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  1. Article ; Online: Eradicating gross tumor disease: a prerequisite for efficient radioimmunotherapy?

    Deutsch, Eric / Levy, Antonin

    Journal of the National Cancer Institute

    2024  

    Abstract: Radiotherapy may induce off-target antitumor "abscopal" immunostimulatory but also immunosuppressive effects. Several preclinical and early clinical studies revealed promising results when combining radiation therapy with immunostimulatory agents. ... ...

    Abstract Radiotherapy may induce off-target antitumor "abscopal" immunostimulatory but also immunosuppressive effects. Several preclinical and early clinical studies revealed promising results when combining radiation therapy with immunostimulatory agents. However, most immunoradiotherapy randomized trials showed disappointing results in patients with advanced tumors. On the contrary, encouraging outcomes were suggested when immunotherapy was delivered on top of gross disease elimination with curative-intent radiotherapy. In this review, we highlight available results from randomized trials and discuss the potential impact of overall tumor burden on the observed efficacy of radioimmunotherapy.
    Language English
    Publishing date 2024-03-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2992-0
    ISSN 1460-2105 ; 0027-8874 ; 0198-0157
    ISSN (online) 1460-2105
    ISSN 0027-8874 ; 0198-0157
    DOI 10.1093/jnci/djae071
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    Uh III Zs.131: Show issues Location:
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  2. Article ; Online: Increased abscopal responses after radiation therapy for oligoprogressive patients receiving immune checkpoint inhibitors?

    Doyen, Jérôme / Levy, Antonin

    Translational cancer research

    2023  Volume 12, Issue 4, Page(s) 713–716

    Language English
    Publishing date 2023-03-15
    Publishing country China
    Document type Editorial ; Comment
    ZDB-ID 2901601-0
    ISSN 2219-6803 ; 2218-676X
    ISSN (online) 2219-6803
    ISSN 2218-676X
    DOI 10.21037/tcr-23-37
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Local Immunoradiotherapy in Patients With Metastatic Soft-Tissue Sarcoma.

    Levy, Antonin / Deutsch, Eric / Le Péchoux, Cécile

    JAMA oncology

    2024  

    Language English
    Publishing date 2024-04-11
    Publishing country United States
    Document type Journal Article
    ISSN 2374-2445
    ISSN (online) 2374-2445
    DOI 10.1001/jamaoncol.2024.0308
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  4. Article ; Online: Systematic endoscopic staging of mediastinum in locally advanced NSCLC: a SEISMIC change?

    Botticella, Angela / Levy, Antonin / Le Pechoux, Cécile

    The Lancet. Respiratory medicine

    2024  

    Language English
    Publishing date 2024-03-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 2686754-0
    ISSN 2213-2619 ; 2213-2600
    ISSN (online) 2213-2619
    ISSN 2213-2600
    DOI 10.1016/S2213-2600(24)00068-7
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    Zs.A 7041: Show issues Location:
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  5. Article ; Online: Indications and Parameters Around Postoperative Radiation Therapy for Lung Cancer.

    Levy, Antonin / Mercier, Olaf / Le Péchoux, Cécile

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology

    2022  Volume 40, Issue 6, Page(s) 556–566

    Abstract: Patients with locally advanced resected non-small-cell lung cancer present a high risk of relapse. Although adjuvant platinum-based chemotherapy has become the standard of care, the role of postoperative radiation therapy (PORT) has been controversial ... ...

    Abstract Patients with locally advanced resected non-small-cell lung cancer present a high risk of relapse. Although adjuvant platinum-based chemotherapy has become the standard of care, the role of postoperative radiation therapy (PORT) has been controversial for years. In patients with incomplete resection, PORT should be proposed, on the basis of a strong consensus, despite the absence of randomized evidence. In patients with completely resected (R0) non-small-cell lung cancer, a meta-analysis showed poorer outcomes after PORT in the absence of mediastinal involvement (pN0 and pN1). In patients with pN2, the role of PORT was less clear and required further research. The meta-analysis included trials using older radiation techniques and poorer quality of surgery according to today's standards, and selection of patients was not positron emission tomography-based. Newer retrospective and nonrandomized studies and subgroup analyses of randomized trials evaluating adjuvant chemotherapy suggested a survival benefit of PORT in patients with pN2 R0. Two recent randomized trials (Lung ART and PORT-C) evaluating conformal PORT versus no PORT retrieved no disease-free survival advantage for stage IIIA-N2 patients, even if mediastinal relapse was significantly decreased with PORT. PORT had no effect on survival, possibly given the high rate of distant relapse and risk of additional cardiopulmonary toxicity. Ongoing and future analyses are planned in Lung ART to identify patients for whom PORT could be recommended. Incorporation of newer systemic treatments (immune checkpoint inhibitors or targeted therapy in oncogene-addicted patients) is underway in the neoadjuvant and/or adjuvant setting. Better identification of patients at a high risk of disease recurrence, with analysis of circulating tumor DNA, on the basis of the detection of postsurgical minimal (or molecular) residual disease is warranted in future studies.
    MeSH term(s) Aged ; Carcinoma, Non-Small-Cell Lung/mortality ; Carcinoma, Non-Small-Cell Lung/pathology ; Carcinoma, Non-Small-Cell Lung/therapy ; Chemoradiotherapy, Adjuvant ; Clinical Decision-Making ; Female ; Humans ; Lung Neoplasms/mortality ; Lung Neoplasms/pathology ; Lung Neoplasms/therapy ; Male ; Middle Aged ; Neoplasm Staging ; Pneumonectomy/adverse effects ; Pneumonectomy/mortality ; Radiation Dosage ; Radiotherapy, Adjuvant ; Radiotherapy, Conformal/adverse effects ; Radiotherapy, Conformal/mortality ; Risk Assessment ; Risk Factors ; Time Factors ; Treatment Outcome
    Language English
    Publishing date 2022-01-05
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 604914-x
    ISSN 1527-7755 ; 0732-183X
    ISSN (online) 1527-7755
    ISSN 0732-183X
    DOI 10.1200/JCO.21.01774
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    Zs.A 1847: Show issues Location:
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    Zs.MO 650: Show issues

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  6. Article: Radiotherapy tumor volume for limited-stage small cell lung cancer: less is more.

    Levy, Antonin / Faivre-Finn, Corinne

    Annals of translational medicine

    2020  Volume 8, Issue 17, Page(s) 1114

    Language English
    Publishing date 2020-11-03
    Publishing country China
    Document type Editorial ; Comment
    ZDB-ID 2893931-1
    ISSN 2305-5847 ; 2305-5839
    ISSN (online) 2305-5847
    ISSN 2305-5839
    DOI 10.21037/atm.2020.04.45
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  7. Article ; Online: Radiosurgery in Patients With Small Cell Lung Cancer With Brain Metastases: A Call for Prospective Evidence.

    Le Pechoux, Cecile / Levy, Antonin

    JAMA oncology

    2020  Volume 6, Issue 7, Page(s) 1037–1038

    MeSH term(s) Brain ; Brain Neoplasms/radiotherapy ; Brain Neoplasms/surgery ; Cohort Studies ; Humans ; Lung Neoplasms/surgery ; Prospective Studies ; Radiosurgery ; Small Cell Lung Carcinoma/surgery
    Language English
    Publishing date 2020-06-03
    Publishing country United States
    Document type Journal Article ; Comment
    ISSN 2374-2445
    ISSN (online) 2374-2445
    DOI 10.1001/jamaoncol.2020.1245
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  8. Article ; Online: 1-week hypofractionated adjuvant whole-breast radiotherapy: towards a new standard?

    Levy, Antonin / Rivera, Sofia

    Lancet (London, England)

    2020  Volume 395, Issue 10237, Page(s) 1588–1589

    MeSH term(s) Breast ; Radiation Dose Hypofractionation
    Keywords covid19
    Language English
    Publishing date 2020-04-28
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(20)30978-8
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    Ua VI Zs.5: Show issues Location:
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  9. Article ; Online: Postoperative radiotherapy results in 192 epithelial thymic tumours patients with 10 years of follow-up.

    Lopez, Hugo / Botticella, Angela / Belkhir, Farid / Besse, Benjamin / Fadel, Elie / Mercier, Olaf / Levy, Antonin / Le Péchoux, Cécile

    Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

    2024  Volume 195, Page(s) 110272

    Abstract: Purpose: To assess the prognostic factors and patterns of failure of patients consecutively treated with surgery and postoperative radiation therapy (PORT) for thymic epithelial tumours (TET).: Patients and methods: Data from 192 TET patients who ... ...

    Abstract Purpose: To assess the prognostic factors and patterns of failure of patients consecutively treated with surgery and postoperative radiation therapy (PORT) for thymic epithelial tumours (TET).
    Patients and methods: Data from 192 TET patients who were operated and received PORT at a single centre from 1990 to 2019 was retrospectively analysed.
    Results: Most patients had thymoma (77 %, B247%), were classified Masaoka-Koga stage III (35 %) or IV (32 %) and had a R0 (75 %) resection. Radiotherapy was delivered at a median dose of 50.4 Gy (range, 42-66 Gy; ≥ 60 Gy in 17 %), 63 (33 %) patients were treated by intensity-modulated radiation therapy and elective nodal radiotherapy was used for 37 %. At a median follow-up of 10.9 years, the 10-year overall survival (OS) and progression-free survival (PFS) rates were 62 % (95 % CI: 54-70 %) and 47 % (95 % CI: 39-55 %), respectively. Locoregional recurrence (LRR) occurred in 72/192 (38 %) patients, distributed as 6 local, 45 regional and 21 both local and regional. LRR were mainly located to the pleura: 66/72 (92 %) and 16/72 (22 %; 16/192 in total, 8 %) were in-field. Distant relapse (DR) were observed in 30 patients (16 %), resulting in 10-year locoregional (LRC) and distant control rates of 58 % (95 % CI: 50-66 %) and 82 % (95 % CI: 77-88 %), respectively. In the multivariate analysis, Masaoka-Koga stage (HR [hazard ratio]: 1.9; p = 0.001), thymic carcinomas/neuroendocrine tumours (TC) (HR: 1.6; p = 0.045) and ECOG PS > 1 (HR: 1.9; p = 0.02) correlated with poorer OS. Higher Masaoka-Koga stage (HR: 2.6; p < 0.001) associated with a decreased LRC but not R1 status (HR: 1.2; p = 0.5) or WHO histology classification. TC (HR: 3.4; p < 0.001) and a younger age (HR: 2.5; p = 0.02) correlated with DR.
    Conclusion: Approximately one-third of the TET in our study experienced a LRR, mainly to the pleura, and 8% in total were in-field. The place of radiotherapy should be better defined in higher risk thymoma patients within prospective randomized studies.
    MeSH term(s) Humans ; Thymus Neoplasms/radiotherapy ; Thymus Neoplasms/pathology ; Thymus Neoplasms/mortality ; Thymus Neoplasms/surgery ; Male ; Female ; Middle Aged ; Aged ; Adult ; Retrospective Studies ; Follow-Up Studies ; Neoplasms, Glandular and Epithelial/radiotherapy ; Neoplasms, Glandular and Epithelial/pathology ; Neoplasms, Glandular and Epithelial/mortality ; Neoplasms, Glandular and Epithelial/surgery ; Aged, 80 and over ; Young Adult ; Neoplasm Recurrence, Local ; Radiotherapy, Adjuvant ; Radiotherapy, Intensity-Modulated/methods ; Adolescent ; Thymoma/radiotherapy ; Thymoma/pathology ; Thymoma/mortality ; Prognosis ; Survival Rate
    Language English
    Publishing date 2024-04-12
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 605646-5
    ISSN 1879-0887 ; 0167-8140
    ISSN (online) 1879-0887
    ISSN 0167-8140
    DOI 10.1016/j.radonc.2024.110272
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    Zs.A 1926: Show issues Location:
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  10. Article ; Online: Stage III NSCLC in Low- and Middle-Income Countries: Where Are We in 2021?

    Botticella, Angela / Levy, Antonin / Le Pechoux, Cécile

    Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer

    2021  Volume 16, Issue 10, Page(s) 1605–1606

    MeSH term(s) Carcinoma, Non-Small-Cell Lung/pathology ; Developing Countries ; Humans ; Lung Neoplasms/pathology ; Neoplasm Staging
    Language English
    Publishing date 2021-09-22
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2432037-7
    ISSN 1556-1380 ; 1556-0864
    ISSN (online) 1556-1380
    ISSN 1556-0864
    DOI 10.1016/j.jtho.2021.08.003
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