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  1. Article ; Online: Medical communications ushers in the dawn of Augmented Intelligence.

    Lewis, Matt E

    Current medical research and opinion

    2024  Volume 40, Issue 1, Page(s) 3–4

    Language English
    Publishing date 2024-01-03
    Publishing country England
    Document type Editorial
    ZDB-ID 80296-7
    ISSN 1473-4877 ; 0300-7995
    ISSN (online) 1473-4877
    ISSN 0300-7995
    DOI 10.1080/03007995.2023.2290389
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    Zs.A 955: Show issues Location:
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  2. Article ; Online: The AI Roadmap - charting our future in healthcare communications.

    Lewis, Matt / Mercer, Elizabeth

    Current medical research and opinion

    2024  Volume 40, Issue 1, Page(s) 5–7

    Abstract: Figure: see text]. ...

    Abstract [Figure: see text].
    MeSH term(s) Humans ; Delivery of Health Care ; Artificial Intelligence
    Language English
    Publishing date 2024-01-03
    Publishing country England
    Document type Journal Article ; Video-Audio Media
    ZDB-ID 80296-7
    ISSN 1473-4877 ; 0300-7995
    ISSN (online) 1473-4877
    ISSN 0300-7995
    DOI 10.1080/03007995.2023.2261737
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  3. Article ; Online: The phylogeny and divergence times of leaf-mining flies (Diptera: Agromyzidae) from anchored phylogenomics

    Xuan, Jing-Li / Scheffer, Sonja J. / Lewis, Matt / Cassel, Brian K. / Liu, Wan-Xue / Wiegmann, Brian M.

    Molecular Phylogenetics and Evolution. 2023 July, v. 184 p.107778-

    2023  

    Abstract: Leaf-mining flies (Diptera: Agromyzidae) are a diverse clade of phytophagous Diptera known largely for their economic impact as leaf- or stem-miners on vegetable and ornamental plants. Higher-level phylogenetic relationships of Agromyzidae have remained ... ...

    Abstract Leaf-mining flies (Diptera: Agromyzidae) are a diverse clade of phytophagous Diptera known largely for their economic impact as leaf- or stem-miners on vegetable and ornamental plants. Higher-level phylogenetic relationships of Agromyzidae have remained uncertain because of challenges in sampling of both taxa and characters for morphology and PCR-based Sanger-era molecular systematics. Here, we used hundreds of orthologous single-copy nuclear loci obtained from anchored hybrid enrichment (AHE) to reconstruct phylogenetic relationships among the major lineages of leaf-mining flies. The resulting phylogenetic trees are highly congruent and well-supported, except for a few deep nodes, when using different molecular data types and phylogenetic methods. Based on divergence time dating using a relaxed clock model-based analysis, leaf-mining flies are shown to have diversified in multiple lineages since the early Paleocene, approximately 65 million years ago. Our study not only reveals a revised classification system of leaf-mining flies, but also provides a new phylogenetic framework to understand their macroevolution.
    Keywords Agromyzidae ; Paleocene epoch ; economic impact ; hybrids ; molecular systematics ; phylogeny ; polymerase chain reaction ; vegetables ; Diptera ; Leaf-miner ; Phylogenomics ; Divergence times
    Language English
    Dates of publication 2023-07
    Publishing place Elsevier Inc.
    Document type Article ; Online
    ZDB-ID 33610-5
    ISSN 1095-9513 ; 1055-7903
    ISSN (online) 1095-9513
    ISSN 1055-7903
    DOI 10.1016/j.ympev.2023.107778
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  4. Article ; Online: From policy to practice: Lessons learned from an open science funding initiative.

    Dumanis, Sonya B / Ratan, Kristen / McIntosh, Souad / Shah, Hetal V / Lewis, Matt / Vines, Timothy H / Schekman, Randy / Riley, Ekemini A

    PLoS computational biology

    2023  Volume 19, Issue 12, Page(s) e1011626

    Language English
    Publishing date 2023-12-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2193340-6
    ISSN 1553-7358 ; 1553-734X
    ISSN (online) 1553-7358
    ISSN 1553-734X
    DOI 10.1371/journal.pcbi.1011626
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  5. Article ; Online: The phylogeny and divergence times of leaf-mining flies (Diptera: Agromyzidae) from anchored phylogenomics.

    Xuan, Jing-Li / Scheffer, Sonja J / Lewis, Matt / Cassel, Brian K / Liu, Wan-Xue / Wiegmann, Brian M

    Molecular phylogenetics and evolution

    2023  Volume 184, Page(s) 107778

    Abstract: Leaf-mining flies (Diptera: Agromyzidae) are a diverse clade of phytophagous Diptera known largely for their economic impact as leaf- or stem-miners on vegetable and ornamental plants. Higher-level phylogenetic relationships of Agromyzidae have remained ... ...

    Abstract Leaf-mining flies (Diptera: Agromyzidae) are a diverse clade of phytophagous Diptera known largely for their economic impact as leaf- or stem-miners on vegetable and ornamental plants. Higher-level phylogenetic relationships of Agromyzidae have remained uncertain because of challenges in sampling of both taxa and characters for morphology and PCR-based Sanger-era molecular systematics. Here, we used hundreds of orthologous single-copy nuclear loci obtained from anchored hybrid enrichment (AHE) to reconstruct phylogenetic relationships among the major lineages of leaf-mining flies. The resulting phylogenetic trees are highly congruent and well-supported, except for a few deep nodes, when using different molecular data types and phylogenetic methods. Based on divergence time dating using a relaxed clock model-based analysis, leaf-mining flies are shown to have diversified in multiple lineages since the early Paleocene, approximately 65 million years ago. Our study not only reveals a revised classification system of leaf-mining flies, but also provides a new phylogenetic framework to understand their macroevolution.
    MeSH term(s) Genomics ; Phylogeny ; Diptera/genetics ; Animals ; Likelihood Functions ; Genetic Loci
    Language English
    Publishing date 2023-04-07
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 33610-5
    ISSN 1095-9513 ; 1055-7903
    ISSN (online) 1095-9513
    ISSN 1055-7903
    DOI 10.1016/j.ympev.2023.107778
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Identity and Host Plant of Diatraea postlineella Schaus (Lepidoptera: Crambidae), the Guatemalan Sugarcane Borer

    Solis, M. Alma / Scheffer, Sonja J. / Lewis, Matt L. / Rendón, Pedro

    Proceedings of the Entomological Society of Washington. 2021 Oct. 28, v. 123, no. 3, p. 638-651

    2021  , Page(s) 638–651

    Abstract: Diatraea postlineella Schaus, 1922, that we call the Guatemalan sugarcane borer, was described from Quirigua, Guatemala, based on one male specimen; the host was unknown. Recently, more specimens of D. postlineella from Guatemala were discovered and ... ...

    Abstract Diatraea postlineella Schaus, 1922, that we call the Guatemalan sugarcane borer, was described from Quirigua, Guatemala, based on one male specimen; the host was unknown. Recently, more specimens of D. postlineella from Guatemala were discovered and reared on sugarcane (Saccharum officinarum L.). Based on these specimens, morphological and molecular characters support the status of D. postlineella as a separate species. The DNA sequence from the COI barcode region and host plant are reported for the first time. Diatraea postlineella is closely related to D. crambidoides (Grote) and D. mitteri Solis. Photographs of the adults and their genitalia, a comparison of external characters, and a table of male and female genitalia characters to identify the three species are provided. A distribution map of the three species, which includes holotype localities and specimens used for the neighbor-joining cluster analysis, is provided.
    Keywords Diatraea saccharalis ; Saccharum officinarum ; cluster analysis ; female genitalia ; holotypes ; host plants ; males ; nucleotide sequences ; sugarcane ; Guatemala
    Language English
    Dates of publication 2021-1028
    Size p. 638-651
    Publishing place The Entomological Society of Washington
    Document type Article ; Online
    ZDB-ID 2533731-2
    ISSN 0013-8797
    ISSN 0013-8797
    DOI 10.4289/0013-8797.123.3.637
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  7. Article ; Online: Combined molnupiravir-nirmatrelvir treatment improves the inhibitory effect on SARS-CoV-2 in macaques.

    Rosenke, Kyle / Lewis, Matt C / Feldmann, Friederike / Bohrnsen, Eric / Schwarz, Benjamin / Okumura, Atsushi / Bohler, W Forrest / Callison, Julie / Shaia, Carl / Bosio, Catharine M / Lovaglio, Jamie / Saturday, Greg / Jarvis, Michael A / Feldmann, Heinz

    JCI insight

    2023  Volume 8, Issue 4

    Abstract: The periodic emergence of SARS-CoV-2 variants of concern (VOCs) with unpredictable clinical severity and ability to escape preexisting immunity emphasizes the continued need for antiviral interventions. Two small molecule inhibitors, molnupiravir (MK- ... ...

    Abstract The periodic emergence of SARS-CoV-2 variants of concern (VOCs) with unpredictable clinical severity and ability to escape preexisting immunity emphasizes the continued need for antiviral interventions. Two small molecule inhibitors, molnupiravir (MK-4482), a nucleoside analog, and nirmatrelvir (PF-07321332), a 3C-like protease inhibitor, have recently been approved as monotherapy for use in high-risk patients with COVID-19. As preclinical data are only available for rodent and ferret models, here we assessed the efficacy of MK-4482 and PF-07321332 alone and in combination against infection with the SARS-CoV-2 Delta VOC in the rhesus macaque COVID-19 model. Macaques were infected with the SARS-CoV-2 Delta variant and treated with vehicle, MK-4482, PF-07321332, or a combination of MK-4482 and PF-07321332. Clinical exams were performed at 1, 2, and 4 days postinfection to assess disease and virological parameters. Notably, use of MK-4482 and PF-07321332 in combination improved the individual inhibitory effect of both drugs, resulting in milder disease progression, stronger reduction of virus shedding from mucosal tissues of the upper respiratory tract, stronger reduction of viral replication in the lower respiratory tract, and reduced lung pathology. Our data strongly indicate superiority of combined MK-4482 and PF-07321332 treatment of SARS-CoV-2 infections as demonstrated in the closest COVID-19 surrogate model of human infection.
    MeSH term(s) Animals ; Humans ; SARS-CoV-2 ; Macaca mulatta ; COVID-19 ; Ferrets ; Lactams ; Leucine ; Nitriles ; Antiviral Agents
    Chemical Substances molnupiravir (YA84KI1VEW) ; Lactams ; Leucine (GMW67QNF9C) ; Nitriles ; Antiviral Agents
    Language English
    Publishing date 2023-02-22
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Intramural
    ISSN 2379-3708
    ISSN (online) 2379-3708
    DOI 10.1172/jci.insight.166485
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  8. Article: A primer on wireless networks.

    Lewis, Matt

    Family practice management

    2004  Volume 11, Issue 2, Page(s) 69–70

    MeSH term(s) Ambulatory Care Information Systems ; Computer Security ; Computers, Handheld ; Family Practice/organization & administration ; Humans ; Internet ; Medical Records Systems, Computerized ; Practice Management, Medical ; Radio Waves ; Systems Integration ; United States
    Language English
    Publishing date 2004-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1226804-5
    ISSN 1069-5648
    ISSN 1069-5648
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  9. Article: Tidal range energy resource assessment of the Gulf of California, Mexico

    Mejia-Olivares, Carlos Joel / Haigh, Ivan D / Angeloudis, Athanasios / Lewis, Matt J / Neill, Simon P

    Renewable energy. 2020 Aug., v. 155

    2020  

    Abstract: There is growing interest in harnessing renewable energy resources in Latin America. Converting the energy of the tides into electricity has the distinct advantage of being predictable, yet the tidal range resource of Latin America is largely ... ...

    Abstract There is growing interest in harnessing renewable energy resources in Latin America. Converting the energy of the tides into electricity has the distinct advantage of being predictable, yet the tidal range resource of Latin America is largely unquantified. The northern part of the Gulf of California (GC) in Mexico has a relatively large mean tidal range (4m–5m), and so could be a potential site for tidal range energy exploitation. A detailed quantification of the theoretical tidal range energy resource was performed using tidal level predictions from a depth-averaged barotropic hydrodynamic model. In addition, a 0-D operation modelling approach was applied to determine the power that can be technically extracted at four key sites. The results show that the annual energy yield ranges from 20 to 50 kWh/m2, while the maximum values are between 45 and 50 kWh/m2 in the vicinity of the Gulf of Santa Clara. Within the region, the Gulf of Santa Clara is one of the most promising, delivering a technical annual energy output of 125 GWh (ebb-only generation), 159 GWh (two-way) and 174 GWh (two-way with pumping) within an impoundment area of 10 km2. This equates to 50%, 40% and 33% of the absolute energy conversion relative to a much-studied reference site (Swansea Bay, UK) that has been under consideration as the world’s first tidal lagoon power plant. This study provides the basis for more detailed analysis of the GC to guide selection of suitable sites for tidal range energy exploitation in the region.
    Keywords electricity ; energy conversion ; hydrologic models ; power plants ; prediction ; renewable energy sources ; tides ; Gulf of California ; Latin America ; Mexico ; United Kingdom
    Language English
    Dates of publication 2020-08
    Size p. 469-483.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 2001449-1
    ISSN 0960-1481
    ISSN 0960-1481
    DOI 10.1016/j.renene.2020.03.086
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  10. Article: A standardised tidal-stream power curve, optimised for the global resource

    Lewis, Matt / O’Hara Murray, Rory / Fredriksson, Sam / Maskell, John / de Fockert, Anton / Neill, Simon P / Robins, Peter E

    Renewable energy. 2021 June, v. 170

    2021  

    Abstract: Tidal-stream energy resource can be predicted deterministically, provided tidal harmonics and turbine-device characteristics are known. Many turbine designs exist, all having different characteristics (e.g. rated speed), which creates uncertainty in ... ...

    Abstract Tidal-stream energy resource can be predicted deterministically, provided tidal harmonics and turbine-device characteristics are known. Many turbine designs exist, all having different characteristics (e.g. rated speed), which creates uncertainty in resource assessment or renewable energy system-design decision-making. A standardised normalised tidal-stream power-density curve was parameterised with data from 14 operational horizontal-axis turbines (e.g. mean cut-in speed was ∼30% of rated speed). Applying FES2014 global tidal data (1/16° gridded resolution) up to 25 km from the coast, allowed optimal turbine rated speed assessment. Maximum yield was found for turbine rated speed ∼97% of maximum current speed (maxU) using the 4 largest tidal constituents (M2, S2, K1 and O1) and ∼87% maxU for a “high yield” scenario (highest Capacity Factor in top 5% of yield cases); with little spatial variability found for either. Optimisation for firm power (highest Capacity Factor with power gaps less than 2 h), which is important for problematic or expensive energy-storage cases (e.g. off-grid), turbine rated speed of ∼56% maxU was found – but with spatial variability due to tidal form and maximum current speed. We find optimisation and convergent design is possible, and our standardised power curve should help future research in resource and environmental impact assessment.
    Keywords coasts ; decision making ; energy ; environmental assessment ; uncertainty ; water power
    Language English
    Dates of publication 2021-06
    Size p. 1308-1323.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 2001449-1
    ISSN 1879-0682 ; 0960-1481
    ISSN (online) 1879-0682
    ISSN 0960-1481
    DOI 10.1016/j.renene.2021.02.032
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