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Artikel: Expression profile of miRNAs computationally predicted to target PDL-1 in cervical tissues of different histology groups.

Leventakou, Danai / Gouloumi, Alina-Roxani / Spathis, Aris / Pouliakis, Abraham / Koufopoulos, Nektarios / Pergialiotis, Vassilios / Drakakis, Peter / Panayiotides, Ioannis G / Kottaridi, Christine

Frontiers in cell and developmental biology

2023 Band 11, Seite(n) 1101041

Abstract: Background: ...

Abstract	Background:
Sprache	Englisch
Erscheinungsdatum	2023-02-24
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article ; Review
ZDB-ID	2737824-X
ISSN	2296-634X
ISSN	2296-634X
DOI	10.3389/fcell.2023.1101041
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Diagnostic Challenges during Inflammation and Cancer: Current Biomarkers and Future Perspectives in Navigating through the Minefield of Reactive versus Dysplastic and Cancerous Lesions in the Digestive System.

Pateras, Ioannis S / Igea, Ana / Nikas, Ilias P / Leventakou, Danai / Koufopoulos, Nektarios I / Ieronimaki, Argyro Ioanna / Bergonzini, Anna / Ryu, Han Suk / Chatzigeorgiou, Antonios / Frisan, Teresa / Kittas, Christos / Panayiotides, Ioannis G

International journal of molecular sciences

2024 Band 25, Heft 2

Abstract: In the setting of pronounced inflammation, changes in the epithelium may overlap with neoplasia, often rendering it impossible to establish a diagnosis with certainty in daily clinical practice. Here, we discuss the underlying molecular mechanisms ... ...

Abstract	In the setting of pronounced inflammation, changes in the epithelium may overlap with neoplasia, often rendering it impossible to establish a diagnosis with certainty in daily clinical practice. Here, we discuss the underlying molecular mechanisms driving tissue response during persistent inflammatory signaling along with the potential association with cancer in the gastrointestinal tract, pancreas, extrahepatic bile ducts, and liver. We highlight the histopathological challenges encountered in the diagnosis of chronic inflammation in routine practice and pinpoint tissue-based biomarkers that could complement morphology to differentiate reactive from dysplastic or cancerous lesions. We refer to the advantages and limitations of existing biomarkers employing immunohistochemistry and point to promising new markers, including the generation of novel antibodies targeting mutant proteins, miRNAs, and array assays. Advancements in experimental models, including mouse and 3D models, have improved our understanding of tissue response. The integration of digital pathology along with artificial intelligence may also complement routine visual inspections. Navigating through tissue responses in various chronic inflammatory contexts will help us develop novel and reliable biomarkers that will improve diagnostic decisions and ultimately patient treatment.
Mesh-Begriff(e)	Humans ; Animals ; Mice ; Artificial Intelligence ; Neoplasms/diagnosis ; Inflammation ; Biomarkers ; Hyperplasia ; Digestive System
Chemische Substanzen	Biomarkers
Sprache	Englisch
Erscheinungsdatum	2024-01-19
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms25021251
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: HPV16

Konstantopoulos, Georgios / Leventakou, Danai / Saltiel, Despoina-Rozi / Zervoudi, Efthalia / Logotheti, Eirini / Pettas, Spyros / Karagianni, Korina / Daiou, Angeliki / Hatzistergos, Konstantinos E / Dafou, Dimitra / Arsenakis, Minas / Kottaridi, Christine

Viruses

2024 Band 16, Heft 1

Abstract: Human Papillomaviruses have been associated with the occurrence of cervical cancer, the fourth most common cancer that affects women globally, while 70% of cases are caused by infection with the high-risk types HPV16 and HPV18. The integration of these ... ...

Abstract	Human Papillomaviruses have been associated with the occurrence of cervical cancer, the fourth most common cancer that affects women globally, while 70% of cases are caused by infection with the high-risk types HPV16 and HPV18. The integration of these viruses' oncogenes
Mesh-Begriff(e)	Female ; Humans ; B7-H1 Antigen/genetics ; Human papillomavirus 16/genetics ; Immune Evasion ; MicroRNAs/genetics ; Uterine Cervical Neoplasms/genetics ; Uterine Cervical Neoplasms/virology ; Oncogene Proteins, Viral/genetics
Chemische Substanzen	B7-H1 Antigen ; MicroRNAs ; MIRN143 microRNA, human ; E6 protein, Human papillomavirus type 16 ; Oncogene Proteins, Viral ; HIF1A protein, human
Sprache	Englisch
Erscheinungsdatum	2024-01-12
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v16010113
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: The T350G Variation of Human Papillomavirus 16 E6 Gene Prevails in Oropharyngeal Cancer from a Small Cohort of Greek Patients

Kottaridi, Christine / Resta, Panagiota / Leventakou, Danai / Gioti, Katerina / Zygouras, Ioannis / Gouloumi, Alina-Roxani / Sakagiannis, Georgios / Alzahrani, Khalid J. / Venetikou, Maria S. / Anthouli-Anagnostopoulou, Fragkiski / Beloukas, Apostolos

Viruses. 2022 Aug. 04, v. 14, no. 8

2022

Abstract: Recent trends have shown a dramatic rise in the incidence of oropharyngeal squamous cell carcinoma strongly associated with high-risk human papillomavirus (HPV) of type 16. The genetic variability of HPV16 has been extensively studied in cervical cancer ... ...

Abstract	Recent trends have shown a dramatic rise in the incidence of oropharyngeal squamous cell carcinoma strongly associated with high-risk human papillomavirus (HPV) of type 16. The genetic variability of HPV16 has been extensively studied in cervical cancer but there are very limited published data concerning the genetic variations of this HPV type in oropharyngeal cancer. In the present study, the genetic variations of HPV16 E6 gene sequences originated from a small cohort of Greek patients diagnosed with oropharyngeal cancer were assessed. The vast majority of the sequences clustered within the European variant branch. The T350G variation was found to be the predominant one. This finding may indicate the need for further studies that could explain the possible impact of this variant in the pathomechanisms of oropharyngeal cancer.
Schlagwörter	Human papillomavirus type 16 ; genes ; genetic variation ; humans ; oropharyngeal neoplasms ; squamous cell carcinoma ; uterine cervical neoplasms
Sprache	Englisch
Erscheinungsverlauf	2022-0804
Erscheinungsort	Multidisciplinary Digital Publishing Institute
Dokumenttyp	Artikel
ZDB-ID	2516098-9
ISSN	1999-4915
ISSN	1999-4915
DOI	10.3390/v14081724
Datenquelle	NAL Katalog (AGRICOLA)

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Artikel: Malignant Brenner Tumor of the Ovary: A Systematic Review of the Literature.

Koufopoulos, Nektarios I / Pouliakis, Abraham / Samaras, Menelaos G / Kotanidis, Christakis / Boutas, Ioannis / Kontogeorgi, Adamantia / Dimas, Dionysios / Sitara, Kyparissia / Zacharatou, Andriani / Ieronimaki, Argyro-Ioanna / Spathis, Aris / Leventakou, Danai / Zanelli, Magda / Pateras, Ioannis S / Panayiotides, Ioannis G / Palicelli, Andrea / Syrios, John

Cancers

2024 Band 16, Heft 6

Abstract: Background: Malignant Brenner tumors are rare ovarian tumors, accounting for less than 1% of malignant ovarian neoplasms. The aim of this manuscript is to systematically review the current literature concerning malignant Brenner tumors.: Methods: We ... ...

Abstract	Background: Malignant Brenner tumors are rare ovarian tumors, accounting for less than 1% of malignant ovarian neoplasms. The aim of this manuscript is to systematically review the current literature concerning malignant Brenner tumors. Methods: We searched three medical databases (PubMed, Scopus, and Web of Science) for relevant articles published until 15 September 2023. Results: After applying inclusion and exclusion criteria, 48 manuscripts describing 115 cases were included in this study from the English literature. Conclusions: We analyzed the demographic, clinical, pathological, and oncological characteristics of 115 patients with malignant Brenner tumors. The statistical analysis showed that recurrence was marginally statistically significantly related to tumor stage and was more common in patients with ascites and in women with abnormal CA-125 levels; patients that were treated with lymphadenectomy had better disease-specific survival.
Sprache	Englisch
Erscheinungsdatum	2024-03-09
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article ; Review
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers16061106
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Cervical HPV Infections, Sexually Transmitted Bacterial Pathogens and Cytology Findings-A Molecular Epidemiology Study.

Valasoulis, George / Pouliakis, Abraham / Michail, Georgios / Magaliou, Ioulia / Parthenis, Christos / Margari, Niki / Kottaridi, Christine / Spathis, Aris / Leventakou, Danai / Ieronimaki, Argyro-Ioanna / Androutsopoulos, Georgios / Panagopoulos, Periklis / Daponte, Alexandros / Tsiodras, Sotirios / Panayiotides, Ioannis G

Pathogens (Basel, Switzerland)

2023 Band 12, Heft 11

Abstract: Prevalent cervical HPV infection and high-risk HPV persistence consequences have been extensively investigated in the literature; nevertheless, any causative interrelations of other sexually transmitted bacterial infections (STIs) with cervical HPV ... ...

Abstract	Prevalent cervical HPV infection and high-risk HPV persistence consequences have been extensively investigated in the literature; nevertheless, any causative interrelations of other sexually transmitted bacterial infections (STIs) with cervical HPV infection have not yet been fully elucidated. This study aimed to investigate the possible association of STIs with cervical cytology aberrations and HPV genotyping results in a representative sample of predominantly young Greek women. Liquid-based cytology and molecular detection for bacterial STIs and HPV as well as extended HPV genotyping were simultaneously assessed in cervical samples from 2256 individuals visiting several urban outpatient Gynecology Departments for well-woman visits or cervical screening throughout a 20-month period. All specimens were centrally processed with validated molecular assays. The mean age of the studied women was 37.0 ± 11.7 years; 722 women (33.30%) tested positive for STI (mean age 34.23 ± 10.87 years). A higher mean age (38.34 ± 11.83 years (
Sprache	Englisch
Erscheinungsdatum	2023-11-14
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article
ZDB-ID	2695572-6
ISSN	2076-0817
ISSN	2076-0817
DOI	10.3390/pathogens12111347
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: A Case of Prostatic Signet-Ring Cell-like Carcinoma with Pagetoid Spread and Intraductal Carcinoma and Long-Term Survival: PD-L1 and Mismatch Repair System Proteins (MMR) Immunohistochemical Evaluation with Systematic Literature Review.

Koufopoulos, Nektarios / Ieronimaki, Argyro-Ioanna / Zacharatou, Andriani / Gouloumis, Alina Roxana / Leventakou, Danai / Boutas, Ioannis / Dimas, Dionysios T / Kontogeorgi, Adamantia / Sitara, Kyparissia / Khaldi, Lubna / Zanelli, Magda / Palicelli, Andrea

Journal of personalized medicine

2023 Band 13, Heft 6

Abstract: Prostatic adenocarcinoma (PA) is the second most common malignancy in men globally. Signet-ring cell-like adenocarcinoma (SRCC) is a very rare PA subtype, with around 200 cases reported in the English literature. Histologically, the tumor cells show a ... ...

Abstract	Prostatic adenocarcinoma (PA) is the second most common malignancy in men globally. Signet-ring cell-like adenocarcinoma (SRCC) is a very rare PA subtype, with around 200 cases reported in the English literature. Histologically, the tumor cells show a vacuole compressing the nucleus to the periphery. Pagetoid spread in acini and ducts is usually related to metastases from urothelial or colorectal carcinomas, less commonly associated with intraductal carcinoma (IC); histologically, the tumor cells grow between the acinar secretory and basal cell layers. To our knowledge, we report the first prostatic SRCC (Gleason score 10, stage pT3b) associated with IC and pagetoid spread to prostatic acini and seminal vesicles. To our systematic literature review (PRISMA guidelines), it is the first tested case for both PD-L1 (<1% of positive tumor cells, clone 22C3) and mismatch repair system proteins (MMR) (MLH1+/MSH2+/PMS2+/MSH6+). We found no SRCC previously tested for MMR, while only four previous cases showed high expression of another PD-L1 clone (28-8). Finally, we discussed the differential diagnoses of prostatic SRCC.
Sprache	Englisch
Erscheinungsdatum	2023-06-19
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article ; Review
ZDB-ID	2662248-8
ISSN	2075-4426
ISSN	2075-4426
DOI	10.3390/jpm13061016
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Significance of

Pantazopoulos, Theodoros / Leventakou, Danai / Koufopoulos, Nektarios / Pouliakis, Abraham / Economopoulou, Panagiota / Glava, Chryssoula / Tzardi, Maria / Kafiri, Georgia / Kittas, Christos / Korkolopoulou, Penelope / Arapantoni-Dadioti, Petroula / Sotiriou, Helen / Filippidis, Theodoros / Maragoudakis, Pavlos / Giotakis, Ioannis / Panayiotides, Ioannis G / Psyrri, Amanda / Delides, Alexandros

Anticancer research

2023 Band 43, Heft 4, Seite(n) 1709–1717

Abstract: Background/aim: Adenoid cystic carcinoma (ACC) is an aggressive neoplasm even though it has low-grade histological appearance and slow growth. The aim of this study was to identify the immunohistochemical and molecular characteristics of ACC, as well as ...

Abstract	Background/aim: Adenoid cystic carcinoma (ACC) is an aggressive neoplasm even though it has low-grade histological appearance and slow growth. The aim of this study was to identify the immunohistochemical and molecular characteristics of ACC, as well as their correlation with the clinical course of patients. Patients and methods: This is a retrospective multicenter analysis. We included 50 patients diagnosed with ACC in the head and neck between 2000 and 2021. The expression of MYB proto-oncogene transcription factor (MYB), neurotrophic tyrosine kinase receptor (NTRK), human epidermal receptor-2 (HER-2), and Ki-67 was examined through immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH). We also performed a clinical follow-up of the patients. Results: The median age of the patients was 58.5 years; moreover, 54% of the patients were male. Compared with female patients, male patients were at a higher risk of both recurrence and death. No HER-2-positive cases were revealed. MYB expression was positive in 28 (56%) cases. However, MYB expression did not significantly affect survival. NTRK expression was positive in eight (16%) cases. NTRK-positive patients had worse overall survival (OS) than NTRK-negative patients (p=0.0246). Additionally, the percentage of NTRK-stained cells was negatively correlated with disease-free survival (p=0.0016) and OS (p=0.0027). Conclusion: There was no correlation between MYB positivity and survival. Contrarily, NTRK-positive patients had worse survival, indicating that NTRK is a negative prognostic factor. Tropomyosin receptor kinase inhibitors can be used to treat these patients. Furthermore, MYB-targeted inhibitors are promising therapeutic agents.
Mesh-Begriff(e)	Humans ; Male ; Female ; Middle Aged ; Carcinoma, Adenoid Cystic/pathology ; Receptor Protein-Tyrosine Kinases ; In Situ Hybridization, Fluorescence ; Head and Neck Neoplasms/genetics ; Immunohistochemistry ; Biomarkers, Tumor/metabolism
Chemische Substanzen	Receptor Protein-Tyrosine Kinases (EC 2.7.10.1) ; Biomarkers, Tumor
Sprache	Englisch
Erscheinungsdatum	2023-02-22
Erscheinungsland	Greece
Dokumenttyp	Multicenter Study ; Journal Article
ZDB-ID	604549-2
ISSN	1791-7530 ; 0250-7005
ISSN (online)	1791-7530
ISSN	0250-7005
DOI	10.21873/anticanres.16323
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Human Papillomavirus 16 DNA Methylation Patterns and Investigation of Integration Status in Head and Neck Cancer Cases.

Zygouras, Ioannis / Leventakou, Danai / Pouliakis, Abraham / Panagiotou, Styliana / Tsakogiannis, Dimitris / Konstantopoulos, Georgios / Logotheti, Eirini / Samaras, Menelaos / Kyriakopoulou, Zaharoula / Beloukas, Apostolos / Pateras, Ioannis S / Delides, Alexandros / Psyrri, Amanda / Panayiotides, Ioannis G / Yiangou, Minas / Kottaridi, Christine

International journal of molecular sciences

2023 Band 24, Heft 19

Abstract: Persistent high-risk human papillomavirus (HPV) infection is a pivotal factor in the progression of cervical cancer. In recent years, an increasing interest has emerged in comprehending the influence of HPV on head and neck squamous cell carcinoma (HNSCC) ...

Abstract	Persistent high-risk human papillomavirus (HPV) infection is a pivotal factor in the progression of cervical cancer. In recent years, an increasing interest has emerged in comprehending the influence of HPV on head and neck squamous cell carcinoma (HNSCC). Notably, it is well established that HPV-associated HNSCC show cases with distinct molecular and clinical attributes compared to HPV-negative cases. The present study delves into the epigenetic landscape of HPV16, specifically its
Mesh-Begriff(e)	Female ; Humans ; Squamous Cell Carcinoma of Head and Neck/genetics ; Squamous Cell Carcinoma of Head and Neck/complications ; Human Papillomavirus Viruses ; Carcinoma, Squamous Cell/pathology ; DNA Methylation ; Papillomavirus Infections/complications ; Papillomavirus Infections/genetics ; Head and Neck Neoplasms/genetics ; Head and Neck Neoplasms/complications ; DNA/metabolism ; Oncogene Proteins, Viral/genetics ; Oncogene Proteins, Viral/metabolism ; DNA, Viral/genetics ; DNA, Viral/metabolism
Chemische Substanzen	DNA (9007-49-2) ; Oncogene Proteins, Viral ; DNA, Viral
Sprache	Englisch
Erscheinungsdatum	2023-09-26
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms241914593
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Primary Adrenal Lymphomas with Cushing's Syndrome: Two Cases with Evidence of Endogeneous Cortisol Production by the Neoplastic Lymphoid Cells.

Papageorgiou, Sotirios G / Mavroeidi, Ioanna / Kostakis, Marios / Spathis, Aris / Leventakou, Danai / Kritikou, Evangelia / Oikonomopoulos, Nikolaos / Kourkouti, Chrysoula / Krania, Maria / Bouchla, Anthi / Thomopoulos, Thomas / Tsakiraki, Zoi / Markakis, Konstantinos / Panayiotides, Ioannis G / Thomaidis, Nikolaos / Pappa, Vasiliki / Foukas, Periklis G / Peppa, Melpomeni

Journal of clinical medicine

2023 Band 12, Heft 15

Abstract: Primary adrenal lymphoma (PAL) is a rare entity that presents as unilateral or bilateral rapidly growing adrenal masses, with signs and symptoms most commonly related to adrenal insufficiency due to the mass effect on the surrounding tissues. Although ... ...

Abstract	Primary adrenal lymphoma (PAL) is a rare entity that presents as unilateral or bilateral rapidly growing adrenal masses, with signs and symptoms most commonly related to adrenal insufficiency due to the mass effect on the surrounding tissues. Although steroeidogenesis has not been previously described in PAL, we herein report two cases of PAL presenting as adrenal incidentalomas (AIs) that demonstrated autonomous cortisol production. A 52-year-old woman presented with lumbar pain; a computed tomography (CT) scan demonstrated a left AI measuring 8.5 × 15 × 10 cm. Similarly, an 80-year-old woman presented with lumbar pain, demonstrating in a CT scan a bilateral AI (right: 9 × 6.5 cm, left: 3.6 × 3.2 cm). Both cases underwent a full hormonal evaluation according to the algorithm for the investigation of AIs, demonstrating increased 24-h cortisol excretion, suppressed fasting adrenocorticotropic hormone (ACTH) levels, and non-suppressed serum cortisol levels in both the overnight and the low-dose dexamethasone suppression tests, indicating autonomous cortisol secretion and Cushing's syndrome. In a relatively short time, both patients developed night sweats, and their clinical picture deteriorated, while the CT scans showed increased dimensions of the masses with radiological characteristics compatible to lymphoma. Both patients underwent ultrasound-guided biopsies (FNBs), revealing infiltration of the left adrenal by diffuse large B-cell lymphoma in the first case, whereas bilateral adrenal infiltration from the same histological type was noted in the second case. Subsequently, they were treated with immunochemotherapy, but the second patient died from an infection shortly after the initiation of the treatment. To our knowledge, this is the first report of PAL presenting with Cushing's syndrome due to autonomous cortisol production, indicating that neoplastic lymphoid cells in PAL might acquire the potential for steroidogenesis; therefore, more cases of PAL should be analyzed so as to further elucidate the complex pathogenesis and the natural course of this entity.
Sprache	Englisch
Erscheinungsdatum	2023-07-31
Erscheinungsland	Switzerland
Dokumenttyp	Case Reports
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm12155032
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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