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  1. Article ; Online: Simposio sull'insufficienza cardiaca iniziale [riprodotto da G Ital Cardiol 1972;2:751-7].

    Levi, Gianfranco

    Giornale italiano di cardiologia (2006)

    2021  Volume 22, Issue 1, Page(s) 20–26

    Title translation Symposium on initial heart failure [reproduced from G Ital Cardiol 1972;2:751-7].
    MeSH term(s) Heart Failure ; Humans
    Language Italian
    Publishing date 2021-02-24
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2272414-X
    ISSN 1972-6481 ; 1827-6806
    ISSN (online) 1972-6481
    ISSN 1827-6806
    DOI 10.1714/3502.34876
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Ammalarsi di una patologia rara in tempi di intelligenza artificiale.

    Clerici, Carlo Alfredo / Chopard, Saba / Levi, Giuseppe

    Recenti progressi in medicina

    2024  Volume 115, Issue 2, Page(s) 67–75

    Abstract: Introduction: The text examines the impact of artificial intelligence (AI) in the context of rare diseases, exploring how patients turn to AI resources for health information, especially in situations where doctor-patient communication is limited. The ... ...

    Title translation Rare disease in the age of artificial intelligence.
    Abstract Introduction: The text examines the impact of artificial intelligence (AI) in the context of rare diseases, exploring how patients turn to AI resources for health information, especially in situations where doctor-patient communication is limited. The article features the case of a doctor specializing in clinical psychology and psychotherapy, diagnosed with thymoma and Good's syndrome, who uses AI resources during his illness.
    Methods: The capabilities of five chatbots based on Large Language Models (LLMs), such as GPT-3.5, GPT-4, Bing Chat, Google Bard, and Anthropic Claude are explored. The AIs were queried on various aspects of the disease, from pre-diagnosis and diagnosis to therapeutic, psychological, and caregiver management issues. The responses were evaluated by five experts based on criteria such as: accuracy, relevance, coherence, clarity, practical utility, ethical considerations, empathy, and capacity to respond to questions and concerns.
    Results: The results indicate consistency in the evaluators' assessments, with generally high scores across all dimensions. Particularly, systems like Bard and GPT-4 received high ratings in terms of information accuracy and the ability to respond to questions and concerns. Bing and Claude were appreciated for their empathy and tone. Overall, the AI systems' responses were considered appropriate, respectful of ethics and privacy, and useful in the clinical context.
    Discussion: The article emphasizes the importance of understanding the reliability and precision of responses provided by AI systems in the clinical field. Although these systems offer high-quality responses, there is significant variability in their performance. Healthcare professionals must be aware of these differences and use such tools cautiously. AI can provide support in some aspects of care but cannot replace genuine human empathy and understanding. Integrating AI into clinical practice presents potential but also challenges, particularly the possibility of providing incorrect information.
    Conclusions: The AI systems demonstrate the ability to provide useful advice on clinical and psychological issues, but their use requires caution. It is crucial to distinguish the benefits of AI for patients from the challenges it presents for healthcare professionals. As AI technology continues to evolve, it is essential that its integration into the clinical field is accompanied by continuous research and evaluations, to ensure safe and effective use in the healthcare sector.
    MeSH term(s) Humans ; Rare Diseases/therapy ; Artificial Intelligence ; Reproducibility of Results ; Communication ; Empathy
    Language Italian
    Publishing date 2024-01-30
    Publishing country Italy
    Document type English Abstract ; Journal Article
    ZDB-ID 138266-4
    ISSN 2038-1840 ; 0034-1193
    ISSN (online) 2038-1840
    ISSN 0034-1193
    DOI 10.1701/4197.41839
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Clouds and Radiation in a Mock‐Walker Circulation

    Levi G. Silvers / Thomas Robinson

    Journal of Advances in Modeling Earth Systems, Vol 13, Iss 2, Pp n/a-n/a (2021)

    2021  

    Abstract: Abstract The Walker circulation connects the regions with deep atmospheric convection in the western tropical Pacific to the shallow‐convection, tropospheric subsidence, and stratocumulus cloud decks of the eastern Pacific. The purpose of this study is ... ...

    Abstract Abstract The Walker circulation connects the regions with deep atmospheric convection in the western tropical Pacific to the shallow‐convection, tropospheric subsidence, and stratocumulus cloud decks of the eastern Pacific. The purpose of this study is to better understand the multi‐scale interactions between the Walker circulation, cloud systems, and interactive radiation. To do this we simulate a mock‐Walker Circulation with a full‐physics general circulation model using idealized boundary conditions. Our experiments use a doubly‐periodic domain with grid‐spacing of 1, 2, 25, and 100 km. We thus span the range from General Circulation Models (GCMs) to Cloud‐system Resolving Models (CRMs). Our model is derived from the Geophysical Fluid Dynamics Laboratory atmospheric GCM (AM4.0). We find substantial differences in the mock‐Walker circulation simulated by our GCM‐like and CRM‐like experiments. The CRM‐like experiments have more upper level clouds, stronger overturning circulations, and less precipitation. The GCM‐like experiments have a low‐level cloud fraction that is up to 20% larger. These differences leads to opposite atmospheric responses to changes in the longwave cloud radiative effect (LWCRE). Active LWCRE leads to increased precipitation for our GCMs, but decreased precipitation for our CRMs. The LWCRE leads to a narrower rising branch of the circulation and substantially increases the fraction of precipitation from the large‐scale cloud parameterization. This work demonstrates that a mock‐Walker circulation is a useful generalization of radiative convective equilibrium that includes a large‐scale circulation.
    Keywords cloud radiative effects ; radiative convective equilibrium ; tropical convection ; Walker‐circulation ; Physical geography ; GB3-5030 ; Oceanography ; GC1-1581
    Subject code 551
    Language English
    Publishing date 2021-02-01T00:00:00Z
    Publisher American Geophysical Union (AGU)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Orbital-Optimized Versus Time-Dependent Density Functional Calculations of Intramolecular Charge Transfer Excited States.

    Selenius, Elli / Sigurdarson, Alec Elías / Schmerwitz, Yorick L A / Levi, Gianluca

    Journal of chemical theory and computation

    2024  Volume 20, Issue 9, Page(s) 3809–3822

    Abstract: The performance of time-independent, orbital-optimized calculations of excited states is assessed with respect to charge transfer excitations in organic molecules in comparison to the linear-response time-dependent density functional theory (TD-DFT) ... ...

    Abstract The performance of time-independent, orbital-optimized calculations of excited states is assessed with respect to charge transfer excitations in organic molecules in comparison to the linear-response time-dependent density functional theory (TD-DFT) approach. A direct optimization method to converge on saddle points of the electronic energy surface is used to carry out calculations with the local density approximation (LDA) and the generalized gradient approximation (GGA) functionals PBE and BLYP for a set of 27 excitations in 15 molecules. The time-independent approach is fully variational and provides a relaxed excited state electron density from which the extent of charge transfer is quantified. The TD-DFT calculations are generally found to provide larger charge transfer distances compared to the orbital-optimized calculations, even when including orbital relaxation effects with the
    Language English
    Publishing date 2024-05-02
    Publishing country United States
    Document type Journal Article
    ISSN 1549-9626
    ISSN (online) 1549-9626
    DOI 10.1021/acs.jctc.3c01319
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Calculations of Excited Electronic States by Converging on Saddle Points Using Generalized Mode Following.

    Schmerwitz, Yorick L A / Levi, Gianluca / Jónsson, Hannes

    Journal of chemical theory and computation

    2023  Volume 19, Issue 12, Page(s) 3634–3651

    Abstract: Calculations of excited electronic states are carried out by finding saddle points on the surface describing the variation of the energy of the system as a function of the electronic degrees of freedom. This approach has several advantages over commonly ... ...

    Abstract Calculations of excited electronic states are carried out by finding saddle points on the surface describing the variation of the energy of the system as a function of the electronic degrees of freedom. This approach has several advantages over commonly used methods especially in the context of density functional calculations, as collapse to the ground state is avoided, and yet, the orbitals are variationally optimized for the excited state. Such a state-specific optimization makes it possible to describe excitations with large charge transfer, where calculations based on ground state orbitals, such as linear response time-dependent density functional theory, can be problematic. A generalized mode following method is presented where an
    Language English
    Publishing date 2023-06-07
    Publishing country United States
    Document type Journal Article
    ISSN 1549-9626
    ISSN (online) 1549-9626
    DOI 10.1021/acs.jctc.3c00178
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Mental health first aid for health-care workers during crises.

    Segalovich, Jenny / Levi, Galit / Segev, Ronen

    The lancet. Psychiatry

    2023  Volume 11, Issue 1, Page(s) 13

    MeSH term(s) Humans ; Mental Health ; First Aid ; Health Personnel/psychology
    Language English
    Publishing date 2023-11-28
    Publishing country England
    Document type Letter ; Comment
    ISSN 2215-0374
    ISSN (online) 2215-0374
    DOI 10.1016/S2215-0366(23)00401-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Cell adhesion molecules duringXenopus myogenesis.

    Levi, G

    Cytotechnology

    2012  Volume 11, Issue Suppl 1, Page(s) S91–3

    Abstract: Muscle development is characterized by several cell-recognition events such as the fusion of primary and secondary myoblasts and synaptogenesis. Cell surface adhesion receptors are probably playing an important role in determining the correct evolution ... ...

    Abstract Muscle development is characterized by several cell-recognition events such as the fusion of primary and secondary myoblasts and synaptogenesis. Cell surface adhesion receptors are probably playing an important role in determining the correct evolution of these processes. In this paper we examine the expression of three cell adhesion molecules, N-CAM, N-cadherin and EP-cadherin, duringXenopus larval muscle development. Their differential distribution suggests a specific role for each of these molecules during myogenesis. N-CAM might control the fusion of primary myoblasts as its expression is particularly high in these cells and decreases sharply in myotubes. EP-cadherin is present both in differentiated myotubes and myoblasts and could be involved in secondary myoblast fusion. While N-cadherin appears only much later during muscle differentiation.
    Language English
    Publishing date 2012-02-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1035772-5
    ISSN 0920-9069
    ISSN 0920-9069
    DOI 10.1007/BF00746065
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Book ; Conference proceedings: La terapia intensiva intermedia cardiorespiratoria

    Levi, G. F.

    indicazioni e limiti al trattamento del paziente respiratorio

    1994  

    Institution Fondazione Clinica del Lavoro
    Event/congress International Workshop on Cardiorespiratory Intermediate Intensive Unit (1994, Brescia)
    Author's details International Workshop on Cardiorespiratory Intermediate Intensive Unit, Brescia, 21 - 22 Aprile 1994. Fondazione Clinica del Lavoro di Pavia IRCCS. [Presidente: G. F. Levi]
    Language English ; Italian
    Size 63 S. : graph. Darst.
    Publisher Tipolitografia Fiorucci
    Publishing place Collebeato
    Publishing country Italy
    Document type Book ; Conference proceedings
    HBZ-ID HT014319987
    Database Catalogue ZB MED Medicine, Health

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  9. Article ; Online: The endocycle restores tissue tension in the Drosophila abdomen post wound repair.

    Losick, Vicki P / Duhaime, Levi G

    Cell reports

    2021  Volume 37, Issue 2, Page(s) 109827

    Abstract: Polyploidy frequently arises in response to injury, aging, and disease. Despite its prevalence, major gaps exist in our understanding of how polyploid cells alter tissue function. In the adult Drosophila epithelium, wound healing is dependent on the ... ...

    Abstract Polyploidy frequently arises in response to injury, aging, and disease. Despite its prevalence, major gaps exist in our understanding of how polyploid cells alter tissue function. In the adult Drosophila epithelium, wound healing is dependent on the generation of multinucleated polyploid cells resulting in a permanent change in the epithelial architecture. Here, we study how the wound-induced polyploid cells affect tissue function by altering epithelial mechanics. The mechanosensor nonmuscle myosin II is activated and upregulated in wound-induced polyploid cells and persists after healing completes. Polyploidy enhances relative epithelial tension, which is dependent on the endocycle and not cell fusion post injury. Remarkably, the enhanced epithelial tension mimics the relative tension of the lateral muscle fibers, which are permanently severed by the injury. As a result, we found that the wound-induced polyploid cells remodel the epithelium to maintain fly abdominal movements, which may help compensate for lost tissue tension.
    MeSH term(s) Abdominal Injuries/genetics ; Abdominal Injuries/metabolism ; Abdominal Injuries/pathology ; Animals ; Animals, Genetically Modified ; Biomechanical Phenomena ; Disease Models, Animal ; Drosophila Proteins/metabolism ; Drosophila melanogaster/genetics ; Drosophila melanogaster/metabolism ; Endoreduplication ; Epithelial Cells/metabolism ; Epithelial Cells/pathology ; Mechanotransduction, Cellular ; Myosin Type II/metabolism ; Needlestick Injuries/genetics ; Needlestick Injuries/metabolism ; Needlestick Injuries/pathology ; Polyploidy ; Stress, Mechanical ; Wound Healing
    Chemical Substances Drosophila Proteins ; Myosin Type II (EC 3.6.1.-)
    Language English
    Publishing date 2021-10-13
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Video-Audio Media
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2021.109827
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: A rare case of asthmatic patient with left Chilaiditi's syndrome.

    Scaramozzino, Marco Umberto / Levi, Guido / Plastina, Ubaldo Romeo / Sapone, Giovanni

    Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace

    2023  

    Abstract: The following case report aims to highlight the rarity of the case in question, in which there is left Chilaiditi syndrome in a patient with bronchial asthma. The patient is a 79-year-old woman who arrived in January 2023 at my facility for episodes of ... ...

    Abstract The following case report aims to highlight the rarity of the case in question, in which there is left Chilaiditi syndrome in a patient with bronchial asthma. The patient is a 79-year-old woman who arrived in January 2023 at my facility for episodes of recurrent dyspnea, chest heaviness, wheezing, eructation, dysphagia, epigastric abdominal pain associated with frequent episodes of bronchitis. He performed simple spirometry which showed mixed mild-moderate ventilatory deficit with reduction of small airway volumes, reduced peak expiratory flow and negative broncho reversibility tests for asthma. At 3 months, the patient returned to my attention with a chest radiograph showing marked elevation of the left hemidiaphragm with deviation of the cardiac shadow to the right. He repeated the spirometry which resulted in a clear improvement compared to the previous control with an important variation of the peak respiratory flow during ICS/LABA, the objective finding previously found disappeared, this indicating the presence of an underlying bronchial asthma. The radiological picture was identified by me as Left Chilaiditi Syndrome, as the patient had gastrointestinal symptoms which accompanied the procession of respiratory symptoms. The diagnostic suspicion must be early in these pathologies and the proton pump inhibitors and new generation alginates with the presence of hyaluronic acid and melatonin must also be included in the treatment of the symptoms, which have an important action on gastroesophageal reflux disease (GERD) secondary to this herniation of the viscera into the thoracic cavity. The rarity is represented by the left localization of the diaphragmatic pathology.
    Language English
    Publishing date 2023-10-12
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 1160940-0
    ISSN 1122-0643 ; 1120-0391
    ISSN 1122-0643 ; 1120-0391
    DOI 10.4081/monaldi.2023.2648
    Database MEDical Literature Analysis and Retrieval System OnLINE

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