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  1. Article: Addressing the risk and management of cardiometabolic complications in prostate cancer patients on androgen deprivation therapy and androgen receptor axis-targeted therapy: consensus statements from the Hong Kong Urological Association and the Hong Kong Society of Uro-Oncology.

    Poon, Darren M C / Tan, Guang-Ming / Chan, Kuen / Chan, Marco T Y / Chan, Tim-Wai / Kan, Raymond W M / Lam, Martin H C / Leung, Clarence L H / Wong, Kenneth C W / Kam, Kevin K H / Ng, Chi-Fai / Chiu, Peter K F

    Frontiers in oncology

    2024  Volume 14, Page(s) 1345322

    Abstract: Background: Androgen deprivation therapy (ADT) is the foundational treatment for metastatic prostate cancer (PCa). Androgen receptor (AR) axis-targeted therapies are a new standard of care for advanced PCa. Although these agents have significantly ... ...

    Abstract Background: Androgen deprivation therapy (ADT) is the foundational treatment for metastatic prostate cancer (PCa). Androgen receptor (AR) axis-targeted therapies are a new standard of care for advanced PCa. Although these agents have significantly improved patient survival, the suppression of testosterone is associated with an increased risk of cardiometabolic syndrome. This highlights the urgency of multidisciplinary efforts to address the cardiometabolic risk of anticancer treatment in men with PCa.
    Methods: Two professional organizations invited five urologists, five clinical oncologists, and two cardiologists to form a consensus panel. They reviewed the relevant literature obtained by searching PubMed for the publication period from April 2013 to April 2023, to address three discussion areas: (i) baseline assessment and screening for risk factors in PCa patients before the initiation of ADT and AR axis-targeted therapies; (ii) follow-up and management of cardiometabolic complications; and (iii) selection of ADT agents among high-risk patients. The panel convened four meetings to discuss and draft consensus statements using a modified Delphi method. Each drafted statement was anonymously voted on by every panelist.
    Results: The panel reached a consensus on 18 statements based on recent evidence and expert insights.
    Conclusion: These consensus statements serve as a practical recommendation for clinicians in Hong Kong, and possibly the Asia-Pacific region, in the management of cardiometabolic toxicities of ADT or AR axis-targeted therapies in men with PCa.
    Language English
    Publishing date 2024-01-31
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2024.1345322
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Authors' reply.

    Cho, C L / Leung, Clarence L H / Chan, Wayne K W / Chu, Ringo W H / Law, I C

    Hong Kong medical journal = Xianggang yi xue za zhi

    2016  Volume 22, Issue 2, Page(s) 188–189

    Language English
    Publishing date 2016-04
    Publishing country China
    Document type Letter
    ZDB-ID 1239255-8
    ISSN 1024-2708
    ISSN 1024-2708
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4347: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article: Early postoperative outcome of bipolar transurethral enucleation and resection of the prostate.

    Cho, C L / Leung, Clarence L H / Chan, Wayne K W / Chu, Ringo W H / Law, I C

    Hong Kong medical journal = Xianggang yi xue za zhi

    2015  Volume 21, Issue 6, Page(s) 528–535

    Abstract: Objectives: To report the early postoperative outcome of bipolar transurethral enucleation and resection of the prostate. Our results were compared with those published from various centres.: Setting: Regional hospital, Hong Kong.: Patients: A ... ...

    Abstract Objectives: To report the early postoperative outcome of bipolar transurethral enucleation and resection of the prostate. Our results were compared with those published from various centres.
    Setting: Regional hospital, Hong Kong.
    Patients: A total of 28 consecutive patients who had undergone bipolar transurethral enucleation and resection of the prostate by a single surgeon between January and June 2014. All patients were evaluated preoperatively by physical examination, digital rectal examination, transrectal ultrasonography, and laboratory studies, including measurement of haemoglobin, sodium, and prostate-specific antigen levels. Patients were assessed perioperatively and at 4 weeks and 3 months postoperatively.
    Results: The mean resected specimen weight of prostatic adenoma in 28 patients was 48.2 g with a mean enucleation and resection time of 13.6 and 47.7 minutes, respectively. There was a mean decrease in serum prostate-specific antigen by 85.9% (from 6.4 ng/mL to 0.9 ng/mL) postoperatively. Prostate volume was decreased by 68.2% (from 71.9 cm(3) to 22.9 cm(3)) at 4 weeks postoperatively. The mean postoperative haemoglobin drop was 11.5 g/L. The rate of transient urinary incontinence at 3 months was 3.6%. Patients who underwent bipolar transurethral enucleation and resection of the prostate had a short catheterisation time and hospital stay, which is comparable to conventional transurethral resection of the prostate.
    Conclusions: Bipolar transurethral enucleation and resection of the prostate should become the endourological equivalent to open adenomectomy with fewer complications and short convalescence. The technique of bipolar transurethral enucleation and resection of the prostate can be acquired safely with a relatively short learning curve.
    MeSH term(s) Aged ; Aged, 80 and over ; Follow-Up Studies ; Hemoglobins/analysis ; Hong Kong ; Humans ; Length of Stay ; Male ; Middle Aged ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology ; Postoperative Period ; Prostate/pathology ; Prostate/surgery ; Prostate-Specific Antigen/blood ; Prostatic Hyperplasia/blood ; Prostatic Hyperplasia/pathology ; Prostatic Hyperplasia/surgery ; Transurethral Resection of Prostate/adverse effects ; Transurethral Resection of Prostate/methods ; Treatment Outcome ; Urinary Incontinence/epidemiology ; Urinary Incontinence/etiology
    Chemical Substances Hemoglobins ; Prostate-Specific Antigen (EC 3.4.21.77)
    Language English
    Publishing date 2015-12
    Publishing country China
    Document type Journal Article
    ZDB-ID 1239255-8
    ISSN 1024-2708
    ISSN 1024-2708
    DOI 10.12809/hkmj144457
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 4347: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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