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Article: Novel finely structured polymer aerogels using organogelators as a structure-directing component

Leven, Felix / Ulbricht, Mathias / Limberg, Johannes / Ostermann, Rainer

Journal of materials chemistry A. 2021 Sept. 21, v. 9, no. 36

2021

Abstract: Sorbitol-based organogelators were used to obtain nanostructured, robust polyolefin gels that could be freeze-dried into aerogels. Finding the ideal ratio of polymer to gelator led to homogeneous, fine structures with good mechanical stability and low ... ...

Abstract	Sorbitol-based organogelators were used to obtain nanostructured, robust polyolefin gels that could be freeze-dried into aerogels. Finding the ideal ratio of polymer to gelator led to homogeneous, fine structures with good mechanical stability and low thermal conductivity. The influence of polymer type, molecular weight and concentration was studied with regard to structure, compressive strength and thermal conductivity and a mechanism for the structure formation was postulated. Moreover, Soxhlet extraction was shown as a route to optimize the drying process and partially recover the gelator that is required as a structure-directing component, but partially also necessary in the final composite. The materials presented here are novel and useful composite aerogels with potential applications as insulating materials, porous supports, adsorbents, catalyst carriers and membranes.
Keywords	adsorbents ; aerogels ; catalysts ; compression strength ; freeze drying ; molecular weight ; polyolefin ; solid phase extraction ; thermal conductivity
Language	English
Dates of publication	2021-0921
Size	p. 20695-20702.
Publishing place	The Royal Society of Chemistry
Document type	Article
ZDB-ID	2702232-8
ISSN	2050-7496 ; 2050-7488
ISSN (online)	2050-7496
ISSN	2050-7488
DOI	10.1039/d1ta06161e
Database	NAL-Catalogue (AGRICOLA)

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Book: Meducase

Kamp, M / Leven, F. J

Schlussbericht, Universität Heidelberg ; Bewilligungszeitraum: 01.01.2001 - 30.06.2004

2004

Institution	Klinikum Heidelberg
Author's details	Zuwendungsempfänger: Universitätsklinikum Heidelberg. Projektleiter: F. J. Leven. Fachlicher Bearb. beim BMBF/PT: M. Kamp
Language	German
Size	7 Bl
Publishing place	Heidelberg
Document type	Book
Note	Förderkennzeichen BMBF 01NM077C. - Verbund-Nr. 01020104 ; Unterschiede zwischen dem gedruckten Dokument und der elektronischen Ressource können nicht ausgeschlossen werden
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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Book ; Online: Meducase

Kamp, M / Leven, F. J

Schlussbericht, Universität Heidelberg ; Bewilligungszeitraum: 01.01.2001 - 30.06.2004

2004

Institution	Klinikum Heidelberg
Author's details	Zuwendungsempfänger: Universitätsklinikum Heidelberg. Projektleiter: F. J. Leven. Fachlicher Bearb. beim BMBF/PT: M. Kamp
Language	German
Size	Online-Ressource (8 S., 65,3 KB)
Publisher	Technische Informationsbibliothek u. Universitätsbibliothek
Publishing place	Hannover ; Heidelberg
Document type	Book ; Online
Note	Förderkennzeichen BMBF 01NM077C ; IMD-Felder maschinell generiert ; Unterschiede zwischen dem gedruckten Dokument und der elektronischen Ressource können nicht ausgeschlossen werden
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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Article ; Online: Frequency and predictors for chronic thromboembolic pulmonary hypertension after a first unprovoked pulmonary embolism: Results from PADIS studies.

Fauché, Alexandre / Presles, Emilie / Sanchez, Olivier / Jaïs, Xavier / Le Mao, Raphael / Robin, Philippe / Pernod, Gilles / Bertoletti, Laurent / Jego, Patrick / Parent, Florence / Lemarié, Catherine A / Leven, Florent / Le Roux, Pierre-Yves / Salaun, Pierre-Yves / Nonent, Michel / Girard, Philippe / Lacut, Karine / Savale, Laurent / Mélac, Solen /

Guégan, Marie / Mismetti, Patrick / Laporte, Silvy / Leroyer, Christophe / Montani, David / Couturaud, Francis / Tromeur, Cécile

Journal of thrombosis and haemostasis : JTH

2022 Volume 20, Issue 12, Page(s) 2850–2861

Abstract: Background: Chronic thromboembolic pulmonary hypertension (CTEPH) is a life-threatening complication of a pulmonary embolism (PE) whose incidence and predictors are not precisely determined.: Objective: To determine the frequency and predictors for ... ...

Abstract	Background: Chronic thromboembolic pulmonary hypertension (CTEPH) is a life-threatening complication of a pulmonary embolism (PE) whose incidence and predictors are not precisely determined. Objective: To determine the frequency and predictors for CTEPH after a first unprovoked PE. Patients/methods: In a randomized trial comparing an additional 18-month warfarin versus placebo in patients after a first unprovoked PE initially treated with vitamin K antagonist for 6 months, we applied recommended CTEPH screening strategies through an 8-year follow-up to determine cumulative incidence of CTEPH. CTEPH predictors were estimated using Cox models. Pulmonary vascular obstruction (PVO) and systolic pulmonary arterial pressure (sPAP) at PE diagnosis and 6 months were studied by receiver operating curves analysis. All CTEPH cases and whether they were incident or prevalent were adjudicated. Results: During a median follow-up of 8.7 years, nine CTEPH cases were diagnosed among 371 patients, with a cumulative incidence of 2.8% (95% confidence interval [CI] 0.95-4.64), and of 1.31% (95% CI 0.01-2.60) after exclusion of five cases adjudicated as prevalent. At PE diagnosis, PVO > 45% and sPAP > 56 mmHg were associated with CTEPH with a hazard ratio (HR) of 33.00 (95% CI 1.64-667.00, p = .02) and 12.50 (95% CI 2.10-74.80, p < .01), respectively. Age > 65 years, lupus anticoagulant antibodies and non-O blood groups were also predictive of CTEPH. PVO > 14% and sPAP > 34 mmHg at 6 months were associated with CTEPH (HR 63.90 [95% CI 3.11-1310.00, p < .01]and HR 17.2 [95% CI 2.75-108, p < .01]). Conclusion: After a first unprovoked PE, CTEPH cumulative incidence was 2.8% during an 8-year follow-up. PVO and sPAP at PE diagnosis and at 6 months were the main predictors for CTEPH diagnosis.
MeSH term(s)	Humans ; Aged ; Hypertension, Pulmonary/diagnosis ; Hypertension, Pulmonary/epidemiology ; Hypertension, Pulmonary/complications ; Risk Factors ; Chronic Disease ; Pulmonary Embolism/complications ; Pulmonary Embolism/diagnosis ; Pulmonary Embolism/epidemiology ; Anticoagulants/therapeutic use
Chemical Substances	Anticoagulants
Language	English
Publishing date	2022-09-25
Publishing country	England
Document type	Randomized Controlled Trial ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2112661-6
ISSN	1538-7836 ; 1538-7933
ISSN (online)	1538-7836
ISSN	1538-7933
DOI	10.1111/jth.15866
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Curriculum for medical informatics at the University of Heidelberg/School of Technology Heilbronn.

Leven, F J

Methods of information in medicine

1994 Volume 33, Issue 3, Page(s) 262–7; discussion 282–4

Abstract: The specialized university curriculum for medical informatics at the University of Heidelberg/School of Technology Heilbronn described in this paper is one of the oldest educational approaches in the field of medical informatics, and has been successful ... ...

Abstract	The specialized university curriculum for medical informatics at the University of Heidelberg/School of Technology Heilbronn described in this paper is one of the oldest educational approaches in the field of medical informatics, and has been successful for more than 20 years with more than 600 graduates (Diplom-Informatiker der Medizin). It is based on the concept of medical informatics as an independent medical discipline, and covers the total spectrum ranging from health care economics, biosignal and medical image processing, model building in medicine, to information and knowledge processing in medicine. It is a program of 4.5 years duration with a strong emphasis on the methodological foundations of medical informatics and on practical education in a number of specific laboratories. Thirty-five students are admitted each semester, and in total about 390 students enrolled. The faculty consists of 17 full-time members and about 25 part-time lecturers.
MeSH term(s)	Curriculum ; Germany ; Medical Informatics/education
Language	English
Publishing date	1994-06
Publishing country	Germany
Document type	Journal Article
ZDB-ID	3500-2
ISSN	0026-1270
ISSN	0026-1270
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Twenty Five Years of Medical Informatics Education at Heidelberg/Heilbronn: Discussion of a Specialized Curriculum for Medical Informatics

Leven, F.J. / Haux, R.

Yearbook of Medical Informatics

2000 Volume 09, Issue 01, Page(s) 120–127

Abstract: The specialized university curriculum for medical informatics (MI) at the University of Heidelberg/School of Technology Heilbronn is one of the oldest educational approaches in the field of medical informatics, and has been successful for 25 years with ... ...

Abstract	The specialized university curriculum for medical informatics (MI) at the University of Heidelberg/School of Technology Heilbronn is one of the oldest educational approaches in the field of medical informatics, and has been successful for 25 years with about 1,000 graduates (Diplom-Informatikerin der Medizin or Diplom-Informatiker der Medizin). It belongs to the category of dedicated master’s programs for medical informatics and is based on the concept of medical informatics as a medical discipline in its own right. The curriculum is oriented towards the total spectrum of medical informatics ranging from health care economics, biosignal and medical image processing, medical documentation, to information and knowledge processing in medicine. It is a 4.5-year program with strong emphasis on the methodological foundations of medical informatics and on practical education in a number of specific laboratories. Thirty-five students are admitted each semester, and in total about 440 students are enrolled. The faculty consists of 17 full-time members and about 25 part-time lecturers. We report on characteristics, structure and contents of the new 5th version of the curriculum and discuss the features of a specialized curriculum for medical informatics with respect to the challenges for medical informatics in the 21st century.
Keywords	Medical informatics ; health informatics ; curriculum ; education ; training
Language	English
Publishing date	2000-08-01
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article
ISSN	2364-0502 ; 0943-4747
ISSN (online)	2364-0502
ISSN	0943-4747
DOI	10.1055/s-0038-1637951
Database	Thieme publisher's database

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Article: Challenges in the evolution of the medical informatics program at heidelberg/heilbronn (Germany).

Knaup, P / Haag, M / Leven, F J / Dickhaus, H

Methods of information in medicine

2009 Volume 48, Issue 1, Page(s) 66–75

Abstract: Objective: Health and medical informatics (HMI) is an evolving discipline. Therefore, evolving educational programs in HMI have to take a variety of requirements into account. The aim of this paper is to analyze these requirements and to compare them ... ...

Abstract	Objective: Health and medical informatics (HMI) is an evolving discipline. Therefore, evolving educational programs in HMI have to take a variety of requirements into account. The aim of this paper is to analyze these requirements and to compare them with the medical informatics program Heidelberg/Heilbronn, Germany. Methods: Systematic analysis of the IMIA recommendations on educating HMI, the Bologna declaration, current technological and health care developments and the results of graduates surveys. Results: The latest revision of the Heidelberg/Heilbronn medical informatics program not only takes current developments into account but also realizes the IMIA recommendations, the Bologna declaration and graduates' data and feedback obtained in structured surveys. The topics bioinformatics, IT security and telemedicine were strengthened, taking major research and application trends into account. The program has been transformed into a consecutive bachelor/master program. It qualifies its graduates to work in the field of medical informatics as well as in informatics. Conclusions: Medical informatics is a very broad field. Programs have to make concessions to scope: It is not possible to provide profound knowledge and skills in computer science and also teach a variety of application areas like bioinformatics, public health informatics and clinical informatics in depth within one medical informatics program. Many graduate programs in various nations concentrate on providing HMI skills to health care professionals.
MeSH term(s)	Curriculum ; Education, Graduate/methods ; Education, Graduate/organization & administration ; Educational Status ; Germany ; Humans ; Medical Informatics/education ; Models, Educational ; Program Development ; Program Evaluation
Language	English
Publishing date	2009-01-15
Publishing country	Germany
Document type	Journal Article
ZDB-ID	3500-2
ISSN	0026-1270
ISSN	0026-1270
DOI	10.3414/me9134
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Software engineering education in medical informatics.

Leven, F J

Methods of information in medicine

1989 Volume 28, Issue 4, Page(s) 295–303

Abstract: Requirements and approaches of Software Engineering education in the field of Medical Informatics are described with respect to the impact of (1) experiences characterizing the "software misery", (2) status and tendencies in software methodology, and (3) ...

Abstract	Requirements and approaches of Software Engineering education in the field of Medical Informatics are described with respect to the impact of (1) experiences characterizing the "software misery", (2) status and tendencies in software methodology, and (3) educational status and needs in computer science education influenced by the controversy "theoretical versus practical education". Special attention is directed toward the growing importance of analysis, design methods, and techniques in the professional spectrum of Medical Informatics, the relevance of general principles of systems engineering in health care, the potential of non-procedural programming paradigms, and the intersection of Artificial Intelligence and education. Realizations of and experiences with programs in the field of Software Engineering are reported with respect to special requirements in Medical Informatics.
MeSH term(s)	Artificial Intelligence ; Curriculum ; Efficiency ; Medical Informatics/education ; Software ; Software Design
Language	English
Publishing date	1989-11
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	3500-2
ISSN	0026-1270
ISSN	0026-1270
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: The medical informatics curriculum at the University of Heidelberg/School of Technology Heilbronn: new developments in its 5th revision.

Haux, R / Leven, F J

Studies in health technology and informatics

2000 Volume 57, Page(s) 30–39

Abstract: We report about new developments in the 5th version of the medical informatics program at the University of Heidelberg/School of Technology Heilbronn, reflect our approaches for the revision and discuss our current curriculum in relationship to other ... ...

Abstract	We report about new developments in the 5th version of the medical informatics program at the University of Heidelberg/School of Technology Heilbronn, reflect our approaches for the revision and discuss our current curriculum in relationship to other curricula in health informatics and medical informatics. The specialised university curriculum for medical informatics at the University of Heidelberg/School of Technology Heilbronn is one of the oldest educational approaches in the field of medical informatics. During more than 25 years approx. 1000 students graduated. The program belongs to the category of dedicated master programs for medical informatics and is based on the concept of medical informatics as a medical discipline of its own. It covers the total spectrum of medical informatics ranging from information systems in health care, biosignal and medical image processing, medical documentation, to information and knowledge processing in medicine. It is a 4.5 years program with a strong emphasis on the methodological foundations of medical informatics and on practical education in a number of specific laboratories. For the 5th version of the Heidelberg/Heilbronn curriculum on medical informatics, having started at winter semester 1997/98, we hope to have reflected the evolution of medical informatics as a separate discipline, moving one step further towards educating medical informatics, and not 'just' medicine and informatics.
MeSH term(s)	Curriculum ; Germany ; Humans ; Medical Informatics/education
Language	English
Publishing date	2000
Publishing country	Netherlands
Document type	Journal Article
ISSN	0926-9630
ISSN	0926-9630
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Twenty Five Years of Medical Informatics Education at Heidelberg/Heilbronn: Discussion of a Specialized Curriculum for Medical Informatics.

Leven, F J / Haux, R

Yearbook of medical informatics

2000 , Issue 1, Page(s) 120–127

Abstract	The specialized university curriculum for medical informatics (MI) at the University of Heidelberg/School of Technology Heilbronn is one of the oldest educational approaches in the field of medical informatics, and has been successful for 25 years with about 1,000 graduates (Diplom-lnformatikerin der Medizin or Diplomlnformatiker der Medizin). It belongs to the category of dedicated master's programs for medical informatics and is based on the concept of medical informatics as a medical discipline in its own right. The curriculum is oriented towards the total spectrum of medical informatics ranging from health care economics, biosignal and medical image processing, medical documentation, to information and knowledge processing in medicine. It is a 4.5-year program with strong emphasis on the methodological foundations of medical informatics and on practical education in a number of specific laboratories. Thirty-five students are admitted each semester, and in total about 440 students are enrolled. The faculty consists of 17 full-time members and about 25 parttime lecturers.We report on characteristics, structure and contents of the new 5th version of the curriculum and discuss the features of a specialized curriculum for medical informatics with respect to the challenges for medical informatics in the 21st century.
Language	English
Publishing date	2000
Publishing country	Germany
Document type	Journal Article
ISSN	2364-0502
ISSN (online)	2364-0502
Database	MEDical Literature Analysis and Retrieval System OnLINE

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