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Article: Setting up and managing the Safe Haven Health Information Services. A health information manager's experience.

Letizia, T

Health information management : journal of the Health Information Management Association of Australia

1999 Volume 29, Issue 3, Page(s) 131–132

MeSH term(s)	Australia ; Data Collection ; Hospital Information Systems ; Humans ; Information Management/organization & administration ; Medical Record Administrators ; Medical Records ; Refugees ; Yugoslavia/ethnology
Language	English
Publishing date	1999
Publishing country	Australia
Document type	Journal Article
ISSN	1322-4913
ISSN	1322-4913
DOI	10.1177/183335830002900313
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Article: The role of klotho in systemic sclerosis.

Talotta, R / Bongiovanni, S / Letizia, T / Rigamonti, F / Atzeni, F / Benucci, M / Vago, T / Sarzi-Puttini, P

Reumatismo

2017 Volume 69, Issue 4, Page(s) 156–163

Abstract: The aim was to evaluate the role of klotho in the pathogenesis of systemic sclerosis (SSc), through the measurement of its serum concentration in SSc patients compared to healthy controls, and to assess the association with cutaneous and visceral ... ...

Abstract	The aim was to evaluate the role of klotho in the pathogenesis of systemic sclerosis (SSc), through the measurement of its serum concentration in SSc patients compared to healthy controls, and to assess the association with cutaneous and visceral involvement. Blood samples obtained from both SSc patients and healthy controls were analysed by an ELISA assay for the detection of human klotho. SSc patients were globally evaluated for disease activity and assessed through the modified Rodnan's Skin Score, Medsger's scale, pulmonary function tests, 2D-echocardiography, nailfold capillaroscopy and laboratory tests. Our cohort consisted of 69 SSc patients (61 females, mean age 64.5±12.5 years, median disease duration 9.0 (IQR 8) years) and 77 healthy controls (28 females, mean age 49.7±10.2 years). In the group of SSc patients, 19 (27.5%) suffered from a diffuse form of SSc. All patients were receiving IV prostanoids, and some of them were concomitantly treated with immunosuppressive drugs (prednisone, hydroxychloroquine, mofetil mycophenolate, methotrexate, cyclosporin A and azathioprine). The median serum concentration of klotho was significantly lower in patients compared to controls (0.23 ng/mL vs 0.60 ng/mL; p<0.001). However, Spearman's test showed no significant association between klotho serum levels and disease activity, concerning either clinical, laboratory or instrumental findings. Our data show a significant deficit of klotho in SSc patients although any significant association was detected between klotho serum concentration and the clinical, laboratory or instrumental features of the disease. However, due to the limits of the study, further investigations are required.
MeSH term(s)	Adult ; Aged ; Biomarkers ; Female ; Glucuronidase/blood ; Glucuronidase/physiology ; Humans ; Immunosuppressive Agents/therapeutic use ; Lung/pathology ; Male ; Microscopic Angioscopy ; Middle Aged ; Osteoporosis/etiology ; Prostaglandins/therapeutic use ; Scleroderma, Systemic/blood ; Scleroderma, Systemic/complications ; Scleroderma, Systemic/drug therapy ; Scleroderma, Systemic/pathology ; Statistics, Nonparametric
Chemical Substances	Biomarkers ; Immunosuppressive Agents ; Prostaglandins ; Glucuronidase (EC 3.2.1.31) ; klotho protein (EC 3.2.1.31)
Language	English
Publishing date	2017-12-21
Publishing country	Italy
Document type	Journal Article
ZDB-ID	414816-2
ISSN	2240-2683 ; 0048-7449
ISSN (online)	2240-2683
ISSN	0048-7449
DOI	10.4081/reumatismo.2017.987
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Article: Serum klotho concentrations inversely correlate with the severity of nailfold capillaroscopic patterns in patients with systemic sclerosis.

Talotta, R / Rigamonti, F / Letizia, T / Bongiovanni, S / Ditto, M C / Antivalle, M / Santandrea, S / Atzeni, F / Vago, T / Sarzi-Puttini, P

Reumatismo

2019 Volume 71, Issue 1, Page(s) 19–23

Abstract: Klotho is a transmembrane and soluble glycoprotein that governs vascular integrity. Previous studies have demonstrated reduced serum klotho concentrations in patients with systemic sclerosis (SSc), and it is known that klotho deficiency can impair the ... ...

Abstract	Klotho is a transmembrane and soluble glycoprotein that governs vascular integrity. Previous studies have demonstrated reduced serum klotho concentrations in patients with systemic sclerosis (SSc), and it is known that klotho deficiency can impair the healing of digital ulcers related to microvessel damage. The aim of this study was to evaluate the association between serum klotho levels and nailfold capillaroscopic abnormalities in SSc patients. We retrospectively enrolled 54 consecutive patients with SSc diagnosed on the basis of the 2013 EULAR/ACR criteria [11 with diffuse SSc; 47 females; median age 68.0 years (IQ 18); median disease duration 11.0 years (IQ 7)]. Serum klotho concentrations were determined by means of an enzyme-linked immunosorbent assay. On the basis of the 2000 classification of Cutolo et al., 14 patients had normal nailfold capillaroscopic findings, 8 had an early scleroderma pattern, 21 an active scleroderma pattern, and 11 a late scleroderma pattern. The median serum klotho concentration was 0.29 ng/mL (IQ 1). Regression analysis of variation showed an inverse correlation between serum klotho concentrations and the severity of the capillaroscopic pattern (p=0.02; t -2.2284), which was not influenced by concomitant treatment. Logistic regression did not reveal any significant association between the risk of developing digital ulcers and nailfold capillaroscopic patterns, serum klotho levels, or concomitant medications. The presence of avascular areas significantly correlated with calcinosis (p=0.006). In line with previous studies, our findings confirm that klotho plays a role in preventing microvascular damage detected with nailfold capillaroscopy.
MeSH term(s)	Adult ; Aged ; Antibodies, Antinuclear/blood ; Biomarkers/blood ; Calcinosis/complications ; Female ; Glucuronidase/blood ; Humans ; Male ; Microscopic Angioscopy ; Middle Aged ; Nail Diseases/blood ; Nail Diseases/etiology ; Nails/blood supply ; Regression Analysis ; Retrospective Studies ; Scleroderma, Systemic/blood ; Ulcer/etiology
Chemical Substances	Antibodies, Antinuclear ; Biomarkers ; Glucuronidase (EC 3.2.1.31) ; klotho protein (EC 3.2.1.31)
Language	English
Publishing date	2019-04-01
Publishing country	Italy
Document type	Journal Article
ZDB-ID	414816-2
ISSN	2240-2683 ; 0048-7449
ISSN (online)	2240-2683
ISSN	0048-7449
DOI	10.4081/reumatismo.2019.1129
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Article: Placental ESRRG-CYP19A1

Anelli, Gaia Maria / Mandò, Chiara / Letizia, Teresa / Mazzocco, Martina Ilaria / Novielli, Chiara / Lisso, Fabrizia / Personeni, Carlo / Vago, Tarcisio / Cetin, Irene

Frontiers in pediatrics

2019 Volume 7, Page(s) 154

Abstract: Introduction: ...

Abstract	Introduction:
Language	English
Publishing date	2019-04-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2711999-3
ISSN	2296-2360
ISSN	2296-2360
DOI	10.3389/fped.2019.00154
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Article ; Online: Sodium glucose cotransporters inhibitors in type 1 diabetes.

Dellepiane, Sergio / Ben Nasr, Moufida / Assi, Emma / Usuelli, Vera / Letizia, Teresa / D'Addio, Francesca / Zuccotti, Gian Vincenzo / Fiorina, Paolo

Pharmacological research

2018 Volume 133, Page(s) 1–8

Abstract: Sodium glucose cotransporter inhibitors (SGLTi) are oral hypoglycemic drugs that reduce renal glucose re-uptake and induce glycosuria. SGLTi have been successfully tested in large randomized clinical trials for type 2 diabetes, and several molecules have ...

Abstract	Sodium glucose cotransporter inhibitors (SGLTi) are oral hypoglycemic drugs that reduce renal glucose re-uptake and induce glycosuria. SGLTi have been successfully tested in large randomized clinical trials for type 2 diabetes, and several molecules have been approved in this setting by the international pharmaceutical agencies. Additionally, recent evidence has shown that SGLTi may be useful also in type 1 diabetes (T1D). Indeed, these drugs can be used as an ancillary to insulin to improve glycemic control and reduce insulin dosage, and such regimens have been associated with a lower rate of hypoglycemic episodes. The pharmacological effects of SGLTi therapy are described herein, and we also discuss the future use of SGLTi in T1D.
MeSH term(s)	Animals ; Diabetes Mellitus, Type 1/drug therapy ; Diabetes Mellitus, Type 1/metabolism ; Humans ; Hypoglycemic Agents/therapeutic use ; Sodium-Glucose Transport Proteins/antagonists & inhibitors ; Sodium-Glucose Transport Proteins/metabolism
Chemical Substances	Hypoglycemic Agents ; Sodium-Glucose Transport Proteins
Language	English
Publishing date	2018-04-22
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	1003347-6
ISSN	1096-1186 ; 0031-6989 ; 1043-6618
ISSN (online)	1096-1186
ISSN	0031-6989 ; 1043-6618
DOI	10.1016/j.phrs.2018.04.018
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Article ; Online: The fibroblast growth factor-23 and Vitamin D emerge as nontraditional risk factors and may affect cardiovascular risk.

Masson, S / Agabiti, N / Vago, T / Miceli, M / Mayer, F / Letizia, T / Wienhues-Thelen, U / Mureddu, G F / Davoli, M / Boccanelli, A / Latini, R

Journal of internal medicine

2015 Volume 277, Issue 3, Page(s) 318–330

Abstract: Objectives: Fibroblast growth factor-23 (FGF-23) and vitamin D are hormones involved in phosphate homoeostasis. They also directly influence cardiomyocyte hypertrophy. We examined whether the relationships between levels of vitamin D or FGF-23, cardiac ... ...

Abstract	Objectives: Fibroblast growth factor-23 (FGF-23) and vitamin D are hormones involved in phosphate homoeostasis. They also directly influence cardiomyocyte hypertrophy. We examined whether the relationships between levels of vitamin D or FGF-23, cardiac phenotype and outcome were independent of established cardiac biomarkers in a large cohort of community-dwelling elderly subjects. Design and setting: Plasma levels of FGF-23 and vitamin D were measured in 1851 men and women (65-84 years) resident in the Lazio region of Italy. Participants were referred to eight cardiology centres for clinical examination, electrocardiography, comprehensive Doppler echocardiography and blood sampling. All-cause mortality or hospitalizations were available after a median follow-up of 47 months with record linkage of administrative data. Results: Vitamin D deficiency (<20 ng mL(-1) ) was found in 72.3% of subjects, but FGF-23 levels were normal [74 (58-97) RU per mL]. After adjustment for cardiovascular risk factors and morbidities, low concentrations of vitamin D and high levels of FGF-23 were associated with a higher left ventricular (LV) mass index. Levels of FGF-23 [hazard ratio (HR) (95% confidence interval (CI)) 1.71 (1.28-2.28), P < 0.0001] but not vitamin D [0.76 (0.57-1.01), P = 0.08] were independently associated with mortality after adjustment for clinical risk factors and two cardiac markers together (N-terminal pro-brain natriuretic peptide and high-sensitivity cardiac troponin T), but did not predict hospital admission. People with above median values of FGF-23 and below median values of vitamin D had greater LV hypertrophy and higher mortality. Conclusions: In community-dwelling elderly individuals with highly prevalent vitamin D deficiency, FGF-23 levels were associated with LV hypertrophy and predicted mortality independently of two robust cardiac biomarkers. A causal relationship was not demonstrated, but the hormones involved in mineral metabolism emerged as nontraditional risk factors and may affect cardiovascular risk.
MeSH term(s)	Aged ; Aged, 80 and over ; Biomarkers/metabolism ; Cross-Sectional Studies ; Female ; Fibroblast Growth Factors/metabolism ; Humans ; Hypertrophy, Left Ventricular/blood ; Hypertrophy, Left Ventricular/etiology ; Male ; Phenotype ; Prognosis ; Risk Factors ; Vitamin D/metabolism ; Vitamin D Deficiency/complications
Chemical Substances	Biomarkers ; fibroblast growth factor 23 ; Vitamin D (1406-16-2) ; Fibroblast Growth Factors (62031-54-3)
Language	English
Publishing date	2015-03
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	96274-0
ISSN	1365-2796 ; 0954-6820
ISSN (online)	1365-2796
ISSN	0954-6820
DOI	10.1111/joim.12232
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Article: Primary pulmonary arterial hypertension: Protocol to assess comprehensively in the rat the response to pharmacologic treatments.

Novelli, Deborah / Fumagalli, Francesca / Staszewsky, Lidia / Ristagno, Giuseppe / Olivari, Davide / Masson, Serge / De Giorgio, Daria / Ceriani, Sabina / Massafra, Roberta / De Logu, Francesco / Nassini, Romina / Milioli, Marco / Facchinetti, Fabrizio / Cantoni, Silvia / Trevisani, Marcello / Letizia, Teresa / Russo, Ilaria / Salio, Monica / Latini, Roberto

MethodsX

2019 Volume 7, Page(s) 100771

Abstract: The identification of new treatments for primary pulmonary arterial hypertension (PAH) is a critical unmet need since there is no a definitive cure for this disease yet. Due to the complexity of PAH, a wide set of methods are necessary to assess the ... ...

Abstract	The identification of new treatments for primary pulmonary arterial hypertension (PAH) is a critical unmet need since there is no a definitive cure for this disease yet. Due to the complexity of PAH, a wide set of methods are necessary to assess the response to a pharmacological intervention. Thus, a rigorous protocol is crucial when experimental studies are designed. In the present experimental protocol, a stepwise approach was followed in a monocrotaline-induced PAH model in the rat, moving from the dose finding study of treatment compounds to the recognition of the onset of disease manifestation, in order to identify when to start a curative treatment. A complete multidimensional evaluation of treatment effects represented the last step. The primary study endpoint was the change in right ventricular systolic pressure after 14 days of treatment; echocardiographic and biohumoral markers together with heart and pulmonary arterial morphometric parameters were considered as secondary efficacy and/or safety endpoints and for the evaluation of the biologic coherence in the different results.
Language	English
Publishing date	2019-12-19
Publishing country	Netherlands
Document type	Journal Article
ISSN	2215-0161
ISSN	2215-0161
DOI	10.1016/j.mex.2019.100771
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Article ; Online: Monocrotaline-induced pulmonary arterial hypertension: Time-course of injury and comparative evaluation of macitentan and Y-27632, a Rho kinase inhibitor.

Novelli, Deborah / Fumagalli, Francesca / Staszewsky, Lidia / Ristagno, Giuseppe / Olivari, Davide / Masson, Serge / De Giorgio, Daria / Ceriani, Sabina / Affatato, Roberta / De Logu, Francesco / Nassini, Romina / Milioli, Marco / Facchinetti, Fabrizio / Cantoni, Silvia / Trevisani, Marcello / Letizia, Teresa / Russo, Ilaria / Salio, Monica / Latini, Roberto

European journal of pharmacology

2019 Volume 865, Page(s) 172777

Abstract: Novel pharmacological approaches are needed to improve outcomes of patients with idiopathic pulmonary hypertension. Rho-associated protein kinase (ROCK) inhibitors have shown beneficial effects in preclinical models of pulmonary arterial hypertension ( ... ...

Abstract	Novel pharmacological approaches are needed to improve outcomes of patients with idiopathic pulmonary hypertension. Rho-associated protein kinase (ROCK) inhibitors have shown beneficial effects in preclinical models of pulmonary arterial hypertension (PAH), because of their role in the regulation of pulmonary artery vasoconstrictor tone and remodeling. We compared a ROCK inhibitor, Y-27632, for the first time with the dual endothelin receptor antagonist, macitentan, in a monocrotaline-induced rat pulmonary hypertension model. Different methods (echocardiography, hemodynamics, histology of right ventricle and pulmonary vessels, and circulating biomarkers) showed consistently that 100 mg/kg daily of Y-27632 and 10 mg/kg daily of macitentan slowed the progression of PAH both at the functional and structural levels. Treatments started on day 14 after monocrotaline injection and lasted 14 days. The findings of all experimental methods show that the selective ROCK inhibitor Y-27632 has more pronounced effects than macitentan, but a major limitation to its use is its marked peripheral vasodilating action.
MeSH term(s)	Amides/therapeutic use ; Animals ; Endothelin Receptor Antagonists/therapeutic use ; Heart Ventricles/pathology ; Hemodynamics/drug effects ; Hypertrophy, Right Ventricular/chemically induced ; Hypertrophy, Right Ventricular/drug therapy ; Male ; Monocrotaline ; Protein Kinase Inhibitors/therapeutic use ; Pulmonary Arterial Hypertension/chemically induced ; Pulmonary Arterial Hypertension/drug therapy ; Pulmonary Arterial Hypertension/pathology ; Pulmonary Artery/drug effects ; Pulmonary Artery/pathology ; Pyridines/therapeutic use ; Pyrimidines/therapeutic use ; Rats, Wistar ; Sulfonamides/therapeutic use ; rho-Associated Kinases/antagonists & inhibitors
Chemical Substances	Amides ; Endothelin Receptor Antagonists ; Protein Kinase Inhibitors ; Pyridines ; Pyrimidines ; Sulfonamides ; Y 27632 (138381-45-0) ; Monocrotaline (73077K8HYV) ; rho-Associated Kinases (EC 2.7.11.1) ; macitentan (Z9K9Y9WMVL)
Language	English
Publishing date	2019-11-04
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	80121-5
ISSN	1879-0712 ; 0014-2999
ISSN (online)	1879-0712
ISSN	0014-2999
DOI	10.1016/j.ejphar.2019.172777
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Article ; Online: Measurement of Serum Klotho in Systemic Sclerosis.

Talotta, Rossella / Bongiovanni, Sara / Letizia, Teresa / Rigamonti, Federica / Ditto, Maria Chiara / Atzeni, Fabiola / Salaffi, Fausto / Batticciotto, Alberto / Gerardi, Maria Chiara / Antivalle, Marco / Vago, Tarcisio / Benucci, Maurizio / Sarzi-Puttini, Piercarlo

Disease markers

2017 Volume 2017, Page(s) 9545930

Abstract: Background: The aim of our study was to evaluate the serum concentration of klotho in a cohort of systemic sclerosis (SSc) patients compared to that of healthy controls and to correlate its levels with the degree and the kind of organ involvement.: ... ...

Abstract	Background: The aim of our study was to evaluate the serum concentration of klotho in a cohort of systemic sclerosis (SSc) patients compared to that of healthy controls and to correlate its levels with the degree and the kind of organ involvement. Methods: Blood samples obtained from both patients and controls were collected and analysed by an ELISA test for the determination of human soluble klotho. Scleroderma patients were evaluated for disease activity through clinical, laboratory, and instrumental assessment. Results: Our cohort consisted of 81 SSc patients (74 females, mean age 63.9 ± 13.1 years) and 136 healthy controls (78 females, mean age 50.5 ± 10.7 years). When matched for age, serum klotho concentration significantly differed between controls and patients ( Conclusions: Our data show a lower concentration of klotho in the serum of SSc patients compared to that of healthy controls, without any significant association with clinical manifestations and laboratory and instrumental findings. The association between serum klotho and ACPA positivity requires further investigation.
MeSH term(s)	Adult ; Aged ; Biomarkers/blood ; Case-Control Studies ; Female ; Glucuronidase/blood ; Humans ; Male ; Middle Aged ; Scleroderma, Systemic/blood
Chemical Substances	Biomarkers ; Glucuronidase (EC 3.2.1.31) ; klotho protein (EC 3.2.1.31)
Language	English
Publishing date	2017
Publishing country	United States
Document type	Journal Article
ZDB-ID	604951-5
ISSN	1875-8630 ; 0278-0240
ISSN (online)	1875-8630
ISSN	0278-0240
DOI	10.1155/2017/9545930
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Article ; Online: Duration of Untreated Cardiac Arrest and Clinical Relevance of Animal Experiments: The Relationship Between the "No-Flow" Duration and the Severity of Post-Cardiac Arrest Syndrome in a Porcine Model.

Babini, Giovanni / Grassi, Luigi / Russo, Ilaria / Novelli, Deborah / Boccardo, Antonio / Luciani, Anita / Fumagalli, Francesca / Staszewsky, Lidia / Fiordaliso, Fabio / De Maglie, Marcella / Salio, Monica / Zani, Davide D / Letizia, Teresa / Masson, Serge / Luini, Mario V / Pravettoni, Davide / Scanziani, Eugenio / Latini, Roberto / Ristagno, Giuseppe

Shock (Augusta, Ga.)

2017 Volume 49, Issue 2, Page(s) 205–212

Abstract: Introduction: The study investigated the effect of untreated cardiac arrest (CA), that is, "no-flow" time, on postresuscitation myocardial and neurological injury, and survival in a pig model to identify an optimal duration that adequately reflects the ... ...

Abstract	Introduction: The study investigated the effect of untreated cardiac arrest (CA), that is, "no-flow" time, on postresuscitation myocardial and neurological injury, and survival in a pig model to identify an optimal duration that adequately reflects the most frequent clinical scenario. Methods: An established model of myocardial infarction followed by CA and cardiopulmonary resuscitation was used. Twenty-two pigs were subjected to three no-flow durations: short (8-10 min), intermediate (12-13 min), and long (14-15 min). Left ventricular ejection fraction (LVEF) was assessed together with thermodilution cardiac output (CO) and high sensitivity cardiac troponin T (hs-cTnT). Neurological impairment was evaluated by neurological scores, serum neuron specific enolase (NSE), and histopathology. Results: More than 60% of animals survived when the duration of CA was ≤13 min, compared to only 20% for a duration ≥14 min. Neuronal degeneration and neurological scores showed a trend toward a worse recovery for longer no-flow durations. No animals achieved a good neurological recovery for a no-flow ≥14 min, in comparison to a 56% for a duration ≤13 min (P = 0.043). Serum NSE levels significantly correlated with the no-flow duration (r = 0.892). Longer durations of CA were characterized by lower LVEF and CO compared to shorter durations (P < 0.05). The longer was the no-flow time, the higher was the number of defibrillations delivered (P = 0.043). The defibrillations delivered significantly correlated with LVEF and plasma hs-cTnT. Conclusions: Longer no-flow durations caused greater postresuscitation myocardial and neurological dysfunction and reduced survival. An untreated CA of 12-13 min may be an optimal choice for a clinically relevant model.
MeSH term(s)	Animals ; Cardiopulmonary Resuscitation ; Disease Models, Animal ; Heart Arrest/pathology ; Heart Arrest/therapy ; Male ; Swine
Language	English
Publishing date	2017-05-31
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1185432-7
ISSN	1540-0514 ; 1073-2322
ISSN (online)	1540-0514
ISSN	1073-2322
DOI	10.1097/SHK.0000000000000914
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