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  1. Book: Radiopharmaceutical Therapy

    Bodei, Lisa / Zeglis, Brian M. / Lewis, Jason S.

    2023  

    Author's details Lisa Bodei, MD, PhD is a nuclear medicine physician with extensive experience and expertise in therapeutic and diagnostic applications of nuclear medicine in oncology, particularly with theranostics and the application of genomic technology to further defining the efficacy of theranostics. She is the Director of the Targeted Radionuclide Therapy Section of the Molecular Imaging and Therapy Service in the Department of Radiology, MSKCC. She has authored more than 200 peer-reviewed publications and serves on the editorial boards of several scientific journals. Jason S. Lewis, PhD, is the Emily Tow Chair, Chief of the Radiochemistry and Imaging Sciences Service, and Director of the Radiochemistry and Molecular Imaging Probe Core Facility in the Department of Radiology, MSKCC. He heads a laboratory in the Sloan Kettering Institute's molecular pharmacology program and is a professor at the Gerstner Sloan Kettering Graduate School of BiomedicalSciences. He has published more than 300 pape
    Keywords Radiotherapy ; Cancer therapy ; endoradiotherapy ; Radiotherapeutics ; Cancer Imaging ; Radiobiology ; biochemistry ; Medical Physics ; radiopharmaceutical chemistry ; Radioimmunotherapy ; radiotherapy ; cancer therapy ; cancer imaging ; Medical physics
    Language English
    Size 576 p.
    Edition 1
    Publisher Springer International Publishing
    Document type Book
    Note PDA Manuell_23
    Format 183 x 260 x 35
    ISBN 9783031390043 ; 3031390040
    Database PDA

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  2. Article ; Online: Click Here for Better Chemistry.

    Zeglis, Brian M / Lewis, Jason S

    The New England journal of medicine

    2022  Volume 387, Issue 24, Page(s) 2291–2293

    Language English
    Publishing date 2022-11-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMcibr2213596
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Changing of the Guard at Molecular Imaging & Biology.

    Lewis, Jason S

    Molecular imaging and biology

    2019  Volume 22, Issue 1, Page(s) 1–3

    Language English
    Publishing date 2019-12-02
    Publishing country United States
    Document type Editorial
    ZDB-ID 2079160-4
    ISSN 1860-2002 ; 1536-1632
    ISSN (online) 1860-2002
    ISSN 1536-1632
    DOI 10.1007/s11307-019-01446-y
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  4. Article ; Online: Radiopharmaceuticals for Cancer Diagnosis and Therapy: New Targets, New Therapies-Alpha-Emitters, Novel Targets.

    Taunk, Neil K / Escorcia, Freddy E / Lewis, Jason S / Bodei, Lisa

    Cancer journal (Sudbury, Mass.)

    2024  Volume 30, Issue 3, Page(s) 218–223

    Abstract: Abstract: Radiopharmaceutical therapy has emerged as a promising approach for the treatment of various cancers. The exploration of novel targets such as tumor-specific antigens, overexpressed receptors, and intracellular biomolecules using antibodies, ... ...

    Abstract Abstract: Radiopharmaceutical therapy has emerged as a promising approach for the treatment of various cancers. The exploration of novel targets such as tumor-specific antigens, overexpressed receptors, and intracellular biomolecules using antibodies, peptides, or small molecules has expanded the scope of radiopharmaceutical therapy, enabling precise and effective cancer treatment for an increasing number of tumor types. Alpha emitters, characterized by their high linear energy transfer and short path length, offer unique advantages in targeted therapy due to their potent cytotoxicity against cancer cells while sparing healthy tissues. This article reviews recent advancements in identifying novel targets for radiopharmaceutical therapy and applications in utilizing α-emitters for targeted treatment.
    MeSH term(s) Humans ; Radiopharmaceuticals/therapeutic use ; Neoplasms/therapy ; Neoplasms/diagnosis ; Neoplasms/drug therapy ; Alpha Particles/therapeutic use ; Molecular Targeted Therapy/methods ; Animals
    Language English
    Publishing date 2024-05-14
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2018400-1
    ISSN 1540-336X ; 1528-9117 ; 1081-4442
    ISSN (online) 1540-336X
    ISSN 1528-9117 ; 1081-4442
    DOI 10.1097/PPO.0000000000000720
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  5. Article ; Online: Methods for the Production of Radiolabeled Bioagents for ImmunoPET.

    Arroyo, Alejandro / Lyashchenko, Serge K / Lewis, Jason S

    Methods in molecular biology (Clifton, N.J.)

    2023  Volume 2729, Page(s) 117–142

    Abstract: Immunoglobulin-based positron emission tomography (ImmunoPET) is making increasingly significant contributions to the nuclear imaging toolbox. The exquisite specificity of antibodies combined with the high-resolution imaging of PET enables clinicians and ...

    Abstract Immunoglobulin-based positron emission tomography (ImmunoPET) is making increasingly significant contributions to the nuclear imaging toolbox. The exquisite specificity of antibodies combined with the high-resolution imaging of PET enables clinicians and researchers to localize diseases, especially cancer, with a high degree of spatial certainty. This review focuses on the radiopharmaceutical preparation necessary to obtain those images-the work behind the scenes, which occurs even before the patient or animal is injected with the radioimmunoconjugate. The focus of this methods review will be the chelation of four radioisotopes to their most common and clinically relevant chelators.
    MeSH term(s) Animals ; Humans ; Positron-Emission Tomography/methods ; Radioisotopes ; Radiopharmaceuticals ; Antibodies ; Neoplasms ; Chelating Agents ; Zirconium
    Chemical Substances Radioisotopes ; Radiopharmaceuticals ; Antibodies ; Chelating Agents ; Zirconium (C6V6S92N3C)
    Language English
    Publishing date 2023-11-25
    Publishing country United States
    Document type Review ; Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-3499-8_8
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  6. Article ; Online: State-of-the-Art of Radiometal-based Bioconjugates for Molecular Imaging and Radiotherapy.

    Ma, Michelle T / Lewis, Jason S

    Bioconjugate chemistry

    2021  Volume 32, Issue 7, Page(s) 1175–1176

    MeSH term(s) Metals/chemistry ; Molecular Imaging/methods ; Radiotherapy/methods
    Chemical Substances Metals
    Language English
    Publishing date 2021-07-20
    Publishing country United States
    Document type Editorial
    ZDB-ID 1024041-x
    ISSN 1520-4812 ; 1043-1802
    ISSN (online) 1520-4812
    ISSN 1043-1802
    DOI 10.1021/acs.bioconjchem.1c00303
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    Zs.A 3400: Show issues Location:
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  7. Article: Exploring the PET in vivo generator

    Bauer, David / De Gregorio, Roberto / Pratt, Edwin C / Bell, Abram / Michel, Alexa / Lewis, Jason S

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Purpose: The radionuclide pair cerium-134/lanthanum-134 (: Methods: The precursor PSMA-617 and a macropa-based tetrazine-conjugate (mcp-PEG: Results: In vitro and in vivo studies with both : Conclusion: When employing slow-internalizing vectors, ...

    Abstract Purpose: The radionuclide pair cerium-134/lanthanum-134 (
    Methods: The precursor PSMA-617 and a macropa-based tetrazine-conjugate (mcp-PEG
    Results: In vitro and in vivo studies with both
    Conclusion: When employing slow-internalizing vectors,
    Language English
    Publishing date 2024-04-28
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.04.25.591165
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  8. Article ; Online: Click chemistry: a transformative technology in nuclear medicine.

    Bauer, David / Sarrett, Samantha M / Lewis, Jason S / Zeglis, Brian M

    Nature protocols

    2023  Volume 18, Issue 6, Page(s) 1659–1668

    Abstract: The 2022 Nobel Prize in Chemistry was awarded to Professors K. Barry Sharpless, Morten Meldal and Carolyn Bertozzi for their pioneering roles in the advent of click chemistry. Sharpless and Meldal worked to develop the canonical click reaction-the copper- ...

    Abstract The 2022 Nobel Prize in Chemistry was awarded to Professors K. Barry Sharpless, Morten Meldal and Carolyn Bertozzi for their pioneering roles in the advent of click chemistry. Sharpless and Meldal worked to develop the canonical click reaction-the copper-catalyzed azide-alkyne cycloaddition-while Bertozzi opened new frontiers with the creation of the bioorthogonal strain-promoted azide-alkyne cycloaddition. These two reactions have revolutionized chemical and biological science by facilitating selective, high yielding, rapid and clean ligations and by providing unprecedented ways to manipulate living systems. Click chemistry has affected every aspect of chemistry and chemical biology, but few disciplines have been impacted as much as radiopharmaceutical chemistry. The importance of speed and selectivity in radiochemistry make it an almost tailor-made application of click chemistry. In this Perspective, we discuss the ways in which the copper-catalyzed azide-alkyne cycloaddition, the strain-promoted azide-alkyne cycloaddition and a handful of 'next-generation' click reactions have transformed radiopharmaceutical chemistry, both as tools for more efficient radiosyntheses and as linchpins of technologies that have the potential to improve nuclear medicine.
    MeSH term(s) Click Chemistry/methods ; Copper ; Nuclear Medicine ; Radiopharmaceuticals ; Azides ; Alkynes ; Cycloaddition Reaction
    Chemical Substances Copper (789U1901C5) ; Radiopharmaceuticals ; Azides ; Alkynes
    Language English
    Publishing date 2023-04-26
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2244966-8
    ISSN 1750-2799 ; 1754-2189
    ISSN (online) 1750-2799
    ISSN 1754-2189
    DOI 10.1038/s41596-023-00825-8
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  9. Article: Radiances of Cerenkov-Emitting Isotopes on the IVIS.

    Pratt, Edwin C / Shaffer, Travis M / Bauer, David / Lewis, Jason S / Grimm, Jan

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Cerenkov (or Cherenkov) luminescence occurs when charged particles exceed the phase velocity of a given medium. Cerenkov has gained interest in preclinical space as well as in clinical trials for optical visualization of numerous radionuclides. However, ... ...

    Abstract Cerenkov (or Cherenkov) luminescence occurs when charged particles exceed the phase velocity of a given medium. Cerenkov has gained interest in preclinical space as well as in clinical trials for optical visualization of numerous radionuclides. However, Cerenkov intensity has to be inferred from alternative databases with energy emission spectra, or theoretical fluence estimates. Here we present the largest experimental dataset of Cerenkov emitting isotopes recorded using the IVIS optical imaging system. We report Cerenkov measurements spanning orders of magnitude normalized to the activity concentration for 21 Cerenkov emitting isotopes, covering electron, alpha, beta minus, and positron emissions. Isotopes measured include Carbon-11, Fluorine-18, Phosphorous-32, Scandium-47, Copper-64, Copper-67, Gallium-68, Arsenic-72, Bromine-76, Yttrium-86, Zirconium-89, Yttrium-90, Iodine-124, Iodine-131, Cerium-134, Lutetium-177, Lead-203, Lead-212, Radium-223, Actinium-225, and Thorium-227. We hope this updating resource will serve as a rank ordering for comparing isotopes for Cerenkov luminescence in the visible window and serve as a rule of thumb for comparing Cerenkov intensities in vitro and in vivo.
    Methods: All Cerenkov emitting radionuclides were either produced at Memorial Sloan Kettering Cancer Center (Carbon-11,
    Language English
    Publishing date 2023-01-20
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.01.18.524625
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  10. Article ; Online: PET and Optical Imaging of Caveolin-1 in Gastric Tumors.

    Surendra Panikar, Sandeep / Shmuel, Shayla / Lewis, Jason S / Pereira, Patrícia M R

    ACS omega

    2023  Volume 8, Issue 39, Page(s) 35884–35892

    Abstract: Previous studies have suggested tumoral caveolin-1 (CAV1) as a predictive biomarker for the response to anti-HER2 antibody drug therapies in gastric tumors. In this study, radiolabeled and fluorescently labeled anti-CAV1 antibodies were developed and ... ...

    Abstract Previous studies have suggested tumoral caveolin-1 (CAV1) as a predictive biomarker for the response to anti-HER2 antibody drug therapies in gastric tumors. In this study, radiolabeled and fluorescently labeled anti-CAV1 antibodies were developed and tested as an immunoPET or optical imaging agent to detect CAV1 in HER2-positive/CAV1-high NCIN87 gastric tumors. The expression of CAV1 receptors in NCIN87 gastric tumors and nontumor murine organs was determined by Western blot. Binding assays were performed to validate the anti-CAV1 antibody specificity for CAV1-expressing NCIN87 cancer cells. Subcutaneous and orthotopic NCIN87 xenografts were used for PET imaging and
    Language English
    Publishing date 2023-09-15
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.3c03614
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