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Article: Redox Regulation of Mitochondrial Potassium Channels Activity.

Lewandowska, Joanna / Kalenik, Barbara / Wrzosek, Antoni / Szewczyk, Adam

2024 Volume 13, Issue 4

Abstract: Redox reactions exert a profound influence on numerous cellular functions with mitochondria playing a central role in orchestrating these processes. This pivotal involvement arises from three primary factors: (1) the synthesis of reactive oxygen species ( ...

Abstract	Redox reactions exert a profound influence on numerous cellular functions with mitochondria playing a central role in orchestrating these processes. This pivotal involvement arises from three primary factors: (1) the synthesis of reactive oxygen species (ROS) by mitochondria, (2) the presence of a substantial array of redox enzymes such as respiratory chain, and (3) the responsiveness of mitochondria to the cellular redox state. Within the inner mitochondrial membrane, a group of potassium channels, including ATP-regulated, large conductance calcium-activated, and voltage-regulated channels, is present. These channels play a crucial role in conditions such as cytoprotection, ischemia/reperfusion injury, and inflammation. Notably, the activity of mitochondrial potassium channels is intricately governed by redox reactions. Furthermore, the regulatory influence extends to other proteins, such as kinases, which undergo redox modifications. This review aims to offer a comprehensive exploration of the modulation of mitochondrial potassium channels through diverse redox reactions with a specific focus on the involvement of ROS.
Language	English
Publishing date	2024-04-03
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox13040434
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Bilateral dentoalveolar asymmetries in female patients with adolescent idiopathic scoliosis.

Lewandowska, Joanna / Opydo-Szymaczek, Justyna / Mehr, Katarzyna / Głowacki, Jakub

Acta of bioengineering and biomechanics

2020 Volume 21, Issue 4, Page(s) 53–62

Abstract: Purpose: The aim of this cross-sectional research was to quantify left-right dentoalveolar fluctuating (FA) and directional asymmetries (DA) in patients with adolescent idiopathic scoliosis and to assess the relationship between these asymmetries and ... ...

Abstract	Purpose: The aim of this cross-sectional research was to quantify left-right dentoalveolar fluctuating (FA) and directional asymmetries (DA) in patients with adolescent idiopathic scoliosis and to assess the relationship between these asymmetries and the side, location, and severity of scoliosis. Materials and methods: The study group comprised of 60 females aged 12-16 years, with idiopathic scoliosis, and 54 healthy controls. Measurements were made with the use of digital caliper on full-mouth dental casts. The following variables were measured from each subject: a shift of the incisor midline, left and right incisor overjet, deviation of canine and buccal segment relation as well as maxillary and mandibular arch chords. The data were statistically analyzed with significance taken as p < 0.05. Results: Statistically significant differences in the mean shift of the incisor midline, buccal segment relation on the left and canine deviation on the left between the control group and the study group were detected ( p = 0.0419, p = 0.0.458 and p = 0.0204, respectively). FA of the midline deviation and canine deviation were statistically significantly higher for subjects with IS, compared to healthy controls ( p = 0.0315 and p = 0.0415, respectively). Neither direction of the curve nor apical vertebra's location or apical translation significantly affected the magnitude of dentoalveolar asymmetries. Conclusions: Our results confirmed that bilateral asymmetries are a common feature of the young females' occlusion. Individuals with IS show higher tendency to Angle Class II malocclusion, as well as higher FA of incisor midline discrepancy and canine deviation, compared to the controls.
MeSH term(s)	Adolescent ; Alveolar Process/pathology ; Child ; Female ; Humans ; Incisor/pathology ; Malocclusion, Angle Class II/pathology ; Scoliosis/pathology
Language	English
Publishing date	2020-02-05
Publishing country	Poland
Document type	Journal Article
ZDB-ID	2559094-7
ISSN	1509-409X
ISSN	1509-409X
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: The Influence of Urban Conditions on the Phenology of Aesculus hippocastanum L. Using the Example of Wroclaw (Poland)

Orzechowska-Szajda, Iwona Dominika / Sobolewski, Robert Krzysztof / Lewandowska, Joanna / Kowalska, Paulina / Kalbarczyk, Robert

Forests. 2020 Nov. 26, v. 11, no. 12

2020

Abstract: The differences in plant phenology between rural and urban areas are the subject of research conducted all over the world. There are few studies aimed at assessing the impact of the urban heat island on plant vegetation only in urban areas. The aim of ... ...

Abstract	The differences in plant phenology between rural and urban areas are the subject of research conducted all over the world. There are few studies aimed at assessing the impact of the urban heat island on plant vegetation only in urban areas. The aim of this study is to assess the impact of the distance from the city center and the form of land cover on the phenological development of trees using the example of the horse chestnut (Aesculus hippocastanum L.). The research area covered the entire city of Wrocław. In order to best capture the impact of the distance from the city center on the rate of changes of individual phenophases, 3 areas were designated—at a distance of 1 km, 2 km and 5 km. The study assessed the average duration of individual phenological phases along with the variability characteristics for leafing, flowering and fruiting in relation to the designated zones and classified forms of land cover based on mean value (x¯) and standard deviation (±SD) in individual weeks of the year. For the leafing and flowering phases, the frequency of the occurrence of phases in individual weeks of the year was analyzed in relation to the designated zones and classified land use methods. The results obtained on the basis of phenological observations carried out in 2017 in Wrocław confirmed the extension of the period of vegetation in the city center in relation to its peripheries. Trees growing in road lanes entered the vegetation period later and defoliated faster, which confirms the negative impact of street conditions on the development of trees in urban space. Thus, the growing season in road lanes is shorter and due to the 1-year observation period, it is justified to conduct further observations.
Keywords	Aesculus hippocastanum ; area ; duration ; flowering ; forests ; frequency ; fruiting ; growing season ; heat island ; land cover ; land use ; occurrence ; phenology ; research ; standard deviation ; trees ; variability ; Poland
Language	English
Dates of publication	2020-1126
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
Note	NAL-light
ZDB-ID	2527081-3
ISSN	1999-4907
ISSN	1999-4907
DOI	10.3390/f11121261
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Level of physical activity of physical education students according to criteria of the IPAQ questionnaire and the recommendation of WHO experts

Pastuszak Anna / Lisowski Krzysztof / Lewandowska Joanna / Buśko Krzysztof

Biomedical Human Kinetics, Vol 6, Iss

2014 Volume 1

Abstract: Study aim: Systematic physical activity is an effective preventive measure that supports the preservation of physical health and psychological health. Three expressions employed that relate to the work carried out with MET-min/week as a measure of the ... ...

Abstract	Study aim: Systematic physical activity is an effective preventive measure that supports the preservation of physical health and psychological health. Three expressions employed that relate to the work carried out with MET-min/week as a measure of the level of total physical activity are intense activity, moderate activity, and walking. These were applied to students studying Physical Education. In the process, those who failed to meet the requirements for the ‘sufficient’ level according to IPAQ criteria and as recommended by the WHO were identified.
Keywords	ipaq ; recommendations who ; physical activity ; students ; Sports medicine ; RC1200-1245 ; Physiology ; QP1-981
Language	English
Publishing date	2014-01-01T00:00:00Z
Publisher	Sciendo
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: DNA methylation in cancer development, diagnosis and therapy--multiple opportunities for genotoxic agents to act as methylome disruptors or remediators.

Lewandowska, Joanna / Bartoszek, Agnieszka

Mutagenesis

2011 Volume 26, Issue 4, Page(s) 475–487

Abstract: The role of DNA methylation and recently discovered hydroxymethylation in the function of the human epigenome is currently one of the hottest topics in the life sciences. Progress in this field of research has been further accelerated by the discovery ... ...

Abstract	The role of DNA methylation and recently discovered hydroxymethylation in the function of the human epigenome is currently one of the hottest topics in the life sciences. Progress in this field of research has been further accelerated by the discovery that alterations in the methylome are not only associated with key functions of cells and organisms, such as development, differentiation and gene expression, but may underlie a number of human diseases, including cancer. This review describes both well established and more recent observations concerning alterations in the methylome, i.e. the global and local distribution of 5-methylcytosines, involved in its normal functions. Then, the changes in DNA methylation pattern seen in cancer cells are discussed in the context of their utilisation in cancer diagnostics and treatment. On this basis, comparisons are made between natural covalent DNA modification and that induced by genotoxic agents, chemical carcinogens and antitumour drugs as regards their impact on epigenetic mechanisms. The available data suggest that DNA damage by genotoxins can mimic epigenetic markers and in consequence disrupt the proper function of the epigenome. On the other hand, the same processes in cancer cells, e.g. DNA demethylation as a result of DNA methyltransferase blocking or the induction of DNA repair by DNA adducts, may restore the activity of hypermethylated anticancer genes. The observed multiple mechanisms by which genotoxic agents directly affect methylome function suggest that chemical carcinogens act primarily as epigenome disruptors, whereas mutations are secondary events that occur at later stages of cancer development when genome-protecting mechanisms have already been deregulated.
MeSH term(s)	Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; DNA Damage ; DNA Methylation/drug effects ; DNA Methylation/genetics ; Gene Silencing/drug effects ; Humans ; Mutagens/toxicity ; Neoplasms/diagnosis ; Neoplasms/drug therapy ; Neoplasms/genetics ; Neoplasms/pathology
Chemical Substances	Antineoplastic Agents ; Mutagens
Language	English
Publishing date	2011-07
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	632903-2
ISSN	1464-3804 ; 0267-8357
ISSN (online)	1464-3804
ISSN	0267-8357
DOI	10.1093/mutage/ger019
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Article: BiosurfactantâProtein Mixtures: Quillaja Bark Saponin at Water/Air and Water/Oil Interfaces in Presence of Î²-Lactoglobulin

Piotrowski, Marek / Lewandowska Joanna / Wojciechowski Kamil

Journal of physical chemistry. 2012 Apr. 26, v. 116, no. 16

2012

Abstract: The adsorption kinetics of mixtures of a biosurfactant Quillaja Bark Saponin (QBS) with a globular protein, Î²-lactoglobulin (Î²-LG) at the water/air and water/tetradecane interfaces was investigated by measuring dynamic interfacial tension with ... ...

Abstract	The adsorption kinetics of mixtures of a biosurfactant Quillaja Bark Saponin (QBS) with a globular protein, Î²-lactoglobulin (Î²-LG) at the water/air and water/tetradecane interfaces was investigated by measuring dynamic interfacial tension with axisymmetric drop shape analysis (ADSA) and maximum bubble pressure (MBP) techniques. With bulk concentration of Î²-LG fixed at 10ââ· M, the most pronounced synergistic effects in the rate of the QBS adsorption at both interfaces were observed at low biosurfactant concentrations (5 Ã 10ââ·â1 Ã 10ââµ M). The synergistic effect due to a protein-biosurfactant complex formation is clearly noticeable, yet less pronounced than, e.g., previously studied QBS/lysozyme mixtures. The surface pressures attained at water/oil interface are higher than in the water/air system, although, at high biosurfactant/protein ratios, the presence of Î²-LG decelerates adsorption of the QBS/Î²-LG complex onto the water/tetradecane interface. In analogy to mixtures of synthetic surfactants with proteins, the adsorbed layer gets dominated by QBS at higher biosurfactant concentrations, although the presence of Î²-LG affects the surface pressures attained even at QBS/Î²-LG ratios as high as 10â´. The synergistic effects are much less noticeable in foamability and emulsion formation/stability, as probed by the modified Bikermanâs and dynamic light scattering (DLS) techniques, respectively.
Keywords	Quillaja ; adsorption ; air ; bark ; beta-lactoglobulin ; biosurfactants ; emulsions ; light scattering ; lysozyme ; oils ; saponins ; surface tension ; synergism
Language	English
Dates of publication	2012-0426
Size	p. 4843-4850.
Publishing place	American Chemical Society
Document type	Article
ISSN	1520-5207
DOI	10.1021%2Fjp301174d
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Biosurfactant-protein mixtures: Quillaja Bark Saponin at water/air and water/oil interfaces in presence of β-lactoglobulin.

Piotrowski, Marek / Lewandowska, Joanna / Wojciechowski, Kamil

The journal of physical chemistry. B

2012 Volume 116, Issue 16, Page(s) 4843–4850

Abstract: The adsorption kinetics of mixtures of a biosurfactant Quillaja Bark Saponin (QBS) with a globular protein, β-lactoglobulin (β-LG) at the water/air and water/tetradecane interfaces was investigated by measuring dynamic interfacial tension with ... ...

Abstract	The adsorption kinetics of mixtures of a biosurfactant Quillaja Bark Saponin (QBS) with a globular protein, β-lactoglobulin (β-LG) at the water/air and water/tetradecane interfaces was investigated by measuring dynamic interfacial tension with axisymmetric drop shape analysis (ADSA) and maximum bubble pressure (MBP) techniques. With bulk concentration of β-LG fixed at 10(-7) M, the most pronounced synergistic effects in the rate of the QBS adsorption at both interfaces were observed at low biosurfactant concentrations (5 × 10(-7)-1 × 10(-5) M). The synergistic effect due to a protein-biosurfactant complex formation is clearly noticeable, yet less pronounced than, e.g., previously studied QBS/lysozyme mixtures. The surface pressures attained at water/oil interface are higher than in the water/air system, although, at high biosurfactant/protein ratios, the presence of β-LG decelerates adsorption of the QBS/β-LG complex onto the water/tetradecane interface. In analogy to mixtures of synthetic surfactants with proteins, the adsorbed layer gets dominated by QBS at higher biosurfactant concentrations, although the presence of β-LG affects the surface pressures attained even at QBS/β-LG ratios as high as 10(4). The synergistic effects are much less noticeable in foamability and emulsion formation/stability, as probed by the modified Bikerman's and dynamic light scattering (DLS) techniques, respectively.
MeSH term(s)	Adsorption ; Air ; Alkanes/chemistry ; Lactoglobulins/chemistry ; Models, Molecular ; Molecular Conformation ; Plant Bark/chemistry ; Quillaja/chemistry ; Saponins/chemistry ; Surface Properties ; Surface-Active Agents/chemistry ; Water/chemistry
Chemical Substances	Alkanes ; Lactoglobulins ; Saponins ; Surface-Active Agents ; n-tetradecane (03LY784Y58) ; Water (059QF0KO0R)
Language	English
Publishing date	2012-04-26
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1520-5207
ISSN (online)	1520-5207
DOI	10.1021/jp301174d
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Les télécoms en Europe centrale

Lewandowska, Joanna

Le courrier des pays de l'Est : politique, économie et société (4.2001), p. 52-68

privatisations et libéralisation

2001 , Page(s) 52–68

Author's details	Joanna Lewandowska
Keywords	Telekommunikationspolitik ; Deregulierung ; Privatisierung ; Auslandsinvestition ; Osteuropa
Language	French
Publisher	La Documentation Française
Publishing place	Paris
Document type	Article
Note	Zsfassung in engl. Sprache
ZDB-ID	973815-0
Database	ECONomics Information System

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Article: Somatotype variables related to muscle torque and power in judoists.

Lewandowska, Joanna / Buśko, Krzysztof / Pastuszak, Anna / Boguszewska, Katarzyna

Journal of human kinetics

2011 Volume 30, Page(s) 21–28

Abstract: The purpose of this study was to examine the relationship between somatotype, muscle torque and power output in judoists. Thirteen judoists (age 18.4±3.1 years, body height 178.6±8.2 cm, body mass 82.3±15.9 kg) volunteered to participate in this study. ... ...

Abstract	The purpose of this study was to examine the relationship between somatotype, muscle torque and power output in judoists. Thirteen judoists (age 18.4±3.1 years, body height 178.6±8.2 cm, body mass 82.3±15.9 kg) volunteered to participate in this study. Somatotype was determined using the Heath-Carter method. Maximal muscle torques of elbow, shoulder, knee, hip and trunk flexors as well as extensors were measured under static conditions. Power outputs were measured in 5 maximal cycle ergometer exercise bouts, 10 s each, at increasing external loads equal to 2.5, 5.0, 7.5, 10.0 and 12.5% of body weight. The Pearson's correlation coefficients were calculated between all parameters. The mean somatotype of judoists was: 3.5-5.9-1.8 (values for endomorphy, mesomorphy and ectomorphy, respectively). The values (mean±SD) of sum of muscle torque of ten muscle groups (TOTAL) was 3702.2±862.9 N x m. The power output ranged from 393.2±79.4 to 1077.2±275.4 W. The values of sum of muscle torque of right and left upper extremities (SUE), sum of muscle torque of right and left lower extremities (SLE), sum of muscle torque of the trunk (ST) and TOTAL were significantly correlated with the mesomorphic component (0.68, 0.80, 0.71 and 0.78, respectively). The ectomorphic component correlated significantly with values of SUE, SLE, ST and TOTAL (-0.69, -0.81, -0.71 and -0.79, respectively). Power output was also strongly correlated with both mesomorphy (positively) and ectomorphy (negatively). The results indicated that the values of mesomorphic and ectomorphic somatotype components influence muscle torque and power output, thus body build could be an important factor affecting results in judo.
Language	English
Publishing date	2011-12-25
Publishing country	Poland
Document type	Journal Article
ZDB-ID	2503989-1
ISSN	1899-7562 ; 1640-5544
ISSN (online)	1899-7562
ISSN	1640-5544
DOI	10.2478/v10078-011-0069-y
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Somatic profile of competitive sport climbers.

Tomaszewski, Paweł / Gajewski, Jan / Lewandowska, Joanna

Journal of human kinetics

2011 Volume 29, Page(s) 107–113

Abstract: Since rock climbing grows in popularity, the number of the respective scientific reports increases. However, those concerning anthropometric profile of elite climbers are scarce and inconsistent, thus the aim of the study was to describe the ... ...

Abstract	Since rock climbing grows in popularity, the number of the respective scientific reports increases. However, those concerning anthropometric profile of elite climbers are scarce and inconsistent, thus the aim of the study was to describe the anthropometric characteristics of competitive sport climbers. Male rock climbers (n = 21) aged 17 - 29 years took part in the study; their climbing ability ranged from 6b to 8c in the French scale. Body height, body mass, arm span, length and girths of both extremities, shoulder and pelvis widths, as well as thickness of 5 skinfolds were determined. From these, body mass index (BMI), body fat content and selected anthropometric indices were calculated. Data collected for climbers were compared with those of untrained students (n = 165) of Warsaw Technical University. Although no between-group differences were found for body height, body mass, BMI or body fat content, the climbers exhibited significantly (p<0.001) lower pelvis-to-shoulder ratio, longer lower extremities (p<0.05), and greater arm length and arm span (p<0.001) compared to untrained students. The results of this study do not support the view that climbers are small in stature and of low body mass. It seems that the core of the issue is not in body size but rather in specific body proportions and this may be of great importance in selecting subjects to competitive sport climbing.
Language	English
Publishing date	2011-10-04
Publishing country	Poland
Document type	Journal Article
ZDB-ID	2503989-1
ISSN	1899-7562 ; 1640-5544
ISSN (online)	1899-7562
ISSN	1640-5544
DOI	10.2478/v10078-011-0044-7
Database	MEDical Literature Analysis and Retrieval System OnLINE

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