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  1. Article ; Online: Novel therapeutic directions in Cushing's syndrome.

    Levy, Andrew

    Expert review of endocrinology & metabolism

    2019  Volume 1, Issue 2, Page(s) 199–207

    Abstract: Cushing's disease is the most common cause of endogenous hypercortisolemia. It is a rare disease of unknown etiology that is prone to relapse and damaging to quality of life, even in remission. A significant proportion of patients are not cured by ... ...

    Abstract Cushing's disease is the most common cause of endogenous hypercortisolemia. It is a rare disease of unknown etiology that is prone to relapse and damaging to quality of life, even in remission. A significant proportion of patients are not cured by primary surgical treatment, and adjuvant radiotherapy has become an increasingly unattractive proposition for clinicians who wish to spare their patients hypopituitarism and other potential complications. The few effective pharmacological options that are available currently tend to have dose-limiting side effects and new alternatives that are safer and more effective than the adrenal cortical enzyme inhibitors and adrenolytic drugs would be most welcome. This article discusses preliminary efficacy data for several potential new groups of drugs.
    Language English
    Publishing date 2019-02-12
    Publishing country England
    Document type Journal Article
    ISSN 1744-8417
    ISSN (online) 1744-8417
    DOI 10.1586/17446651.1.2.199
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book: The man who got lost in duty free

    Levy, Andrew

    (Video casebook: medicine ; 2)

    1999  

    Author's details Andrew Levy
    Series title Video casebook: medicine ; 2
    Video casebook ; medicine
    Video casebook ; medicine
    Collection Video casebook ; medicine
    Video casebook ; medicine
    Keywords Diagnostic Techniques and Procedures / case report ; Diagnostic Techniques and Procedures / problems and exercises
    Language English
    Size IX, 158 S. : Ill.
    Publisher Blackwell Science
    Publishing place London u.a.
    Publishing country Great Britain
    Document type Book
    Note Systemvoraussetzungen: Windows 95/98/NT, 486 DX2 Processor, 16 Mb RAM, 10 MB free hard disk space, 16 Bit colour screen driver, 4 speed CD-ROM Drive, Sound Card; Macintosh, 68030 processor, 16 Mb RAM, System 7.1, Double speed CD-ROM drive
    Accompanying material 1 CD-ROM (12 cm)
    HBZ-ID HT011105527
    ISBN 0-632-05382-8 ; 978-0-632-05382-7
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1999 A 6156 order for loan Magazin
    1999 MO 130 <<[Begleitmaterial]>> order for loan Magazin

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  3. Book: The toy boy and the burgundy car

    Levy, Andrew

    (Video casebook: medicine ; 1)

    1999  

    Author's details Andrew Levy
    Series title Video casebook: medicine ; 1
    Video casebook ; medicine
    Video casebook ; medicine
    Collection Video casebook ; medicine
    Video casebook ; medicine
    Keywords Diagnostic Techniques and Procedures / case report ; Diagnostic Techniques and Procedures / problems and exercises
    Language English
    Size IX, 160 S. : Ill.
    Publisher Blackwell Science
    Publishing place London u.a.
    Publishing country Great Britain
    Document type Book
    Note Systemvoraussetzungen: Windows 95/98/NT, 486 DX2 Processor, 16 Mb RAM, 10 MB free hard disk space, 16 Bit colour screen driver, 4 speed CD-ROM Drive, Sound Card; Macintosh, 68030 processor, 16 Mb RAM, System 7.x, Double speed CD-ROM drive
    Accompanying material 1 CD-ROM (12 cm)
    HBZ-ID HT011105407
    ISBN 0-632-05122-1 ; 978-0-632-05122-9
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1999 A 6155 order for loan Magazin
    1999 MO 129 <<[Begleitmaterial]>> order for loan Magazin

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  4. Article ; Online: Migraine as an allostatic reset triggered by unresolved interoceptive prediction errors.

    Sedley, William / Kumar, Sukhbinder / Jones, Siobhan / Levy, Andrew / Friston, Karl / Griffiths, Tim / Goldsmith, Paul

    Neuroscience and biobehavioral reviews

    2024  Volume 157, Page(s) 105536

    Abstract: Until now, a satisfying account of the cause and purpose of migraine has remained elusive. We explain migraine within the frameworks of allostasis (the situationally-flexible, forward-looking equivalent of homeostasis) and active inference (interacting ... ...

    Abstract Until now, a satisfying account of the cause and purpose of migraine has remained elusive. We explain migraine within the frameworks of allostasis (the situationally-flexible, forward-looking equivalent of homeostasis) and active inference (interacting with the environment via internally-generated predictions). Due to its multimodality, and long timescales between cause and effect, allostasis is inherently prone to catastrophic error, which might be impossible to correct once fully manifest, an early indicator which is elevated prediction error (discrepancy between prediction and sensory input) associated with internal sensations (interoception). Errors can usually be resolved in a targeted manner by action (correcting the physiological state) or perception (updating predictions in light of sensory input); persistent errors are amplified broadly and multimodally, to prioritise their resolution (the migraine premonitory phase); finally, if still unresolved, progressive amplification renders further changes to internal or external sensory inputs intolerably intense, enforcing physiological stability, and facilitating accurate allostatic prediction updating. As such, migraine is an effective 'failsafe' for allostasis, however it has potential to become excessively triggered, therefore maladaptive.
    MeSH term(s) Humans ; Allostasis/physiology ; Migraine Disorders ; Interoception/physiology ; Sensation ; Homeostasis
    Language English
    Publishing date 2024-01-06
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 282464-4
    ISSN 1873-7528 ; 0149-7634
    ISSN (online) 1873-7528
    ISSN 0149-7634
    DOI 10.1016/j.neubiorev.2024.105536
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1371: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Molecular Insights into IQSEC2 Disease.

    Levy, Nina S / Borisov, Veronika / Lache, Orit / Levy, Andrew P

    International journal of molecular sciences

    2023  Volume 24, Issue 5

    Abstract: Recent insights into IQSEC2 disease are summarized in this review as follows: (1) Exome sequencing of IQSEC2 patient DNA has led to the identification of numerous missense mutations that delineate at least six and possibly seven essential functional ... ...

    Abstract Recent insights into IQSEC2 disease are summarized in this review as follows: (1) Exome sequencing of IQSEC2 patient DNA has led to the identification of numerous missense mutations that delineate at least six and possibly seven essential functional domains present in the IQSEC2 gene. (2) Experiments using IQSEC2 transgenic and knockout (KO) mouse models have recapitulated the presence of autistic-like behavior and epileptic seizures in affected animals; however, seizure severity and etiology appear to vary considerably between models. (3) Studies in IQSEC2 KO mice reveal that IQSEC2 is involved in inhibitory as well as stimulatory neurotransmission. The overall picture appears to be that mutated or absent IQSEC2 arrests neuronal development, resulting in immature neuronal networks. Subsequent maturation is aberrant, leading to increased inhibition and reduced neuronal transmission. (4) The levels of Arf6-GTP remain constitutively high in IQSEC2 knockout mice despite the absence of IQSEC2 protein, indicating impaired regulation of the Arf6 guanine nucleotide exchange cycle. (5) A new therapy that has been shown to reduce the seizure burden for the IQSEC2 A350V mutation is heat treatment. Induction of the heat shock response may be responsible for this therapeutic effect.
    MeSH term(s) Animals ; Mice ; Autistic Disorder/genetics ; Epilepsy/genetics ; Guanine Nucleotide Exchange Factors/genetics ; Mice, Knockout ; Mutation ; Nerve Tissue Proteins/metabolism ; Seizures/genetics ; Humans
    Chemical Substances Guanine Nucleotide Exchange Factors ; IQSEC2 protein, mouse ; Nerve Tissue Proteins ; IQSEC2 protein, human
    Language English
    Publishing date 2023-03-05
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24054984
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The Role of Haptoglobin Polymorphism in Cardiovascular Disease in the Setting of Diabetes.

    Somer, Shmuel / Levy, Andrew P

    International journal of molecular sciences

    2020  Volume 22, Issue 1

    Abstract: Atherosclerotic cardiovascular disease (CVD) is the major cause of morbidity and mortality in individuals with diabetes mellitus (DM). Preclinical models have suggested that excessive oxidative stress and hyperglycemia are directly responsible for this ... ...

    Abstract Atherosclerotic cardiovascular disease (CVD) is the major cause of morbidity and mortality in individuals with diabetes mellitus (DM). Preclinical models have suggested that excessive oxidative stress and hyperglycemia are directly responsible for this pathological association. However, numerous clinical trials involving the administration of high doses of the antioxidant vitamin E or attempts at strict glycemic control have failed to show a significant reduction of CVD in DM patients. We describe here a possible explanation for the failure of these trials, that being their lack of proper patient selection. The haptoglobin (Hp) genotype is a major determinant of the risk of CVD in the setting of DM. Treatment of individuals with the high-risk Hp genotype with antioxidants or aggressive glycemic control has shown benefit in several small studies. These studies suggest a precision medicine-based approach to preventing diabetes complications. This approach would have a profound effect on the costs of diabetes care and could dramatically reduce morbidity from diabetes.
    MeSH term(s) Cardiovascular Diseases/blood ; Cardiovascular Diseases/drug therapy ; Cardiovascular Diseases/genetics ; Diabetes Mellitus/blood ; Diabetes Mellitus/drug therapy ; Diabetes Mellitus/genetics ; Genetic Predisposition to Disease/genetics ; Genotype ; Glycated Hemoglobin A/metabolism ; Haptoglobins/genetics ; Humans ; Polymorphism, Genetic ; Vitamin E/therapeutic use ; Vitamins/therapeutic use
    Chemical Substances Glycated Hemoglobin A ; Haptoglobins ; Vitamins ; Vitamin E (1406-18-4)
    Language English
    Publishing date 2020-12-30
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms22010287
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: The rational for and efficacy of subchondroplasty in the injured worker.

    Levy, Andrew S / Cousins, Kevin

    Journal of orthopaedics

    2020  Volume 22, Page(s) 48–52

    Abstract: Objective: Evaluation and treatment of workplace knee injuries with pre existing arthritis is difficult from both a causality and a clinical perspective. The current study evaluates the relevance and treatment of the bone marrow edema (BME) in injured ... ...

    Abstract Objective: Evaluation and treatment of workplace knee injuries with pre existing arthritis is difficult from both a causality and a clinical perspective. The current study evaluates the relevance and treatment of the bone marrow edema (BME) in injured workers.
    Methods: 179 patients who injured their knee at work and were found to have arthritis and BME and subsequently underwent subchondral calcium phosphate injections (subchondroplasty) were reviewed.
    Results: Radiographic arthritic status was Kellgren Lawrence 3-4 in 56%. Cartilage status was outerbridge III/IV. 86% reported marked improvement at 6 months. 74% at 3 years and 83% at 5 years. RTW was 78% at 3 months & 85% by 6 months. Survivorship was 98% at one year, 86% at 2 years, 81% at 5 years & 76% at 7 years post op.
    Conclusions: BME (associated with trabecular fracture) is an objective measure of causality in the injured worker. The treatment of BME positive arthritis in injured workers is highly successful in terms of decreasing pain, improving function and expediting return to work.
    Language English
    Publishing date 2020-03-27
    Publishing country India
    Document type Journal Article
    ZDB-ID 2240839-3
    ISSN 0972-978X
    ISSN 0972-978X
    DOI 10.1016/j.jor.2020.03.047
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: In the Body's Eye: The computational anatomy of interoceptive inference.

    Allen, Micah / Levy, Andrew / Parr, Thomas / Friston, Karl J

    PLoS computational biology

    2022  Volume 18, Issue 9, Page(s) e1010490

    Abstract: A growing body of evidence highlights the intricate linkage of exteroceptive perception to the rhythmic activity of the visceral body. In parallel, interoceptive inference theories of affective perception and self-consciousness are on the rise in ... ...

    Abstract A growing body of evidence highlights the intricate linkage of exteroceptive perception to the rhythmic activity of the visceral body. In parallel, interoceptive inference theories of affective perception and self-consciousness are on the rise in cognitive science. However, thus far no formal theory has emerged to integrate these twin domains; instead, most extant work is conceptual in nature. Here, we introduce a formal model of cardiac active inference, which explains how ascending cardiac signals entrain exteroceptive sensory perception and uncertainty. Through simulated psychophysics, we reproduce the defensive startle reflex and commonly reported effects linking the cardiac cycle to affective behaviour. We further show that simulated 'interoceptive lesions' blunt affective expectations, induce psychosomatic hallucinations, and exacerbate biases in perceptual uncertainty. Through synthetic heart-rate variability analyses, we illustrate how the balance of arousal-priors and visceral prediction errors produces idiosyncratic patterns of physiological reactivity. Our model thus offers a roadmap for computationally phenotyping disordered brain-body interaction.
    MeSH term(s) Brain ; Emotions/physiology ; Heart Rate/physiology ; Interoception/physiology
    Language English
    Publishing date 2022-09-13
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2193340-6
    ISSN 1553-7358 ; 1553-734X
    ISSN (online) 1553-7358
    ISSN 1553-734X
    DOI 10.1371/journal.pcbi.1010490
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: fNIRS a novel neuroimaging tool to investigate olfaction, olfactory imagery, and crossmodal interactions: a systematic review.

    Boot, Eleanor / Levy, Andrew / Gaeta, Giuliano / Gunasekara, Natalie / Parkkinen, Emilia / Kontaris, Emily / Jacquot, Muriel / Tachtsidis, Ilias

    Frontiers in neuroscience

    2024  Volume 18, Page(s) 1266664

    Abstract: Olfaction is understudied in neuroimaging research compared to other senses, but there is growing evidence of its therapeutic benefits on mood and well-being. Olfactory imagery can provide similar health benefits as olfactory interventions. Harnessing ... ...

    Abstract Olfaction is understudied in neuroimaging research compared to other senses, but there is growing evidence of its therapeutic benefits on mood and well-being. Olfactory imagery can provide similar health benefits as olfactory interventions. Harnessing crossmodal visual-olfactory interactions can facilitate olfactory imagery. Understanding and employing these cross-modal interactions between visual and olfactory stimuli could aid in the research and applications of olfaction and olfactory imagery interventions for health and wellbeing. This review examines current knowledge, debates, and research on olfaction, olfactive imagery, and crossmodal visual-olfactory integration. A total of 56 papers, identified using the PRISMA method, were evaluated to identify key brain regions, research themes and methods used to determine the suitability of fNIRS as a tool for studying these topics. The review identified fNIRS-compatible protocols and brain regions within the fNIRS recording depth of approximately 1.5 cm associated with olfactory imagery and crossmodal visual-olfactory integration. Commonly cited regions include the orbitofrontal cortex, inferior frontal gyrus and dorsolateral prefrontal cortex. The findings of this review indicate that fNIRS would be a suitable tool for research into these processes. Additionally, fNIRS suitability for use in naturalistic settings may lead to the development of new research approaches with greater ecological validity compared to existing neuroimaging techniques.
    Language English
    Publishing date 2024-01-31
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2411902-7
    ISSN 1662-453X ; 1662-4548
    ISSN (online) 1662-453X
    ISSN 1662-4548
    DOI 10.3389/fnins.2024.1266664
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Supporting Parents During Cardiology Fellowship: Because Life Happens.

    Jarvie, Jennifer L / Levy, Andrew E

    Journal of the American Heart Association

    2019  Volume 8, Issue 14, Page(s) e013392

    Abstract: See Article Mwakyanjala et al. ...

    Abstract See Article Mwakyanjala et al.
    MeSH term(s) Cardiology/education ; Education, Medical, Graduate ; Fellowships and Scholarships ; Female ; Humans ; Parenting ; Parents ; Pregnancy
    Language English
    Publishing date 2019-07-09
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 2653953-6
    ISSN 2047-9980 ; 2047-9980
    ISSN (online) 2047-9980
    ISSN 2047-9980
    DOI 10.1161/JAHA.119.013392
    Database MEDical Literature Analysis and Retrieval System OnLINE

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