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  1. Article ; Online: 'And then there was silence': shaping practice through the experience of parents' emotions.

    Levy, Sharon

    Journal of research in nursing : JRN

    2023  Volume 28, Issue 8, Page(s) 596–605

    Abstract: Background: Spina bifida, the most common Neural Tube Defect occurring around 28 days following conception, is often discovered in a routine ultrasound examination. Nurses offer continuous support for families who care for children with disabilities, ... ...

    Abstract Background: Spina bifida, the most common Neural Tube Defect occurring around 28 days following conception, is often discovered in a routine ultrasound examination. Nurses offer continuous support for families who care for children with disabilities, associated with this diagnosis.
    Aim: To articulate and analyse parents' recollection of the emotions they experienced when they were informed by professionals that their unborn baby may have neurological disabilities.
    Method: Qualitative study, using participatory visual narrative method, engaging parents caring for young children with Spina bifida.
    Results: The emotions parents described, surfacing at the point of diagnosis, and the crafted stories they shared, demonstrated the significance and the long-lasting impact of their experience. Disclosing sensitive information and the way it is shared has a significant role in shaping how families adjust to caring for disabled children.
    Conclusion: Role and care transitions of parents who choose to keep their babies, despite their impending disability, is a lengthy and complex process. Nurses should be aware of and informed by the origin story, to offer appropriate support throughout this period. Policies to promote integration with services delivered by 'not for profit' organisations will benefit family-focused and person-centred care.
    Language English
    Publishing date 2023-12-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 2173772-1
    ISSN 1744-988X ; 1744-9871
    ISSN (online) 1744-988X
    ISSN 1744-9871
    DOI 10.1177/17449871231216057
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Commentary: The engagement of nursing and healthcare researchers with digital technologies: lessons learnt in an Australian university.

    Levy, Sharon

    Journal of research in nursing : JRN

    2022  Volume 27, Issue 7, Page(s) 604–605

    Language English
    Publishing date 2022-08-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 2173772-1
    ISSN 1744-988X ; 1744-9871
    ISSN (online) 1744-988X
    ISSN 1744-9871
    DOI 10.1177/17449871221087307
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  3. Article ; Online: Cardioversion of recent-onset atrial fibrillation using intravenous antiarrhythmics: A European perspective.

    Lévy, Samuel

    Journal of cardiovascular electrophysiology

    2021  Volume 32, Issue 12, Page(s) 3259–3269

    Abstract: Pharmacological cardioversion using intravenous antiarrhythmic agents is commonly indicated in symptomatic patients with recent-onset atrial fibrillation (AF). Except in hemodynamically unstable patients who require emergency direct current electrical ... ...

    Abstract Pharmacological cardioversion using intravenous antiarrhythmic agents is commonly indicated in symptomatic patients with recent-onset atrial fibrillation (AF). Except in hemodynamically unstable patients who require emergency direct current electrical cardioversion, for the majority of hemodynamically stable patients, pharmacological cardioversion represents a valid option and requires the clinician to be familiar with the properties and use of antiarrhythmic agents. The main characteristics of selected intravenous antiarrhythmic agents for conversion of recent-onset AF, the reported success rates, and possible adverse events are discussed. Among intravenous antiarrhythmics, flecainide, propafenone, amiodarone, sotalol, dofetilide, ibutilide, and vernakalant are commonly used. Antazoline, an old antihistaminic agent with antiarrhythmic properties was also reported to give encouraging results in Poland. Intravenous flecainide and propafenone are the only Class I agents still recommended by recent guidelines. Intravenous new Class III agents as dofetilide and ibutilide have high and rapid efficacy in converting AF to sinus rhythm but require strict surveillance with electrocardiogram (ECG) monitoring during and after intravenous administration because of the potential risk of QT prolongation and Torsades de Pointes, which can be prevented and properly managed. Vernakalant, a partial atrial selective was shown to have a high success rate and to be safe in real-life use.
    MeSH term(s) Administration, Intravenous ; Amiodarone/therapeutic use ; Anti-Arrhythmia Agents/therapeutic use ; Atrial Fibrillation/chemically induced ; Atrial Fibrillation/diagnosis ; Atrial Fibrillation/drug therapy ; Electric Countershock ; Humans
    Chemical Substances Anti-Arrhythmia Agents ; Amiodarone (N3RQ532IUT)
    Language English
    Publishing date 2021-10-25
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1025989-2
    ISSN 1540-8167 ; 1045-3873
    ISSN (online) 1540-8167
    ISSN 1045-3873
    DOI 10.1111/jce.15264
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    Zs.A 2863: Show issues Location:
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  4. Article ; Online: A proposal for an oral health educational programme for the first 1000 days of life: from pregnancy to childhood.

    Marquillier, T / Azogui-Levy, S / Tenenbaum, A

    European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry

    2023  Volume 24, Issue 6, Page(s) 803–806

    Abstract: Aim: The aim of this paper is to highlight the need to consider oral health during the first 1000 days of a child's life with a view to developing appropriate educational programmes.: Context: The first 1000 days of life represent a window of ... ...

    Abstract Aim: The aim of this paper is to highlight the need to consider oral health during the first 1000 days of a child's life with a view to developing appropriate educational programmes.
    Context: The first 1000 days of life represent a window of opportunity for prevention in children. This concept is built on a consideration of the overall health of mother and child, taking into account social inequalities in health. It is now established that the oral health of the mother determines the oral health of her child. Furthermore, parents' knowledge and behaviour have a direct influence on their child's health.
    Conclusion: The majority of the population does not have the necessary skills to adopt behaviours that promote oral health. The need for oral health education begins in the first 1000 days of life. Following the model of family health education, these programmes would involve providing pregnant women and, therefore, families with the skills they need to manage their own oral health and that of their future child as early as possible.
    MeSH term(s) Child ; Humans ; Female ; Pregnancy ; Oral Health ; Socioeconomic Factors ; Health Education, Dental ; Mothers ; Parents
    Language English
    Publishing date 2023-09-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 2472851-2
    ISSN 1996-9805 ; 1818-6300
    ISSN (online) 1996-9805
    ISSN 1818-6300
    DOI 10.1007/s40368-023-00846-7
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  5. Article ; Online: Hein Wellens 'A wonderful human being'.

    Lévy, Samuel

    European heart journal

    2020  Volume 41, Issue 30, Page(s) 2834–2835

    Language English
    Publishing date 2020-08-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehaa568
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  6. Article ; Online: The role of addiction-medicine specialists in the global fight against addiction.

    Levy, Sharon

    Nature medicine

    2020  Volume 26, Issue 4, Page(s) 456

    MeSH term(s) Addiction Medicine/education ; Addiction Medicine/history ; Addiction Medicine/organization & administration ; Addiction Medicine/trends ; Education, Medical/organization & administration ; Education, Medical/standards ; Education, Medical/trends ; Geography ; Global Health/standards ; Global Health/trends ; History, 20th Century ; History, 21st Century ; Humans ; Interdisciplinary Communication ; Opioid-Related Disorders/epidemiology ; Opioid-Related Disorders/therapy ; Patient Care Team/organization & administration ; Patient Care Team/standards ; Patient Care Team/trends ; Physicians/history ; Physicians/organization & administration ; Physicians/supply & distribution ; Specialization/history ; Specialization/standards ; Specialization/trends ; Substance-Related Disorders/epidemiology ; Substance-Related Disorders/prevention & control ; Substance-Related Disorders/therapy ; Translational Medical Research/organization & administration ; Translational Medical Research/standards ; Translational Medical Research/trends ; United States/epidemiology
    Language English
    Publishing date 2020-04-08
    Publishing country United States
    Document type Historical Article ; Journal Article
    ZDB-ID 1220066-9
    ISSN 1546-170X ; 1078-8956
    ISSN (online) 1546-170X
    ISSN 1078-8956
    DOI 10.1038/s41591-020-0830-7
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  7. Article: A Case of Bilateral Inflammatory Breast Cancer.

    Levy, Sydney / Hanna, Mariam

    Cureus

    2023  Volume 15, Issue 6, Page(s) e40101

    Abstract: Inflammatory breast cancer (IBC) is an aggressive form of breast carcinoma. Bilateral occurrences of IBC within a short time frame are rare, particularly without significant surgical intervention. This case presents a patient with contralateral ... ...

    Abstract Inflammatory breast cancer (IBC) is an aggressive form of breast carcinoma. Bilateral occurrences of IBC within a short time frame are rare, particularly without significant surgical intervention. This case presents a patient with contralateral recurrence of IBC less than a year after the initial diagnosis. A 39-year-old female was diagnosed with stage IV inflammatory breast cancer in her left breast. Less than a year later, extensive disease was found in her right breast. The patient had received incomplete treatment for the left IBC due to barriers to accessing care. Imaging confirmed the presence of inflammatory breast cancer in the contralateral breast, along with regional adenopathy and metastases. The patient began a chemotherapy regimen similar to her previous treatment. This case highlights the uncommon occurrence of contralateral recurrence of IBC and the hypothesized mechanism of lymphatic spread, suggesting local metastasis rather than a new primary tumor. The patient's incomplete treatment and lack of surgical intervention likely contributed to the development of contralateral IBC. The case underscores the importance of magnetic resonance imaging (MRI) in evaluating soft tissue and lymphatic changes in IBC. Barriers to care negatively impact prognosis, emphasizing the need for timely follow-up, diagnostic imaging, and oncologic therapy for successful treatment.
    Language English
    Publishing date 2023-06-07
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.40101
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  8. Article: AI-driven designed protein epigenomics.

    Levy, Shiri / Ruohola-Baker, Hannele

    Clinical research in oncology

    2023  Volume 1, Issue 1, Page(s) 1–3

    Abstract: The biological revolutions of computationally designed proteins, induced pluripotent stem cells (iPSCs), and the CRISPR-Cas9 system finally enables modifications that can spur deep understanding of spatial requirement of epigenetic information. This ... ...

    Abstract The biological revolutions of computationally designed proteins, induced pluripotent stem cells (iPSCs), and the CRISPR-Cas9 system finally enables modifications that can spur deep understanding of spatial requirement of epigenetic information. This commentary describes the utility of a computationally designed protein, EED Binder (EB), when fused to dCas9 (EBdCas9) for identifying critical sites of PRC2 dependent histone H3K27me3 marks in the chromatin. By using EBdCas9 and gRNA, PRC2 function can be inhibited at specific loci, resulting in precise reduction of EZH2 and H3K27me3 marks, and in some (but not all) locations, activation of the gene and functional outcomes (such as regulation of cell cycle or trophoblast transdifferentiation). Interestingly, a functional TATA box located more than 500bp upstream of a TBX18 TSS was found to be repressed by PRC2, supporting the theory that epigenetic regulators control the repression of transcriptional elements on the promoter region. The EBdCas9 technology may provide a useful tool for controlling gene regulation through epigenomic control.
    Language English
    Publishing date 2023-12-01
    Publishing country United States
    Document type Journal Article
    DOI 10.46439/oncology.1.01
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  9. Article ; Online: Substance Use Screening, Brief Intervention, and Referral to Treatment in Pediatric Primary Care, School-Based Health Clinics, and Mental Health Clinics.

    Calihan, Jessica B / Levy, Sharon

    The Psychiatric clinics of North America

    2023  Volume 46, Issue 4, Page(s) 749–760

    Abstract: Adolescent cannabis use is a modifiable health behavior with potential adverse developmental, cognitive, psychological, and health effects. Over the last 2 decades, work to promote implementation of screening, brief intervention, and referral to ... ...

    Abstract Adolescent cannabis use is a modifiable health behavior with potential adverse developmental, cognitive, psychological, and health effects. Over the last 2 decades, work to promote implementation of screening, brief intervention, and referral to treatment has improved screening, use of validated screening tools, and preventive messaging. Current intervention strategies for cannabis use are associated with modest, short-term effects, and referral to treatment is limited by availability of resources for adolescent substance use. This article provides an update on the evidence base for screening, brief intervention, referral to treatment, and the current state of implementation focused on management of cannabis use disorder.
    MeSH term(s) Adolescent ; Humans ; Child ; Crisis Intervention ; Mental Health ; Mass Screening ; Primary Health Care ; Substance-Related Disorders/diagnosis ; Substance-Related Disorders/therapy ; Referral and Consultation
    Language English
    Publishing date 2023-09-14
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 431518-2
    ISSN 1558-3147 ; 0193-953X
    ISSN (online) 1558-3147
    ISSN 0193-953X
    DOI 10.1016/j.psc.2023.03.001
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  10. Article ; Online: Reply.

    Levy, Samuel / Bergamaschi, Anna

    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

    2023  Volume 22, Issue 3, Page(s) 673–674

    Language English
    Publishing date 2023-10-19
    Publishing country United States
    Document type Letter
    ZDB-ID 2119789-1
    ISSN 1542-7714 ; 1542-3565
    ISSN (online) 1542-7714
    ISSN 1542-3565
    DOI 10.1016/j.cgh.2023.09.038
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