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  1. Book: HIV vaccines and cure

    Zhang, Linqi / Lewin, Sharon R.

    the path towards finding an effective cure and vaccine

    (Advances in experimental medicine and biology ; 1075)

    2018  

    Author's details Linqi Zhang, Sharon R. Lewin, editors
    Series title Advances in experimental medicine and biology ; 1075
    Collection
    Language English
    Size xv, 318 Seiten, Illustrationen, 23.5 cm x 15.5 cm
    Publisher Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book
    HBZ-ID HT019765652
    ISBN 978-981-13-0483-5 ; 9789811304842 ; 981-13-0483-1 ; 981130484X
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 3192 -1075- not available for loan Zeitschriften-Lesesaal

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  2. Article ; Online: Expanding the toolbox of HIV self-testing at home: the importance of user choice and feedback.

    Williamson, Deborah A / Lewin, Sharon R

    The Medical journal of Australia

    2022  Volume 217, Issue 3, Page(s) 141–142

    MeSH term(s) Feedback ; HIV Infections/diagnosis ; Humans ; Self-Testing ; Sexually Transmitted Diseases
    Language English
    Publishing date 2022-07-11
    Publishing country Australia
    Document type Editorial ; Comment
    ZDB-ID 186082-3
    ISSN 1326-5377 ; 0025-729X
    ISSN (online) 1326-5377
    ISSN 0025-729X
    DOI 10.5694/mja2.51649
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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  3. Article ; Online: Combination treatment prevents HIV re-emergence in monkeys.

    Lewin, Sharon R

    Nature

    2018  Volume 563, Issue 7731, Page(s) 333–335

    MeSH term(s) Animals ; Antibodies ; Extracellular Space ; HIV ; Haplorhini ; Immunosuppressive Agents
    Chemical Substances Antibodies ; Immunosuppressive Agents
    Language English
    Publishing date 2018-11-07
    Publishing country England
    Document type News ; Comment
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/d41586-018-06818-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Editorial: Strategies and barriers for hepatitis B cure: implications for HIV.

    Revill, Peter A / Lewin, Sharon R

    Current opinion in HIV and AIDS

    2021  Volume 15, Issue 3, Page(s) 151–156

    MeSH term(s) Antiviral Agents/therapeutic use ; HIV Infections/drug therapy ; Hepatitis B/drug therapy ; Humans
    Chemical Substances Antiviral Agents
    Language English
    Publishing date 2021-03-01
    Publishing country United States
    Document type Editorial
    ZDB-ID 2502511-9
    ISSN 1746-6318 ; 1746-630X
    ISSN (online) 1746-6318
    ISSN 1746-630X
    DOI 10.1097/COH.0000000000000620
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: A cure for HIV: how would we know?

    Zerbato, Jennifer M / Lewin, Sharon R

    The lancet. HIV

    2020  Volume 7, Issue 5, Page(s) e304–e306

    MeSH term(s) HIV Infections ; HIV Seropositivity ; HIV-1 ; Hematopoietic Stem Cell Transplantation ; Humans
    Language English
    Publishing date 2020-03-10
    Publishing country Netherlands
    Document type Journal Article ; Comment
    ISSN 2352-3018
    ISSN (online) 2352-3018
    DOI 10.1016/S2352-3018(20)30075-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Toll-like Receptor 7 Agonists in People Living With HIV: Implications for Immunotherapeutic Strategies for an HIV Cure.

    Rasmussen, Thomas A / Lewin, Sharon R

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2020  Volume 72, Issue 11, Page(s) e825–e827

    MeSH term(s) HIV Infections ; HIV-1 ; Humans ; Immunotherapy ; Toll-Like Receptor 7 ; Virus Latency
    Chemical Substances Toll-Like Receptor 7
    Language English
    Publishing date 2020-10-29
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciaa1539
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Kick and kill for HIV latency.

    Lewin, Sharon R / Rasmussen, Thomas A

    Lancet (London, England)

    2020  Volume 395, Issue 10227, Page(s) 844–846

    MeSH term(s) Anti-HIV Agents ; HIV Infections ; HIV-1 ; Humans
    Chemical Substances Anti-HIV Agents
    Language English
    Publishing date 2020-02-19
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(20)30264-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Reducing the gap between the diagnosis and treatment of HIV infection.

    Singh, Kasha P / Lewin, Sharon R

    The Medical journal of Australia

    2019  Volume 210, Issue 6, Page(s) 261–262

    MeSH term(s) Acquired Immunodeficiency Syndrome ; Australia ; HIV Infections ; Humans
    Language English
    Publishing date 2019-03-30
    Publishing country Australia
    Document type Editorial ; Comment
    ZDB-ID 186082-3
    ISSN 1326-5377 ; 0025-729X
    ISSN (online) 1326-5377
    ISSN 0025-729X
    DOI 10.5694/mja2.50114
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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  9. Article ; Online: Viral, inflammatory, and reservoir characteristics of posttreatment controllers.

    McMahon, James / Lewin, Sharon R / Rasmussen, Thomas A

    Current opinion in HIV and AIDS

    2021  Volume 16, Issue 5, Page(s) 249–256

    Abstract: Purpose of review: To provide an overview of studies to date that have identified posttreatment controllers (PTCs) and to explore current evidence around clinical characteristics, immune effector function, and inflammatory and viral reservoir ... ...

    Abstract Purpose of review: To provide an overview of studies to date that have identified posttreatment controllers (PTCs) and to explore current evidence around clinical characteristics, immune effector function, and inflammatory and viral reservoir characteristics that may underlie the control mechanism.
    Recent findings: PTCs are broadly defined as individuals capable of maintaining control of HIV replication after cessation of antiretroviral therapy (ART). While starting ART early after HIV infection is associated with PTC, genetic disposition or CD8+ T-cell function do not appear to explain this phenomenon, but these features have not been exhaustively analyzed in PTCs. A lower frequency of latently infected cells prior to stopping ART has been associated with achieving PTC, including a lower level of intact HIV DNA, but more studies are needed to map the genetic location, epigenetic characteristics, and tissue distribution of the intact HIV reservoir in PTCs.
    Summary: Current studies are small and heterogeneous and there is a significant need to agree on a uniform definition of PTC. Many aspects of PTC are still unexplored including whether specific features of genetic disposition, immune effector functions, and/or viral reservoir characteristics play a role in PTC. A large multisite international cohort study could aide in providing the important insights needed to fully understand PTC.
    MeSH term(s) CD4-Positive T-Lymphocytes ; CD8-Positive T-Lymphocytes ; Cohort Studies ; HIV Infections/drug therapy ; Humans ; Viral Load ; Virus Replication
    Language English
    Publishing date 2021-08-09
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2502511-9
    ISSN 1746-6318 ; 1746-630X
    ISSN (online) 1746-6318
    ISSN 1746-630X
    DOI 10.1097/COH.0000000000000699
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Immune checkpoint blockade in HIV.

    Gubser, Celine / Chiu, Chris / Lewin, Sharon R / Rasmussen, Thomas A

    EBioMedicine

    2022  Volume 76, Page(s) 103840

    Abstract: Antiretroviral therapy (ART) has dramatically improved life expectancy for people with HIV (PWH) and helps to restore immune function but is not curative and must be taken lifelong. Achieving long term control of HIV in the absence of ART will likely ... ...

    Abstract Antiretroviral therapy (ART) has dramatically improved life expectancy for people with HIV (PWH) and helps to restore immune function but is not curative and must be taken lifelong. Achieving long term control of HIV in the absence of ART will likely require potent T cell function, but chronic HIV infection is associated with immune exhaustion that persists even on ART. This is driven by elevated expression of immune checkpoints that provide negative signalling to T cells. In individuals with cancer, immune checkpoint blockade augments tumour-directed T-cell responses resulting in significant clinical cures. There is therefore high interest if ICB can contribute to HIV cure or remission by reversing HIV-latency and/or drive recovery of HIV-specific T-cells. We here review recent evidence on the role of immune checkpoints in persistent HIV infection and discuss the potential for employing immune checkpoint blockade as a therapeutic approach to target HIV persistence on ART.
    MeSH term(s) CD4-Positive T-Lymphocytes ; HIV Infections/drug therapy ; HIV-1 ; Humans ; Immune Checkpoint Inhibitors/pharmacology ; Immune Checkpoint Inhibitors/therapeutic use
    Chemical Substances Immune Checkpoint Inhibitors
    Language English
    Publishing date 2022-02-02
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2851331-9
    ISSN 2352-3964
    ISSN (online) 2352-3964
    DOI 10.1016/j.ebiom.2022.103840
    Database MEDical Literature Analysis and Retrieval System OnLINE

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