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  1. Article ; Online: Cytomegalovirus (CMV) Viremia in People With Human Immunodeficiency Virus (HIV): Should We Treat the CMV? or the HIV? or Both?

    Levi, Laura I / Molina, Jean-Michel

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2023  Volume 76, Issue 6, Page(s) 975–976

    Abstract: Cytomegalovirus (CMV) viremia in persons with human immunodeficiency virus (HIV) reflects the level of immunodeficiency. In the absence of CMV end-organ disease, early start of effective antiretroviral therapy is the only treatment required and is most ... ...

    Abstract Cytomegalovirus (CMV) viremia in persons with human immunodeficiency virus (HIV) reflects the level of immunodeficiency. In the absence of CMV end-organ disease, early start of effective antiretroviral therapy is the only treatment required and is most often sufficient to control CMV replication.
    MeSH term(s) Humans ; Cytomegalovirus ; HIV ; Viremia/drug therapy ; Cytomegalovirus Infections/drug therapy ; Cytomegalovirus Infections/epidemiology ; HIV Infections/complications ; HIV Infections/drug therapy
    Language English
    Publishing date 2023-01-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciad011
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  2. Article: Arthritogenic Alphaviruses: A Worldwide Emerging Threat?

    Levi, Laura I / Vignuzzi, Marco

    Microorganisms

    2019  Volume 7, Issue 5

    Abstract: Arthritogenic alphaviruses are responsible for a dengue-like syndrome associated with severe debilitating polyarthralgia that can persist for months or years and impact life quality. Chikungunya virus is the most well-known member of this family since it ...

    Abstract Arthritogenic alphaviruses are responsible for a dengue-like syndrome associated with severe debilitating polyarthralgia that can persist for months or years and impact life quality. Chikungunya virus is the most well-known member of this family since it was responsible for two worldwide epidemics with millions of cases in the last 15 years. However, other arthritogenic alphaviruses that are as of yet restrained to specific territories are the cause of neglected tropical diseases: O'nyong'nyong virus in Sub-Saharan Africa, Mayaro virus in Latin America, and Ross River virus in Australia and the Pacific island countries and territories. This review evaluates their emerging potential in light of the current knowledge for each of them and in comparison to chikungunya virus.
    Language English
    Publishing date 2019-05-14
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms7050133
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  3. Article: Arthritogenic Alphaviruses: A Worldwide Emerging Threat?

    Levi, Laura I / Vignuzzi, Marco

    Microorganisms. 2019 May 14, v. 7, no. 5

    2019  

    Abstract: Arthritogenic alphaviruses are responsible for a dengue-like syndrome associated with severe debilitating polyarthralgia that can persist for months or years and impact life quality. Chikungunya virus is the most well-known member of this family since it ...

    Abstract Arthritogenic alphaviruses are responsible for a dengue-like syndrome associated with severe debilitating polyarthralgia that can persist for months or years and impact life quality. Chikungunya virus is the most well-known member of this family since it was responsible for two worldwide epidemics with millions of cases in the last 15 years. However, other arthritogenic alphaviruses that are as of yet restrained to specific territories are the cause of neglected tropical diseases: O’nyong’nyong virus in Sub-Saharan Africa, Mayaro virus in Latin America, and Ross River virus in Australia and the Pacific island countries and territories. This review evaluates their emerging potential in light of the current knowledge for each of them and in comparison to chikungunya virus.
    Keywords Chikungunya virus ; Mayaro virus ; Ross River virus ; disease outbreaks ; quality of life ; tropical diseases ; viruses ; Australia ; Latin America ; Pacific Ocean Islands ; Sub-Saharan Africa
    Language English
    Dates of publication 2019-0514
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms7050133
    Database NAL-Catalogue (AGRICOLA)

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  4. Article ; Online: Facial nerve palsy as a possible adverse drug reaction of the modified vaccinia ankara-bavarian nordic (MVA-BN) smallpox vaccine: A pharmacovigilance analysis.

    Chouchana, Laurent / Fournier, Dorine / Lebrun-Vignes, Bénédicte / Florence, Sophie / Levi, Laura I / Charlier, Caroline / Foirest, Claire

    The Journal of infection

    2023  Volume 86, Issue 3, Page(s) 256–308

    MeSH term(s) Humans ; Smallpox Vaccine/adverse effects ; Vaccinia ; Facial Nerve ; Pharmacovigilance ; Drug-Related Side Effects and Adverse Reactions ; Paralysis/chemically induced ; Antibodies, Viral
    Chemical Substances smallpox and monkeypox vaccine modified vaccinia ankara-bavarian nordic (TU8J357395) ; Smallpox Vaccine ; Antibodies, Viral
    Language English
    Publishing date 2023-01-08
    Publishing country England
    Document type Letter
    ZDB-ID 424417-5
    ISSN 1532-2742 ; 0163-4453
    ISSN (online) 1532-2742
    ISSN 0163-4453
    DOI 10.1016/j.jinf.2023.01.005
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  5. Article ; Online: The defective component of viral populations.

    Rezelj, Veronica V / Levi, Laura I / Vignuzzi, Marco

    Current opinion in virology

    2018  Volume 33, Page(s) 74–80

    Abstract: Particles containing degenerate forms of the viral genome which interfere with virus replication and are non-replicative per se are known as defective interfering particles (DIPs). DIPs are likely to be produced upon infection by any virus in vitro and ... ...

    Abstract Particles containing degenerate forms of the viral genome which interfere with virus replication and are non-replicative per se are known as defective interfering particles (DIPs). DIPs are likely to be produced upon infection by any virus in vitro and in nature. Until recently, roles of these non-viable particles as members of a multi-component viral system have been overlooked. In this review, we cover the most recent studies that shed light on critical roles of DIPs during the course of infection, including: the modulation of virus replication, innate immune responses, disease outcome and virus persistence, as well as the evolution of the viral population. Together, these reports allow us to conceive a more complete picture of the virion population, and highlight the fact that DIPs are not a negligible subset of this population but instead can greatly influence the fate of infection.
    MeSH term(s) Defective Viruses/genetics ; Evolution, Molecular ; Genetics, Population ; Population Dynamics ; Virus Replication ; Viruses/genetics ; Viruses/growth & development ; Viruses/immunology
    Language English
    Publishing date 2018-08-09
    Publishing country Netherlands
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
    ZDB-ID 2611378-8
    ISSN 1879-6265 ; 1879-6257
    ISSN (online) 1879-6265
    ISSN 1879-6257
    DOI 10.1016/j.coviro.2018.07.014
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  6. Article ; Online: Investigation of a

    Faury, Hélène B / Awad, Zeina / Jolivet, Sarah / Le Neindre, Killian / Couturier, Jeanne / Godmer, Alexandre / Colle, Raphaël / Levi, Laura I / Cambau, Emmanuelle / Barbut, Frédéric

    Infection control and hospital epidemiology

    2023  Volume 44, Issue 8, Page(s) 1342–1344

    Abstract: We describe a case of healthcare-associated bloodstream infection due ... ...

    Abstract We describe a case of healthcare-associated bloodstream infection due to
    MeSH term(s) Humans ; Mycobacterium fortuitum ; Mycobacterium Infections, Nontuberculous/diagnosis ; Mycobacterium Infections, Nontuberculous/microbiology ; Nontuberculous Mycobacteria/genetics ; Cross Infection/microbiology ; Water ; Sepsis ; Catheters
    Chemical Substances Water (059QF0KO0R)
    Language English
    Publishing date 2023-02-20
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 639378-0
    ISSN 1559-6834 ; 0195-9417 ; 0899-823X
    ISSN (online) 1559-6834
    ISSN 0195-9417 ; 0899-823X
    DOI 10.1017/ice.2022.263
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  7. Article ; Online: Convalescent Plasma Therapy in Immunocompromised Patients Infected With the BA.1 or BA.2 Omicron SARS-CoV-2.

    Richier, Quentin / De Valence, Benjamin / Chopin, Dorothée / Gras, Emmanuelle / Levi, Laura I / Abi Aad, Yasmine / Pacanowski, Jérôme / Meynard, Jean-Luc / Plaçais, Léo / Fey, Dorothée / Couture, Priscille / Martin-Blondel, Guillaume / Pestre, Vincent / Woessner, Juliette / Ancellin, Sophie / Weyrich, Pierre / Carpentier, Benjamin / Idri, Salim / Tiberghien, Pierre /
    Surgers, Laure / Hueso, Thomas / Lacombe, Karine

    Influenza and other respiratory viruses

    2024  Volume 18, Issue 3, Page(s) e13272

    Abstract: The emergence of SARS-CoV-2 Omicron variant has led to a complete reconfiguration of the therapeutic landscape, with all monoclonal antibodies having lost any neutralization activity. We report here a case series of 75 immunocompromised patients infected ...

    Abstract The emergence of SARS-CoV-2 Omicron variant has led to a complete reconfiguration of the therapeutic landscape, with all monoclonal antibodies having lost any neutralization activity. We report here a case series of 75 immunocompromised patients infected by the Omicron variant who benefited from COVID-19 convalescent plasma (CCP). At Day 28, the overall survival was 76% (95% CI 67-86) with no significant difference in the clinical outcome between patients with hematological malignancies, solid organ transplantation or autoimmune diseases. No safety concern was reported during the course of the study. These results showed that CCP is well tolerated and represents a treatment option for immunocompromised patients who remain highly impacted by the COVID19 epidemic.
    MeSH term(s) Humans ; COVID-19/therapy ; COVID-19 Serotherapy ; SARS-CoV-2 ; Immunization, Passive ; Immunocompromised Host ; Antibodies, Viral/therapeutic use ; Antibodies, Neutralizing
    Chemical Substances Antibodies, Viral ; Antibodies, Neutralizing
    Language English
    Publishing date 2024-03-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 2274538-5
    ISSN 1750-2659 ; 1750-2640
    ISSN (online) 1750-2659
    ISSN 1750-2640
    DOI 10.1111/irv.13272
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  8. Article ; Online: Cytomegalovirus viremia and risk of disease progression and death in HIV-positive patients starting antiretroviral therapy.

    Levi, Laura I / Sharma, Shweta / Schleiss, Mark R / Furrer, Hansjakob / Nixon, Daniel E / Blackstad, Mark / Hernandez-Alvarado, Nelmary / Dwyer, Dominic E / Borges, Alvaro H / Lane, H Clifford / Lundgren, Jens / Neaton, James D / Molina, Jean-Michel

    AIDS (London, England)

    2022  Volume 36, Issue 9, Page(s) 1265–1272

    Abstract: Objective: The aim of this study was to assess the prevalence of cytomegalovirus (CMV) viremia in HIV-positive patients starting antiretroviral therapy (ART) and to evaluate its impact on clinical outcomes.: Design: A retrospective analysis of four ... ...

    Abstract Objective: The aim of this study was to assess the prevalence of cytomegalovirus (CMV) viremia in HIV-positive patients starting antiretroviral therapy (ART) and to evaluate its impact on clinical outcomes.
    Design: A retrospective analysis of four clinical trials (INSIGHT FIRST, SMART, START, and ANRS REFLATE TB).
    Methods: Stored plasma samples from participants were used to measure CMV viremia at baseline prior to initiating ART and at visits through 1 year of follow-up after ART initiation. CMV viremia was measured centrally using a quantitative PCR assay. Within FIRST, associations of CMV viremia at baseline and through 8 months of ART were examined with a composite clinical outcome of AIDS, serious non-AIDS events, or death using Cox proportional hazards regression.
    Results: Samples from a total of 3176 participants, 1169 from FIRST, 137 from ANRS REFLATE TB, 54 from SMART, and 1816 from START were available with baseline CMV viremia prevalence of 17, 26, 0, and 1%, respectively. Pooled across trials, baseline CMV viremia was associated with low CD4 + T-cell counts and high HIV RNA levels. In FIRST, CMV viremia was detected in only 5% of participants between baseline and month 8. After adjustment for CD4 + T-cell count and HIV RNA levels, hazard ratios for risk of clinical outcomes was 1.15 (0.86-1.54) and 2.58 (1.68-3.98) in FIRST participants with baseline and follow-up CMV viremia, respectively.
    Conclusion: Baseline CMV viremia in HIV-positive patients starting ART is associated with advanced infection and only persistent CMV viremia after ART initiation is associated with a higher risk of morbidity and mortality.
    MeSH term(s) CD4 Lymphocyte Count ; Cytomegalovirus/genetics ; Cytomegalovirus Infections/complications ; Disease Progression ; HIV Infections/complications ; HIV Infections/drug therapy ; HIV Seropositivity/complications ; Humans ; RNA/therapeutic use ; Retrospective Studies ; Viremia/drug therapy
    Chemical Substances RNA (63231-63-0)
    Language English
    Publishing date 2022-04-19
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 639076-6
    ISSN 1473-5571 ; 0269-9370 ; 1350-2840
    ISSN (online) 1473-5571
    ISSN 0269-9370 ; 1350-2840
    DOI 10.1097/QAD.0000000000003238
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  9. Article ; Online: Cutaneous diphtheria: three case-reports to discuss determinants of re-emergence in resource-rich settings.

    Levi, Laura I / Barbut, Frédéric / Chopin, Dorothée / Rondeau, Paul / Lalande, Valérie / Jolivet, Sarah / Badell, Edgar / Brisse, Sylvain / Lacombe, Karine / Surgers, Laure

    Emerging microbes & infections

    2021  Volume 10, Issue 1, Page(s) 2300–2302

    Abstract: Diphtheria is a re-emerging disease in resource-rich settings. We here report three cases of cutaneous diphtheria diagnosed and managed in our infectious disease department and discuss the determinants of its re-emergence. Migration, travel and vaccine ... ...

    Abstract Diphtheria is a re-emerging disease in resource-rich settings. We here report three cases of cutaneous diphtheria diagnosed and managed in our infectious disease department and discuss the determinants of its re-emergence. Migration, travel and vaccine scepticism are key factors not only for diphtheria re-emergence, but for the future of most preventable diseases.
    MeSH term(s) Adolescent ; Adult ; Communicable Diseases, Emerging/diagnosis ; Communicable Diseases, Emerging/microbiology ; Corynebacterium/classification ; Corynebacterium/genetics ; Corynebacterium/isolation & purification ; Diphtheria/diagnosis ; Diphtheria/microbiology ; Female ; Humans ; Male ; Middle Aged ; Transients and Migrants/statistics & numerical data
    Language English
    Publishing date 2021-11-18
    Publishing country United States
    Document type Case Reports ; Letter
    ZDB-ID 2681359-2
    ISSN 2222-1751 ; 2222-1751
    ISSN (online) 2222-1751
    ISSN 2222-1751
    DOI 10.1080/22221751.2021.2008774
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  10. Article ; Online: Defective viral genomes from chikungunya virus are broad-spectrum antivirals and prevent virus dissemination in mosquitoes.

    Levi, Laura I / Rezelj, Veronica V / Henrion-Lacritick, Annabelle / Erazo, Diana / Boussier, J / Vallet, Thomas / Bernhauerová, Veronika / Suzuki, Yasutsugu / Carrau, Lucia / Weger-Lucarelli, James / Saleh, Maria-Carla / Vignuzzi, Marco

    PLoS pathogens

    2021  Volume 17, Issue 2, Page(s) e1009110

    Abstract: Defective viral genomes (DVGs) are truncated and/or rearranged viral genomes produced during virus replication. Described in many RNA virus families, some of them have interfering activity on their parental virus and/or strong immunostimulatory potential, ...

    Abstract Defective viral genomes (DVGs) are truncated and/or rearranged viral genomes produced during virus replication. Described in many RNA virus families, some of them have interfering activity on their parental virus and/or strong immunostimulatory potential, and are being considered in antiviral approaches. Chikungunya virus (CHIKV) is an alphavirus transmitted by Aedes spp. that infected millions of humans in the last 15 years. Here, we describe the DVGs arising during CHIKV infection in vitro in mammalian and mosquito cells, and in vivo in experimentally infected Aedes aegypti mosquitoes. We combined experimental and computational approaches to select DVG candidates most likely to have inhibitory activity and showed that, indeed, they strongly interfere with CHIKV replication both in mammalian and mosquito cells. We further demonstrated that some DVGs present broad-spectrum activity, inhibiting several CHIKV strains and other alphaviruses. Finally, we showed that pre-treating Aedes aegypti with DVGs prevented viral dissemination in vivo.
    MeSH term(s) Aedes/virology ; Animals ; Antiviral Agents/pharmacology ; Chikungunya Fever/immunology ; Chikungunya Fever/transmission ; Chikungunya Fever/virology ; Chikungunya virus/genetics ; Chikungunya virus/growth & development ; Chikungunya virus/isolation & purification ; Defective Viruses/genetics ; Genome, Viral ; Humans ; Mosquito Vectors/virology ; Virus Replication
    Chemical Substances Antiviral Agents
    Language English
    Publishing date 2021-02-08
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2205412-1
    ISSN 1553-7374 ; 1553-7374
    ISSN (online) 1553-7374
    ISSN 1553-7374
    DOI 10.1371/journal.ppat.1009110
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