-effectiveness can be addressed by simply adjusting the required score for indication, without the need to modify the entire evaluation scheme.
    Language English
    Publishing date 2024-01-30
    Publishing country Brazil
    Document type Journal Article ; Review
    ZDB-ID 2428110-4
    ISSN 1808-8686 ; 1808-8694
    ISSN (online) 1808-8686
    ISSN 1808-8694
    DOI 10.1016/j.bjorl.2024.101394
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Leishmania braziliensis causing human disease in Northeast Brazil presents loci with genotypes in long-term equilibrium.

    Silva, Juliana A / Pinheiro, Ana Isabelle / Dourado, Maria Luiza / Medina, Lilian / Queiroz, Adriano / Guimarães, Luiz Henrique / Lessa, Marcus Miranda / Lago, Ednaldo L / Machado, Paulo Roberto L / Wilson, Mary E / Carvalho, Edgar M / Schriefer, Albert

    PLoS neglected tropical diseases

    2022  Volume 16, Issue 6, Page(s) e0010390

    Abstract: Background: Leishmaniases are neglected tropical diseases that inflict great burden to poor areas of the globe. Intense research has aimed to identify parasite genetic signatures predictive of infection outcomes. Consistency of diagnostic tools based on ...

    Abstract Background: Leishmaniases are neglected tropical diseases that inflict great burden to poor areas of the globe. Intense research has aimed to identify parasite genetic signatures predictive of infection outcomes. Consistency of diagnostic tools based on these markers would greatly benefit from accurate understanding of Leishmania spp. population genetics. We explored two chromosomal loci to characterize a population of L. braziliensis causing human disease in Northeast Brazil.
    Methodology/principal findings: Two temporally distinct samples of L. braziliensis were obtained from patients attending the leishmaniasis clinic at the village of Corte de Pedra: (2008-2011) primary sample, N = 120; (1999-2001) validation sample, N = 35. Parasites were genotyped by Sanger's sequencing of two 600 base pairs loci starting at nucleotide positions 3,074 and 425,451 of chromosomes 24 and 28, respectively. Genotypes based on haplotypes of biallelic positions in each locus were tested for several population genetic parameters as well as for geographic clustering within the region. Ample geographic overlap of genotypes at the two loci was observed as indicated by non-significant Cusick and Edward's comparisons. No linkage disequilibrium was detected among combinations of haplotypes for both parasite samples. Homozygous and heterozygous genotypes displayed Hardy-Weinberg equilibrium (HWE) at both loci in the two samples when straight observed and expected counts were compared by Chi-square (p>0.5). However, Bayesian statistics using one million Monte-Carlo randomizations disclosed a less robust HWE for chromosome 24 genotypes, particularly in the primary sample (p = 0.04). Fixation indices (Fst) were consistently lower than 0.05 among individuals of the two samples at both tested loci, and no intra-populational structuralization could be detected using STRUCTURE software.
    Conclusions/significance: These findings suggest that L. braziliensis can maintain stable populations in foci of human leishmaniasis and are capable of robust genetic recombination possibly due to events of sexual reproduction during the parasite's lifecycle.
    MeSH term(s) Bayes Theorem ; Brazil/epidemiology ; Genotype ; Humans ; Leishmania braziliensis/genetics ; Leishmaniasis/parasitology ; Leishmaniasis, Cutaneous/epidemiology ; Leishmaniasis, Cutaneous/parasitology
    Language English
    Publishing date 2022-06-15
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2429704-5
    ISSN 1935-2735 ; 1935-2735
    ISSN (online) 1935-2735
    ISSN 1935-2735
    DOI 10.1371/journal.pntd.0010390
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Safety for the Rhinologist in the Age of COVID-19: Mask Use, Nasal Corticosteroids, Saline Irrigation, and Endoscopic Procedures - Literature Review.

    Kosugi, Eduardo Macoto / Villa, Jonatas Figueiredo / Ramos, Henrique Faria / Luz-Matsumoto, Gabriela Ricci / Serrano, Thiago Luis Infanger / Campos, Carlos Augusto Correia de / Barreto, Carolina Cincurá / Lima, Clara Mônica / Fornazieri, Marco Aurélio / Piltcher, Otavio / Lessa, Marcus Miranda / Romano, Fabrizio Ricci

    International archives of otorhinolaryngology

    2022  Volume 26, Issue 1, Page(s) e137–e147

    Abstract: ... ...

    Abstract Introduction
    Language English
    Publishing date 2022-01-25
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 2578584-9
    ISSN 1809-4864 ; 1809-9777
    ISSN (online) 1809-4864
    ISSN 1809-9777
    DOI 10.1055/s-0041-1740988
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Case Report: Unusual Presentation of Pharyngeal Mucosal Leishmaniasis due to

    Figueiredo, Lorena Pinheiro / Almeida, Laiana do Carmo / Magalhães, Andréa / Arruda, Sérgio / Lessa, Marcus M / Carvalho, Edgar M

    The American journal of tropical medicine and hygiene

    2020  Volume 103, Issue 4, Page(s) 1493–1495

    Abstract: Mucosal leishmaniasis (ML) affects predominantly the nose and occurs usually weeks or months after the cure of the primary cutaneous lesion. The pathology of ML is characterized by an exaggerated inflammatory reaction with infiltration of lymphocytes, ... ...

    Abstract Mucosal leishmaniasis (ML) affects predominantly the nose and occurs usually weeks or months after the cure of the primary cutaneous lesion. The pathology of ML is characterized by an exaggerated inflammatory reaction with infiltration of lymphocytes, macrophages, and plasma cells. There is also a paucity of parasites and a strong delayed-type hypersensitivity reaction. Herein, we report a case of a young man who had a large ulcer in his left leg and complained of dysphagia. In nasofibrolaryngoscopy, there were nodular lesions in the oropharynx and rhinopharynx. The skin lesion biopsy showed a chronic inflammation with amastigotes inside macrophages, and DNA of
    MeSH term(s) Antiprotozoal Agents/therapeutic use ; Cytokines/drug effects ; Cytokines/metabolism ; Deglutition Disorders/drug therapy ; Deglutition Disorders/etiology ; Humans ; Leishmania braziliensis/drug effects ; Leishmania braziliensis/isolation & purification ; Leishmaniasis, Mucocutaneous/diagnosis ; Leishmaniasis, Mucocutaneous/drug therapy ; Leishmaniasis, Mucocutaneous/pathology ; Macrophages/parasitology ; Male ; Meglumine Antimoniate/therapeutic use ; Middle Aged ; Nasopharynx/parasitology ; Nasopharynx/pathology ; Oropharynx/parasitology ; Oropharynx/pathology ; Skin/parasitology ; Skin/pathology
    Chemical Substances Antiprotozoal Agents ; Cytokines ; Meglumine Antimoniate (75G4TW236W)
    Language English
    Publishing date 2020-07-30
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2942-7
    ISSN 1476-1645 ; 0002-9637
    ISSN (online) 1476-1645
    ISSN 0002-9637
    DOI 10.4269/ajtmh.20-0219
    Database MEDical Literature Analysis and Retrieval System OnLINE

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