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  1. Article: La prise en charge actuelle des traumatismes graves du foie.

    Létoublon, C

    Annales de chirurgie

    2005  Volume 130, Issue 2, Page(s) 60–62

    Title translation Nonoperative management of complex hepatic injuries.
    MeSH term(s) Embolization, Therapeutic ; Humans ; Liver/injuries ; Risk Factors ; Wounds and Injuries/therapy
    Language French
    Publishing date 2005-02
    Publishing country France
    Document type Editorial
    ZDB-ID 222253-x
    ISSN 0003-3944
    ISSN 0003-3944
    DOI 10.1016/j.anchir.2005.01.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Comment je fais: un tamponnement péri-hépatique.

    Letoublon, C

    Journal de chirurgie

    2004  Volume 141, Issue 1, Page(s) 27–30

    Title translation How I do it: perihepatic tamponnade.
    MeSH term(s) Digestive System Surgical Procedures/methods ; Humans ; Liver/injuries ; Liver/surgery
    Language French
    Publishing date 2004-03-10
    Publishing country France
    Document type Journal Article
    ZDB-ID 218138-1
    ISSN 1773-0422 ; 0021-7697
    ISSN (online) 1773-0422
    ISSN 0021-7697
    DOI 10.1016/s0021-7697(04)95290-8
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  3. Article: A propos de laparotomie écourtée et des "règles de l'art" du tamponnement périhépatique.

    Létoublon, C

    Annales de chirurgie

    2003  Volume 128, Issue 10, Page(s) 734; author reply 734–5

    Title translation Shortened laparotomy and the "art rules" of peripheral packing.
    MeSH term(s) Humans ; Laparotomy/methods ; Liver/injuries ; Liver/surgery
    Language French
    Publishing date 2003-12-22
    Publishing country France
    Document type Comment ; Letter
    ZDB-ID 222253-x
    ISSN 0003-3944
    ISSN 0003-3944
    DOI 10.1016/j.anchir.2003.10.019
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  4. Article ; Online: Management of blunt hepatic trauma.

    Letoublon, C / Amariutei, A / Taton, N / Lacaze, L / Abba, J / Risse, O / Arvieux, C

    Journal of visceral surgery

    2016  Volume 153, Issue 4 Suppl, Page(s) 33–43

    Abstract: For the last 20 years, nonoperative management (NOM) of blunt hepatic trauma (BHT) has been the initial policy whenever this is possible (80% of cases), i.e., in all cases where the hemodynamic status does not demand emergency laparotomy. NOM relies upon ...

    Abstract For the last 20 years, nonoperative management (NOM) of blunt hepatic trauma (BHT) has been the initial policy whenever this is possible (80% of cases), i.e., in all cases where the hemodynamic status does not demand emergency laparotomy. NOM relies upon the coexistence of three highly effective treatment modalities: radiology with contrast-enhanced computerized tomography (CT) and hepatic arterial embolization, intensive care surveillance, and finally delayed surgery (DS). DS is not a failure of NOM management but rather an integral part of the surgical strategy. When imposed by hemodynamic instability, the immediate surgical option has seen its effectiveness transformed by development of the concept of abbreviated (damage control) laparotomy and wide application of the method of perihepatic packing (PHP). The effectiveness of these two conservative and cautious strategies for initial management is evidenced by current experience, but the management of secondary events that may arise with the most severe grades of injury must be both rapid and effective.
    MeSH term(s) Embolization, Therapeutic ; Hemorrhage/therapy ; Humans ; Intra-Abdominal Hypertension ; Liver/injuries ; Liver Diseases/therapy ; Peritoneal Diseases/therapy ; Postoperative Care ; Reoperation ; Tomography, X-Ray Computed ; Wounds, Nonpenetrating/complications ; Wounds, Nonpenetrating/surgery ; Wounds, Nonpenetrating/therapy
    Language English
    Publishing date 2016-08
    Publishing country France
    Document type Journal Article ; Review
    ISSN 1878-7886
    ISSN (online) 1878-7886
    DOI 10.1016/j.jviscsurg.2016.07.005
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  5. Article ; Online: Management of splenic and pancreatic trauma.

    Girard, E / Abba, J / Cristiano, N / Siebert, M / Barbois, S / Létoublon, C / Arvieux, C

    Journal of visceral surgery

    2016  Volume 153, Issue 4 Suppl, Page(s) 45–60

    Abstract: The spleen and pancreas are at risk for injury during abdominal trauma. The spleen is more commonly injured because of its fragile structure and its position immediately beneath the ribs. Injury to the more deeply placed pancreas is classically ... ...

    Abstract The spleen and pancreas are at risk for injury during abdominal trauma. The spleen is more commonly injured because of its fragile structure and its position immediately beneath the ribs. Injury to the more deeply placed pancreas is classically characterized by discordance between the severity of pancreatic injury and its initial clinical expression. For the patient who presents with hemorrhagic shock and ultrasound evidence of major hemoperitoneum, urgent "damage control" laparotomy is essential; if splenic injury is the cause, prompt "hemostatic" splenectomy should be performed. Direct pancreatic injury is rarely the cause of major hemorrhage unless a major neighboring vessel is injured, but if there is destruction of the pancreatic head, a two-stage pancreatoduodenectomy (PD) may be indicated. At open laparotomy when the patient's hemodynamic status can be stabilized, it may be possible to control splenic bleeding without splenectomy; it is always essential to search for injury to the pancreatic duct and/or the adjacent duodenum. Pancreatic contusion without ductal rupture is usually treated by drain placement adjacent to the injury; ductal injuries of the pancreatic body or tail are treated by resection (distal pancreatectomy with or without splenectomy), with generally benign consequences. For injuries of the pancreatic head with pancreatic duct disruption, wide drainage is usually performed because emergency PD is a complex gesture prone to poor results. Postoperatively, the placement of a ductal stent by endoscopic retrograde catheterization may be decided, while management of an isolated pancreatic fistula is often straightforward. Non-operative management is the rule for the trauma victim who is hemodynamically stable. In addition to the clinical examination and conventional laboratory tests, investigations should include an abdominothoracic CT scan with contrast injection, allowing identification of all traumatized organs and assessment of the severity of injury. In this context, non-operative management (NOM) has gradually become the standard as long as the patient remains hemodynamically stable and there is no suspicion of injury to hollow viscera, with the patient being carefully monitored on a surgical service. The development of arteriography with splenic artery embolization has increased the rate of splenic salvage; this can be performed electively based on specific indications (blush on CT, pseudoaneurysm, arteriovenous fistula), and may also be considered for severe splenic injury, abundant hemoperitoneum, or severe polytrauma. For pancreatic injury, in addition to CT scan, magnetic resonance pancreatography (MRCP) or even endoscopic retrograde cholangiopancreatography (ERCP) may be necessary to identify a ductal rupture. If the pancreatic duct is intact, laboratory and CT imaging surveillance is performed just as for splenic injury. In case of pancreatic ductal injury, ERCP stenting can be considered. However, if this is unsuccessful, the therapeutic decision can be difficult: while NOM can still be successful, complications may arise that are difficult to treat while distal pancreatectomy, although initially more agressive may avoid these complications if performed early.
    MeSH term(s) Abdominal Injuries/complications ; Abdominal Injuries/surgery ; Angiography ; Embolization, Therapeutic ; Hemoperitoneum/diagnostic imaging ; Humans ; Infection/complications ; Laparotomy ; Pancreas/injuries ; Pancreaticoduodenectomy ; Postoperative Complications ; Spleen/injuries ; Splenectomy
    Language English
    Publishing date 2016-08
    Publishing country France
    Document type Journal Article ; Review
    ISSN 1878-7886
    ISSN (online) 1878-7886
    DOI 10.1016/j.jviscsurg.2016.04.005
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  6. Article ; Online: Preventable deaths in a French regional trauma system: A six-year analysis of severe trauma mortality.

    Girard, E / Jegousso, Q / Boussat, B / François, P / Ageron, F-X / Letoublon, C / Bouzat, P

    Journal of visceral surgery

    2018  Volume 156, Issue 1, Page(s) 10–16

    Abstract: Background: Analyzing mortality in a mature trauma system is useful to improve quality of care of severe trauma patients. Standardization of error reporting can be done using the classification of the Joint Commission on the Accreditation of Healthcare ... ...

    Abstract Background: Analyzing mortality in a mature trauma system is useful to improve quality of care of severe trauma patients. Standardization of error reporting can be done using the classification of the Joint Commission on the Accreditation of Healthcare Organizations (JCAHO). The aim of our study was to describe preventable deaths in our trauma system and to classify errors according to the JCAHO taxonomy.
    Methods: We performed a six-year retrospective study using the registry of the Northern French Alps trauma network (TRENAU). Consecutive patients who died in the prehospital field or within their stay at hospital were included. An adjudication committee analyzed deaths to identify preventable or potentially preventable deaths from 2009 to 2014. All errors were classified using the JCAHO taxonomy.
    Results: Within the study period, 503 deaths were reported among 7484 consecutive severe trauma patients (overall mortality equal to 6.7%). Seventy-two (14%) deaths were judged as potentially preventable and 36 (7%) deaths as preventable. Using the JACHO taxonomy, 170 errors were reported. These errors were detected both in the prehospital setting and in the hospital phase. Most were related to clinical performance of physicians and consisted of rule-based or knowledge based failures. Prevention or mitigation of errors required an improvement of communication among caregivers.
    Conclusions: Standardization of error reporting is the first step to improve the efficiency of trauma systems. Preventable deaths are frequently related to clinical performance in the early phase of trauma management. Universal strategies are necessary to prevent or mitigate these errors.
    MeSH term(s) Adult ; Aged ; Chi-Square Distribution ; Female ; France/epidemiology ; Hospital Mortality ; Humans ; Injury Severity Score ; Intensive Care Units/statistics & numerical data ; Male ; Medical Errors/classification ; Medical Errors/mortality ; Medical Errors/prevention & control ; Medical Errors/statistics & numerical data ; Middle Aged ; Mortality, Premature/trends ; Registries ; Retrospective Studies ; Statistics, Nonparametric ; Time Factors ; Trauma Centers/statistics & numerical data ; Wounds and Injuries/mortality
    Language English
    Publishing date 2018-05-26
    Publishing country France
    Document type Journal Article ; Multicenter Study ; Observational Study
    ISSN 1878-7886
    ISSN (online) 1878-7886
    DOI 10.1016/j.jviscsurg.2018.05.002
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  7. Article ; Online: Damage control laparotomy.

    Letoublon, C / Reche, F / Abba, J / Arvieux, C

    Journal of visceral surgery

    2011  Volume 148, Issue 5, Page(s) e366–70

    MeSH term(s) Abdominal Injuries/surgery ; Humans ; Laparotomy/methods ; Liver/injuries
    Language English
    Publishing date 2011-10
    Publishing country France
    Document type Journal Article
    ISSN 1878-7886
    ISSN (online) 1878-7886
    DOI 10.1016/j.jviscsurg.2011.09.010
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  8. Article: Traumatismes du pancréas.

    Arvieux, C / Létoublon, C

    Annales de chirurgie

    2005  Volume 130, Issue 3, Page(s) 190–198

    Abstract: If an emergency laparotomy is necessary, a damage control laparotomy may be useful. If during the laparotomy the hemodynamic is stabilised, the severity is depending on the existence of a ductal injury and an associated duodenal lesion. Surgical ... ...

    Title translation Traumatic pancreatic injuries.
    Abstract If an emergency laparotomy is necessary, a damage control laparotomy may be useful. If during the laparotomy the hemodynamic is stabilised, the severity is depending on the existence of a ductal injury and an associated duodenal lesion. Surgical indications and techniques are described in these different cases. If no laparotomy, the location and type of injury is assessed by CT scan, magnetic resonance cholangiopancreatography or ERCP. Injury of the pancreatic duct is the main part of prognosis and indications. The non operative treatment in case of ductal injury remains controversial.
    MeSH term(s) Cholangiopancreatography, Endoscopic Retrograde ; Cholangiopancreatography, Magnetic Resonance ; Hemodynamics ; Humans ; Laparotomy ; Pancreas/injuries ; Pancreas/surgery ; Pancreatic Ducts/injuries ; Pancreatic Ducts/surgery ; Wounds and Injuries ; Wounds, Nonpenetrating/diagnosis ; Wounds, Nonpenetrating/surgery
    Language French
    Publishing date 2005-03
    Publishing country France
    Document type English Abstract ; Journal Article ; Review
    ZDB-ID 222253-x
    ISSN 0003-3944
    ISSN 0003-3944
    DOI 10.1016/j.anchir.2005.02.002
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  9. Article ; Online: Evaluation of a biodegradable PLA-PEG-PLA internal biliary stent for liver transplantation: in vitro degradation and mechanical properties.

    Girard, Edouard / Chagnon, Grégory / Moreau-Gaudry, Alexandre / Letoublon, Christian / Favier, Denis / Dejean, Stéphane / Trilling, Bertrand / Nottelet, Benjamin

    Journal of biomedical materials research. Part B, Applied biomaterials

    2020  Volume 109, Issue 3, Page(s) 410–419

    Abstract: Internal biliary stenting during biliary reconstruction in liver transplantation decrease anastomotic biliary complications. Implantation of a resorbable internal biliary stent (RIBS) is interesting since it would avoid an ablation gesture. The objective ...

    Abstract Internal biliary stenting during biliary reconstruction in liver transplantation decrease anastomotic biliary complications. Implantation of a resorbable internal biliary stent (RIBS) is interesting since it would avoid an ablation gesture. The objective of present work was to evaluate adequacy of selected PLA-b-PEG-b-PLA copolymers for RIBS aimed to secure biliary anastomose during healing and prevent complications, such as bile leak and stricture. The kinetics of degradation and mechanical properties of a RIBS prototype were evaluated with respect to the main bile duct stenting requirements in liver transplantation. For this purpose, RIBS degradation under biliary mimicking solution versus standard phosphate buffer control solution was discussed. Morphological changes, mass loss, water uptake, molecular weight, permeability, pH variations, and mechanical properties were examined over time. The permeability and mechanical properties were evaluated under simulated biliary conditions to explore the usefulness of a PLA-b-PEG-b-PLA RIBS to secure biliary anastomosis. Results showed no pH influence on the kinetics of degradation, with degradable RIBS remaining impermeable for at least 8 weeks, and keeping its mechanical properties for 10 weeks. Complete degradation is reached at 6 months. PLA-b-PEG-b-PLA RIBS have the required in vitro degradation characteristics to secure biliary anastomosis in liver transplantation and envision in vivo applications.
    MeSH term(s) Absorbable Implants ; Liver Transplantation ; Polyesters ; Polyethylene Glycols ; Stents
    Chemical Substances Polyesters ; polylactide-polyethylene glycol-polylactide ; Polyethylene Glycols (3WJQ0SDW1A)
    Language English
    Publishing date 2020-09-02
    Publishing country United States
    Document type Evaluation Study ; Journal Article
    ZDB-ID 2099992-6
    ISSN 1552-4981 ; 1552-4973 ; 0021-9304
    ISSN (online) 1552-4981
    ISSN 1552-4973 ; 0021-9304
    DOI 10.1002/jbm.b.34709
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  10. Article ; Online: Cinétique de variation sérique des métalloprotéïnases matricielles (MMP-1, -2, -7 et -9) et de TIMP-1 : un facteur prédictif de récidive après traitement radical des métastases hépatiques de cancers colorectaux ?

    Frenoux, Coralie / Rebischung, Christine / Quesada, Jean-Louis / Mendosa, Christophe / Letoublon, Christian / Trocmé, Candice

    Bulletin du cancer

    2018  Volume 105, Issue 10, Page(s) 884–895

    Abstract: Introduction: Recurrence after liver surgery or radiofrequency is a clinical and biological challenge because it worsens the colorectal cancer prognosis. To date, no biomarker is yet validated to predict the recurrence in order to intensify adjuvant ... ...

    Title translation How to predict the relapse after surgery or radiofrequency of liver metastases of colorectal cancer? Interest of the serum kinetic variation of a matrix metalloproteinase cluster.
    Abstract Introduction: Recurrence after liver surgery or radiofrequency is a clinical and biological challenge because it worsens the colorectal cancer prognosis. To date, no biomarker is yet validated to predict the recurrence in order to intensify adjuvant therapy for patients with higher risk. Matrix metalloproteinases play a major role in the metastasis dissemination and tumoral microenvironment and could be a potential biomarker of interest.
    Methods: Forty-four patients with liver metastasis treated by surgery or radiofrequency were enrolled in this study. Serum levels of MMP-1, MMP-2, MMP-7, MMP-9 and TIMP-1 were monitored in Elisa after therapy and correlated to the recurrence from January 2004 to December 2007. After the curative treatment, patients were assessed for the recurence for two years by CT-scan and examination.
    Results: Post-operative serum level of MMP-9 was significantly higher between J0, J1 and J45 after liver surgery or radiofrequency (***P≤0.001). Level of MMP-2 was significantly increased at M3 and M6 (***P≤0.001) but does not appear to be a risk factor of liver recurrence. The level of TIMP-1 at J0 is a deleterious factor (HR=1.76, P=0.042*).
    Conclusion: This is the first study wich correlates the post-operative level of 4 MMPs and TIMP-1 with the risk of liver recurrence after surgery or radiofrequency. Serum TIMP-1 level at J0 could be helpful to identify patients with higher risk but these results need to be confirmed in a large-scale study.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Biomarkers, Tumor/blood ; Catheter Ablation ; Clinical Enzyme Tests ; Colorectal Neoplasms/pathology ; Female ; Humans ; Liver Neoplasms/diagnosis ; Liver Neoplasms/secondary ; Liver Neoplasms/surgery ; Male ; Matrix Metalloproteinase 1/blood ; Matrix Metalloproteinase 7/blood ; Matrix Metalloproteinase 9/blood ; Middle Aged ; Neoplasm Recurrence, Local/blood ; Neoplasm Recurrence, Local/diagnosis ; Time Factors ; Tissue Inhibitor of Metalloproteinase-1/blood ; Tissue Inhibitor of Metalloproteinase-2/blood
    Chemical Substances Biomarkers, Tumor ; TIMP1 protein, human ; TIMP2 protein, human ; Tissue Inhibitor of Metalloproteinase-1 ; Tissue Inhibitor of Metalloproteinase-2 (127497-59-0) ; MMP7 protein, human (EC 3.4.24.23) ; Matrix Metalloproteinase 7 (EC 3.4.24.23) ; MMP9 protein, human (EC 3.4.24.35) ; Matrix Metalloproteinase 9 (EC 3.4.24.35) ; MMP1 protein, human (EC 3.4.24.7) ; Matrix Metalloproteinase 1 (EC 3.4.24.7)
    Language French
    Publishing date 2018-09-20
    Publishing country France
    Document type Journal Article
    ZDB-ID 213270-9
    ISSN 1769-6917 ; 0007-4551
    ISSN (online) 1769-6917
    ISSN 0007-4551
    DOI 10.1016/j.bulcan.2018.07.007
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