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  1. Article ; Online: Pediatric Samples with Colorful Clues.

    Li, Xu / Interiano, Cristina / Leung-Pineda, Van

    Clinical chemistry

    2024  Volume 70, Issue 4, Page(s) 683–684

    MeSH term(s) Humans ; Child ; Excipients
    Chemical Substances Excipients
    Language English
    Publishing date 2024-04-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 80102-1
    ISSN 1530-8561 ; 0009-9147
    ISSN (online) 1530-8561
    ISSN 0009-9147
    DOI 10.1093/clinchem/hvae011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Preliminary Investigation into the Prevalence of G6PD Deficiency in a Pediatric African American Population Using a Near-Patient Diagnostic Platform.

    Leung-Pineda, Van / Weinzierl, Elizabeth P / Rogers, Beverly B

    Diagnostics (Basel, Switzerland)

    2023  Volume 13, Issue 24

    Abstract: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is prevalent in the African American population. We identified eighteen G6PD-deficient samples (9%) in a study of residual, de-identified whole blood specimens from 200 African American pediatric ... ...

    Abstract Glucose-6-phosphate dehydrogenase (G6PD) deficiency is prevalent in the African American population. We identified eighteen G6PD-deficient samples (9%) in a study of residual, de-identified whole blood specimens from 200 African American pediatric patients using a point-of-care instrument. This highlights the possibility of a rapid time to result for G6PD testing, which can be valuable in some clinical scenarios.
    Language English
    Publishing date 2023-12-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics13243647
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Is It Really Methemoglobin?

    Leung-Pineda, Van / Weinzierl, Elizabeth P

    Clinical chemistry

    2021  Volume 66, Issue 8, Page(s) 1118–1119

    MeSH term(s) Child ; Chronic Disease ; Female ; Hemoglobins, Abnormal/analysis ; Humans ; Methemoglobin/analysis ; Methemoglobinemia/blood ; Methemoglobinemia/diagnosis
    Chemical Substances Hemoglobins, Abnormal ; hemoglobin Saskatoon (69670-54-8) ; Methemoglobin (9008-37-1)
    Language English
    Publishing date 2021-02-18
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 80102-1
    ISSN 1530-8561 ; 0009-9147
    ISSN (online) 1530-8561
    ISSN 0009-9147
    DOI 10.1093/clinchem/hvaa062
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Determination of Voriconazole Concentrations in Serum by GC-MS.

    Smith, Alisha / Leung-Pineda, Van

    Journal of clinical laboratory analysis

    2015  Volume 30, Issue 5, Page(s) 411–417

    Abstract: Background: Voriconazole is a broad spectrum triazole antifungal drug used to treat systemic fungal infections. Therapeutic drug monitoring of voriconazole is necessary for achieving maximal efficiency without inducing toxic side effects. Other ... ...

    Abstract Background: Voriconazole is a broad spectrum triazole antifungal drug used to treat systemic fungal infections. Therapeutic drug monitoring of voriconazole is necessary for achieving maximal efficiency without inducing toxic side effects. Other publications have reported methods for measuring voriconazole in serum using high-performance liquid chromatography (HPLC) and liquid chromatography tandem mass spectrometry (LC-MS/MS). Here, we report for the first time a method for the measurement of voriconazole in serum samples using gas chromatography mass spectrometry (GC-MS).
    Methods: Protein precipitation with methanol was used to extract the antifungal that was derivatized with BSTFA (Sigma-Aldrich, St. Louis, MO) and analyzed by GC-MS. Linearity, sensitivity, precision, accuracy, and drug interferences were evaluated for this assay.
    Results: Our method was linear up to 10 μg/ml of voriconazole. The LOQ was determined to be 0.4 μg/ml. CV for between-day precision was <12%. Correlation with an established LC-MS/MS yielded a R2 of 0.96. Tested drugs did not result in >10% error in measurement.
    Conclusion: To our knowledge, we report here the first GC-MS method for voriconazole measurement with acceptable performance. We hope that this method allows clinical laboratories without HPLC or LC-MS/MS instrumentation to measure voriconazole.
    MeSH term(s) Antifungal Agents/blood ; Drug Monitoring ; Gas Chromatography-Mass Spectrometry/methods ; Humans ; Time Factors ; Voriconazole/blood
    Chemical Substances Antifungal Agents ; Voriconazole (JFU09I87TR)
    Language English
    Publishing date 2015-09-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 645095-7
    ISSN 1098-2825 ; 0887-8013
    ISSN (online) 1098-2825
    ISSN 0887-8013
    DOI 10.1002/jcla.21871
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2471: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Severe Abdominal Pain with Hyponatremia.

    Leung-Pineda, Van / Wilson, Don P

    Clinical chemistry

    2017  Volume 63, Issue 9, Page(s) 1544–1545

    MeSH term(s) Abdominal Pain/diagnosis ; Adolescent ; Female ; Humans ; Hydroxymethylbilane Synthase/genetics ; Hyponatremia/diagnosis ; Mutation ; Porphyria, Acute Intermittent/blood ; Porphyria, Acute Intermittent/diagnosis ; Porphyria, Acute Intermittent/genetics
    Chemical Substances Hydroxymethylbilane Synthase (EC 2.5.1.61)
    Language English
    Publishing date 2017-08-29
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 80102-1
    ISSN 1530-8561 ; 0009-9147
    ISSN (online) 1530-8561
    ISSN 0009-9147
    DOI 10.1373/clinchem.2017.271163
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Increased aminotransferases in a 12-year-old girl.

    Smith, Alisha / Leung-Pineda, Van

    Clinical chemistry

    2014  Volume 60, Issue 6, Page(s) 901–902

    MeSH term(s) Child ; Female ; Humans ; Transaminases/metabolism ; Transaminases/urine
    Chemical Substances Transaminases (EC 2.6.1.-)
    Language English
    Publishing date 2014-05-28
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 80102-1
    ISSN 1530-8561 ; 0009-9147
    ISSN (online) 1530-8561
    ISSN 0009-9147
    DOI 10.1373/clinchem.2013.217760
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  7. Article: Longitudinal evaluation of the Abbott ARCHITECT SARS-CoV-2 IgM and IgG assays in a pediatric population.

    Interiano, Cristina / Muze, Sheicho / Turner, Brian / Gonzalez, Mark / Rogers, Beverly / Jerris, Robert / Weinzierl, Elizabeth / Elkhalifa, Mohamed / Leung-Pineda, Van

    Practical laboratory medicine

    2021  Volume 25, Page(s) e00208

    Abstract: Background: Clinical laboratory testing has been an essential part of COVID-19 management. Serology can provide valuable information regarding a patient's exposure to virus, and may have a larger role to play as vaccines becomes available. Limited data ... ...

    Abstract Background: Clinical laboratory testing has been an essential part of COVID-19 management. Serology can provide valuable information regarding a patient's exposure to virus, and may have a larger role to play as vaccines becomes available. Limited data is available on the serological response in pediatric patients. Here we investigate the use of one manufacturer's commercial assays for detecting IgM and IgG in an exclusively pediatric population.
    Methods: Abbott SARS-CoV-2 IgM and IgG assays were performed on an Abbott ARCHITECT i1000. For specificity studies, we tested 78 patient specimens collected before the COVID-19 pandemic, and 66 specimens from patients who tested negative for SARS-CoV-2 nucleic acid amplification test (NAAT) during the COVID-19 pandemic. For sensitivity we tested 181 specimens from 41 patients with a positive NAAT result. Precision data was acquired for 20 days.
    Results: For IgM, the highest qualitative positive agreement with molecular results was observed to be 15-30 days after a positive NAAT result or after symptom onset. For IgG, the highest positive agreement was 31-60 days after a positive NAAT result or 61-90 days after the start of symptoms. IgM started to decline 30 days after NAAT results and faded by 90 days. IgG started to decrease 60 days after a positive NAAT result.
    Conclusion: The Abbott IgM and IgG assays have negative agreements of 98.7-100% relative to NAAT results. The IgM and IgG levels assayed by these methods start to decline months after positive molecular results and onset of symptoms in a pediatric population.
    Language English
    Publishing date 2021-02-19
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2834973-8
    ISSN 2352-5517
    ISSN 2352-5517
    DOI 10.1016/j.plabm.2021.e00208
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Dataset for longitudinal evaluation of the Abbott ARCHITECT SARS-CoV-2 IgM and IgG assays in a pediatric population divided by age.

    Interiano, Cristina / Muze, Sheicho / Turner, Brian / Gonzalez, Mark / Rogers, Beverly / Jerris, Robert / Weinzierl, Elizabeth / Elkhalifa, Mohamed / Leung-Pineda, Van

    Data in brief

    2021  Volume 36, Page(s) 107110

    Abstract: Background: SARS-CoV-2 infection in children does not seem to follow the same pattern as in adults. Limited information is published on the level of antibody production and the duration of antibody response in children with COVID-19. Moreover, it is ... ...

    Abstract Background: SARS-CoV-2 infection in children does not seem to follow the same pattern as in adults. Limited information is published on the level of antibody production and the duration of antibody response in children with COVID-19. Moreover, it is unknown if all children have a similar immune response to the infection, or if there are age dependent differences. In these data, we look at the IgM and IgG levels and duration of two age groups infected by the SARS-CoV-2 virus.
    Methods: Residual laboratory specimens from pediatric patients positive for SARS-CoV-2 infection were tested for IgM and IgG against SARS-CoV-2 using an automated Abbott ARCHITECT i1000. We tested 181 specimens from 41 patients with a positive molecular result. Data was grouped either as time after nucleic acid amplification test (NAAT) or time after symptom onset. Patient samples were divided into 2 age groups: 0 to 11 years old and 12 to 19 years old. The assays detect IgM against the spike protein and IgG against the nucleocapsid protein.
    Language English
    Publishing date 2021-04-30
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2786545-9
    ISSN 2352-3409 ; 2352-3409
    ISSN (online) 2352-3409
    ISSN 2352-3409
    DOI 10.1016/j.dib.2021.107110
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Severe Hypercholesterolemia and Cutaneous Xanthomas in a 3-Year-Old Boy.

    Leung-Pineda, Van / Wilson, Don P

    Clinical chemistry

    2016  Volume 62, Issue 6, Page(s) 899–900

    MeSH term(s) Child, Preschool ; Humans ; Hypercholesterolemia/complications ; Hypercholesterolemia/diagnosis ; Hypercholesterolemia/physiopathology ; Liver/pathology ; Male ; Skin Abnormalities/physiopathology ; Xanthomatosis/complications ; Xanthomatosis/diagnosis ; Xanthomatosis/physiopathology
    Language English
    Publishing date 2016-05-27
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 80102-1
    ISSN 1530-8561 ; 0009-9147
    ISSN (online) 1530-8561
    ISSN 0009-9147
    DOI 10.1373/clinchem.2015.250431
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Dataset for longitudinal evaluation of the Abbott ARCHITECT SARS-CoV-2 IgM and IgG assays in a pediatric population divided by age

    Interiano, Cristina / Muze, Sheicho / Turner, Brian / Gonzalez, Mark / Rogers, Beverly / Jerris, Robert / Weinzierl, Elizabeth / Elkhalifa, Mohamed / Leung-Pineda, Van

    Data in Brief. 2021 June, v. 36

    2021  

    Abstract: SARS-CoV-2 infection in children does not seem to follow the same pattern as in adults. Limited information is published on the level of antibody production and the duration of antibody response in children with COVID-19. Moreover, it is unknown if all ... ...

    Abstract SARS-CoV-2 infection in children does not seem to follow the same pattern as in adults. Limited information is published on the level of antibody production and the duration of antibody response in children with COVID-19. Moreover, it is unknown if all children have a similar immune response to the infection, or if there are age dependent differences. In these data, we look at the IgM and IgG levels and duration of two age groups infected by the SARS-CoV-2 virus.Residual laboratory specimens from pediatric patients positive for SARS-CoV-2 infection were tested for IgM and IgG against SARS-CoV-2 using an automated Abbott ARCHITECT i1000. We tested 181 specimens from 41 patients with a positive molecular result. Data was grouped either as time after nucleic acid amplification test (NAAT) or time after symptom onset. Patient samples were divided into 2 age groups: 0 to 11 years old and 12 to 19 years old. The assays detect IgM against the spike protein and IgG against the nucleocapsid protein.
    Keywords COVID-19 infection ; Severe acute respiratory syndrome coronavirus 2 ; antibody formation ; automation ; data collection ; gene amplification ; nucleocapsid proteins ; patients
    Language English
    Dates of publication 2021-06
    Publishing place Elsevier Inc.
    Document type Article
    ZDB-ID 2786545-9
    ISSN 2352-3409
    ISSN 2352-3409
    DOI 10.1016/j.dib.2021.107110
    Database NAL-Catalogue (AGRICOLA)

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